Quality of clothing fabrics in terms of their comfort properties

Quality of various clothing woven fabrics with respect to their comfort properties, such as electro-physical properties, air permeability, and compression properties has been studied. Fabrics are produced from cotton and cotton/polyester fibre blends in plain, twill, satin and basket weave. Results show that cotton fabrics have lower values of the volume resistivity, air permeability and compressive resilience but higher values of effective relative dielectric permeability and compressibility as compared to fabrics that have been produced from cotton/PES fibre blends. Regression analysis shows a strong linear correlative relationship between the air permeability and the porosity of the woven fabrics with very high coefficient of linear correlation (0.9807). It is also observed that comfort properties are determined by the structure of woven fabrics (raw material composition, type of weave) as well as by the fabrics surface condition. Findings of the studies have been used for estimating the quality of woven fabrics in terms of their comfort properties by the application of ranking method. It is concluded that the group of cotton fabrics exhibits better quality of comfort as compared to the group of cotton/PES blend fabrics.

Compression and strength behaviour of viscose/polypropylene nonwoven fabrics

Compression and strength properties of viscose/polypropylene nonwoven fabrics has been studied. Compressionbehavior of the nonwoven samples (sample compressibility, sample thickness loss & sample compressive resilience) havebeen analyzed considering the magnitude of applied pressure, fabric weight, fabric thickness, and the porosity of thesamples. Based on the calculated porosity of the samples, pore compression behavior (pore compressibility, porosity loss &pore compressive resilience) are determined. Equations for the determination of pore compressibility, porosity loss, and porecompressive resilience, are established. Tensile strength and elongation as well as bursting strength and ball traverseelongation are also determined. The results show that the sample compression behavior as well as pore compressionbehavior depend on the magnitude of applied pressure. At the high level of applied pressure, a sample with highercompressibility has the lower sample compressive resilience. Differences in pore compressibility and porosity loss betweeninvestigated samples have also been registered, except in pore compressive resilience. Sample with the higher fabric weight,higher thickness, and lower porosity shows the lower sample compressibility, pore compressibility, sample thickness loss,porosity loss, and tensile elongation, but the higher tensile strength, bursting strength, and ball traverse elongation

TET-mediated DNA hydroxymethylation is negatively influenced by the PARP-dependent PARylation

Background Poly(ADP-ribosyl)ation (PARylation), a posttranslational modification introduced by PARP-1 and PARP-2, has first been implicated in DNA demethylation due to its role in base excision repair. Recent evidence indicates a direct influence of PARP-dependent PARylation on TET enzymes which catalyse hydroxymethylation of DNA—the first step in DNA demethylation. However, the exact nature of influence that PARylation exerts on TET activity is still ambiguous. In our recent study, we have observed a negative influence of PARP-1 on local TET-mediated DNA demethylation of a single gene and in this study, we further explore PARP–TET interplay. Results Expanding on our previous work, we show that both TET1 and TET2 can be in vitro PARylated by PARP-1 and PARP-2 enzymes and that TET1 PARylation negatively affects the TET1 catalytic activity in vitro. Furthermore, we show that PARylation inhibits TET-mediated DNA demethylation at the global genome level in cellulo. Conclusions According to our findings, PARP inhibition can positively influence TET activity and therefore affect global levels of DNA methylation and hydroxymethylation. This gives a strong rationale for future examination of PARP inhibitors' potential use in the therapy of cancers characterised by loss of 5-hydroxymethylcytosine

EpiCRISPR targeted methylation of Arx gene initiates transient switch of mouse pancreatic alpha to insulin-producing cells

Introduction: Beta cell dysfunction by loss of beta cell identity, dedifferentiation, and the presence of polyhormonal cells are main characteristics of diabetes. The straightforward strategy for curing diabetes implies reestablishment of pancreatic beta cell function by beta cell replacement therapy. Aristaless-related homeobox (Arx) gene encodes protein which plays an important role in the development of pancreatic alpha cells and is a main target for changing alpha cell identity. Results: In this study we used CRISPR/dCas9-based epigenetic tools for targeted hypermethylation of Arx gene promoter and its subsequent suppression in mouse pancreatic αTC1-6 cell line. Bisulfite sequencing and methylation profiling revealed that the dCas9-Dnmt3a3L-KRAB single chain fusion constructs (EpiCRISPR) was the most efficient. Epigenetic silencing of Arx expression was accompanied by an increase in transcription of the insulin gene (Ins2) mRNA on 5th and 7th post-transfection day, quantified by both RT-qPCR and RNA-seq. Insulin production and secretion was determined by immunocytochemistry and ELISA assay, respectively. Eventually, we were able to induce switch of approximately 1% of transiently transfected cells which were able to produce 35% more insulin than Mock transfected alpha cells. Conclusion: In conclusion, we successfully triggered a direct, transient switch of pancreatic alpha to insulin-producing cells opening a future research on promising therapeutic avenue for diabetes management. 1 Introductio

Genotoxic potential of Cotinus coggygria Scop. (Anacardiaceae) stem extract in vivo

The intention was to evaluate the possible in vivo genotoxic potential in different cell-types, of a methanol extract obtained from the plant stem of Cotinus coggygria Scop., using the sex-linked recessive lethal (or SLRL) test and alkaline comet assay. The SLRL test, revealed the genotoxic effect of this extract in postmeiotic and premeiotic germ-cell lines. The comet assay was carried out on rat liver and bone marrow at 24 and 72 h after intraperitoneal administration. For genotoxic evaluation, three concentrations of the extract were tested, viz., 500, 1000 and 2000 mg/kg body weight (bw), based on the solubility limit of the extract in saline. Comet tail moment and total scores in the group treated with 500 mg/kg bw, 24 and 72 h after treatment, were not significantly different from the control group, whereas in the groups of animals, under the same conditions, but with 1000 and 2000 mg/kg bw of the extract, scores were statistically so. A slight decrease in the comet score and tail moment observed in all the doses in the 72 h treatment, gave to understand that DNA damage induced by Cotinus coggygria extract decreased with time. The results of both tests revealed the genotoxic effect of Cotinus coggygria under our experimental conditions

A note on NLSP based on the generated pseudo-operations

The aim of this paper is to study sustainability of the pseudo-linear superposition principle, that is, of the nonlinear superposition principle (NLSP) observed in the pseudo-analysis' framework and to discuss some possible extensions. © 2011 IEEE

A human mandible (BH-1) from the Pleistocene deposits of Mala Balanica cave (Sićevo Gorge, Niš, Serbia)

Neandertals and their immediate predecessors are commonly considered to be the only humans inhabiting Europe in the Middle and early Late Pleistocene. Most Middle Pleistocene western European specimens show evidence of a developing Neandertal morphology, supporting the notion that these traits evolved at the extreme West of the continent due, at least partially, to the isolation produced by glacial events. The recent discovery of a mandible, BH-1, from Mala Balanica (Serbia), with primitive character states comparable with Early Pleistocene mandibular specimens, is associated with a minimum radiometric date of 113 + 72 − 43 ka. Given the fragmented nature of the hemi-mandible and the fact that primitive character states preclude assignment to a species, the taxonomic status of the specimen is best described as an archaic Homo sp. The combination of primitive traits and a possible Late Pleistocene date suggests that a more primitive morphology, one that does not show Neandertal traits, could have persisted in the region. Different hominin morphologies could have survived and coexisted in the Balkans, the hotspot of biodiversity. This first hominin specimen to come from a secure stratigraphic context in the Central Balkans indicates a potentially important role for the region in understanding human evolution in Europe that will only be resolved with more concentrated research efforts in the area

Compression and strength behaviour of viscose/polypropylene nonwoven fabrics

329-337Compression and strength properties of viscose/polypropylene nonwoven fabrics has been studied. Compression behavior of the nonwoven samples (sample compressibility, sample thickness loss & sample compressive resilience) have been analyzed considering the magnitude of applied pressure, fabric weight, fabric thickness, and the porosity of the samples. Based on the calculated porosity of the samples, pore compression behavior (pore compressibility, porosity loss & pore compressive resilience) are determined. Equations for the determination of pore compressibility, porosity loss, and pore compressive resilience, are established. Tensile strength and elongation as well as bursting strength and ball traverse elongation are also determined. The results show that the sample compression behavior as well as pore compression behavior depend on the magnitude of applied pressure. At the high level of applied pressure, a sample with higher compressibility has the lower sample compressive resilience. Differences in pore compressibility and porosity loss between investigated samples have also been registered, except in pore compressive resilience. Sample with the higher fabric weight, higher thickness, and lower porosity shows the lower sample compressibility, pore compressibility, sample thickness loss, porosity loss, and tensile elongation, but the higher tensile strength, bursting strength, and ball traverse elongation

Žetva i skladištenje Miscanthus×giganteus Greef et Deu.

Miscanthus (Miscanthus×giganteus Greef et Deu.) represents a new perennial crop for biomass production, grown and used specifically as energy source (i.e. „bioenergy crop“) for combustion in boiler systems. At the end of September, miscanthus crops form maximal biomass of aboveground parts. With the transition to winter dormancy (since the end of October till the beginning of April) water content in the crop is gradually decreased by stem dessication. With the shifting of harvest time to the interval: end of December – end of March, overall miscanthus biomass is decreased, due to defiliation and falling-off of stem tops, but, because of decreased water content (≤30%) and the content of nitrogen compounds (<0,7%) the obtained biomass is more convenient for combustion. For harvesting and baling of aboveground parts, only few days without precipitation and snow cover are sufficient, which is necessary for the operation of machines. For long-term storage, very loose piling of bales is necessary.Мискантус (Miscanthus×giganteus Greef et Deu.) представља нов вишегодишњи усев за производњу биомасе, који се специфично узгаја и користи као енергетска сировина за сагоревање у котловским постројењима. Крајем септембра усев мискантуса образује максималну биомасу надземног дела. Преласком у фазу зимског мировања (од краја октобра до почетка априла) садржај влаге у усеву се постепено смањује сушењем стабала и листова. Померањем времена жетве на период: крај децембра до крај марта, укупна биомаса мискантуса се смањује, због опадања листова и врхова стабала, али услед мањег садржаја воде (≤30%) и мање количине азотних материја (<0,7%) добијена биомаса је квалитетнија за сагоревање. За извођење жетве кошењем надземних делова усева и његовим балирањем, неопходно само неколико дана без падавина и снежног покривача, због кретања жетвене механизације по површини терена. За дуготрајно складиштење потребно је веома растресито слагање бала