Hansen's disease in a native-born, United States resident, after a brief stay in an endemic area abroad

AbstractDespite the overall decline in number of leprosy cases in the United States, small numbers of patients with the disease continue to be reported, predominantly among immigrant populations. Occasional cases occur among native-born American residents, predominantly from the southern United States. The source of the reservoir and transmission among indigenous HD cases remains unexplained, although armadillos in the state of Texas and Louisiana have been implicated. Since most patients among the indigenous cases occur in older age groups, the possibility of reactivation of the disease through immunosenescence has been raised. In most patients, unfamiliarity with the clinical picture of HD among physicians in the United States accounts for delayed or incorrect diagnosis. High index of suspicion in a patient with unusual skin lesions, particularly with sensory loss, should be followed by a biopsy looking for the characteristic histologic changes found in various forms of leprosy. Reversal reactions and erythema nodosum leprosum are relatively frequent complications of treatment. Treatment and periodic follow-up of these patients should be done, preferably by physicians with experience with the disease entity

Dynamically variable spot size laser system

A Dynamically Variable Spot Size (DVSS) laser system for bonding metal components includes an elongated housing containing a light entry aperture coupled to a laser beam transmission cable and a light exit aperture. A plurality of lenses contained within the housing focus a laser beam from the light entry aperture through the light exit aperture. The lenses may be dynamically adjusted to vary the spot size of the laser. A plurality of interoperable safety devices, including a manually depressible interlock switch, an internal proximity sensor, a remotely operated potentiometer, a remotely activated toggle and a power supply interlock, prevent activation of the laser and DVSS laser system if each safety device does not provide a closed circuit. The remotely operated potentiometer also provides continuous variability in laser energy output

The Stability of an Isotropic Cosmological Singularity in Higher-Order Gravity

We study the stability of the isotropic vacuum Friedmann universe in gravity theories with higher-order curvature terms of the form $(R_{ab}R^{ab})^{n}$ added to the Einstein-Hilbert Lagrangian of general relativity on approach to an initial cosmological singularity. Earlier, we had shown that, when $$, a special isotropic vacuum solution exists which behaves like the radiation-dominated Friedmann universe and is stable to anisotropic and small inhomogeneous perturbations of scalar, vector and tensor type. This is completely different to the situation that holds in general relativity, where an isotropic initial cosmological singularity is unstable in vacuum and under a wide range of non-vacuum conditions. We show that when $n\neq 1$, although a special isotropic vacuum solution found by Clifton and Barrow always exists, it is no longer stable when the initial singularity is approached. We find the particular stability conditions under the influence of tensor, vector, and scalar perturbations for general $n$ for both solution branches. On approach to the initial singularity, the isotropic vacuum solution with scale factor $a(t)=t^{P_{-}/3}$ is found to be stable to tensor perturbations for $0.5<n< 1.1309$ and stable to vector perturbations for $0.861425 < n \leq 1$, but is unstable as $t \to 0$ otherwise. The solution with scale factor $a(t)=t^{P_{+}/3}$ is not relevant to the case of an initial singularity for $n>1$ and is unstable as $t \to 0$ for all $n$ for each type of perturbation.Comment: 25 page

Open letter to Prime Minister David Cameron on food poverty in the UK

There is a worrying gap in health circumstances and outcomes between rich and poor people in the UK. Complex though the reasons for this inequality are, the reality is that many hardworking families in the UK are living in poverty and do not have enough income for a decent diet. UK food prices have risen by 12% in real terms since 2007, returning the cost of food relative to other goods to that in the 1990s

Extension rates across the northern Shanxi Grabens, China, from Quaternary geology, seismicity and geodesy

Discrepancies between geological, seismic and geodetic rates of strain can indicate that rates of crustal deformation, and hence seismic hazard, are varying through time. Previous studies in the northern Shanxi Grabens, at the northeastern corner of the Ordos Plateau in northern China, have found extension rates of anywhere between 0 and 6 mm a−1 at an azimuth of between 95° and 180°. In this paper we determine extension rates across the northern Shanxi Grabens from offset geomorphological features and a variety of Quaternary dating techniques (including new IRSL and Ar-Ar ages), a Kostrov summation using a 700 yr catalogue of historical earthquakes, and recent campaign GPS measurements. We observe good agreement between Quaternary, seismic and geodetic rates of strain, and we find that the northern Shanxi Grabens are extending at around 1–2 mm a−1 at an azimuth of ≈151°. The azimuth of extension is particularly well constrained and can be reliably inferred from catalogues of small earthquakes. We do not find evidence for any substantial variations in extension rate through time, though there is a notable seismic moment rate deficit since 1750. This deficit could indicate complex fault interactions across large regions, aseismic accommodation of deformation, or that we are quite late in the earthquake cycle with the potential for larger earthquakes in the relatively near future

Prevalence of non-aureus Staphylococcus species causing intramammary infections in Canadian dairy herds

Non-aureus staphylococci (NAS), the microorganisms most frequently isolated from bovine milk worldwide, are a heterogeneous group of numerous species. To establish their importance as a group, the distribution of individual species needs to be determined. In the present study, NAS intramammary infection (IMI) was defined as a milk sample containing ≥1,000 cfu/mL in pure or mixed culture that was obtained from a cohort of cows assembled by the Canadian Bovine Mastitis Research Network. Overall, 6,213 (6.3%) of 98,233 quarter-milk samples from 5,149 cows and 20,305 udder quarters were associated with an NAS IMI. Of the 6,213 phenotypically identified NAS isolates, 5,509 (89%) were stored by the Canadian Bovine Mastitis Research Network Mastitis Pathogen Collection and characterized using partial sequencing of the rpoB housekeeping gene, confirming 5,434 isolates as NAS. Prevalence of each NAS species IMI was estimated using Bayesian models, with presence of a specific NAS species as the outcome. Overall quarter-level NAS IMI prevalence was 26%. The most prevalent species causing IMI were Staphylococcus chromogenes (13%), Staphylococcus simulans (4%), Staphylococcus haemolyticus (3%), Staphylococcus xylosus (2%), and Staphylococcus epidermidis (1%). The prevalence of NAS IMI as a group was highest in first-parity heifers and was evenly distributed throughout cows in parities ≥2. The IMI prevalence of some species such as S. chromogenes, S. simulans, and S. epidermidis differed among parities. Overall prevalence of NAS IMI was 35% at calving, decreased over the next 10 d, and then gradually increased until the end of lactation. The prevalence of S. chromogenes, Staphylococcus gallinarum, Staphylococcus cohnii, and Staphylococcus capitis was highest at calving, whereas the prevalence of S. chromogenes, S. haemolyticus, S. xylosus, and S. cohnii increased during lactation. Although the overall prevalence of NAS IMI was similar across barn types, the prevalence of S. simulans, S. xylosus, S. cohnii, Staphylococcus saprophyticus, S. capitis, and Staphylococcus arlettae IMI was higher in tie-stall barns; the prevalence of S. epidermidis IMI was lowest; and the prevalence of S. chromogenes and Staphylococcus sciuri IMI was highest in bedded-pack barns. Staphylococcus simulans, S. epidermidis, S. xylosus, and S. cohnii IMI were more prevalent in herds with intermediate to high bulk milk somatic cell count (BMSCC) and S. haemolyticus IMI was more prevalent in herds with high BMSCC, whereas other common NAS species IMI were equally prevalent in all 3 BMSCC categories. Distribution of NAS species IMI differed among the 4 regions of Canada. In conclusion, distribution differed considerably among NAS species IMI; therefore, accurate identification (species level) is essential for studying NAS epidemiology

Pathways into services for offenders with intellectual disabilities : childhood experience, diagnostic information and offence variables

The patterns and pathways into intellectual disability (ID) offender services were studied through case file review for 477 participants referred in one calendar year to community generic, community forensic, and low, medium, and maximum secure services. Data were gathered on referral source, demographic information, index behavior, prior problem behaviors, diagnostic information, and abuse or deprivation. Community referrers tended to refer to community services and secure service referrers to secure services. Physical and verbal violence were the most frequent index behaviors, whereas contact sexual offenses were more prominent in maximum security. Age at first incident varied with security, with the youngest in maximum secure services. Attention-deficit/hyperactivity disorder or conduct disorder was the most frequently recorded diagnosis, and severe deprivation was the most frequent adverse developmental experience. Fire starting, theft, and road traffic offenses did not feature prominently. Generic community services accepted a number of referrals with forensic-type behavior and had higher proportions of both women and people with moderate or severe ID

Bodies, Representations, Situations, Practices: qualitative research on affect, emotion and feeling

We introduce this special issue of Qualitative Research in Psychology by discussing four themes which, in our view, characterise the collective significance of the papers in this special issue. Even in highlighting these thematic similarities, however, we point to important differences in their manifestation across different papers. In discussing bodies, we highlight an underexplored distinction between the body as ground of experience and the body as the enabler of experience. We also draw attention to three issues relating to (linguistic) representations of feelings, emotions and affect: the problem of ineffability; the role of naming feeling; and how to methodologically and analytically account for differences in the ways that feelings are talked about and named. Regarding situatedness in space and time, we note at least four analytical positions, which frame and reveal different aspects of affective phenomena. Finally, with respect to affective practices we identify two quite different approaches that, whilst sharing some characteristics, are different enough to warrant further specification when researchers deploy this term. Whilst welcoming the apparent trend away from purely language-based methods, we also offer some suggestions for how researchers can move further down this path. Nonetheless qualitative research on feeling, affect and emotion is in fine fettle. As the contributions attest, the time is ripe for this special issue of Qualitative Research in Psychology

The Variable Vector Countermeasure Suit (V2Suit) for space habitation and exploration

The “Variable Vector Countermeasure Suit (V2Suit) for Space Habitation and Exploration” is a novel system concept that provides a platform for integrating sensors and actuators with daily astronaut intravehicular activities to improve health and performance, while reducing the mass and volume of the physiologic adaptation countermeasure systems, as well as the required exercise time during long-duration space exploration missions. The V2Suit system leverages wearable kinematic monitoring technology and uses inertial measurement units (IMUs) and control moment gyroscopes (CMGs) within miniaturized modules placed on body segments to provide a “viscous resistance” during movements against a specified direction of “down”—initially as a countermeasure to the sensorimotor adaptation performance decrements that manifest themselves while living and working in microgravity and during gravitational transitions during long-duration spaceflight, including post-flight recovery and rehabilitation. Several aspects of the V2Suit system concept were explored and simulated prior to developing a brassboard prototype for technology demonstration. This included a system architecture for identifying the key components and their interconnects, initial identification of key human-system integration challenges, development of a simulation architecture for CMG selection and parameter sizing, and the detailed mechanical design and fabrication of a module. The brassboard prototype demonstrates closed-loop control from “down” initialization through CMG actuation, and provides a research platform for human performance evaluations to mitigate sensorimotor adaptation, as well as a tool for determining the performance requirements when used as a musculoskeletal deconditioning countermeasure. This type of countermeasure system also has Earth benefits, particularly in gait or movement stabilization and rehabilitation.United States. National Aeronautics and Space Administration (Innovative Advanced Concepts Grant NNX11AR25G)United States. National Aeronautics and Space Administration (Innovative Advanced Concepts Grant NNX12AQ58G