Measles vaccine: induced specific antibody in normal and undernourished infants

Two hundred and twenty tree children were studied regarding their response to the measles vaccine. The antibody response was measured by hemaglutination inhibition technique. Among the variables studied only the children's age at the time the vaccine was done had influence on the seroconvertion. Sex and nutritional status had no influence on the seroconvertion. A theoric model was designed to find at what age the vaccine had the best effect in preventing mortality. The age predicte was seven months.Foi estudada a indução de anticorpos anti-sarampo em 223 crianças nutridas e desnutridas vacinadas entre 6 e 24 meses e naquelas que permaneceram soronegativas com 1 dose da vacina realizada antes dos 12 meses que foram revacinadas após os 12 meses. A determinação de anticorpos anti-sarampo foi realizada pelas técnicas de inibição da hemaglutinação e de soroneutralização. Observamos que a taxa de soroconversão aumentou progressivamente com a idade, sendo de 43% aos 6 meses e de 80% aos 15 meses. A taxa de soroconversão em crianças marasmáticas foi semelhante à obtida em crianças nutridas, concordando com a literatura que vem demonstrando que crianças desnutridas não apresentam alteração na capacidade de resposta humoral à vacina. Utilizando os dados de mortalidade por sarampo e as taxas de soroconversão à vacina, idealizou-se um modelo hipotético para a avaliação da aplicação da vacina em diferentes idades e suas conseqüências em têrmos de mortalidade, e observou-se que quando a vacina é realizada em idades precoces (6-7 meses) o número de óbito esperado é inferior ao esperado quando a vacina é realizada em idades posteriores (9-11 meses), indicando que a proposta atual do Ministério da Saúde de aplicar dose única aos 9 meses, teoricamente aumentaria o risco de mortalidade. Considerando o número de crianças protegidas com 1 dose de vacina aplicada antes dos 12 meses e o número de crianças protegidas com a revacinação a taxa de soroconversão foi de 84,3%

Inquérito sorológico de sarampo em crianças de 5 a 15 meses de idade, em Curitiba e São José dos Pinhais, Estado do Paraná, Brasil, 1983

A serological survey intended to evaluate the causes of the high incidence of frequent outbreaks of measles in the cities of Curitiba and S. José dos Pinhais, Paraná, shows that of children vaccinated between 7 and 10 months of age, only 44% are protected, whereas in those vaccinated between the 11th and 15th months, the level of protection rises to 65.1%. Samples taken in non-vaccinated children at the 5th, 6th and 7th months of age showed protection level of 56.7%, 28.6% and 14.8% respectively. The children vaccinated during the 7th and 8th months of age had a percentage of protection of 50.8, and those vaccinated from the 9th month on, a percentage of 75.75. The geometric averages of antibody titers are also lower in those vaccinated before 9 months of age as compared to those vaccinated after this age.Inquérito sorológico, realizado para avaliar os motivos da alta incidência e surtos freqüentes de sarampo nas cidades de Curitiba e São José dos Pinhais - Paraná (Brasil), revela que entre 7 e 10 meses de idade só 44% das crianças vacinadas estão protegidas e que entre o 11º e 15º mês o índice de proteção se eleva para 65,1%. As não vacinadas, ao 5º, 6º e 7º mês de idade apresentaram percentuais de proteção de 56,7, 28,6 e 14,8, respectivamente. As crianças que foram vacinadas ao 7º e 8º mês apresentaram percentuais de proteção de 50,8 e as vacinadas a partir do 9º mês, de 75,75%. As médias geométricas dos títulos de anticorpos também foram menores nas vacinadas antes dos 9 meses, em relação às vacinadas a partir desta idade

Study of the B−→Λc+Λˉc−K−B^{-} \to \Lambda_{c}^{+} \bar{\Lambda}_{c}^{-} K^{-} decay

The decay $B^{-} \to \Lambda_{c}^{+} \bar{\Lambda}_{c}^{-} K^{-}$ is studied in proton-proton collisions at a center-of-mass energy of $\sqrt{s}=13$ TeV using data corresponding to an integrated luminosity of 5 $\mathrm{fb}^{-1}$ collected by the LHCb experiment. In the $\Lambda_{c}^+ K^{-}$ system, the $\Xi_{c}(2930)^{0}$ state observed at the BaBar and Belle experiments is resolved into two narrower states, $\Xi_{c}(2923)^{0}$ and $\Xi_{c}(2939)^{0}$, whose masses and widths are measured to be $$m(\Xi_{c}(2923)^{0}) = 2924.5 \pm 0.4 \pm 1.1 \,\mathrm{MeV}, \\ m(\Xi_{c}(2939)^{0}) = 2938.5 \pm 0.9 \pm 2.3 \,\mathrm{MeV}, \\ \Gamma(\Xi_{c}(2923)^{0}) = \phantom{000}4.8 \pm 0.9 \pm 1.5 \,\mathrm{MeV},\\ \Gamma(\Xi_{c}(2939)^{0}) = \phantom{00}11.0 \pm 1.9 \pm 7.5 \,\mathrm{MeV},$$ where the first uncertainties are statistical and the second systematic. The results are consistent with a previous LHCb measurement using a prompt $\Lambda_{c}^{+} K^{-}$ sample. Evidence of a new $\Xi_{c}(2880)^{0}$ state is found with a local significance of $3.8\,\sigma$, whose mass and width are measured to be $2881.8 \pm 3.1 \pm 8.5\,\mathrm{MeV}$ and $12.4 \pm 5.3 \pm 5.8 \,\mathrm{MeV}$, respectively. In addition, evidence of a new decay mode $\Xi_{c}(2790)^{0} \to \Lambda_{c}^{+} K^{-}$ is found with a significance of $3.7\,\sigma$. The relative branching fraction of $B^{-} \to \Lambda_{c}^{+} \bar{\Lambda}_{c}^{-} K^{-}$ with respect to the $B^{-} \to D^{+} D^{-} K^{-}$ decay is measured to be $2.36 \pm 0.11 \pm 0.22 \pm 0.25$, where the first uncertainty is statistical, the second systematic and the third originates from the branching fractions of charm hadron decays.Comment: All figures and tables, along with any supplementary material and additional information, are available at https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-028.html (LHCb public pages

Asociación entre la presencia de anticuerpos contra Leptospira y lesiones renales en bovinos

El estudio tuvo como objetivo determinar la posible relación entre la presencia de lesiones denominadas «Riñón con Manchas Blancas» (RMB) y la seroprevalencia de Leptospira spp en bovinos sacrificados en el matadero del cantón Manta, provincia Manabí, Ecuador. Se tomaron muestras de sangre a 320 bovinos para detectar anticuerpos contra bacterias del género Leptospira utilizando la técnica de microaglutinación. Asi-mismo, se hizo una revisión macroscópica de los riñones y se tomaron muestras para el análisis histopatológico. La seroprevalencia de Leptospira spp fue de 50.9% y la fre-cuencia de lesiones renales fue de 18.13%. Se encontró la presencia de los ocho serovares evaluados, siendo mayor la frecuencia de los serovares Pomona, Icterohaemorragiae y Bratislava. Los animales serológicamente positivos a Leptospira presentan 40.56 más probabilidad de presentar lesiones específicas asociadas con la enfermedad al momento del sacrificio (p<0.00001; OR=40.56; IC 95%= 9.86-169.79). Se determinó asociación signi-ficativa entre la presencia de lesiones renales con los serovares Icterohaemorragiae, Canicola, Hardjo y Wolffi. No se encontró asociación entre la presencia de lesiones con el sexo de los animales ni con el cantón de procedencia. Se concluye que existe relación entre la seroprevalencia a Leptospira spp y la presencia de lesiones renales (RMB)

Improved measurement of CPCP violation parameters in Bs0→J/ψK+K−B_s^0\to J/\psi K^+K^- decays in the vicinity of the ϕ(1020)\phi(1020) resonance

The decay-time-dependent $CP$ asymmetry in $B_s^0\to J/\psi(\to \mu^+\mu^-) K^+ K^-$ decays is measured using proton-proton collision data, corresponding to an integrated luminosity of $6 {\rm fb}^{-1}$, collected with the LHCb detector at a center-of-mass energy of 13 TeV. Using a sample of approximately 349 000 $B_s^0$ signal decays with an invariant $K^+ K^-$ mass in the vicinity of the $\phi(1020)$ resonance, the $CP$-violating phase $\phi_s$ is measured, along with the difference in decay widths of the light and heavy mass eigenstates of the $B_s^0$-$\overline{B}_s^0$ system, $\Delta\Gamma_s$, and the difference of the average $B_s^0$ and $B^0$ meson decay widths, $\Gamma_s-\Gamma_d$. The values obtained are $\phi_s = -0.039 \pm 0.022 \pm 0.006$ rad, $\Delta\Gamma_s = 0.0845 \pm 0.0044 \pm 0.0024 ~{\rm ps}^{-1}$ and $\Gamma_s-\Gamma_d = -0.056^{\:+\:0.0013}_{\:-\:0.0015} \pm 0.0014 ~{\rm ps}^{-1}$, where the first uncertainty is statistical and the second systematic. These are the most precise single measurements to date and are consistent with expectations based on the Standard Model and with the previous LHCb analyses of this decay. These results are combined with previous independent LHCb measurements. The phase $\phi_s$ is also measured independently for each polarization state of the $K^+K^-$ system and shows no evidence for polarization dependence.The decay-time-dependent $CP$ asymmetry in $B^0_s\to J/\psi(\to \mu^{+}\mu^{-}) K^{+}K^{-}$ decays is measured using proton-proton collision data, corresponding to an integrated luminosity of 6 $fb^{-1}$, collected with the LHCb detector at a center-of-mass energy of 13 TeV. Using a sample of approximately 349 000 $B^{0}_{s}$ signal decays with an invariant $K^{+}K^{-}$ mass in the vicinity of the $\phi(1020)$ resonance, the $CP$-violating phase $\phi_s$ is measured, along with the difference in decay widths of the light and heavy mass eigenstates of the $B^0_s$-$\bar{B}^0_s$ system, $\Delta\Gamma_s$, and the difference of the average $B^0_s$ and $B^0$ meson decay widths, $\Gamma_s-\Gamma_d$. The values obtained are $\phi_s = \ -0.039 \pm 0.022 \pm 0.006$ rad, $\Delta\Gamma_s = 0.0845 \pm 0.0044 \pm 0.0024$ ps$^{-1}$ and $\Gamma_s-\Gamma_d = -0.0056 ^{+ 0.0013}_{-0.0015} \pm 0.0014$ ps$^{-1}$, where the first uncertainty is statistical and the second systematic. These are the most precise single measurements to date and are consistent with expectations based on the Standard Model and with the previous LHCb analyses of this decay. These results are combined with previous independent LHCb measurements. The phase $\phi_s$ is also measured independently for each polarization state of the $K^{+}K^{-}$ system and shows no evidence for polarization dependence

Observation of Ξb0→Ξc+Ds−\Xi_b^0 \rightarrow \Xi_c^+ D_s^- and Ξb−→Ξc0Ds−\Xi_b^- \rightarrow \Xi_c^0 D_s^- decays

International audienceThe $\Xi_b^0 \rightarrow \Xi_c^+ D_s^-$ and $\Xi_b^- \rightarrow \Xi_c^0 D_s^-$ decays are observed for the first time using proton-proton collision data collected by the LHCb experiment at a centre-of-mass energy of $\sqrt{s}=13\mathrm{TeV}$, corresponding to an integrated luminosity of $5.1\mathrm{fb}^{-1}$. The relative branching fractions times the beauty-baryon production cross-sections are measured to be \begin{align*} \mathcal{R}\left(\frac{\Xi_b^0}{\Lambda_b^0}\right) \equiv \frac{\sigma\left(\Xi_b^0\right)}{\sigma\left(\Lambda_b^0\right)} \times \frac{\mathcal{B}\left(\Xi_b^0 \rightarrow \Xi_c^+ D_s^-\right)}{\mathcal{B}\left(\Lambda_b^0 \rightarrow \Lambda_c^0 D_s^-\right)} =(15.8\pm1.1\pm0.6\pm7.7)\%, \mathcal{R}\left(\frac{\Xi_b^-}{\Lambda_b^0}\right) \equiv \frac{\sigma\left(\Xi_b^-\right)}{\sigma\left(\Lambda_b^0\right)} \times \frac{\mathcal{B}\left(\Xi_b^- \rightarrow \Xi_c^0 D_s^-\right)}{\mathcal{B}\left(\Lambda_b^0 \rightarrow \Lambda_c^0 D_s^-\right)} =(16.9\pm1.3\pm0.9\pm4.3)\%, \end{align*} where the first uncertainties are statistical, the second systematic, and the third due to the uncertainties on the branching fractions of relevant charm-baryon decays. The masses of $\Xi_b^0$ and $\Xi_b^-$ baryons are measured to be $m_{\Xi_b^0}=5791.12\pm0.60\pm0.45\pm0.24\mathrm{MeV}/c^2$ and $m_{\Xi_b^-}=5797.02\pm0.63\pm0.49\pm0.29\mathrm{MeV}/c^2$, where the uncertainties are statistical, systematic, and those due to charm-hadron masses, respectively

Measurement of CP violation in B0→ψ(→ℓ+ℓ−)KS0(→π+π−)B^0\to\psi(\to\ell^+\ell^-)K^0_S(\to\pi^+\pi^-) decays

International audienceA measurement of time-dependent CP violation in the decays of $B^0$ and $\overline{B}^0$ mesons to the final states $J/\psi(\to\mu^+\mu^-)K^0_S$, $\psi(2S)(\to\mu^+\mu^-)K^0_S$ and $J/\psi(\to e^+e^-)K^0_S$ with $K^0_S\to\pi^+\pi^-$ is presented. The data correspond to an integrated luminosity of 6 fb${}^{-1}$ collected at a centre-of-mass energy of $\sqrt{s}=13$ TeV with the LHCb detector. The CP-violation parameters are measured to be \begin{align*} S_{\psi K^0_S} &= 0.717 \pm 0.013 (\text{stat}) \pm 0.008 (\text{syst}), \\ C_{\psi K^0_S} &= 0.008 \pm 0.012 (\text{stat}) \pm 0.003 (\text{syst}). \end{align*} This measurement of $S_{\psi K^0_S}$ represents the most precise single measurement of the CKM angle $\beta$ to date and is more precise than the current world average. In addition, measurements of the CP-violation parameters of the individual channels are reported and a combination with the LHCb Run 1 measurements is performed

Measurement of CP violation in B0→ψ(→ℓ+ℓ−)KS0(→π+π−)decaysB^0\to \psi(\to\ell^+\ell^-)K^0_\mathrm{S}(\to \pi^+\pi^-)decays

A measurement of time-dependent $C\!P$ violation in the decays of $B^0$ and $\overline{B}^0$ mesons to the final states ${J\!/\!\psi(\to\mu^+\mu^-)K^0_\mathrm{S}}$, $\psi(2S)(\to\mu^+\mu^-)K^0_\mathrm{S}$ and $J\!/\!\psi(\to e^+e^-)K^0_\mathrm{S}$ with $K^0_\mathrm{S}\pi^+\pi^-$ is presented. The data correspond to an integrated luminosity of $6\,\mathrm{fb}^{-1}$ collected at a centre-of-mass energy of $\sqrt{s}=13\,\mathrm{TeV}$ with the LHCb detector. The $C\!P$-violation parameters are measured to be \begin{align*} S_{\psi K^0_\mathrm{S}} &= 0.717 \pm 0.013\,(\text{stat}) \pm 0.008\,(\text{syst}), \\ C_{\psi K^0_\mathrm{S}} &= 0.008 \pm 0.012\,(\text{stat}) \pm 0.003\,(\text{syst}). \end{align*} This measurement of $S_{\psi K^0_\mathrm{S}}$ represents the most precise single measurement of the CKM angle $\beta$ to date and is more precise than the current world average. In addition, measurements of the $C\!P$-violation parameters of the individual channels are reported and a combination with the LHCb Run 1 measurements is performed.A measurement of time-dependent CP violation in the decays of $B^0$ and $\overline{B}^0$ mesons to the final states $J/\psi(\to\mu^+\mu^-)K^0_S$, $\psi(2S)(\to\mu^+\mu^-)K^0_S$ and $J/\psi(\to e^+e^-)K^0_S$ with $K^0_S\to\pi^+\pi^-$ is presented. The data correspond to an integrated luminosity of 6 fb${}^{-1}$ collected at a centre-of-mass energy of $\sqrt{s}=13$ TeV with the LHCb detector. The CP-violation parameters are measured to be \begin{align*} S_{\psi K^0_S} &= 0.717 \pm 0.013 (\text{stat}) \pm 0.008 (\text{syst}), \\ C_{\psi K^0_S} &= 0.008 \pm 0.012 (\text{stat}) \pm 0.003 (\text{syst}). \end{align*} This measurement of $S_{\psi K^0_S}$ represents the most precise single measurement of the CKM angle $\beta$ to date and is more precise than the current world average. In addition, measurements of the CP-violation parameters of the individual channels are reported and a combination with the LHCb Run 1 measurements is performed