Capitalismo de austeridad / empobrecimiento: ¿Qué podemos aprender del socialismo venezolano?

In this article, we begin by discussing austerity/immiseration capitalism in Europe and the U.S. We go on to contrast this with twenty-first century socialism in the making, as an alternative to neoliberal capitalism in the Bolivarian Republic of Venezuela. Next we analyse opposition to the Bolivarian Revolution, with respect to internal and external forces, both of which are interlinked. We conclude with some thoughts about possible future developments in Europe and the U.S. respectively.En este artículo, comenzaremos hablando sobre el capitalismo de austeridad / empobrecimiento en Europa y EE. UU. Continuaremos comparándolo con el socialismo del siglo XXI en sus inicios, como alternativa al capitalismo neoliberal en la República Bolivariana de Venezuela. Después, analizaremos la oposición a la Revolución Bolivariana, con respecto a las fuerzas internas y externas, ambas relacionadas. Por último, concluiremos con algunas ideas sobre posibles desarrollos futuros en Europa y EE. UU., respectivamente

Barriers to Exercise and Nutrition for Special Olympics Athletes

Problem People with intellectual disability (ID) have higher rates of obesity. Special Olympics Vermont (SOVT) athletes compete in sports events throughout the year. Athletes may lose fitness between seasons. Their nutrition habits remain unknown. •Barriers to exercise and nutrition remain unknown. Goal We were tasked with designing a successful exercise and nutrition program for SOVT athletes.https://scholarworks.uvm.edu/comphp_gallery/1215/thumbnail.jp

How data visualisation using historical medical journals can contribute to current debates around antibiotic use and antimicrobial resistance in primary care

BackgroundThe early years of antibiotic use in primary care (c1950-1969) has received little attention. Medical journals provide a rich source for studying historic healthcare practitioners’ views and interests, with the potential to inform contemporary debate around issues of overuse and antimicrobial resistance. AimsPilot study to test the application of digital methods to interrogate historical medical journal data in relation to antibiotic use.Methods / ApproachMeta-data and scanned articles were extracted from the online British Journal of General Practice (BJGP) archive from inception (1953) to 1969. Searchable text was generated using an application called ABBYY optical character recognition, and Python used to generate data visualisations exploring (1) how BJGP changed during the period, (2) mentions of terms ‘antibiotic(s)’, ‘penicillin’, ‘resistance/resistant’ and mapping when and where they occurred.Results / EvaluationFrom 1953-1969, BJGP expanded in terms of number of annual issues (4 to 17) and annual pages (&lt;25 to &gt;1100). Heatmap visualisations were used to facilitate understanding of the frequency with which use of the term ‘antibiotic(s)’ occurred. By 1969 an article mentioning ‘antibiotic(s)’ was published monthly. Bigram searches found ‘treatment’ and ‘therapy’ to be the two most common terms that appeared with ‘antibiotic(s)’. The fourth and seventh most common terms were ‘resistant’ (first appearing in 1955) and ‘resistance’ (1962).ConclusionsThis pilot work shows that primary care publications increased considerably between 1953-1969. Articles on antibiotics featured frequently in relation to therapeutic intervention, and concerns around resistance occurred at an early stage. This approach provides new insights into how attitudes and behaviours around antibiotic use by primary care have evolved over time. It may also have the potential to inform study of the future use of antibiotics in primary care. <br/

Jubilee mugs:the monarchy and the Sex Pistols

With rare exceptions sociologists have traditionally had little to say about the British monarchy. In the exceptional cases of the Durkheimian functionalism of Shills and Young (1953), the left humanism of Birnbaum (1955), or the archaic state/backward nation thesis of Nairn (1988), the British nation has been conceived as a homogenous mass. The brief episode of the Sex Pistols' Jubilee year song 'God Save the Queen' exposed some of the divisions within the national 'mass', forcing a re-ordering of the balance between detachment and belonging to the Royal idea. I argue that the song acted as a kind of 'breaching experiment'. Its wilful provocation of Royalist sentiment revealed the level of sanction available to the media-industrial complex to enforce compliance to British self-images of loyal and devoted national communicants

Reviews

Charles Williams: The Third Inkling. Grevel Lindop. Reviewed by Scott McLaren. The Chapel of the Thorn: A Dramatic Poem. Charles Williams. Edited and Introduced by Sørina Higgins. Reviewed by Scott McLaren. Women and C.S. Lewis: What His Life and Literature Reveal For Today’s Culture. Carolyn Curtis and Mary Pomroy Key, eds. Reviewed by Rebekah Choat. Tolkien Among the Moderns. Edited by Ralph C. Wood. Reviewed by Andrew C. Stout. Tolkien. Raymond Edwards. Reviewed by Cait Coker. Children into Swans: Fairy Tales and the Pagan Imagination. Jan Beveridge. Reviewed by Brian Roberts. Trilby/The Crumb Fairy. Charles Nodier. Translated and adapted by Ruth Berman. Reviewed by Kelly Orazi. The Prince of the Aquamarines. Louise Cavalier Levesque. Trans. and with an afterword by Ruth Berman. Reviewed by Kelly Orazi. The Lessons of Nature in Mythology. Rachel S. McCoppin. Reviewed by Kristine Larsen. Hither Shore: Jahrbuch der Deutschen Tolkien Gesellschaft. Special issue: Nature and Landscape in Tolkien. Ed. Thomas Fornet-Ponse et al. Reviewed by Janet Brennan Croft. Seven: An Anglo-American Literary Review. Ed. Marjorie Lamp Mead. Reviewed by Janet Brennan Croft. Tolkien Studies: An Annual Scholarly Review. Ed. Michael D.C. Drout, Verlyn Flieger, and David Bratman. Reviewed by Janet Brennan Croft. The Skill of a Seeker: Rowling, Religion and Gen 9/11. Marilyn R. Pukkila. Reviewed by Emily Moniz Mirova. Light: C.S. Lewis\u27s First and Final Short Story. Charlie W. Starr. Reviewed by Melody Green. The Story of Kullervo. J.R.R. Tolkien. Edited and introduced by Verlyn Flieger. Reviewed by Mike Foster. The Victorian Approach to Modernism in the Fiction of Dorothy L. Sayers. Aoife Leahy. Reviewed by Joe R. Christopher. Reading Joss Whedon. Rhonda V. Wilcox, Tanya R. Cochran, Cynthea Masson, and David Lavery, eds. Reviewed by by Janet Brennan Croft

UKIRT under new management: status and plans

The United Kingdom Infrared Telescope (UKIRT) observatory has been transferred to the ownership of the University of Hawaii (UH) and is now being managed by UH. We have established partnerships with several organizations to utilize the UKIRT for science projects and to support its operation. Our main partners are the U.S. Naval Observatory (USNO), the East Asian Observatory (EAO), and the UKIRT microlensing team (JPL/IPAC/OSU/Vanderbilt). The USNO is working on deep northern hemisphere surveys in the H and K bands and the UKIRT microlensing team is running a monitoring campaign of the Galactic bulge. EAO, UH, and USNO have individual P.I. research programs. Most of the observations are using the Wide Field Camera (WFCAM), but the older suite of cassegrain instruments are still fully operational. Data processing and archiving continue to be done CASU and WSA in the UK. We are working on a concept to upgrade the WFCAM with new larger infrared detector arrays for substantially improved survey efficiency

The Atacama Cosmology Telescope: Detection or Sunyaev-Zel'Dovich Decrement in Groups and Clusters Associated with Luminous Red Galaxies

We present a detection of the Sunyaev-Zel'dovich (SZ) decrement associated with the Luminous Red Galaxy (LRG) sample of the Sloan Digital Sky Survey. The SZ data come from 148 GHz maps of the equatorial region made by the Atacama Cosmology Telescope (ACT). The LRG sample is divided by luminosity into four bins, and estimates for the central Sunyaev-Zel'dovich temperature decrement are calculated through a stacking process. We detect and account for a bias of the SZ signal due to weak radio sources. We use numerical simulations to relate the observed decrement to Y(sub 200) and clustering properties to relate the galaxy luminosity bins to mass. We also use a relation between BCG luminosity and cluster mass based on stacked gravitational lensing measurements to estimate the characteristic halo masses. The masses are found to be in the range approx.10(exp 13) - 10(exp 14)/h Stellar Mass, a lower range than has been previously probed

The genetic heterogeneity and mutational burden of engineered melanomas in zebrafish models.

BACKGROUND: Melanoma is the most deadly form of skin cancer. Expression of oncogenic BRAF or NRAS, which are frequently mutated in human melanomas, promote the formation of nevi but are not sufficient for tumorigenesis. Even with germline mutated p53, these engineered melanomas present with variable onset and pathology, implicating additional somatic mutations in a multi-hit tumorigenic process. RESULTS: To decipher the genetics of these melanomas, we sequence the protein coding exons of 53 primary melanomas generated from several BRAF(V600E) or NRAS(Q61K) driven transgenic zebrafish lines. We find that engineered zebrafish melanomas show an overall low mutation burden, which has a strong, inverse association with the number of initiating germline drivers. Although tumors reveal distinct mutation spectrums, they show mostly C > T transitions without UV light exposure, and enrichment of mutations in melanogenesis, p53 and MAPK signaling. Importantly, a recurrent amplification occurring with pre-configured drivers BRAF(V600E) and p53-/- suggests a novel path of BRAF cooperativity through the protein kinase A pathway. CONCLUSION: This is the first analysis of a melanoma mutational landscape in the absence of UV light, where tumors manifest with remarkably low mutation burden and high heterogeneity. Genotype specific amplification of protein kinase A in cooperation with BRAF and p53 mutation suggests the involvement of melanogenesis in these tumors. This work is important for defining the spectrum of events in BRAF or NRAS driven melanoma in the absence of UV light, and for informed exploitation of models such as transgenic zebrafish to better understand mechanisms leading to human melanoma formation

A genome-wide association study of resistance to HIV infection in highly exposed uninfected individuals with hemophilia A

Human genetic variation contributes to differences in susceptibility to HIV-1 infection. To search for novel host resistance factors, we performed a genome-wide association study (GWAS) in hemophilia patients highly exposed to potentially contaminated factor VIII infusions. Individuals with hemophilia A and a documented history of factor VIII infusions before the introduction of viral inactivation procedures (1979-1984) were recruited from 36 hemophilia treatment centers (HTCs), and their genome-wide genetic variants were compared with those from matched HIV-infected individuals. Homozygous carriers of known CCR5 resistance mutations were excluded. Single nucleotide polymorphisms (SNPs) and inferred copy number variants (CNVs) were tested using logistic regression. In addition, we performed a pathway enrichment analysis, a heritability analysis, and a search for epistatic interactions with CCR5 Δ32 heterozygosity. A total of 560 HIV-uninfected cases were recruited: 36 (6.4%) were homozygous for CCR5 Δ32 or m303. After quality control and SNP imputation, we tested 1 081 435 SNPs and 3686 CNVs for association with HIV-1 serostatus in 431 cases and 765 HIV-infected controls. No SNP or CNV reached genome-wide significance. The additional analyses did not reveal any strong genetic effect. Highly exposed, yet uninfected hemophiliacs form an ideal study group to investigate host resistance factors. Using a genome-wide approach, we did not detect any significant associations between SNPs and HIV-1 susceptibility, indicating that common genetic variants of major effect are unlikely to explain the observed resistance phenotype in this populatio