585 research outputs found
La médiation culturelle à l’école primaire :: approche théorique et dispositif pratique dans une classe de 6ème HARMOS
La médiation culturelle, telle qu’elle est envisagée par S. Boimare (2012), consiste à dispenser aux élèves une heure de culture humaniste journalière, tout au long de leur scolarité. Il s’agit, en prenant appui sur des textes littéraires fondamentaux en lien avec le programme, tels que les mythes, les contes, la poésie, ou encore tous les textes qui s’inscrivent dans la littérature que l’on peut qualifier de noble, d’amener les élèves à débattre de leurs idées et à s’approprier les ressorts de l’écriture, tout en développant chez eux l’art de penser et leur capacité à réfléchir. À travers une approche théorique et un dispositif pratique réalisé dans une classe d’école primaire de 6ème HARMOS, nous avons cherché à mieux comprendre sur quels fondements repose la médiation culturelle et ce que suppose une approche pédagogique qui s’en inspire. Nous avons également voulu démontrer en quoi la médiation culturelle peut être une aide pour les enfants en difficulté dans les apprentissages, tout en étant un facteur de stimulation et de motivation pour les autres élèves et les enseignants
Collagen fiber network infiltration : permeability and capillary infiltration
International audienceIn dentin restoration, collagen fiber network infiltration is an issue. Using data from the litterature, we have constructed a relevant numerical geometrical model of the network. The specificity of our model is that the fibers are taken into account implicitly using a regularized Heaviside function. This function is either used to set the viscosity or to localize the contact line where capillary forces are applied. A level set technique with respect to fluid infiltration front tracking in five fiber networks using the level set method and Navier-Stokes equations with capillary terms is used to point out efficient critical infiltration parameters. A variational formulation which can be implemented in FEM is proposed both for the infiltration front and the contact line. Because of lack of knowledge on fiber orientation, different configurations were tested through permeability assessment of the whole network. Fiber orientation, interfibrillar space and contact angle influence were investigated
Exploiting the Time-Reversal Operator for Adaptive Optics, Selective Focusing and Scattering Pattern Analysis
We report on the experimental measurement of the backscattering matrix of a
weakly scattering medium in optics, composed of a few dispersed gold nanobeads.
The DORT method (Decomposition of the Time Reversal Operator) is applied to
this matrix and we demonstrate selective and efficient focusing on individual
scatterers, even through an aberrating layer. Moreover, we show that this
approach provides the decomposition of the scattering pattern of a single
nanoparticle. These results open important perspectives for optical imaging,
characterization and selective excitation of nanoparticles.Comment: 10 page
Control of chaotic advection
A method of chaos reduction for Hamiltonian systems is applied to control
chaotic advection. By adding a small and simple term to the stream function of
the system, the construction of invariant tori has a stabilization effect in
the sense that these tori act as barriers to diffusion in phase space and the
controlled Hamiltonian system exhibits a more regular behaviour
Early effects of mood stabilizers on the Akt/GSK-3β signaling pathway and on cell survival and proliferation
Rationale: Lithium, some of the anticonvulsants, and several second-generation antipsychotic drugs are common medications widely prescribed to treat bipolar disorder. Molecular targets and cellular events that mediate their effects have been described for these drugs but are only partially unraveled. Few comparative studies have been performed. Objectives: We evaluated seven mood stabilizers (MS) in the same in vitro system and found several differences and similarities in their cellular mechanisms (proliferation and cell survival). As some MS were previously shown to activate the Akt/GSK-3β axis, this pathway was explored for other drugs. Materials and methods: The SH-SY5Y cells were cultured in RPMI-1640 medium. Effects of MS drugs on serum-induced cell proliferation and on slowing of cell death were analyzed. Phosphorylation and expression of Akt-1 and GSK-3β mRNA and protein were assessed for the seven drugs as well. Results: Lithium, Valproate, Olanzapine, and Clozapine enhance proliferation and protect cells against serum withdrawal-induced injury. These drugs also activate Akt-1 and GSK-3β phosphorylation. Interestingly, gene expression of Akt-1 mRNA and protein, but not GSK-3β, was increased. The other drugs Lamotrigine, Haloperidol, and Carbamazepine did not affect cellular events nor activate Akt/GSK-3β axis. Conclusion: Valproate and atypical antipsychotics (Olanzapine and Clozapine) regulate SH-SY5Y cell proliferation and survival, activate the Akt/GSK-3β axis, and stimulate gene expression of Akt-1 mRNA and protein, as does Lithium. The other medications have no effect. The study shows the importance of the Akt/GSK-3 axis in MS actions but also pinpoints a different dependence of these drugs on this signaling axi
Saint-Vit – Les Petites Bussières
Date de l'opération : 2001 (PT) C’est suite à l’extension d’un lotissement que des sondages archéologiques ont mis au jour une partie des vestiges d’un sanctuaire gallo-romain au nord-est de la commune de Saint-Vit (Doubs). Cette opération d’évaluation, menée par David Billoin (AFAN), a permis de révéler un site riche tant sur le plan des vestiges architecturaux (sanctuaire à double cella, décors sculptés, etc.) que sur celui du mobilier, dont la période d’activité s’étend sur cinq siècles. S..
Saint-Vit – Les Petites Bussières
Date de l'opération : 2001 (PT) C’est suite à l’extension d’un lotissement que des sondages archéologiques ont mis au jour une partie des vestiges d’un sanctuaire gallo-romain au nord-est de la commune de Saint-Vit (Doubs). Cette opération d’évaluation, menée par David Billoin (AFAN), a permis de révéler un site riche tant sur le plan des vestiges architecturaux (sanctuaire à double cella, décors sculptés, etc.) que sur celui du mobilier, dont la période d’activité s’étend sur cinq siècles. S..
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