Stability of Intercelular Exchange of Biochemical Substances Affected by Variability of Environmental Parameters

Communication between cells is realized by exchange of biochemical substances. Due to internal organization of living systems and variability of external parameters, the exchange is heavily influenced by perturbations of various parameters at almost all stages of the process. Since communication is one of essential processes for functioning of living systems it is of interest to investigate conditions for its stability. Using previously developed simplified model of bacterial communication in a form of coupled difference logistic equations we investigate stability of exchange of signaling molecules under variability of internal and external parameters.Comment: 11 pages, 3 figure

Comment on `Experimental and Theoretical Constraints of Bipolaronic Superconductivity in High TcT_{c} Materials: An Impossibility'

We show that objections raised by Chakraverty $et$ $al$ (Phys. Rev. Lett. 81, 433 (1998)) to the bipolaron model of superconducting cuprates are the result of an incorrect approximation for the bipolaron energy spectrum and misuse of the bipolaron theory. The consideration, which takes into account the multiband energy structure of bipolarons and the unscreened electron-phonon interaction clearly indicates that cuprates are in the Bose-Einstein condensation regime with mobile charged bosons.Comment: 1 page, no figure

Agronomic Characteristics of Novi Sad Winter Vetch Cultivars

Genus Vicia. contains important annual food and forage species such as field bean, V. faba., narbon vetch, V. narbonensis, and common vetch, V. sativa (Maxted, 1995), while Hungarian V. pannonica Crantz and hairy vetch V. villosa also play an important role in the Balkans. Winter vetches are excellent forage catch crops useful for sustainable agriculture and organic farming (Ċupina et al., 2004). Our study was aimed at determining the agronomic characteristics of the winter vetch cultivars developed in Novi Sad, assessing thus their ability for successful growing in the prevailing conditions of Serbia and Montenegro

Uticaj endotelina i L-NAME na koncentraciju mokraćne kiseline i uree u plazmi kod Wistar pacova

Effects of endothelins, which include vasoconstriction and vasodilatation are possible by different molecular mechanisms. Endothelins induce increased synthesis of nitric oxide which in turn inhibits the synthesis of endothelin. Changes in biochemical parameters connected with the increased and decreased synthesis of nitric oxide are not thoroughly examined yet. In a series of experiments we compared the effects of endothelin (ET-1) on the inhibition of nitric oxide synthase (NOS), as well as the effects of L-nitro arginin metal estar (L-NAME) on plasma urea and uric acid concentration. Experiments were performed on anesthetized female adult Wistar rats. The experimental groups received an i. v. bolus of ET-1, L-NAME or saline. All parameters, heamodynamic and biochemical, were measured before the animals were sacrificed. L-NAME increased the mean arterial pressure, decreased renal blood flow and increased vascular resistance in carotid and renal arteries and increased in plasma uric acid and urea concentrations. ET- 1 significantly decreased uric acid concentration in the plasma but did not effect plasma urea concentration compared to the control group. These differences show complex relations of nitric oxide with cellular signalization compared to the basic NO-cGMP pathway.Efekti endotelina koji uključuju vazokonstrikciju I vazodilataciju ostvaruju se različitim molekularnim mehanizmima. Endotelin indukuje povećanu sintezu azotnog oksida za koji se smatra da povratno inhibira sintezu endotelina. Promene biohemijskih parametara vezanih za povećanu i smanjenu sintezu NO nisu dovoljno proučene. U ovom radu su upoređeni efekti endotelina (ET-1) i inhibitora NOS-a, L-NAME na koncentraciju mokraćne kiseline i uree u plazmi. Eksperimenti su izvedeni na anesteziranim odraslim NW pacovima, ženskog pola. Eksperimentalne životinje su u i.v. bolusu primale ET-1, L-NAME ili fiziološki rastvor. Svi hemodinamski i biohemijski parametri su mereni pre žrtvovanja. L-NAME dovodi do povećanja srednjeg arterijskog pritiska smanjenja renalnog protoka i povećanja vaskularnog otpora u karotidnoj i renalnoj arteriji i povećanja koncentracije mokraćne kiseline i uree u plazmi. ET-1 značajno smanjuje koncentraciju mokraćne kiseline u plazmi ali ne utiče na koncentraciju uree u odnosu na kontrolu. Ove razlike pokazuju kompleksnije relacije NO-a sa ćelijskom signalizacijom u odnosu na osnovni NO-cGMP put

Dijagnoza, anestezija i operativni zahvat kod rupture mokraćne bešike novorođene ždrebadi

This study describes methods for the diagnosis, anesthesia and operative repair in 4 neonatal foals with urinary bladder rupture. Diagnosis was based on case history, clinical signs, changes in serum chemistry analyzes (hyponatremia, hyperkalemia, hypochloremia, metabolic acidosis and increased serum creatinine and urea nitrogen levels), abdominocentesis, ultrasound and electrocardiographs. As electrolyte abnormalities and acid-base derangement can lead to the development of cardiac arrhythmia during general anesthesia, surgical treatment of urinary bladder rupture in neonatal foals should be performed when the animal's condition has been stabilized. This includes infusion of physiological saline solution, 5 % glucose infusion with insulin (0.1U/kg) and 1.4% sodiumdrogencarbonate.Ova studija opsuje dijagnostikovanje, anesteziju i operativni tretman pri rupturi mokraćne bešike novorođene ždrebadi. Dijagnoza je zasnovana na istoriji bolesti, kliničkim simptomima, promenama u serumu ustanovljenim biohemijskim analizama (hiponatrijemija, hipokalijemija, hipohloremija, metabolička acidoza sa porastom nivoa serumskog kreatinina i ureje), abdominocintezi, ultrazvuku i elektrokardiografiji. Kao što poremećaji elektrolita i acido-bazne ravnoteže mogu dovesti do pojave srčane aritmije u toku opšte anestezije, hirurški tretman rupture bešike kod novorođene ždrebadi može biti primenjen kada je stabilizovano zdravstveno stanje životinje. Ovo uključuje infuziju fiziološkog rastvora, 5% glukoze sa insulinom (0,1 U/kg) i 1,4% Na-bikarbonat

MEDICINAL PROPERTIES OF BUCKWHEAT PRODUCTS AND HONEY IN COMPLIANCE WITH FOOD SAFETY REGULATORY REQUIREMENTS

Buckwheat (Fagopyrum esculentum Moench) is a gluten-free pseudo-cereal and honey plant. Buckwheat grain yields vary greatly and depend on the genotype, agro-ecological conditions of production and harvesting method. The grain yield of the 'Novosadska' variety variеs 1.5-3 t ha-1and the honey yield amounts and more than 300 kg ha-1. Buckwheat grain contains: carbohydrates, proteins, fats, organic acids and rutin (quercetin-3-rutinosid), minerals (potassium, phosphorus, calcium, magnesium, sodium, iodine, zinc, bromine and iron), vitamins (D2-ergokalciferol, D3-holekalciferol, P-bioflavonoids, vitamins group B: B1-Thiamine, B2-Riboflavin, B3-niacin, B4-Choline, B5-Pantothenic acid, B6-Piridoxin, B9-Folate; and vitamin E-Tocopherols. 'Novosadska' buckwheat contains the highest level of phenolic acids, proanthocyanidins, flavones and flavonols. Buckwheat honey is dark color, which it gets from polyphenols. Polyphenols is antioxidants, organic compounds which affect the quality of food, especially the color and taste. In accordance with the law on food safety, the interests of consumers must be ensured the highest level of protection. Phenolic antioxidants from honey are bioavailable and increase the antioxidant activity of plasma. Buckwheat honey has a beneficial effect on bronchitis and cough, hypertension, arteriosclerosis, of heart disease, liver and intestinal diseases and has antibacterial effects

Algae as a source of bioactive compounds to prevent the development of type 2 diabetes mellitus

Type 2 diabetes mellitus is a complicated metabolic disorder characterized by hyperglycemia and glucose intolerance. It is considered a new pandemic and its control involves numerous challenges. Although many of the measures are based on improving life habits, diet is also of vital importance due to bioactive compounds present in food. In this regard, several raw materials have been investigated whose bioactivities seem to slow the progression of this disease. Within these matrices, there are algae of importance, such as brown algae, showing to have beneficial effects on glycemic control. These pieces of evidence are increasing every day due to the development of cell or animal models, which lead to the conclusion that bioactive compounds may have direct effects on decreasing hyperglycemia, enhancing insulin secretion and preventing the formation of amyloid plaques.Serbian co-authors thank the Ministry of Education, Science, and Technological Development of the Republic of Serbia for the support within the contracts for the realization and financing of scientific research work in 2021 ; financial support from Programa de Cooperación Interreg V-A España—Portugal (POCTEP) 2014–2020; MICINN supporting the Ramón&Cajal grant for M.A. Prieto; to Xunta de Galicia and University of Vigo supporting the pre-doctoral grants for A.G. Pereira, and P. García-Oliveira; to Ibero-American Program on Science and Technology for financial support. This project has received funding from the Bio Based Industries Joint Undertaking (JU); the JU receives support from the European Union’s Horizon 2020 research and innovation program and the Bio Based Industries Consortium.info:eu-repo/semantics/publishedVersio