Variability estimation in ground motion around Istanbul based on the probabilistic dynamic rupture scenarios along the North Anatolian fault

International audienceVariability of ground motion estimation according to various earthquake scenarios is studied in the region of the Sea of Marmara around Istanbul, Turkey, through numerical simulations using a 3D finite-difference method with CPU-GPU implementation. The earthquake scenarios dynamically simulated based on mechanical models are given with probability according to the geological, geophysical and seismological hypotheses. We adopt a 3D geological model of the Sea of Marmara taken into account of the basin structure (down to about 10 km depth) and the existence of the Sea layer (1.5 km depth at max.). Although beneath the land part around the Sea of Marmara is briefly a 1D structure, the influence of the 3D structure of the basin on the ground motion caused by the earthquakes along the North Anatolian fault is significant. Various earthquake scenarios of a magnitude of about 7 lead to a very heterogeneous ground motion pattern. For the selected points, we carry out statistical analysis on its characterization. In Istanbul area, a very strong ground motion (peak ground velocity larger than 1 m/s) may not be the most probable scenario, but has a probability of a few percents in the case where the stress drop is extremely high enough to lead to a super-shear rupture propagation

An out-of-core GPU approach for accelerating geostatistical interpolation

International audienceGeostatistical methods provide a powerful tool to understand the complexity of data arising from Earth sciences. Since the mid 70's, this numerical approach is widely used to understand the spatial variation of natural phenomena in various domains like Oil and Gas, Mining or Environmental Industries. Considering the huge amount of data available, standard implementations of these numerical methods are not efficient enough to tackle current challenges in geosciences. Moreover, most of the software packages available for geostatisticians are designed for a usage on a desktop computer due to the trial and error procedure used during the interpolation. The Geological Data Management (GDM) software package developed by the French geological survey (BRGM) is widely used to build reliable three-dimensional geological models that require a large amount of memory and computing resources. Considering the most time-consuming phase of kriging methodology, we introduce an efficient out-of-core algorithm that fully benefits from graphics cards acceleration on desktop computer. This way we are able to accelerate kriging on GPU with data 4 times bigger than a classical in-core GPU algorithm, with a limited loss of performances

Antifungal Activity and In Silico Studies on 2-Acylated Benzo- and Naphthohydroquinones

The high rates of morbidity and mortality due to fungal infections are associated with a limited antifungal arsenal and the high toxicity of drugs. Therefore, the identification of novel drug targets is challenging due to the several resemblances between fungal and human cells. Here, we report the in vitro antifungal evaluation of two acylphenols series, namely 2-acyl-1,4-benzo- and 2-acyl-1,4-naphthohydroquinones. The antifungal properties were assessed on diverse Candida and filamentous fungi strains through the halo of inhibition (HOI) and minimal inhibitory concentration (MIC). The antifungal activities of 2-acyl-1,4-benzohydroquinone derivatives were higher than those of the 2-acyl-1,4-naphthohydroquinone analogues. The evaluation indicates that 2-octanoylbenzohydroquinone 4 is the most active member of the 2-acylbenzohydroquinone series, with MIC values ranging from 2 to 16 μg/mL. In some fungal strains (i.e., Candida krusei and Rhizopus oryzae), such MIC values of compound 4 (2 and 4 μg/mL) were comparable to that obtained by amphotericin B (1 μg/mL). The compound 4 was evaluated for its antioxidant activity by means of FRAP, ABTS and DPPH assays, showing moderate activity as compared to standard antioxidants. Molecular docking studies of compound 4 and ADMET predictions make this compound a potential candidate for topical pharmacological use. The results obtained using the most active acylbenzohydroquinones are promising because some evaluated Candida strains are known to have decreased sensitivity to standard antifungal treatments

SPECFEM/specfem3d: SPECFEM3D v4.1.0

<p>New in SPECFEM3D v4.1.0:</p> <ul> <li>HDF5 file IO support</li> <li>local time stepping (LTS)</li> <li>strain seismograms</li> <li>movie output for stresses</li> <li>reuse feature for external STF</li> <li>various updates and improvements (including updated HIP and CUDA support)</li> </ul> <p><em>many thanks for all your contributions to this version</em>: Rahul Garg, Hom Nath Gharti, Masaru Nagaso, Elif Oral, Daniel Peter</p&gt

SPECFEM/specfem3d_globe: SPECFEM3D_GLOBE v8.1.0

<p>New in SPECFEM3D_GLOBE v8.1.0:</p> <ul> <li>adds EMC model support</li> <li>minor fixes and code improvements (including newer HIP and CUDA configuration)</li> <li>updates ADIOS2 and LIBXSMM calls</li> </ul> <p><em>with many thanks for contributions to this version</em>: Daniel Peter, Julien Thurin, Lucas Sawade</p&gt