Contours déformables et reconstruction tomographique en imagerie médicale

Cet article traite de la segmentation automatique des images reconstruites en tomographie par émission, afin d'améliorer l'interprétation des images pour le diagnostic des médecins. Les approches classiques des contours actifs déformables pour la segmentation ne permettent pas de bien segmenter les données reconstruites qui sont bruitées. Aussi, nous proposons de traiter simultanément la reconstruction et la segmentation en résolvant un système de deux EDP, l'une permettant la reconstruction avec régularisation prenant en compte les discontinuités, et l'autre la segmentation par l'évolution de courbes planes

A new application of smart walker for quantitative analysis of human walking

International audienceThis paper presents a new nonintrusive device for everyday gait analysis and health monitoring. The system is a standard rollator equipped with encoders and inertial sensors. The assisted walking of 25 healthy elderly and 23 young adults are compared to develop walking quality index. The subjects were asked to walk on a straight trajectory and an L-shaped trajectory respectively. The walking trajectory, which is missing in other gait analysis methods, is calculated based on the encoder data. The obtained trajectory and steps are compared with the results of a motion capture system. The gait analysis results show that new index obtained by using the walker measurements, and not available otherwise, are very discriminating, e.g., the elderly have larger lateral motion and maneuver area, smaller angular velocity during turning, their walking accuracy is lower and turning ability is weaker although they have almost the same walking velocity as the young people

Fluid challenges in intensive care : the FENICE study A global inception cohort study

Erratum: Fluid challenges in intensive care: the FENICE study A global inception cohort study (vol 41, pg 1529, 2015) https://doi.org/10.1007/s00134-015-4003-yFluid challenges (FCs) are one of the most commonly used therapies in critically ill patients and represent the cornerstone of hemodynamic management in intensive care units. There are clear benefits and harms from fluid therapy. Limited data on the indication, type, amount and rate of an FC in critically ill patients exist in the literature. The primary aim was to evaluate how physicians conduct FCs in terms of type, volume, and rate of given fluid; the secondary aim was to evaluate variables used to trigger an FC and to compare the proportion of patients receiving further fluid administration based on the response to the FC. This was an observational study conducted in ICUs around the world. Each participating unit entered a maximum of 20 patients with one FC. 2213 patients were enrolled and analyzed in the study. The median [interquartile range] amount of fluid given during an FC was 500 ml (500-1000). The median time was 24 min (40-60 min), and the median rate of FC was 1000 [500-1333] ml/h. The main indication for FC was hypotension in 1211 (59 %, CI 57-61 %). In 43 % (CI 41-45 %) of the cases no hemodynamic variable was used. Static markers of preload were used in 785 of 2213 cases (36 %, CI 34-37 %). Dynamic indices of preload responsiveness were used in 483 of 2213 cases (22 %, CI 20-24 %). No safety variable for the FC was used in 72 % (CI 70-74 %) of the cases. There was no statistically significant difference in the proportion of patients who received further fluids after the FC between those with a positive, with an uncertain or with a negatively judged response. The current practice and evaluation of FC in critically ill patients are highly variable. Prediction of fluid responsiveness is not used routinely, safety limits are rarely used, and information from previous failed FCs is not always taken into account.Peer reviewe

A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)

Meeting abstrac

Nat Genet

The function of the majority of genes in the mouse and human genomes remains unknown. The mouse embryonic stem cell knockout resource provides a basis for the characterization of relationships between genes and phenotypes. The EUMODIC consortium developed and validated robust methodologies for the broad-based phenotyping of knockouts through a pipeline comprising 20 disease-oriented platforms. We developed new statistical methods for pipeline design and data analysis aimed at detecting reproducible phenotypes with high power. We acquired phenotype data from 449 mutant alleles, representing 320 unique genes, of which half had no previous functional annotation. We captured data from over 27,000 mice, finding that 83% of the mutant lines are phenodeviant, with 65% demonstrating pleiotropy. Surprisingly, we found significant differences in phenotype annotation according to zygosity. New phenotypes were uncovered for many genes with previously unknown function, providing a powerful basis for hypothesis generation and further investigation in diverse systems.Comment in : Genetic differential calculus. [Nat Genet. 2015] Comment in : Scaling up phenotyping studies. [Nat Biotechnol. 2015

XIII. Sur une famille d'expressions proverbiales du dialecte de Pékin

Teboul Michel. XIII. Sur une famille d'expressions proverbiales du dialecte de Pékin. In: Bulletin de l'Ecole française d'Extrême-Orient. Tome 62, 1975. pp. 487-503

Les premiers développements de l'astronomie chinoise des Royaumes Combattants au déhut de l'ère chrétienne

Teboul Michel. Les premiers développements de l'astronomie chinoise des Royaumes Combattants au déhut de l'ère chrétienne. In: Bulletin de l'Ecole française d'Extrême-Orient. Tome 71, 1982. pp. 147-168