A current review of causation and management of functional myopia

A current review of the proposed causes and controls concerning the management of functional myopia is discussed. Nutritional-Disease, Mechanical-Anatomical, Environmental, and Genetic theories are reviewed. Topics concerning the controls of myopia include orthokeratology, vision training, surgery, pharmaceuticals and bifocals. A macroscopic theory of myopia development is presented and the merits of the various methods of control are evaluated

A Preliminary Report on the Frequency of Scrapie Susceptibility Alleles in Hampshire Sheep

Blood samples were collected from a total of 201 animals in five purebred Hampshire sheep flocks. DNA was isolated from the samples, and the protein-coding region of the prion protein gene was amplified using the polymerase chain reaction. The allelic frequencies of the prion protein codons 171 and 136 were determined. Results revealed that the codon 171 alleles Q, R, and H were present at frequencies of 72%, 27% and 1%, respectively. A subset of samples (n=48) was randomly selected for codon 136 genotyping. The codon 136 V allele, an allele not frequently observed in Suffolk sheep, was present in animals from three of five flocks at a frequency ranging from 7 to 33% of the animals tested within each flock. These data comprise the first report on the prevalence of scrapie susceptibility alleles in Hampshire sheep

Correction to: Genomic diversity and population structure of the Leonberger dog breed.

An amendment to this paper has been published and can be accessed via the original article

Livestock grazing and vegetative filter strip buffer effects on runoff sediment, nitrate, and phosphorus losses

Livestock grazing in the Midwestern United States can result in significant levels of runoff sediment and nutrient losses to surface water resources. Some of these contaminants can increase stream eutrophication and are suspected of contributing to hypoxic conditions in the Gulf of Mexico. This research quantified effects of livestock grazing management practices and vegetative filter strip buffers on runoff depth and mass losses of total solids, nitrate-nitrogen (NO3-N), and ortho-phosphorus (PO4-P) under natural hydrologic conditions. Runoff data were collected from 12 rainfall events during 2001 to 2003 at an Iowa State University research farm in central Iowa, United States. Three vegetative buffers (paddock area:vegetative buffer area ratios of 1:0.2, 1:0.1, and 1:0 no buffer [control]) and three grazing management practices (continuous, rotational, and no grazing [control]) comprised nine treatment combinations (vegetative buffer ratio/grazing management practice) replicated in three 1.35 ha (3.34 ac) plot areas. The total 4.05 ha (10.02 ac) study area also included nine 0.4 ha (1.0 ac) paddocks and 27 vegetative buffer runoff collection units distributed in a randomized complete block design. The study site was established on uneven terrain with a maximum of 15% slopes and consisted of approximately 100% cool-season smooth bromegrass. Average paddock and vegetative buffer plant tiller densities estimated during the 2003 project season were approximately 62 million and 93 million tillers ha−1 (153 million and 230 million tillers ac−1), respectively. Runoff sample collection pipe leakage discovered and corrected during 2001 possibly reduced runoff depth and affected runoff contaminant mass losses data values. Consequently, 2001 runoff analysis results were limited to treatment comparisons within the 2001 season and were not compared with 2002 and 2003 data. Analysis results from 2001 showed no significant differences in average losses of runoff, total solids, NO3-N, and PO4-P among the nine vegetative buffer/grazing practice treatment combinations. Results from 2002 indicated significantly higher losses of runoff and total solids from 1:0 no buffer/rotational grazing and 1:0 no buffer/continuous grazing treatment combination plots, respectively, compared among other 2002 season treatment combinations. The 2003 results showed significantly higher runoff and total solids losses from 1:0 no buffer/no grazing treatment combination plots compared among all 2003 treatment combinations and from 1:0.1 vegetative buffer/no grazing treatment combination plots compared among all 2003 treatment combinations and with respective 2002 treatment combinations. However, the 2003 results indicated effective vegetative buffer performance with significantly lower runoff, total solids, and NO3-N losses from the larger 1:0.2 buffer area compared among the smaller 1:0.1 buffer area and 1:0 no buffer treatment combinations. The 2003 results also indicated a highly significant increase in losses of NO3-N from 1:0.1 buffer/no grazing treatment combination plots compared among other 2003 season treatment combinations and with respective 2002 treatment combinations. Overall results from this study suggest a shift from significantly higher 2002 season plot losses of continuous and rotational grazing treatment combinations to significantly higher 2003 season losses of no grazing treatment combinations. We speculate this shift to significantly higher runoff and contaminant losses from no grazing treatment combination plots during 2003 reflects the variability inherent to a complex and dynamic soil-water environment of livestock grazing areas. However, we also hypothesize the environmental conditions that largely consisted of a dense perennial cool-season grass type, high-relief landscape, and relatively high total rainfall depth may not necessarily include livestock grazing activities

U-series Disequilibria in Guatemalan Lavas, Crustal Contamination, and Implications for Magma Genesis Along the Central American Subduction Zone

New U-series results indicate that Guatemalan volcanic rocks display both 238U and 230Th excesses. 230Th excess is restricted to volcanoes in central Guatemala, both along and behind the front. 230Th excess correlates with a number of incompatible element ratios, such as Th/Nb and Ba/Th. It also shows a negative correlation with MgO. Guatemalan volcanic rocks have (230Th/232Th) ratios that overlap those of Costa Rican volcanics and are therefore considerably lower than the unusually high ratios characterizing volcanic rocks from Nicaragua. Along-arc variations in (230Th/232Th) therefore mirror those of a number of diagnostic geochemical parameters, such as Ba/La, which are symmetrical about a peak in west central Nicaragua. The one siliceous lava analyzed, from the Cerro Quemado dome complex, has a recognizable crustal imprint, distinguished, for instance, by high Th/Nb and low Ba/Th. In mafic samples, 238U excess is attributed to addition of a U-enriched fluid component from the subducting Cocos plate. Our preferred explanation for 230Th excess in Guatemalan mafic samples, on the other hand, is crustal contamination, consistent with the relatively high Th/Nb and low Ba/Th ratios in these samples. We suspect, however, that crustal contamination only exerts a sizable control over the U-series disequilibrium of mafic magmas in Guatemala, and not elsewhere along the Central American volcanic front. This agrees with previously published trace element and isotopic evidence that throughout Central America, with the exception of Guatemala, mafic magmas are largely uncontaminated by crustal material.The work was supported by NSF grant OCE-0405666

Genome-Wide Analyses for Osteosarcoma in Leonberger Dogs Reveal the CDKN2A/B Gene Locus as a Major Risk Locus

Dogs represent a unique spontaneous cancer model. Osteosarcoma (OSA) is the most common primary bone tumor in dogs (OMIA 001441-9615), and strongly resembles human forms of OSA. Several large- to giant-sized dog breeds, including the Leonberger, have a greatly increased risk of developing OSA. We performed genome-wide association analysis with high-density imputed SNP genotype data from 273 Leonberger cases with a median age of 8.1 [3.1–13.5] years and 365 controls older than eight years. This analysis revealed significant associations at the CDKN2A/B gene locus on canine chromosome 11, mirroring previous findings in other dog breeds, such as the greyhound, that also show an elevated risk for OSA. Heritability (h2SNP) was determined to be 20.6% (SE = 0.08; p-value = 5.7 × 10−4) based on a breed prevalence of 20%. The 2563 SNPs across the genome accounted for nearly all the h2SNP of OSA, with 2183 SNPs of small effect, 316 SNPs of moderate effect, and 64 SNPs of large effect. As with many other cancers it is likely that regulatory, non-coding variants underlie the increased risk for cancer development. Our findings confirm a complex genetic basis of OSA, moderate heritability, and the crucial role of the CDKN2A/B locus leading to strong cancer predisposition in dogs. It will ultimately be interesting to study and compare the known genetic loci associated with canine OSA in human OSA

Pathogenic variants in COL6A3 cause Ullrich-like congenital muscular dystrophy in young Labrador Retriever dogs

The collagen VI-related muscular dystrophies in people include a broad spectrum of diseases ranging from the severe Ullrich congenital muscular dystrophy to the mild Bethlem myopathy. Clinical features are attributable to both muscle and connective tissue and include progressive muscle weakness and respiratory failure, hyperlaxity of distal joints, and progressive contracture of large joints. Here we describe two different COL6A3 pathogenic variants in Labrador Retriever dogs that result in autosomal recessive or autosomal dominant congenital myopathies with hyperlaxity of distal joints and joint contracture, similar to the condition in people

Changing gender roles and attitudes and their implications for well-being around the new millennium

<b>Purpose</b><p></p> Given evidence that gender role attitudes (GRAs) and actual gender roles impact on well-being, we examine associations between GRAs, three roles (marital status, household chore division, couple employment) and psychological distress in working-age men and women. We investigate time-trends reflecting broader social and economic changes, by focusing on three age groups at two dates.<p></p> <b>Methods</b><p></p> We used British Household Panel Survey data from 20- to 64-year-olds in heterosexual couple households in 1991 (N = 5,302) and 2007 (N = 6,621). We examined: levels of traditional GRAs according to gender, age, date, household and employment roles; associations which GRAs and roles had with psychological distress (measured via the GHQ-12); whether psychological distress increased when GRAs conflicted with actual roles; and whether any of these associations differed according to gender, age or date.<p></p> <b>Results</b><p></p> Gender traditionalism was lower among women, younger people, those participating in 2007 and in ‘less traditional’ relationships and households. Psychological distress was higher among those with more traditional GRAs and, particularly among men, for those not employed, and there was some evidence of different patterns of association according to age-group. There was limited evidence, among women only, of increased psychological distress when GRAs and actual roles conflicted and/or reductions when GRAs and roles agreed, particularly in respect of household chores and paid employment.<p></p> <b>Conclusions</b><p></p> Although some aspects of gender roles and attitudes (traditionalism and paid employment) are associated with well-being, others (marital status and household chores), and attitude-role consistency, may have little impact on the well-being of contemporary UK adults.<p></p&gt