Bortezomib just for induction or also for maintenance in myeloma patients with renal impairment?

Bortezomib before and after autologous stem cell transplantation overcomes the negative prognostic impact of renal impairment in newly diagnosed multiple myeloma: a subgroup analysis from the HOVON-65/GMMG-HD4 trial

Sundman transformation and alternative tangent structures

A geometric approach to Sundman transformation defined by basic functions for systems of second-order differential equations is developed and the necessity of a change of the tangent structure by means of the function defining the Sundman transformation is shown. Among other applications of such theory we study the linearisability of a system of second-order differential equations and in particular the simplest case of a second-order differential equation. The theory is illustrated with several examples

Order and disorder in product innovation models

This article argues that the conceptual development of product innovation models goes hand in hand with paradigmatic changes in the field of organization science. Remarkable similarities in the change of organizational perspectives and product innovation models are noticeable. To illustrate how changes in the organizational paradigm are being translated into changes in new product development (NPD) practices, five NPD models are presented: the sequential, compression, flexible, integrative and improvisational models. The evolution of product innovation management shows a move from planned and mechanistic, towards emergent and organic models. Such a process of re-orientation poses several challenges that are presented in the form of six propositions: from universal to contingent models, from invariant to flexible practices, from avoiding risks to taking advantage of opportunities, from planning to learning, from exclusive teams to inclusive networks, from structure to structured chaos

Valuation of fresh produce at Local Markets, consumer´sperspectives

[resumo][abstract

Aplicaciones basadas en las propiedades eléctricas y térmicas de recubrimientos de sílice-cb obtenidos por el método sol-gel

En los últimos años el interés en los recubrimientos obtenidos por sol-gel ha aumentado mucho en aplicaciones de protección y refuerzo de superficies contra la corrosión. Asimismo, el uso de polimorfos de carbono (nanofibras de carbono, grafeno, grafito...) para mejorar las propiedades mecánicas y conferirle propiedades conductoras a algunos materiales, también se ha desarrollado mucho en los últimos años. En trabajos previos se prepararon y estudiaron recubrimientos híbridos de sílice-CB obtenidos por el método sol-gel. Mediante el estudio de la microestructura y composición de estos recubrimientos (SEM, Raman, ATD-TG, y FT-IR) y de las propiedades eléctricas se obtuvo que en función la temperatura de sinterización de los recubrimientos, se podía controlar la respuesta eléctrica de los composites. Esto permite abrir enormemente el campo de aplicaciones, ya que para temperaturas de sinterización por debajo de 400ºC se consiguen resistividades del orden de 10-4Ωm, apropiadas para aplicaciones en dispositivos electrónicos, electrodos, apantallamiento de interferencias electromagnéticas y radiofreciencia, etc; mientras que para temperaturas de sinterización por encima de 400ºC, obtenemos recubrimientos más resistivos que pueden aplicarse como dispositivos calefactores, anticongelantes. Por tanto, el objetivo de este trabajo es desarrollar más profundamente estas aplicaciones, así como diseñar experimentos que demuestren las múltiples posibilidades que estos recubrimientos conductores obtenidos por sol-gel pueden aportar

Roadmap to cure multiple myeloma

Despite significant advances in the treatment of multiple myeloma which had led to unprecedented rates of response and survival, patients still relapse, and cure remains elusive. We propose in this review a roadmap to achieve the dream of cure for multiple myeloma based on five complementary strategies. First, to increase knowledge about disease pathogenesis with a focus on the biology of circulating tumor cells, responsible for dissemination and extramedullary disease, and minimal residual disease clones who represent the reservoir of clonal evolution and disease recurrence. Second, to consider undetectable measurable residual disease (MRD), defined by high-sensitive techniques, as the new endpoint of therapy. Third, to treat disease causation instead of symptomatology through early detection and intervention. Thereby, by treating high-risk smoldering myeloma patients early, we may not only contribute to delay disease progression into active disease but also to increase the cure rates. Fourth, to use the most active scheme in standard-risk patients if the cure is in the horizon. Fifth, to investigate experimental therapies in newly diagnosed patients with high-risk MM, implementing early rescue intervention strategies with the goal of eradicating all tumor clones, and achieving minimal residual disease negativity

Methodology to Evaluate the Embodied Primary Energy and CO2 Production at Each Stage of the Life Cycle of Prefabricated Structural Systems: The Case of the Solar Decathlon Competition

The construction industry is responsible for a high percentage of the energy consumed on the planet and the emission of greenhouse gases, therefore it is considered necessary to rethink many of the processes that this industry carries out in order to reduce its environmental impact. For this, one of the paths could take into account the Life Cycle Assessment of the used materials, for which it is necessary to evaluate this aspect through indicators that allow the qualification and quantification of the weight of these environmental impacts. In this context, this article presents a methodological proposal for the quantitative evaluation of the embodied primary energy and CO2 production at each stage of the life cycle of prefabricated structural systems, taking as case studies eight prototypes from the “Solar Decathlon” competition in its editions of Europe (2014), United States (2015) and Latin America (2015), through a Simplified Life Cycle Analysis, using the Eco Audit tool from CES Edupack. Through this analysis, conclusions are drawn about the optimization of a structural system with lower environmental demand and the possibilities of transferring knowledge from this competition to be applied in innovative systems of new housing model

Sources and pathways of trace elements in urban environments: A multielemental qualitative approach

A geochemical model of an urban environment is presented in which multielemental tracers are used to characterise the circulation of trace elements in particulate matter_atmospheric aerosol, street dust and urban soil, within a city

Online, social media and mobile technologies for psychosis treatment: a systematic review on novel user-led interventions

Internet and mobile-based interventions provide a unique opportunity to deliver cost-effective, accessible, time-unlimited support to people with psychosis. The aims of this study were to systematically compile and analyze the evidence on the acceptability, feasibility, safety and benefits of online and mobile-based interventio is for psychosis. Methods: Systematic review of peer-reviewed studies examining the usability, acceptability, feasibility, safety or efficacy of user-led, Internet or mobile-based interventions, with at least 80% of participants diagnosed with schizophrenia-spectrum disorders. Results: Of 38 potentially relevant articles, 12 were eligible for inclusion. Interventions included web-based psycho-education; web-based psycho-education plus moderated forums for patients and supporters; integrated web-based therapy, social networking and peer and expert moderation; web-based CBT; personalized advice based on clinical monitoring; and text messaging interventions. Results showed that 74–86% of patients used the web-based interventions efficiently, 75–92% perceived them as positive and useful, and 70–86% completed or were engaged with the interventions over the follow-up. Preliminary evidence indicated that online and mobile-based interventions show promise in improving positive psychotic symptoms, hospital admissions, socialization, social connectedness, depression and medication adherence. Conclusions: Internet and mobile-based interventions for psychosis seem to be acceptable and feasible and have the potential to improve clinical and social outcomes. The heterogeneity, poor quality and early state of current research precludes any definite conclusions. Future research should investigate the efficacy of online and mobile interventions through controlled, well-powered studies, which investigate intervention and patient factors associated with take-up and intervention effects

Supporting collaborative improvement of resources in the Khresmoi health information system

Since medical knowledge relies on both scientific knowledge and real-life experience, the importance of user contributions to improve resources in health systems cannot be underestimated. We present work from the Khresmoi project which aims to develop a multilingual multimodal search and access system for biomedical information and documents. Khresmoi targets three distinct user classes with differing levels of medical knowledge and information requirements, namely: general public, general practitioners, and, as an example of an area of clinical expertise, radiologists. The Khresmoi system will provide these users with valuable (whose quality has been evaluated and approved) and enriched (meta information from biomedical knowledge bases is added) medical information, selected to fit their medical knowledge and their preferred language. The system will include novel collaborative components of the system are designed to provide means for users to contribute to the system’s knowledge by adding or correcting annotations to the documents, as well as a collaborative platform where they will be able to share their own files and both annotate and discuss them