Transparency in mineral extraction: the commodity story, the Dodd-Frank, and the emergence of \u27conflict-free\u27

The U.S. Dodd-Frank Wall Street Reform and Consumer Protection Act of 2010 includes two sections impacting the nonfuel minerals industries: the first targets \u27conflict minerals,\u27 and the second is centered on extractive industry transparency. Seeking to explain the importance of extractive industries in the creation of the modern context, my thesis begins with the commodity story of digital technology. In an era characterized by an increased curiosity into the origin of things, my work focuses on the resource geographies of minerals under neoliberalism to explain the reasons bringing extractive industry transparency onto the global agenda. After situating the issue within the global historical context and exploring the environmental and social injustices associated with mineral extraction, the importance of transparency initiatives is clear. The conflict minerals law is designed to sever the link between armed conflict in the Democratic Republic of Congo and the trade of minerals necessary in digital technology. In doing so, measures included in the law will help inform consumers whether or not producers of digital technology are sourcing minerals from belligerents in central Africa. The very process this U.S. legislation seeks to disentangle is the global commodity chain created by the expansion of neoliberal capitalism. My research illuminates the challenges in the first attempt to systematically certify metallic minerals as well as the political mechanisms currently underway to increase transparency in nonfuel mineral extraction and production

Does Fatigue Impact Static and Dynamic Balance Variables in Athletes with Previously Ankle Injury?

International Journal of Exercise Science 12(3): 1121-1137, 2019. Ankle injury, resulting in deficits in static and dynamic balance, can result in significant time loss to sport, affect daily activities and potentially place athletes at greater risk of re-injury. In order to identify athletes at risk of ankle injury accurate and reliable balance assessment tools are required. The purpose of the current study was to quantify reliability of static and dynamic balance variables in currently healthy, previously injured, athletes (n = 19) and assess the impact of an intense intermittent zig-zag running protocol to volitional exhaustion, rated by RPE, on balance variables. A test re-test design assessed short-term reliability and measurement error by computing ICC and 95% limits of agreement (LoA). The Y balance test was deemed a reliable measuring tool for assessing dynamic balance, recording strong reliability (ICC = 0.96, 95% LoA from -95.7 to 105.8%). A HURlabs iBalance force platform assessed the static balance variables sway velocity and C90area; sway velocity (mmˑs-1) recorded strong reliability (ICC = 0.79). Significant post-fatiguing protocol increases (p \u3c 0.001) were detected in single-leg static balance for both C90area (mm2) and sway velocity (mmˑs-1) assessed on stable and unstable surfaces (stable: 227 ± 84 vs. 366 ± 146 mm2and 18.6 ± 4.2 vs. 22.9 ± 5.3 mmˑs-1: unstable; 275 ± 128 vs. 370 ± 140 mm2and 19.3 ± 4.3 vs. 21.5 ± 4.0 mmˑs-1). Non-significant post-fatiguing protocol differences (p \u3e 0.05) were detected in dynamic balance variables (anterior, posteromedial, posterolateral and composite reach scores) measured at 4-min after completing the protocol. Further research should investigate the effects of fatigue on dynamic YBT variables immediately post-exercise and determine if differences exist when comparing previously injured and un-injured limbs

Spatiotemporal patterns in the distribution and abundance of the introduced Redbreast Sunfish (Lepomis auritus) and native Longear Sunfish (L. megalotis; Centrarchidae) in reservoirs of the Tennessee River drainage

The Redbreast Sunfish (Lepomis auritus) was introduced in the Tennessee River drainage (TRD) in the 1940s, and contemporary anecdotal evidence suggests that L. auritus is possibly displacing the native Longear Sunfish (Lepomis megalotis). This study aimed to characterize temporal patterns in regional abundances of L. auritus and L. megalotis populations in the TRD based on a multiyear analysis of historical and contemporary fish assemblage datasets (percent abundance, density, biomass). Results indicate that L. megalotis abundance declined in reservoirs where L. auritus was found in high or increasing abundances. Also, L. auritus surpassed L. megalotis in mean percent abundance in Nickajack-Chickamauga River section and has consequently shifted Lepomis species composition. Although it is difficult to isolate causal variables, the interaction of both biotic (i.e., L. auritus competition) and abiotic (i.e., geographic variables, land use, and water quality) factors likely explain the changes in L. megalotis abundance and variability within river sections

Inconsistent screening for lead endangers vulnerable children: policy lessons from South Bend and Saint Joseph County, Indiana, USA

Lead exposure is a major health hazard affecting children and their growth and is a concern in many urban areas around the world. One such city in the United States (US), South Bend Indiana, gained attention for its high levels of lead in blood and relatively low testing rates for children. We assessed current lead screening practices in South Bend and the surrounding St. Joseph County (SJC). The 2005–2015 lead screening data included 18,526 unique children. Lead screening rates ranged from 4.7 to 16.7%. More than 75% of children had ‘elevated blood lead levels’ (EBLL) ≥ 1 micrograms per deciliter (µg/Dl) and 9.7% had an EBLL ≥ 5 μg/dL. Over 65% of the census tracts in SJC had mean EBLL ≥ 5 μg/dL, suggesting widespread risk. Inconsistent lead screening rates, coupled with environmental and societal risk factors, put children in SJC at greater risk for harmful lead exposure than children living in states with provisions for universal screening. Indiana and other states should adhere to the US Centers for Disease Control’s guideline and use universal lead testing to protect vulnerable populations

Adverse childhood experiences and early life inflammation in the Avon Longitudinal Study of Parents and Children

BACKGROUND: Adverse childhood experiences (ACEs) have been associated with poorer health across the life course. Previous studies have used cumulative risk scores (ACE scores) or individual ACEs but these two approaches have important shortcomings. ACE scores assume that each adversity is equally important for the outcome of interest and the single adversity approach assumes that ACEs do not co-occur. Latent class analysis (LCA) is an alternative approach to operationalising ACEs data, identifying groups of people co-reporting similar ACEs. Here we apply these three approaches for ACEs operationalisation with inflammation in childhood with the aim of identifying particular ACEs or ACE combinations that are particularly associated with higher inflammation in early life. METHODS: Using data from the Avon Longitudinal Study of Parents and Children (ALSPAC) we compare ACE scores, single adversities and LCA-derived ACE clusters in their relationships with Interleukin-6 at age 9 (n = 4935) and C-Reactive Protein (CRP) at age 9 (n = 4887). ACEs included were parental separation/divorce, parental alcohol problems, parental mental health problems, parental offending, inter-parental violence, parental drug misuse, and physical, emotional and sexual abuse. RESULTS: Two thirds of the sample reported at least one ACE. Mother’s mental health problems was the most frequently reported ACE (32.3 %). LCA identified four ACE classes – ‘Low ACEs’ (81.1 %), ‘Maternal mental health problems’ (10.3 %), ‘Maternal mental health problems and physical abuse’ (6.3 %) and ‘Parental conflict, mental health problems and emotional abuse’ (2.4 %). Parental separation/divorce was associated with higher IL-6. Parental alcohol problems, paternal mental health problems, parental convictions and emotional abuse were associated with lower levels of IL-6. Associations for paternal mental health problems and emotional abuse were only observed for boys. ACE score and LCA-derived ACE classes were not associated with differences in IL-6. Girls in the ‘Maternal mental health problems’ cluster had lower CRP levels. CONCLUSIONS: Specific adversities and adversity combinations are important for differences in childhood inflammation. Some associations were only observed for girls or boys

Inhaled hypertonic saline for cystic fibrosis: reviewing the potential evidence for modulation of neutrophil signalling and function.

Cystic fibrosis (CF) is a multisystem disorder with significantly shortened life expectancy. The major cause of mortality and morbidity is lung disease with increasing pulmonary exacerbations and decline in lung function predicting significantly poorer outcomes. The pathogenesis of lung disease in CF is characterised in part by decreased airway surface liquid volume and subsequent failure of normal mucociliary clearance. This leads to accumulation of viscous mucus in the CF airway, providing an ideal environment for bacterial pathogens to grow and colonise, propagating airway inflammation in CF. The use of nebulised hypertonic saline (HTS) treatments has been shown to improve mucus clearance in CF and impact positively upon exacerbations, quality of life, and lung function. Several mechanisms of HTS likely improve outcome, resulting in clinically relevant enhancement in disease parameters related to increase in mucociliary clearance. There is increasing evidence to suggest that HTS is also beneficial through its anti-inflammatory properties and its ability to reduce bacterial activity and biofilm formation. This review will first describe the use of HTS in treatment of CF focusing on its efficacy and tolerability. The emphasis will then change to the potential benefits of aerosolized HTS for the attenuation of receptor mediated neutrophil functions, including down-regulation of oxidative burst activity, adhesion molecule expression, and the suppression of neutrophil degranulation of proteolytic enzymes

The effect of the decoy molecule PA401 on CXCL8 levels in bronchoalveolar lavage fluid of patients with cystic fibrosis.

BACKGROUND: The chemokine interleukin-8 (CXCL8) is a key mediator of inflammation in airways of patients with cystic fibrosis (CF). Glycosaminoglycans (GAGs) possess the ability to influence the chemokine profile of the CF lung by binding CXCL8 and protecting it from proteolytic degradation. CXCL8 is maintained in an active state by this glycan interaction thus increasing infiltration of immune cells such as neutrophils into the lungs. As the CXCL8-based decoy PA401 displays no chemotactic activity, yet demonstrates glycan binding affinity, the aim of this study was to investigate the anti-inflammatory effect of PA401 on CXCL8 levels, and activity, in CF airway samples in vitro. METHODS: Bronchoalveolar lavage fluid (BALF) was collected from patients with CF homozygous for the ΔF508 mutation (n=13). CXCL8 in CF BALF pre and post exposure to PA401 was quantified by ELISA. Western blot analysis was used to determine PA401 degradation in CF BALF. The ex vivo chemotactic activity of purified neutrophils in response to CF airway secretions was evaluated post exposure to PA401 by use of a Boyden chamber-based motility assay. RESULTS: Exposure of CF BALF to increasing concentrations of PA401 (50-1000pg/ml) over a time course of 2-12h in vitro, significantly reduced the level of detectable CXCL8 (P CONCLUSION: PA401 can disrupt CXCL8:GAG complexes, rendering the chemokine susceptible to proteolytic degradation. Clinical application of a CXCL8 decoy, such as PA401, may serve to decrease the inflammatory burden in the CF lung in vivo

Ethnic Minority Microparticles have Distinct Pro-Thrombotic and Pro-Oxidative Phenotypes and Interact Differentially with Endothelial Cells in vitro: Implications for Risk to Cardiovascular Disease.

open access articleEthnic minority individuals are disproportionately susceptible to endothelial dysfunction and cardiovascular disease (CVD). Microparticles (MP) are biologically active membrane-bound nanovesicles released from cells that act as biomolecular shuttles. Plasma MP was isolated from healthy White, Black African, and South Asian individuals and analysed using flow cytometry. Their effects and interactions were assessed using fluorescence, confocal, and scanning electron microscopy. Total MP and a sub-population of smaller MP associated with dysfunction and disease progression were significantly increased in Black African individuals. Pro-thrombotic and pro-oxidant MP were substantially more numerous in Black African individuals. The tissue factor activity of ethnic minority MP was significantly greater than White MP. Ethnic minority MP induced significantly greater functional changes and morphology to an endothelial cell line in vitro and integrated into endothelial cells noticeably more than White MP. These data imply distinct differences in ethnic minority MP, suggesting a role in CVD susceptibility

Human papillomavirus infection : protocol for a randomised controlled trial of imiquimod cream (5%) versus podophyllotoxin cream (0.15%), in combination with quadrivalent human papillomavirus or control vaccination in treatment and prevention of recurrence of anogenital warts (HIPvac trial)

BACKGROUND: Anogenital warts are the second most common sexually transmitted infection diagnosed in sexual health services in England. About 90% of genital warts are caused by human papillomavirus (HPV) types 6 or 11, and half of episodes diagnosed are recurrences. The best and most cost-effective treatment for patients with anogenital warts is unknown. The commonly used treatments are self-administered topical agents, podophyllotoxin (0.15% cream) or imiquimod (5% cream), or cryotherapy with liquid nitrogen. Quadrivalent HPV (qHPV) vaccination is effective in preventing infection, and disease, but whether it has any therapeutic effect is not known. METHODS AND DESIGN: To investigate the efficacy of clearance and prevention of recurrence of external anogenital warts by topical treatments, podophyllotoxin 0.15% cream or imiquimod 5% cream, in combination with a three-dose regimen of qHPV or control vaccination. 500 adult patients presenting with external anogenital warts with either a first or subsequent episode of anogenital warts will be entered into this randomised, controlled partially blinded 2 × 2 factorial trial. DISCUSSION: The trial is expected to provide the first high-quality evidence of the comparative efficacy and cost-effectiveness of the two topical treatments in current use, as well as investigate the potential benefit of HPV vaccination, in the management of anogenital warts. TRIAL REGISTRATION: The trial was registered prior to starting recruitment under the following reference numbers: International Standard Randomized Controlled Trial Number (ISRCTN) Registry - ISRCTN32729817 (registered 25 July 2014); European Union Clinical Trials Register (EudraCT) - 2013-002951-14 (registered 26 June 2013)