Immediately restored dental implants for partial-arch applications : a literature update

This article carries out a literature update on immediately restored dental implants in partially edentulous patients. A search was made in Medline of all articles published between the year 2000 and February 2007, including all articles published in both English and Spanish, in which immediate restoration of implants was made of partially edentulous areas with a minimum of 12 implants and six months follow-up. Certain decisive factors exist for the success of this technique in partially edentulous patients, such as primary stability, a roughened implant surface, and the absence of parafunctional habits in patients acceptable for this type of treatment. Following the analysis of these studies of immediate restoration of teeth in partially edentulous areas, a weighted mean survival of 95.39% was observed. In spite of the high success rate, major controversy still exists on this subject resulting in few studies and short follow-up periods, making the routine use of this technique questionable

Processing and characterization of binary poly(hydroxybutyrate) (PHB) and poly(caprolactone) (PCL) blends with improved impact properties

The final publication is available at Springer via http://dx.doi.org/10.1007/s00289-016-1659-6[EN] The present work is focused on the development of binary blends from poly(hydroxybutyrate) (PHB) and poly(caprolactone) (PCL). Miscibility, mechanical and thermal properties as well as blends morphology are evaluated in terms of the blend composition. Binary PHB PCL blends were manufactured by melt compounding in a twin screw co-rotating extruder and injection molded. The composition of PHB PCL covered the full range between individual polymers at 25 wt% increments. The obtained results show that PCL acts as an impact modifier, thus leading to an increase in flexibility and ductility as the PCL content in the PHB PCL blends increases with a noticeable increase in elongation at break and on the energy absorption in impact conditions. The tensile strength and the elastic modulus decrease with increasing PCL content in the PHB PCL blends; nevertheless, the flexural strength and the flexural modulus reach the highest values for the PHB PCL blends containing 25 wt% PCL, with a remarkable decrease over this composition. The analysis of fractured surfaces by field emission scanning electron microscopy and thermal properties obtained by differential scanning calorimetry (DSC) and TGA give clear evidences of the immiscibility of these two biodegradable polymers. Additionally, DSC results showed an increase in crystallinity of both PHB and PCL with regard to individual polymers for PHB PCL blends containing 25 wt% PCL. Furthermore, an increase in the degradation onset (T0) of about 30 C higher was detected for the same blends. Dynamic mechanical thermal analysis showed slightly shifted glass transition temperatures of each individual polymer, thus indicating that although both PHB and PCL are not fully miscible, some interactions between them occur.This research was supported by the Ministry of Economy and Competitiveness-MINECO, Ref: MAT2014-59242-C2-1-R. The authors also thank the "Conselleria d'Educacio, Cultura i Esport"-Generalitat Valenciana, Ref: GV/2014/008 for financial support. D. Garcia-Garcia thanks the Spanish Ministry of Education, Culture and Sports for their financial support through an FPU Grant (FPU13/06011).García García, D.; Ferri Azor, JM.; Boronat Vitoria, T.; López-Martínez, J.; Balart Gimeno, RA. (2016). Processing and characterization of binary poly(hydroxybutyrate) (PHB) and poly(caprolactone) (PCL) blends with improved impact properties. 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Eur Polym J 49:1215–1233. doi: 10.1016/j.eurpolymj.2013.01.019Hinueber C, Haeussler L, Vogel R, Bruenig H, Heinrich G, Werner C (2011) Hollow fibers made from a poly(3-hydroxybutyrate)/poly-epsilon-caprolactone blend. eXPRESS Polym Lett 5:643–652. doi: 10.3144/expresspolymlett.2011.62Kumagai Y, Doi Y (1992) Enzymatic degradation and morphologies of binary blends of microbial poly(3-hydroxy butyrate) with poly(epsilon-caprolactone), poly(1,4-butylene adipate and poly(vinyl acetate). Polym Degrad Stab 36:241–248. doi: 10.1016/0141-3910(92)90062-aAvella M, Martuscelli E, Raimo M (2000) Review—properties of blends and composites based on poly(3-hydroxy)butyrate (PHB) and poly(3-hydroxybutyrate-hydroxyvalerate) (PHBV) copolymers. 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Impact of Social Media on TV Content Consumption: New Market Strategies, Scenarios and Trends

The mass adoption of Social Media together with the proliferation and widely usage of multi-connected companion devices have tremendously transformed the TV/video consumption paradigm, opening the door to a new range of possibilities. This Special Issue has aimed at analyzing, from different point of views, the impact of Social Media and social interaction tools on the TV/video consumption area. The targeted topics of this Special Issue and a general overview of the accepted articles are provided in this Guest Editorial

Effect of meal composition and alcohol consumption on postprandial glucose concentration in subjects with type 1 diabetes: a randomized crossover trial

[EN] Introduction Meal composition is known to affect glycemic variability and glucose control in type 1 diabetes. The objective of this work was to evaluate the effect of high carbohydrate meals of different nutritional composition and alcohol on the postprandial glucose response in patients with type 1 diabetes. Research design and methods Twelve participants were recruited to this randomized crossover trial. Following a 4-week run-in period, participants received a mixed meal on three occasions with the same carbohydrate content but different macronutrient composition: high protein-high fat with alcohol (0.7g/kg body weight, beer), high protein-high fat without alcohol, and low protein-low fat without alcohol at 2-week intervals. Plasma and interstitial glucose, insulin, glucagon, growth hormone, cortisol, alcohol, free fatty acids, lactate, and pH concentrations were measured during 6 hours. A statistical analysis was then carried out to determine significant differences between studies. Results Significantly higher late postprandial glucose was observed in studies with higher content of fats and proteins (p=0.0088). This was associated with lower time in hypoglycemia as compared with the low protein and fat study (p=0.0179), at least partially due to greater glucagon concentration in the same period (p=0.04). Alcohol significantly increased lactate, decreased pH and growth hormone, and maintained free fatty acids suppressed during the late postprandial phase (p<0.001), without significant changes in plasma glucose. Conclusions Our data suggest that the addition of proteins and fats to carbohydrates increases late postprandial blood glucose. Moreover, alcohol consumption together with a mixed meal has relevant metabolic effects without any increase in the risk of hypoglycemia, at least 6 hours postprandially.This paper presents independent research financially supported by Ministerio de Economia y Competitividad (MINECO) (DPI2016--78831-C2--1--R), Agencia Estatal de Investigacion (PID2019--107722RB--C21/AEI/10.13039/501100011033), and the European Union through FEDER funds.García, A.; Moscardo-Garcia, V.; Ramos-Prol, A.; Diaz, J.; Boronat, M.; Bondía Company, J.; Rossetti, P. (2021). Effect of meal composition and alcohol consumption on postprandial glucose concentration in subjects with type 1 diabetes: a randomized crossover trial. BMJ Open Diabetes Research & Care. 9(1):1-8. https://doi.org/10.1136/bmjdrc-2021-002399189

Complete Integration of Team Project-Based Learning Into a Database Syllabus

Team project-based learning (TPBL) combines two learning techniques: 1) project-based learning (PBL) and 2) teamwork. This combination leverages the learning outcomes of both methods and places students in a real work situation where they must develop and solve a real project while working as a team. TPBL has been used in two advanced database subjects in Jaume I University (UJI)’s Computer Science degree program. This learning method was used for four years (academic years from 2018/2019 to 2021/2022) with positive outcomes. This study presents the project development, which includes teamwork formation, activities, timetable, and exercised learning competencies (both soft and specific). Further, the project’s results were evaluated from three different perspectives: 1) teamwork evaluation by teammates; 2) students’ opinions on the subject and project; and 3) subject final grades

Aprendizaje basado en proyectos y trabajo en equipo para mejorar las competencias básicas

El aprendizaje basado en proyectos es una técnica de enseñanza/aprendizaje que utiliza un proyecto como eje principal del proceso de aprendizaje. Este aprendizaje, combinado con el trabajo en equipo permite mejorar la adquisición tanto de las competencias específicas como de las básicas. Desde hace tres años, en las asignaturas de bases de datos avanzadas del Grado de Ingeniería Informática de la Universidad Jaume I se utiliza de forma combinada el aprendizaje basado en proyectos y el trabajo en equipo. En este artículo se presenta la experiencia adquirida, las actividades del proyecto y las competencias alcanzadas en cada actividad. Por último, se analiza y evalúan los resultados obtenidos, proponiendo una serie de actuaciones de trabajo futuras

Behavioral and Cognitive Improvement Induced by Novel Imidazoline I2 Receptor Ligands in Female SAMP8 Mice

As populations increase their life expectancy, age-related neurodegenerative disorders such as Alzheimer's disease have become more common. I2-Imidazoline receptors (I2-IR) are widely distributed in the central nervous system, and dysregulation of I2-IR in patients with neurodegenerative diseases has been reported, suggesting their implication in cognitive impairment. This evidence indicates that high-affinity selective I2-IR ligands potentially contribute to the delay of neurodegeneration. In vivo studies in the female senescence accelerated mouse-prone 8 mice have shown that treatment with I2-IR ligands, MCR5 and MCR9, produce beneficial effects in behavior and cognition. Changes in molecular pathways implicated in oxidative stress, inflammation, synaptic plasticity, and apoptotic cell death were also studied. Furthermore, treatments with these I2-IR ligands diminished the amyloid precursor protein processing pathway and increased Aβ degrading enzymes in the hippocampus of SAMP8 mice. These results collectively demonstrate the neuroprotective role of these new I2-IR ligands in a mouse model of brain aging through specific pathways and suggest their potential as therapeutic agents in brain disorders and age-related neurodegenerative diseases. Keywords Imidazoline I2 receptors (2-imidazolin-4-yl)phosphonates Behavior Cognition Neurodegeneration Neuroprotection Agin

Seguimiento de las guías españolas para el manejo del asma por el médico de atención primaria: un estudio observacional ambispectivo

Objetivo Evaluar el grado de seguimiento de las recomendaciones de las versiones de la Guía española para el manejo del asma (GEMA 2009 y 2015) y su repercusión en el control de la enfermedad. Material y métodos Estudio observacional y ambispectivo realizado entre septiembre del 2015 y abril del 2016, en el que participaron 314 médicos de atención primaria y 2.864 pacientes. Resultados Utilizando datos retrospectivos, 81 de los 314 médicos (25, 8% [IC del 95%, 21, 3 a 30, 9]) comunicaron seguir las recomendaciones de la GEMA 2009. Al inicio del estudio, 88 de los 314 médicos (28, 0% [IC del 95%, 23, 4 a 33, 2]) seguían las recomendaciones de la GEMA 2015. El tener un asma mal controlada (OR 0, 19, IC del 95%, 0, 13 a 0, 28) y presentar un asma persistente grave al inicio del estudio (OR 0, 20, IC del 95%, 0, 12 a 0, 34) se asociaron negativamente con tener un asma bien controlada al final del seguimiento. Por el contrario, el seguimiento de las recomendaciones de la GEMA 2015 se asoció de manera positiva con una mayor posibilidad de que el paciente tuviera un asma bien controlada al final del periodo de seguimiento (OR 1, 70, IC del 95%, 1, 40 a 2, 06). Conclusiones El escaso seguimiento de las guías clínicas para el manejo del asma constituye un problema común entre los médicos de atención primaria. Un seguimiento de estas guías se asocia con un control mejor del asma. Existe la necesidad de actuaciones que puedan mejorar el seguimiento por parte de los médicos de atención primaria de las guías para el manejo del asma. Objective: To assess the degree of compliance with the recommendations of the 2009 and 2015 versions of the Spanish guidelines for managing asthma (Guía Española para el Manejo del Asma [GEMA]) and the effect of this compliance on controlling the disease. Material and methods: We conducted an observational ambispective study between September 2015 and April 2016 in which 314 primary care physicians and 2864 patients participated. Results: Using retrospective data, we found that 81 of the 314 physicians (25.8%; 95% CI 21.3–30.9) stated that they complied with the GEMA2009 recommendations. At the start of the study, 88 of the 314 physicians (28.0%; 95% CI 23.4–33.2) complied with the GEMA2015 recommendations. Poorly controlled asthma (OR, 0.19; 95% CI 0.13–0.28) and persistent severe asthma at the start of the study (OR, 0.20; 95% CI 0.12–0.34) were negatively associated with having well-controlled asthma by the end of the follow-up. In contrast, compliance with the GEMA2015 recommendations was positively associated with a greater likelihood that the patient would have well-controlled asthma by the end of the follow-up (OR, 1.70; 95% CI 1.40–2.06). Conclusions: Low compliance with the clinical guidelines for managing asthma is a common problem among primary care physicians. Compliance with these guidelines is associated with better asthma control. Actions need to be taken to improve primary care physician compliance with the asthma management guidelines