Organic Waste-Based Fertilizer in Hydroponics Increases Tomato Fruit Size but Reduces Fruit Quality

In regions with intensive agricultural production, large amounts of organic waste are produced by livestock animals. Liquid digestate from manure-based biogas production could potentially serve as fertilizer if integrated with closed horticultural irrigation systems. The aim of this experiment was to investigate how fertilizer based on liquid biogas by-products of pig manure digestion can affect the growth and production of tomato plants. Integration of a nitrification bioreactor presumes a significantly lower concentration of nutrient solutions and a higher level of oxygenation than classical mineral cultivation. Therefore, additional controls were included. We compared plant growth and fruit quality traits of tomato plants grown in a hydroponic solution with organic fertilizer with two levels of mineral fertilizer. The tomatoes grown with organic waste-based liquid fertilizer showed reduced growth rates but increased mean fruit size, resulting in no significant change in total yield compared with high-mineral cultivation. The growth rate was similarly reduced in plants cultivated with low-mineral fertilizer. Plants cultivated with organic waste-based fertilizer had high Cl− concentration in xylem sap, leaves, and, ultimately, fruits. The leaves of plants cultivated with organic waste-based fertilizer contained higher concentrations of starch and soluble carbohydrate and low concentrations of phosphorous (P) and sulfur (S). The plants grown with organic waste-based or low-mineral medium showed significantly poorer fruit quality than the plants cultivated with the high-mineral solution. The low-mineral treatment increased xylem sap contribution to fruit weight because of higher root power. The organic waste-based fertilization did not change the root power but increased fruit size. In conclusion, organic waste-based cultivation is a possible solution for sustainable plant production in greenhouses. However, additional adjustment of nutrient supply is required to improve fruit quality

Implementation of outpatient schema therapy for borderline personality disorder: study design

ABSTRACT: BACKGROUND: Schema Therapy (ST) is an integrative psychotherapy based upon a cognitive schema model which aims at identifying and changing dysfunctional schemas and modes through cognitive, experiential and behavioral pathways. It is specifically developed for patients with personality disorders. Its effectiveness and efficiency have been demonstrated in a few randomized controlled trials, but ST has not been evaluated in regular mental healthcare settings. This paper describes the study protocol of a multisite randomized 2-group design, aimed at evaluating the implementation of outpatient schema therapy for patients with borderline personality disorder (BPD) in regular mental healthcare and at determining the added value of therapist telephone availability outside office hours in case of crisis. METHODS/DESIGN: Patient outcome measures will be assessed with a semi-structured interview and self-report measures on BPD, therapeutic alliance, quality of life, costs and general psychopathology at baseline, 6, 12, 18 and 36 months. Intention-to-treat analyses will be executed with survival analysis for dichotomous variables, and one-sample t-tests and ANCOVAs for continuous variables with baseline as covariate and condition as between group factor. All tests will be two-tailed with a significance level of 5%. DISCUSSION: The study will provide an answer to the question whether ST can be effectively implemented and whether phone support by the therapist has an additional value. TRIAL REGISTRATION: The Dutch Cochrane Center, NTR (TC = 1781

Detection and localization of early- and late-stage cancers using platelet RNA

Cancer patients benefit from early tumor detection since treatment outcomes are more favorable for less advanced cancers. Platelets are involved in cancer progression and are considered a promising biosource for cancer detection, as they alter their RNA content upon local and systemic cues. We show that tumor-educated platelet (TEP) RNA-based blood tests enable the detection of 18 cancer types. With 99% specificity in asymptomatic controls, thromboSeq correctly detected the presence of cancer in two-thirds of 1,096 blood samples from stage I–IV cancer patients and in half of 352 stage I–III tumors. Symptomatic controls, including inflammatory and cardiovascular diseases, and benign tumors had increased false-positive test results with an average specificity of 78%. Moreover, thromboSeq determined the tumor site of origin in five different tumor types correctly in over 80% of the cancer patients. These results highlight the potential properties of TEP-derived RNA panels to supplement current approaches for blood-based cancer screening

Influence of fertilization, mulch color, early forcing, fruit order, planting date, shading, growing environment, and genotype on the contents of selected phenolics in strawberry (Fragaria x ananassa Duch.) fruits

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Bio-economic evaluation of greenhouse designs for seasonal tomato production in Norway

Greenhouses are complex systems whose size, shape, construction material, and equipment for climate control, lighting and heating can vary largely. The greenhouse design can, together with the outdoor weather conditions, have a large impact on the economic performance and the environmental consequences of the production. The aim of this study was to identify a greenhouse design out of several feasible designs that generated the highest net financial return (NFR) and lowest energy use for seasonal tomato production across Norway. A model-based greenhouse design method, which includes a module for greenhouse indoor climate, a crop growth module for yield prediction, and an economic module, was applied to predict the NFR and energy use. Observed indoor climate and tomato yield were predicted using the climate and growth modules in a commercial greenhouse in southwestern Norway (SW) with rail and grow heating pipes, glass cover, energy screens, and CO2-enrichment. Subsequently, the NFR and fossil fuel use of five combinations of these elements relevant to Norwegian conditions were determined for four locations: Kise in eastern Norway (E), Mære in midwestern Norway (MW), Orre in southwestern Norway (SW) and Tromsø in northern Norway (N). Across designs and locations, the highest NFR was 47.6 NOK m−2 for the greenhouse design with a night energy screen. The greenhouse design with day and night energy screens, fogging and mechanical cooling and heating having the lowest fossil energy used per m2 in all locations had an NFR of −94.8 NOK m−2. The model can be adapted for different climatic conditions using a variation in the design elements. The study is useful at the practical and policy level since it combines the economic module with the environmental impact to measure CO2 emissions

Bio-economic evaluation of greenhouse designs for seasonal tomato production in Norway

Greenhouses are complex systems whose size, shape, construction material, and equipment for climate control, lighting and heating can vary largely. The greenhouse design can, together with the outdoor weather conditions, have a large impact on the economic performance and the environmental consequences of the production. The aim of this study was to identify a greenhouse design out of several feasible designs that generated the highest net financial return (NFR) and lowest energy use for seasonal tomato production across Norway. A model-based greenhouse design method, which includes a module for greenhouse indoor climate, a crop growth module for yield prediction, and an economic module, was applied to predict the NFR and energy use. Observed indoor climate and tomato yield were predicted using the climate and growth modules in a commercial greenhouse in southwestern Norway (SW) with rail and grow heating pipes, glass cover, energy screens, and CO2-enrichment. Subsequently, the NFR and fossil fuel use of five combinations of these elements relevant to Norwegian conditions were determined for four locations: Kise in eastern Norway (E), Mære in midwestern Norway (MW), Orre in southwestern Norway (SW) and Tromsø in northern Norway (N). Across designs and locations, the highest NFR was 47.6 NOK m−2 for the greenhouse design with a night energy screen. The greenhouse design with day and night energy screens, fogging and mechanical cooling and heating having the lowest fossil energy used per m2 in all locations had an NFR of −94.8 NOK m−2. The model can be adapted for different climatic conditions using a variation in the design elements. The study is useful at the practical and policy level since it combines the economic module with the environmental impact to measure CO2 emissions.publishedVersio

Impact of Patient- and Clinician-Reported Cumulative Toxicity on Quality of Life in Patients With Metastatic Castration-Naive Prostate Cancer

International audienceBackground: Current toxicity evaluation is primarily focused on high-grade adverse events (AEs) reported by clinicians. However, the cumulative effect of multiple lower-grade AEs may also impact patients' quality of life (QoL). Further, patient-reported toxicity may be more representative of patients' treatment experiences. This study aimed to determine whether cumulative toxicity comprising all-grade AEs is more associated with QoL than cumulative toxicity comprising high-grade AEs only, and whether patient-reported cumulative toxicity is more associated with QoL than clinician-reported cumulative toxicity. Methods: Patients with metastatic castration-naive prostate cancer participating in the phase III GETUG-AFU 15 trial completed questionnaires on AEs (at 3 and 6 months) and QoL (at baseline and 3 and 6 months). Clinicians reported AEs during clinical visits. Cumulative toxicity scores were calculated for clinicians and patients in 3 ways: total number of high-grade AEs, total number of all-grade AEs, and total number of all AEs multiplied by their grade (severity score). Relationships between cumulative toxicity scores and QoL were studied using longitudinal regression analyses; unstandardized (B) and standardized regression coefficients (beta) are reported. Results: Of 385 patients, 184 with complete QoL and toxicity data were included. Clinician-reported all-grade AEs (B, -2.2; 95% CI, -3.3 to -1.1; P<.01) and severity score (B, -1.4; 95% CI, -2.2 to -0.7; P<.01) were associated with deteriorated physical QoL, whereas the total number of high-grade AEs was not. All patient-reported scores were significantly (P<.01 for all) associated with deteriorated physical and global QoL. Standardized regression coefficients indicated that patient-reported toxicity scores were more associated with QoL outcomes than clinician-reported scores, with the strongest association found for the all-grade AEs and severity cumulative toxicity scores. Conclusions: Patient-and clinician-based cumulative toxicity scores comprising all-grade AEs better reflect impact on patient QoL than toxicity scores comprising high-grade AEs only. To assess the effect of toxicity on QoL, patient-reported cumulative toxicity scores are preferred