Advances in Disease Mechanisms and Translational Technologies: Clinicopathologic Significance of Inflammasome Activation in Autoimmune Diseases

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/154483/1/art41127.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/154483/2/art41127_am.pd

Changing home care aides: Differences between family and non-family care in California Medicaid home and community-based services.

In California Medicaid home-and-community-based services (HCBS), recipients' family members receive payment as home care aides (HCAs). We analyzed data on first-time HCBS recipients to examine factors associated with the likelihood of switching HCAs within the first year of services. Those with family HCAs were less than half as likely to change than those with non-family HCAs and racial/ethnic minorities with non-family HCAs had the highest switching rates. Lower wages and local unemployment were associated with switching of non-family HCAs but not family HCAs. Policymakers can foster continuity of home care by paying family members for home care and raising worker wages

Meta Analysis of Human AlzGene Database: Benefits and Limitations of Using C. elegans for the Study of Alzheimer\u27s Disease and Co-Morbid Conditions

Human genome-wide association studies (GWAS) and linkage studies have identified 695 genes associated with Alzheimer\u27s disease (AD), the vast majority of which are associated with late-onset AD. Although orthologs of these AD genes have been studied in several model species, orthologs in the nematode, Caenorhabditis elegans, remain incompletely identified, with orthologs to only 17 AD-related genes identified in the C. elegans database, WormBase. Therefore, we performed a comprehensive search for additional C. elegans orthologs of AD genes using well-established programs, including OrthoList, which utilizes four ontology prediction programs. We also validated 680 of the AD genes as a unique gene from the AlzGene database, including 431 genes (63%) that are predicted to have orthologs in C. elegans. Another 178 human AD genes (26%) were associated with one or more other neurological diseases, including amyotrophic lateral sclerosis, multiple sclerosis, Parkinson\u27s disease, and schizophrenia. Of these, there were 105 genes (59%) with orthologs in C. elegans. Interestingly, three AD genes (ACE, TNF, and MTHFR) were associated with all four of the other neurological diseases. The human AD genes were enriched in three major ontology pathway groups, including lipoprotein metabolism, hemostasis, and extracellular matrix organizations, as well as in pathways that are amyloid related (NOTCH signaling) and associated with neural (neurotransmitter clearance) and immune (advanced glycation end-product receptor signaling and TRAF6-NF-kappaB) systems. Thus, the results from this study provide a potentially useful system for assessing comorbidities that may be associated with late-onset AD and other neurological conditions. The technical advantages and limitations of the ortholog searches are further discussed

Mechanical Strength Comparison of Hydrated and Dehydrated Pteridium Stems

In this experiment, the mechanical strength of Pteridium stems was tested in two differing conditions: hydrated and dehydrated. It was hypothesized that there would be an increased performance of hydrated stems in the presence of mechanical stress. In order to test this hypothesis, twelve 20 cm pieces of stems were cut in alternation, separating those that would be dehydrated (6) with those that were hydrated (6). The dehydrated specimens were left to dry over a period of 24 hours. The diameters of each individual stem were measured to account for variation in size and remove excess variables. All twelve stems were placed into the Instron individually and their MOE and MOR were measured. Based on the raw data that was obtained from these tests and analysis of the data performed in the form of a paired t-test, it was concluded that there is not a significant difference between the two. Both the MOE’s and MOR’s of the hydrated and dehydrated stems resulted in p values that were more than the significant 0.05 level. Although the data was found not significantly different, it is an important discovery in the scientific community

Low-Quality Housing Is Associated With Increased Risk of Malaria Infection: A National Population-Based Study From the Low Transmission Setting of Swaziland.

BackgroundLow-quality housing may confer risk of malaria infection, but evidence in low transmission settings is limited.MethodsTo examine the relationship between individual level housing quality and locally acquired infection in children and adults, a population-based cross-sectional analysis was performed using existing surveillance data from the low transmission setting of Swaziland. From 2012 to 2015, cases were identified through standard diagnostics in health facilities and by loop-mediated isothermal amplification in active surveillance, with uninfected subjects being household members and neighbors. Housing was visually assessed in a home visit and then classified as low, high, or medium quality, based on housing components being traditional, modern, or both, respectively.ResultsOverall, 11426 individuals were included in the study: 10960 uninfected and 466 infected (301 symptomatic and 165 asymptomatic). Six percent resided in low-quality houses, 26% in medium-quality houses, and 68% in high-quality houses. In adjusted models, low- and medium-quality construction was associated with increased risk of malaria compared with high-quality construction (adjusted odds ratio [AOR], 2.11 and 95% confidence interval [CI], 1.26-3.53 for low vs high; AOR, 1.56 and 95% CI, 1.15-2.11 for medium vs high). The relationship was independent of vector control, which also conferred a protective effect (AOR, 0.67; 95% CI, .50-.90) for sleeping under an insecticide-treated bed net or a sprayed structure compared with neither.ConclusionsOur study adds to the limited literature on housing quality and malaria risk from low transmission settings. Housing improvements may offer an attractive and sustainable additional strategy to support countries in malaria elimination

Effectiveness of Ledipasvir/Sofosbuvir with/without Ribavarin in Liver Transplant Recipients with Hepatitis C.

Background and Aims: Recurrent infection of hepatitis C virus (HCV) in liver transplant (LT) recipients is universal and associated with significant morbidity and mortality. Methods: We retrospectively evaluated the safety and efficacy of ledipasvir/sofosbuvir with and without ribavirin in LT recipients with recurrent genotype 1 hepatitis C. Results: Eighty-five LT recipients were treated for recurrent HCV with ledipasvir/sofosbuvirwith and without ribavirin for 12 or 24 weeks. The mean (± standard deviation [SD]) time from LT to treatment initiation was 68 (±71) months. The mean (± SD) age of the cohort was 63 (±8.6) years old. Most recipients were male (70%). Baseline alanine transaminase, total bilirubin, and HCV ribonucleic acid (RNA) values (± SD) were 76.8 (±126) mg/dL, 0.8 (±1.3) U/L, and 8,010,421.9 (±12,420,985) IU/mL, respectively. Five of 43 recipients who were treated with ribavirin required drug cessation due to side effects, with 4 of those being anemia complications. No recipient discontinued the ledipasvir/sofosbuvir. Eighty-one percent of recipients had undetectable viral levels at 4 weeks after starting therapy, and all recipients had complete viral suppression at the end of therapy. The sustained viral response at 12 weeks after completion of therapy was 94%. Conclusion : Ledipasvir and sofosbuvir with and without ribavirin therapy is an effective and well-tolerated interferon-free treatment for recurrent HCV infection after LT. Anemia is not uncommon in LT recipients receiving ribavirin

Characterization of Fine Particulate Matter and Associations between Particulate Chemical Constituents and Mortality in Seoul, Korea

Background: Numerous studies have linked fine particles [≤ 2.5 µm in aerodynamic diameter (PM2.5)] and health. Most studies focused on the total mass of the particles, although the chemical composition of the particles varies substantially. Which chemical components of fine particles that are the most harmful is not well understood, and research on the chemical composition of PM2.5 and the components that are the most harmful is particularly limited in Asia

Potential of using natural and synthetic binder in wood composites

The physical and mechanical properties of particleboard bonded with different cooking percentages of seaweed (Kappaphycus alvarezii), with different percentages of starch and different percentages of adhesives, and wood plastic composite (WPC) from High-Density Polyethlene (HDPE) with Acacia mangium wood powder were determined in this study. Seaweed mixed with different percentages of sulfuric acid (30%, 50%, 70%) and Sodium Hydroxide (70%, 50%, 30%) were prepared as a binder for particleboard. For a starch-based binder, different percentages of starch (10%, 15%, 20%) were prepared, before producing particleboard with different amounts of binder (20%, 25%, 30%). As for WPC, wood powders were bonded with different percentages of HDPE content (70%, 80%, 90%). Results indicated that WPC at 90% HDPE shows the best performance in the water absorption (0.07%) and thickness swelling test (2.54%). Starch-based particleboard recorded the highest Modulus of Elasticity (MOE) value (1115.07 N/mm2 at 15% starch with 30% amount of binder), while WPC (90% HDPE) and starch-based particleboard (10% starch with 20% amount of binder) both recorded the highest Modulus of Rupture (MOR) at the same value, which is 7.84 N/mm2. Starch-based particleboard has a better internal bond, which is 0.05 N/mm2. However, seaweed-based particleboard has a higher density value, which is 0.6 g/cm3