Studies of CO oxidation on Pt/SnO2 catalyst in a surrogate CO2 laser facility

Samples of 1% Pt/SnO2 catalyst were exposed to a stoichiometric gas mixture of 1% CO and 1.2% O2 in helium over a range of flowrates from 5 to 15 sccm and temperatures from 338 to 394 Kelvin. Reaction rate constants for the catalytic oxidation of carbon monoxide and their temperature dependence were determined and compared with previous literature values

Report to Congress on Waivers Granted Under the Elementary and Secondary Education Act

This is the third annual report to Congress on waivers granted by the U.S. Department of Education, mandated under section 14401(e)(4) of the Elementary and Secondary Education Act (ESEA). Three education laws passed in 1994 — the Goals 2000: Educate America Act, the School-to-Work Opportunities Act, and the reauthorized ESEA — allow the Secretary of Education to grant waivers of certain requirements of federal education programs in cases where a waiver will likely contribute to improved teaching and learning. States and school districts use the waiver authorities to adapt federal programs and use federal funds in ways that address their local needs. The waiver authorities provide additional flexibility to states and school districts in exchange for increased accountability for improving student achievement. The law requires that waiver applicants describe how a waiver would improve instruction and academic performance, and that the waivers conform to the underlying intent and purposes of the affected programs. This report contains five sections. Section I gives an overview of waivers requested and granted from the establishment of the waiver authorities in 1994 through September 30, 1999. Section II provides details about the focus of the waivers that have been granted. Section III examines the progress school districts and states have made under waivers that have been effective for at least two years, as reported by states to the U. S. Department of Education. Section IV reviews the federal and state roles in the administration of the waiver authorities, and Section V contains some conclusions about how waivers contribute to the broader effort to improve teaching and learning for all students

Report to Congress on Waivers Granted Under the Elementary and Secondary Education Act

This is the third annual report to Congress on waivers granted by the U.S. Department of Education, mandated under section 14401(e)(4) of the Elementary and Secondary Education Act (ESEA). Three education laws passed in 1994 — the Goals 2000: Educate America Act, the School-to-Work Opportunities Act, and the reauthorized ESEA — allow the Secretary of Education to grant waivers of certain requirements of federal education programs in cases where a waiver will likely contribute to improved teaching and learning. States and school districts use the waiver authorities to adapt federal programs and use federal funds in ways that address their local needs. The waiver authorities provide additional flexibility to states and school districts in exchange for increased accountability for improving student achievement. The law requires that waiver applicants describe how a waiver would improve instruction and academic performance, and that the waivers conform to the underlying intent and purposes of the affected programs. This report contains five sections. Section I gives an overview of waivers requested and granted from the establishment of the waiver authorities in 1994 through September 30, 1999. Section II provides details about the focus of the waivers that have been granted. Section III examines the progress school districts and states have made under waivers that have been effective for at least two years, as reported by states to the U. S. Department of Education. Section IV reviews the federal and state roles in the administration of the waiver authorities, and Section V contains some conclusions about how waivers contribute to the broader effort to improve teaching and learning for all students

Report to Congress on Waivers Granted Under the Elementary and Secondary Education Act

This is the third annual report to Congress on waivers granted by the U.S. Department of Education, mandated under section 14401(e)(4) of the Elementary and Secondary Education Act (ESEA). Three education laws passed in 1994 — the Goals 2000: Educate America Act, the School-to-Work Opportunities Act, and the reauthorized ESEA — allow the Secretary of Education to grant waivers of certain requirements of federal education programs in cases where a waiver will likely contribute to improved teaching and learning. States and school districts use the waiver authorities to adapt federal programs and use federal funds in ways that address their local needs. The waiver authorities provide additional flexibility to states and school districts in exchange for increased accountability for improving student achievement. The law requires that waiver applicants describe how a waiver would improve instruction and academic performance, and that the waivers conform to the underlying intent and purposes of the affected programs. This report contains five sections. Section I gives an overview of waivers requested and granted from the establishment of the waiver authorities in 1994 through September 30, 1999. Section II provides details about the focus of the waivers that have been granted. Section III examines the progress school districts and states have made under waivers that have been effective for at least two years, as reported by states to the U. S. Department of Education. Section IV reviews the federal and state roles in the administration of the waiver authorities, and Section V contains some conclusions about how waivers contribute to the broader effort to improve teaching and learning for all students

Cigarette smoke extract exacerbates hyperpermeability of cerebral endothelial cells after oxygen glucose deprivation and reoxygenation

Cigarette smoking is a risk factor for stroke and is linked to stroke severity. Previous studies have shown that cigarette smoke extract (CSE) triggers endothelial dysfunction in vitro by initiating oxidative stress and/or an inflammatory response. In addition, cerebral endothelial dysfunction (particularly at the level of the blood-brain barrier [BBB]) contributes to stroke pathogenesis. Therefore, we hypothesized that cigarette smoking may influence stroke, at least in part, by exacerbating ischaemia-induced BBB disruption. To test this, we examined the effect of CSE on the permeability of cerebral endothelial cells exposed to oxygen glucose deprivation and reoxygenation (OGD + RO). We found that the loss of BBB integrity following ischaemic/reperfusion-like conditions was significantly worsened by CSE. Despite this being associated with increased mRNA expression of Nox catalytic subunits, reactive oxygen species (ROS) levels were however markedly lower. Furthermore, this occurred in association with elevated expression of antioxidant enzymes (SOD1, SOD2, and Gpx-1), suggesting an antioxidant defence response. Lastly, we found that CSE significantly upregulated mRNA expression of cytokines (IL-6 and TGF-β). Collectively, these results show that acute exposure to CSE worsens BBB disruption caused by OGD + RO, however, this is not linked to elevated ROS levels but may involve inflammatory mechanisms

Conjugate Meningococcal Vaccines Development: GSK Biologicals Experience

Meningococcal diseases are serious threats to global health, and new vaccines specifically tailored to meet the age-related needs of various geographical areas are required. This paper focuses on the meningococcal conjugate vaccines developed by GSK Biologicals. Two combined conjugate vaccines were developed to help protect infants and young children in countries where the incidence of meningococcal serogroup C or serogroup C and Y disease is important: Hib-MenC-TT vaccine, which offers protection against Haemophilus influenzae type b and Neisseria meningitidis serogroup C diseases, is approved in several countries; and Hib-MenCY-TT vaccine, which adds N. meningitidis serogroup Y antigen, is currently in the final stages of development. Additionally, a tetravalent conjugate vaccine (MenACWY-TT) designed to help protect against four meningococcal serogroups is presently being evaluated for global use in all age groups. All of these vaccines were shown to be highly immunogenic and to have clinically acceptable safety profiles

Protective actions of des-acylated ghrelin on brain injury and blood-brain barrier disruption after stroke in mice

The major ghrelin forms, acylated ghrelin and des-acylated ghrelin, are novel gastrointestinal hormones. Moreover, emerging evidence indicates that these peptides may have other functions including neuro- and vaso-protection. Here, we investigated whether post-stroke treatment with acylated ghrelin or des-acylated ghrelin could improve functional and histological endpoints of stroke outcome in mice after transient middle cerebral artery occlusion (tMCAo). We found that des-acylated ghrelin (1 mg/kg) improved neurological and functional performance, reduced infarct and swelling, and decreased apoptosis. In addition, it reduced blood-brain barrier (BBB) disruption in vivo and attenuated the hyper-permeability of mouse cerebral microvascular endothelial cells after oxygen glucose deprivation and reoxygenation (OGD + RO). By contrast, acylated ghrelin (1 mg/kg or 5 mg/kg) had no significant effect on these endpoints of stroke outcome. Next we found that des-acylated ghrelin's vasoprotective actions were associated with increased expression of tight junction proteins (occludin and claudin-5), and decreased cell death. Moreover, it attenuated superoxide production, Nox activity and expression of 3-nitrotyrosine. Collectively, these results demonstrate that post-stroke treatment with des-acylated ghrelin, but not acylated ghrelin, protects against ischaemia/reperfusion-induced brain injury and swelling, and BBB disruption, by reducing oxidative and/or nitrosative damage

Intrahistiocytic Storage of Clofazimine Crystals in a Cat

A 13-year-old castrated male Maine coon cat with a 5-year history of atypical mycobacteriosis was euthanized and submitted for necropsy. The cat had been kept in clinical remission since diagnosis using a combination of the antimycobacterial drug clofazimine and additional multimodal antimicrobial therapy. Grossly, tissues were diffusely discolored red-brown to yellow. Histologically, the myocardial interstitum was expanded by numerous, often multinucleated cells, which were distended by uniformly shaped acicular cytoplasmic spaces. These cells were immunopositive for CD18 and immunonegative for desmin, suggesting a histiocytic rather than muscular origin. Macrophages in other tissues contained similar acicular spaces. Ultrastructurally, the spaces were surrounded by 2 lipid membranes, resembling an autophagosome. Based on the clinical history and histologic, immunohistochemical, and ultrastructural data, we diagnosed clofazimine crystal storage. To our knowledge, this is the first report of clofazimine storage in a cat or within myocardial interstitial macrophages

High stakes lies: Police and non-police accuracy in detecting deception

This is an Accepted Manuscript of an article published by Taylor & Francis in Psychology, Crime and Law on 26 June 2014 available online: http://wwww.tandfonline.com/10.1080/1068316X.2014.935777To date, the majority of investigations in to accuracy in detecting deception have used low stakes lies as stimulus materials, and findings from these studies suggest that people are generally poor at detecting deception. The research presented here utilised real life, high stakes lies as stimulus materials, to investigate the accuracy of police and non-police observers in detecting deception. It was hypothesised that both police and non-police observers would achieve above chance levels of accuracy in detecting deception, that police officers would be more accurate at detecting deception than non-police observers, that confidence in veracity judgements would be positively related to accuracy, and that consensus judgements would predict veracity. 107 observers (70 police officers and 37 non-police participants) watched 36 videos of people lying or telling the truth in an extremely high stakes, real life situation. Police observers achieved mean accuracy in detecting deception of 72%, non-police observers achieved 68% mean accuracy, and confidence in veracity judgements were positively related to accuracy. Consensus judgements correctly predicted veracity in 92% of cases.ESRC grant number ES/I013288/