Assessment of cockpit interface concepts for data link retrofit

The problem is examined of retrofitting older generation aircraft with data link capability. The approach taken analyzes requirements for the cockpit interface, based on review of prior research and opinions obtained from subject matter experts. With this background, essential functions and constraints for a retrofit installation are defined. After an assessment of the technology available to meet the functions and constraints, candidate design concepts are developed. The most promising design concept is described in detail. Finally, needs for further research and development are identified

Supporting the 'Sharing Institution' - Practical Steps Towards a More Open Teaching and Learning Culture

4th International Conference on Open RepositoriesThis presentation was part of the session : Conference PresentationsDate: 2009-05-19 03:00 PM – 04:30 PMInstitutional repositories for research output have developed progressively over the last few years. Although a primary motivation is Open Access both institutional and academic needs must also be met in order to foster this spirit effectively. There is now a greater emphasis on creating a more open culture for teaching and learning and institutions are again beginning to play their part more readily. On a larger scale, there are pioneering global examples of courses being preserved and complex learning materials being deposited in national and international databases. But what does fostering a more open culture in the practice of teaching mean for the institution itself and its academics? The virtual learning environment has given greater opportunities for effective administration of courses but in other ways it has had the opposite effect on sharing and re-use. There is potential for institutional solutions which are complementary to the global landscape. In this paper we report on the practical experiences and issues met, in setting up a institutional resource, EdShare, as a vehicle for sharing educational materials more easily in a multi-disciplinary institution. With constructive feedback from faculty, within the EdSpace project, EdShare has migrated into a more visual, web 2.0 style, resource with a flexible deposit process promoting 'micro-sharing'. It now offers a range of sharing options to support the teaching workflow in an encouraging atmosphere. Other features will support the growing emphasis on multidisciplinary teaching and collaboration - both internally and externally.JIS

Early diagnosis of acute laryngeal injuries

Most acute laryngeal injuries are caused by motor vehicle accidents. Patients with multiple injuries who present with head or chest wounds should be carefully examined for signs or symptoms of laryngeal trauma. Primary patients with laryngeal injury presenting with life-threatening airway obstruction present a special problem to the accident surgeon. Tracheostomy rather than intubation is then the procedure of choice. A high index of suspicion must be maintained if laryngeal trauma is to be recognized and treated early. Prompt diagnosis and appropriate management is essential in maintaining an airway, preventing subsequent laryngeal stenosis and preserving the quality of the voice.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/23152/1/0000077.pd

Direct evidence of lack of colocalisation of fluorescently labelled gold labels used in correlative light electron microscopy

Fluorescently labelled nanoparticles are routinely used in Correlative Light Electron Microscopy (CLEM) to combine the capabilities of two separate microscope platforms: fluorescent light microscopy (LM) and electron microscopy (EM). The inherent assumption is that the fluorescent label observed under LM colocalises well with the electron dense nanoparticle observed in EM. Herein we show, by combining single molecule fluorescent imaging with optical detection of the scattering from single gold nanoparticles, that for a commercially produced sample of 10 nm gold nanoparticles tagged to Alexa-633 there is in fact no colocalisation between the fluorescent signatures of Alexa-633 and the scattering associated with the gold nanoparticle. This shows that the attached gold nanoparticle quenches the fluorescent signal by ~95%, or less likely that the complex has dissociated. In either scenario, the observed fluorescent signal in fact arises from a large population of untagged fluorophores; rendering these labels potentially ineffective and misleading to the field

Antibody interference and response kinetics of isatuximab plus pomalidomide and dexamethasone in multiple myeloma

The ICARIA-MM study was sponsored by Sanofi. The authors thank, Helgi van de Velde, Valérie Boutet, Shujia Dai, Deborah DiNoto, Graziella Engelvin, Olivier Fedeli, Sébastien Hugla, Dominique Mouret, Béatrice Pradeilles, and Alain Roccon, all employees of Sanofi, for their contribution to the study, technology, and comments on the manuscript. The authors thank the participating patients and their families, and the study centers and investigators, for their contributions to the study. The medical writing support was provided by John Clarke, PhD and Stephanie Brillhart, PhD of Elevate Medical Affairs, contracted by Sanofi Genzyme for publication support services

Winter and spring controls on the summer food web of the coastal West Antarctic Peninsula

Understanding the mechanisms by which climate variability affects multiple trophic levels in food webs is essential for determining ecosystem responses to climate change. Here we use over two decades of data collected by the Palmer Long Term Ecological Research program (PAL-LTER) to determine how large-scale climate and local physical forcing affect phytoplankton, zooplankton and an apex predator along the West Antarctic Peninsula (WAP). We show that positive anomalies in chlorophyll-a (chl-a) at Palmer Station, occurring every 4-6 years, are constrained by physical processes in the preceding winter/spring and a negative phase of the Southern Annular Mode (SAM). Favorable conditions for phytoplankton included increased winter ice extent and duration, reduced spring/summer winds, and increased water column stability via enhanced salinity-driven density gradients. Years of positive chl-a anomalies are associated with the initiation of a robust krill cohort the following summer, which is evident in Adelie penguin diets, thus demonstrating tight trophic coupling. Projected climate change in this region may have a significant, negative impact on phytoplankton biomass, krill recruitment and upper trophic level predators in this coastal Antarctic ecosystem