66 research outputs found
Communication about Disease-Related Malnutrition in the Perspective of Health Professionals in General Practice and Patients
Chronic obstructive pulmonary disease outpatients bear risks of both unplanned weight loss and obesity
Outpatientsâ experiences with unintended weight loss during treatment of disease:A qualitative study
Patientsâ Experiences with Nutritional Care during Hospitalization and Proposals for Improvement
Are nutritional sufficiency of â„75% energy and protein requirements relevant targets in patients at nutritional risk? - A one month follow-up study
Reporting Helicopter Emergency Medical Services in Major Incidents: A Delphi Study
Peer reviewe
Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context
Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts
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