Covid-19 and housing struggles: The (re)makings of austerity, disaster capitalism, and the no return to normal

Seemingly overnight, the use value of housing as a life-nurturing, safe place is at the center of political discourse, policy-making, and new governmentalities. The right to suitable and secure shelter has shifted from the “radical” margins to the object of unprecedented public policy interventions worldwide. Writing collectively from the relative privilege of our (often precarious) homes, we sketch out a space to reflect on the centrality of housing and home to the Covid-19 crisis, to disentangle the key nexus between housing, the aftermath of the 2008 crisis, austerity, and the current pandemic, and connect current responses to longer-term trajectories of dispossession and disposability, bordering, ethno-nationalism, financialization, imperialism, capitalism, patriarchy, and racism. We argue that much is to be learned from collective organizing and mutual aid in the context of previous moments of disaster capitalism

Autonomous Mower Saves Energy and Improves Quality of Tall Fescue Lawn

Battery-powered autonomous mowers are designed to reduce the need of labor for lawn mowing compared with traditional endothermic engine mowers and at the same time to abate local emissions and noise. The aim of this research was to compare autonomous mower with traditional rotary mower on a tall fescue (Festuca arundinacea) lawn under different nitrogen (N) rates. A two-way factor experimental design with three replications was adopted. In the study, fourNrates (0, 50, 100, and 150 kghaL1) and two mowing systems (autonomous mower vs. gasolinepowered walk-behind rotary mower equipped for mulching) were used. As expected, N fertilization increased turf quality. At the end of the trial, the autonomous mower increased turf density (3.2 shoots/cm2) compared with the rotary mower (2.1 shoots/cm2) and decreased average leaf width (2.1 mm) compared with the rotary mower (2.7 mm). Increased density and decreased leaf width with autonomous mowing yielded higher quality turf (7.3) compared with the rotary mower (6.4) and a lower weed incidence (6% and 9% cover for autonomous mower and rotary mower, respectively). Disease incidence and mowing quality were unaffected by the mowing system. The autonomous mower working time was set to 10 hours per day (7.8 hours for mowing and 2.2 hours for recharging) for a surface of 1296 m2. The traditional rotary mower working time for the same surface was 1.02 hours per week. The estimated primary energy consumption for autonomous mower was about 4.80 kWh/week compared with 12.60 kWh/week for gasoline-powered rotary mowing. Based on turf quality aspects and energy consumption, the use of autonomous mowers could be a promising alternative to traditional mowers

Controlling crystallization and its absence: Proteins, colloids and patchy models

The ability to control the crystallization behaviour (including its absence) of particles, be they biomolecules such as globular proteins, inorganic colloids, nanoparticles, or metal atoms in an alloy, is of both fundamental and technological importance. Much can be learnt from the exquisite control that biological systems exert over the behaviour of proteins, where protein crystallization and aggregation are generally suppressed, but where in particular instances complex crystalline assemblies can be formed that have a functional purpose. We also explore the insights that can be obtained from computational modelling, focussing on the subtle interplay between the interparticle interactions, the preferred local order and the resulting crystallization kinetics. In particular, we highlight the role played by ``frustration'', where there is an incompatibility between the preferred local order and the global crystalline order, using examples from atomic glass formers and model anisotropic particles.Comment: 11 pages, 7 figure

Paneth cell ontogeny in term and preterm ovine models

IntroductionPaneth cells are critically important to intestinal health, including protecting intestinal stem cells, shaping the intestinal microbiome, and regulating host immunity. Understanding Paneth cell biology in the immature intestine is often modeled in rodents with little information in larger mammals such as sheep. Previous studies have only established the distribution pattern of Paneth cells in healthy adult sheep. Our study aimed to examine the ontogeny, quantification, and localization of Paneth cells in fetal and newborn lambs at different gestational ages and with perinatal transient asphyxia. We hypothesized that ovine Paneth cell distribution at birth resembles the pattern seen in humans (highest concentrations in the ileum) and that ovine Paneth cell density is gestation-dependent.MethodsIntestinal samples were obtained from 126–127 (preterm, with and without perinatal transient asphyxia) and 140–141 (term) days gestation sheep. Samples were quantified per crypt in at least 100 crypts per animal and confirmed as Paneth cells through in immunohistochemistry.ResultsPaneth cells had significantly higher density in the ileum compared to the jejunum and were absent in the colon.DiscussionExposure to perinatal transient asphyxia acutely decreased Paneth cell numbers. These novel data support the possibility of utilizing ovine models for understanding Paneth cell biology in the fetus and neonate

Phylogenomic analyses of the genus Drosophila reveals genomic signals of climate adaptation

Many Drosophila species differ widely in their distributions and climate niches, making them excellent subjects for evolutionary genomic studies. Here, we have developed a database of high-quality assemblies for 46 Drosophila species and one closely related Zaprionus. Fifteen of the genomes were newly sequenced, and 20 were improved with additional sequencing. New or improved annotations were generated for all 47 species, assisted by new transcriptomes for 19. Phylogenomic analyses of these data resolved several previously ambiguous relationships, especially in the melanogaster species group. However, it also revealed significant phylogenetic incongruence among genes, mainly in the form of incomplete lineage sorting in the subgenus Sophophora but also including asymmetric introgression in the subgenus Drosophila. Using the phylogeny as a framework and taking into account these incongruences, we then screened the data for genome-wide signals of adaptation to different climatic niches. First, phylostratigraphy revealed relatively high rates of recent novel gene gain in three temperate pseudoobscura and five desert-adapted cactophilic mulleri subgroup species. Second, we found differing ratios of nonsynonymous to synonymous substitutions in several hundred orthologues between climate generalists and specialists, with trends for significantly higher ratios for those in tropical and lower ratios for those in temperate-continental specialists respectively than those in the climate generalists. Finally, resequencing natural populations of 13 species revealed tropics-restricted species generally had smaller population sizes, lower genome diversity and more deleterious mutations than the more widespread species. We conclude that adaptation to different climates in the genus Drosophila has been associated with large-scale and multifaceted genomic changes

GWAS of Suicide Attempt in Psychiatric Disorders and Association With Major Depression Polygenic Risk Scores

Objective: More than 90% of people who attempt suicide have a psychiatric diagnosis;however, twin and family studies suggest that the genetic etiology of suicide attempt is partially distinct from that of the psychiatric disorders themselves. The authors present the largest genome-wide association study (GWAS) on suicide attempt, using cohorts of individuals with major depressive disorder, bipolar disorder, and schizophrenia from the Psychiatric Genomics Consortium. Methods: The samples comprised 1,622 suicide attempters and 8,786 nonattempters with major depressive disorder;3,264 attempters and 5,500 nonattempters with bipolar disorder;and 1,683 attempters and 2,946 nonattempters with schizophrenia. A GWAS on suicide attempt was performed by comparing attempters to nonattempters with each disorder, followed by a meta-analysis across disorders. Polygenic risk scoring was used to investigate the genetic relationship between suicide attempt and the psychiatric disorders. Results: Three genome-wide significant loci for suicide attempt were found: one associated with suicide attempt in major depressive disorder, one associated with suicide attempt in bipolar disorder, and one in the meta-analysis of suicide attempt in mood disorders. These associations were not replicated in independent mood disorder cohorts from the UK Biobank and iPSYCH. No significant associations were found in the meta-analysis of all three disorders. Polygenic risk scores for major depression were significantly associated with suicide attempt in major depressive disorder (R-2=0.25%), bipolar disorder (R-2=0.24%), and schizophrenia (R-2=0.40%). Conclusions: This study provides new information on genetic associations and demonstrates that genetic liability for major depression increases risk for suicide attempt across psychiatric disorders. Further collaborative efforts to increase sample size may help to robustly identify genetic associations and provide biological insights into the etiology of suicide attempt