Les enjeux politiques d’une histoire culturelle des idées chez Dewey : l’exemple de la critique du libéralisme dans les années 30

International audienc

A Metallurgical Inspection Method to Assess the Damage in Performance-Limiting Nb3Sn Accelerator Magnet Coils

The design and production of Nb3Sn-based dipole and quadrupole magnets is critical for the realization of the High-Luminosity Large Hadron Collider (HL-LHC) at the European Organization for Nuclear Research (CERN). Nb3Sn superconducting coils are aimed at enhancing the bending and focusing strengths of accelerator magnets for HL-LHC and beyond. Due to the brittle nature of Nb3Sn, the coil fabrication steps are very challenging and require very careful QA/QC. Flaws in the Nb3Sn filaments may lead to quenches, and eventually, performance limitation below nominal during magnet testing. A novel inspection method, including advanced non-destructive and destructive techniques, was developed to explore the root-causes of quenches occurring in performance-limiting coils. The most relevant results obtained for MQXF coils through this innovative inspection method are presented. This approach allows for precise assessment of the physical events associated to the quenches experienced b y magnet coils, mainly occurring under the form of damaged strands with transversely broken sub-elements. Coil-slice preparation, micro-optical observations of transverse and longitudinal cross-sections, and a deep etching technique of copper will be illustrated in the present work, with a focus on the results achieved for a CERN coil from a non-conforming quadrupole magnet prototype, and two coils fabricated in the US, in the framework of the Accelerator Upgrade Project (AUP) collaboration, from two different non-conforming quadrupole magnets, respectively. The results obtained through the proposed inspection method will be illustrated.Comment: Applied Superconductivity Conference 202

Severe Asthma Standard-of-Care Background Medication Reduction With Benralizumab: ANDHI in Practice Substudy

Background: The phase IIIb, randomized, parallel-group, placebo-controlled ANDHI double-blind (DB) study extended understanding of the efficacy of benralizumab for patients with severe eosinophilic asthma. Patients from ANDHI DB could join the 56-week ANDHI in Practice (IP) single-arm, open-label extension substudy. Objective: Assess potential for standard-of-care background medication reductions while maintaining asthma control with benralizumab. Methods: Following ANDHI DB completion, eligible adults were enrolled in ANDHI IP. After an 8-week run-in with benralizumab, there were 5 visits to potentially reduce background asthma medications for patients achieving and maintaining protocol-defined asthma control with benralizumab. Main outcome measures for non-oral corticosteroid (OCS)-dependent patients were the proportions with at least 1 background medication reduction (ie, lower inhaled corticosteroid dose, background medication discontinuation) and the number of adapted Global Initiative for Asthma (GINA) step reductions at end of treatment (EOT). Main outcomes for OCS-dependent patients were reductions in daily OCS dosage and proportion achieving OCS dosage of 5 mg or lower at EOT. Results: For non-OCS-dependent patients, 53.3% (n = 208 of 390) achieved at least 1 background medication reduction, increasing to 72.6% (n = 130 of 179) for patients who maintained protocol-defined asthma control at EOT. A total of 41.9% (n = 163 of 389) achieved at least 1 adapted GINA step reduction, increasing to 61.8% (n = 110 of 178) for patients with protocol-defined EOT asthma control. At ANDHI IP baseline, OCS dosages were 5 mg or lower for 40.4% (n = 40 of 99) of OCS-dependent patients. Of OCS-dependent patients, 50.5% (n = 50 of 99) eliminated OCS and 74.7% (n = 74 of 99) achieved dosages of 5 mg or lower at EOT. Conclusions: These findings demonstrate benralizumab's ability to improve asthma control, thereby allowing background medication reduction

The SIB Swiss Institute of Bioinformatics' resources: focus on curated databases

The SIB Swiss Institute of Bioinformatics (www.isb-sib.ch) provides world-class bioinformatics databases, software tools, services and training to the international life science community in academia and industry. These solutions allow life scientists to turn the exponentially growing amount of data into knowledge. Here, we provide an overview of SIB's resources and competence areas, with a strong focus on curated databases and SIB's most popular and widely used resources. In particular, SIB's Bioinformatics resource portal ExPASy features over 150 resources, including UniProtKB/Swiss-Prot, ENZYME, PROSITE, neXtProt, STRING, UniCarbKB, SugarBindDB, SwissRegulon, EPD, arrayMap, Bgee, SWISS-MODEL Repository, OMA, OrthoDB and other databases, which are briefly described in this article

La connaissance de la nature dans le De Corpore de Hobbes

contribution au colloque Hobbes et la nature, organisé à l’Université Bordeaux-III par Jean Terrel et le LNSInternational audienceno abstrac

Hobbes on sociality and humanity

contribution au colloque Life and community organisé par Lars Toender, à Northwestern University of ChicagoInternational audienceno abstrac

Art d’inventer et vicissitude des choses : que nous est-il permis d’espérer du savoir selon Bacon ?

contribution à la journée d’étude Bacon, les promesses du savoir, organisé par J. Berthier, dans le cadre du séminaire Les origines anglaises de la modernitéInternational audienceno abstrac

La constitution du soi chez Locke, ou la personne humaine comme problème pratique

intervention dans le cadre de la séance De l’identité personnelle à l’identité narrative : la constitution de soi selon Locke et Spinoza, du séminaire du Collège Internationale Relire l’éthique en santé à l’aune d’une anthropologie spinoziste : philosophie de l’âge classique et médecine d’aujourd’hui, organisé par J. HenryInternational audienceno abstrac

Hobbes (1588-1679)

Enregistrements video, site web « Les philosophes et la bible » (site coord. par Raphaële Andrault et Pierre-François Moreau), 20163 vidéos de 15 minutes environ chacune : "Léviathan et Béhémoth", "La Bible dans les limites de la simple raison : le Royaume des Ténèbres et le Royaume du Ciel", "Le germe religieux : le cultiver ou le traiter ?"Enregistrements video, site web « Les philosophes et la bible » (site coord. par Raphaële Andrault et Pierre-François Moreau), 2016http://les-philosophes-et-la-bible.ens-lyon.fr/milanese-arnaud-276536.kjsp?RH=PHILO_CONFERENCIERS&RF=Milanes

"Sensation et phantasme dans le De Corpore : que signifie, chez Hobbes, fonder la philosophie sur la sensation ?"

International audienc