4,035 research outputs found
Cultivating Capital: Country Bankers and the Transformation of the Central Great Plains, 1870-1940
Bankers in the Central Great Plains region of western Kansas played a significant part in transforming their communities from frontier outposts into components of a modern region. Between 1870 and 1940, country bankers came to see themselves as reformers and advisors in the process of transforming their towns into viable parts of a regional economy, and their influence was considerable. This dissertation contextualizes bankers’ multiple functions within rural communities and adds nuance to popular portrayals of predatory moneylenders. Bankers representing towns typically less than 5,000 in population served as economic, social, and political leaders instrumental in their development. The decisions they made shaped the fortunes of a specific set of rural communities as they navigated severe economic, social, and political challenges, but this story of country bankers driving development efforts while balancing the cultural and social traditions of rural America replicates trends from around the U.S. West and the nation. Contrary to the reputation of businessmen as heartless usurers, these bankers operated instead as cultivators of economic, political, and social power within their communities and the region. They shared the interests of farmers and other rural businesspeople in facing the changes of a modernizing nation
Supporting 'design for reuse' with modular design
Engineering design reuse refers to the utilization of any knowledge gained from the design activity to support future design. As such, engineering design reuse approaches are concerned with the support, exploration, and enhancement of design knowledge prior, during, and after a design activity. Modular design is a product structuring principle whereby products are developed with distinct modules for rapid product development, efficient upgrades, and possible reuse (of the physical modules). The benefits of modular design center on a greater capacity for structuring component parts to better manage the relation between market requirements and the designed product. This study explores the capabilities of modular design principles to provide improved support for the engineering design reuse concept. The correlations between modular design and 'reuse' are highlighted, with the aim of identifying its potential to aid the little-supported process of design for reuse. In fulfilment of this objective the authors not only identify the requirements of design for reuse, but also propose how modular design principles can be extended to support design for reuse
NK cell killer immunoglobulin receptor (KIR) reconstitution and interferon production after unrelated donor (URD) transplantation is altered by the T-cell content of the graft and correlates with acute GVHD
Nucleation versus Spinodal decomposition in a first order quark hadron phase transition
We investigate the scenario of homogeneous nucleation for a first order
quark-hadron phase transition in a rapidly expanding background of quark gluon
plasma. Using an improved preexponential factor for homogeneous nucleation
rate, we solve a set of coupled equations to study the hadronization and the
hydrodynamical evolution of the matter. It is found that significant
supercooling is possible before hadronization begins. This study also suggests
that spinodal decomposition competes with nucleation and may provide an
alternative mechanism for phase conversion particularly if the transition is
strong enough and the medium is nonviscous. For weak enough transition, the
phase conversion may still proceed via homogeneous nucleation.Comment: LaTeX, 10 pages with 7 Postscript figures, more discussions and
referencese added, typos correcte
Linear Logic Programming for Narrative Generation
Abstract. In this paper, we explore the use of Linear Logic programming for story generation. We use the language Celf to represent narrative knowledge, and its own querying mechanism to generate story instances, through a number of proof terms. Each proof term obtained is used, through a resource-flow analysis, to build a directed graph where nodes are narrative actions and edges represent inferred causality relationships. Such graphs represent narrative plots structured by narrative causality. Building on previous work evidencing the suitability of Linear Logic as a conceptual model of action and change for narratives, we explore the conditions under which these representations can be operationalized through Linear Logic Programming techniques. This approach is a candidate technique for narrative generation which unifies declarative representations and generation via query and deduction mechanisms
Ecological Transitions in a Coastal Upwelling Ecosystem
The southern California Current Ecosystem (CCE) is a dynamic eastern boundary current ecosystem that is forced by ocean-atmosphere variability on interannual, multidecadal, and long-term secular time scales. Recent evidence suggests that apparent abrupt transitions in ecosystem conditions reflect linear tracking of the physical environment rather than oscillations between alternative preferred states. A space-for-time exchange is one approach that permits use of natural spatial variability in the CCE to develop a mechanistic understanding needed to project future temporal changes. The role of (sub)mesoscale frontal systems in altering rates of nutrient transport, primary and secondary production, export fluxes, and the rates of encounters between predators and prey is an issue central to this pelagic ecosystem and its future trajectory because the occurrence of such frontal features is increasing
Ferromagnetism in Oriented Graphite Samples
We have studied the magnetization of various, well characterized samples of
highly oriented pyrolitic graphite (HOPG), Kish graphite and natural graphite
to investigate the recently reported ferromagnetic-like signal and its possible
relation to ferromagnetic impurities. The magnetization results obtained for
HOPG samples for applied fields parallel to the graphene layers - to minimize
the diamagnetic background - show no correlation with the magnetic impurity
concentration. Our overall results suggest an intrinsic origin for the
ferromagnetism found in graphite. We discuss possible origins of the
ferromagnetic signal.Comment: 11 figure
GRB 081028 and its late-time afterglow re-brightening
‘The definitive version is available at www3.interscience.wiley.com '. Copyright Royal Astronomical SocietySwift captured for the first time a smoothly rising X-ray re-brightening of clear non-flaring origin after the steep decay in a long gamma-ray burst (GRB): GRB 081028. A rising phase is likely present in all GRBs but is usually hidden by the prompt tail emission and constitutes the first manifestation of what is later to give rise to the shallow decay phase. Contemporaneous optical observations reveal a rapid evolution of the injection frequency of a fast cooling synchrotron spectrum through the optical band, which disfavours the afterglow onset (start of the forward shock emission along our line of sight when the outflow is decelerated) as the origin of the observed re-brightening. We investigate alternative scenarios and find that the observations are consistent with the predictions for a narrow jet viewed off-axis. The high on-axis energy budget implied by this interpretation suggests different physical origins of the prompt and (late) afterglow emission. Strong spectral softening takes place from the prompt to the steep decay phase: we track the evolution of the spectral peak energy from the γ-rays to the X-rays and highlight the problems of the high latitude and adiabatic cooling interpretations. Notably, a softening of both the high and low spectral slopes with time is also observed. We discuss the low on-axis radiative efficiency of GRB 081028 comparing its properties against a sample of Swift long GRBs with secure Eγ,iso measurements.Peer reviewe
Silylation of titanium-containing amorphous silica catalyst: effect on the alkenes epoxidation with H2O2
The surface of a Ti/SiO2 catalyst was silylated using hexamethyldisilazane (HMDS) and tetramethyldisilazane (TMDS) as silylating reagents in vapor phase. The silylation of silanol (Si–OH) on the catalysts was confirmed by diffuse reflectance UV-Vis, DRIFT spectroscopy and solid-state 29Si MAS NMR techniques. Silylation with TMDS improves the catalytic performance of Ti/SiO2 catalyst more significantly than with HMDS and this is mainly due to the steric bulk effects of trimethylsilyl groups from HMDS as compared to dimethylsilyl groups from TMDS. The silylation degree with TMDS was found to be higher than with HMDS and no changes in the silylation degree with TMDS was observed for silylation times longer than 2 h. Despite the silylation route employed, the silylated surface is hydrophobic which enhances not only in hydrogen peroxide efficiency but also and in selectivity to epoxide in the epoxidation of alkenes with H2O2. These effects are more evident when the hydrogen peroxide concentration is higher and particularly for the catalyst modified with TMDS.Peer reviewe
Tumor-homing cytotoxic human induced neural stem cells for cancer therapy
Engineered neural stem cells (NSCs) are a promising approach to treating glioblastoma (GBM). The ideal NSC drug carrier for clinical use should be easily isolated and autologous to avoid immune rejection. We transdifferentiated (TD) human fibroblasts into tumor-homing early-stage induced NSCs (h-iNSCTE), engineered them to express optical reporters and different therapeutic gene products, and assessed the tumor-homing migration and therapeutic efficacy of cytotoxic h-iNSCTE in patient-derived GBM models of surgical and nonsurgical disease. Molecular and functional analysis revealed that our single-factor SOX2 TD strategy converted human skin fibroblasts into h-iNSCTE that were nestin+ and expressed pathways associated with tumor-homing migration in 4 days. Time-lapse motion analysis showed that h-iNSCTE rapidly migrated to human GBM cells and penetrated human GBM spheroids, a process inhibited by blockade of CXCR4. Serial imaging showed that h-iNSCTE delivery of the proapoptotic agent tumor necrosis factor-A-related apoptosis-inducing ligand (TRAIL) reduced the size of solid human GBM xenografts 250-fold in 3 weeks and prolonged median survival from 22 to 49 days. Additionally, h-iNSCTE thymidine kinase/ganciclovir enzyme/prodrug therapy (h-iNSCTE-TK) reduced the size of patient-derived GBM xenografts 20-fold and extended survival from 32 to 62 days. Mimicking clinical NSC therapy, h-iNSCTE-TK therapy delivered into the postoperative surgical resection cavity delayed the regrowth of residual GBMs threefold and prolonged survival from 46 to 60 days. These results suggest that TD of human skin into h-iNSCTE is a platform for creating tumor-homing cytotoxic cell therapies for cancer, where the potential to avoid carrier rejection could maximize treatment durability in human trials
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