Alien Registration- Michaud, Annie (Fort Fairfield, Aroostook County)

https://digitalmaine.com/alien_docs/36524/thumbnail.jp

Alien Registration- Michaud, Annie (Caribou, Aroostook County)

https://digitalmaine.com/alien_docs/26078/thumbnail.jp

Le récepteur de l'IL-7 sur les cellules NK matures humaines : nature et fonction

Mémoire numérisé par la Division de la gestion de documents et des archives de l'Université de Montréal

Évaluation électrophysiologique et comportementale de la mémoire implicite chez les personnes âgées

La présente étude vise à explorer différents types de mémoire, à savoir la mémoire explicite et, particulièrement, la mémoire implicite et ce, chez les jeunes adultes et les personnes âgées. Or, on obtient des résultats mitigés en ce qui a trait à la performance implicite des personnes âgées lorsque mesurée uniquement par les tests de mémoire traditonnels. Par conséquent, des mesures électrophysiologiques de l'activité cérébrale ont été utilisées afin de compléter le portrait de la mémoire implicite des sujets. Ainsi, l'activité cérébrale de douze jeunes adultes et seize personnes âgées a été enregistrée lors de la passation de tests de mémoire. Cette étude a fait ressortir une performance au test de mémoire explicite meilleure pour les jeunes adultes, sans toutefois atteindre le seuil de signification. En ce qui concerne la mémoire implicite, la performance des jeunes adultes s'est avérée significativement meilleure que celle des personnes âgées. Par ailleurs, l'analyse de l'activité cérébrale a dévoilé certains indices de traitement de l'information, chez les deux groupes de sujets. De fait, un patron d'ondes s'apparentant à un effet de familiarité, bien que non significatif, est apparu autour de 100 ms et entre 400 ms et 700 ms, ce qui témoigne de la présence de processus qui sous-tendent la performance aux tests de mémoire implicite. Une étude subséquente devra sans contredit réunir des groupes de sujets plus nombreux et choisir une tâche de mémoire implicite mieux adaptée à la population étudiée, afin de maximiser les résultats électrophysiologiques obtenus

Coordination of a bifunctional ligand to a rhodium(III) dimethyl complex : Lewis acidity enhancement by chelation

The addition of the ambiphilic compound (Me2PCH2AlMe2)2 (1) to Cp*RhMe2(DMSO) (DMSO ) dimethylsulfoxide) (2) gives Cp*RhMe2(PMe2CH2AlMe2‚DMSO) (3‚DMSO). The addition of Lewis acids (LA) such as La(dbm)3 (dbm ) dibenzoylmethane) and AlMe3 to a solution of complex 3‚DMSO gives a competition reaction that results in the formation of LA‚DMSO and Cp*RhMe2(PMe2CH2AlMe2) (3). When heated to 40 °C, complex 3 ionizes to a putative zwitterionic species, Cp*Rh+Me(PMe2CH2AlMe3 -) (3′), which is converted to [Cp*Rh(Me)(µ2 -η2 -Me2PCH2)]2 (4) irreversibly. Spin saturation transfer experiments demonstrated that the rate of the methyl abstraction by the alane moiety was 0.76 ( 0.09 s-1 , while the rate of abstraction of the methyl in Cp*RhMe2(PMe3) by AlMe3 was 0.10 ( 0.02 s-1 . The zwitterionic species 3′ could be trapped in solution by addition of PMe3 to afford both Cp*Rh+Me(PMe3)(Me2- PCH2AlMe3 -) (5) and [Cp*Rh+Me(PMe3)(Me2PCH2AlMe2)]AlMe4 - (6). When compound 1 was added to complex 3′, the formation of the zwitterionic complex Cp*Rh+Me(η2 -Me2PCH2Al-Me2CH2PMe2) (7) was observed

Inherited renal tubular dysgenesis: the first patients surviving the neonatal period

Renal tubular dysgenesis (RTD) is a clinical disorder either acquired during fetal development or inherited as an autosomal recessive condition. Inherited RTD is caused by mutations in the genes encoding the components of the renin-angiotensin system angiotensinogen, renin, angiotensin-converting enzyme and angiotensin II receptor type 1. Inherited RTD is characterized by early onset oligohydramnios, skull ossification defects, preterm birth and neonatal pulmonary and renal failure. The histological hallmark is the absence or poor development of proximal tubules. So far, all patients died either in utero or shortly after birth. We report the first patients with inherited RTD surviving the neonatal period and still being alive. Genetic and functional analysis of the renin-angiotensin system contributes to the diagnosis of RTD. In conclusion, the clinical diagnosis of inherited RTD is easily missed after birth without renal biopsy or information on affected family members. Genetic and functional analysis of the renin-angiotensin system contributes to correct diagnosi

Spontaneous neural activity changes after bariatric surgery : a resting-state fMRI study

Background: Metabolic disorders associated with obesity could lead to alterations in brain structure and function. Whether these changes can be reversed after weight loss is unclear. Bariatric surgery provides a unique oppor- tunity to address these questions because it induces marked weight loss and metabolic improvements which in turn may impact the brain in a longitudinal fashion. Previous studies found widespread changes in grey matter (GM) and white matter (WM) after bariatric surgery. However, findings regarding changes in spontaneous neural activity following surgery, as assessed with the fractional amplitude of low frequency fluctuations (fALFF) and regional homogeneity of neural activity (ReHo), are scarce and heterogenous. In this study, we used a longitu- dinal design to examine the changes in spontaneous neural activity after bariatric surgery (comparing pre- to post-surgery), and to determine whether these changes are related to cardiometabolic variables. Methods: The study included 57 participants with severe obesity (mean BMI = 43.1 ± 4.3 kg/m 2 ) who under- went sleeve gastrectomy (SG), biliopancreatic diversion with duodenal switch (BPD), or Roux-en-Y gastric bypass (RYGB), scanned prior to bariatric surgery and at follow-up visits of 4 months ( N = 36), 12 months ( N = 29), and 24 months ( N = 14) after surgery. We examined fALFF and ReHo measures across 1022 cortical and subcor- tical regions (based on combined Schaeffer-Xiao parcellations) using a linear mixed effect model. Voxel-based morphometry (VBM) based on T1-weighted images was also used to measure GM density in the same regions. We also used an independent sample from the Human Connectome Project (HCP) to assess regional differences between individuals who had normal-weight ( N = 46) or severe obesity ( N = 46). Results: We found a global increase in the fALFF signal with greater increase within dorsolateral prefrontal cortex, precuneus, inferior temporal gyrus, and visual cortex. This effect was more significant 4 months after surgery. The increase within dorsolateral prefrontal cortex, temporal gyrus, and visual cortex was more limited after 12 months and only present in the visual cortex after 24 months. These increases in neural activity measured by fALFF were also significantly associated with the increase in GM density following surgery. Furthermore, the in- crease in neural activity was significantly related to post-surgery weight loss and improvement in cardiometabolic variables, such as blood pressure. In the independent HCP sample, normal-weight participants had higher global and regional fALFF signals, mainly in dorsolateral/medial frontal cortex, precuneus and middle/inferior temporal gyrus compared to the obese participants. These BMI-related differences in fALFF were associated with the in- crease in fALFF 4 months post-surgery especially in regions involved in control, default mode and dorsal attention networks. Conclusions: Bariatric surgery-induced weight loss and improvement in metabolic factors are associated with widespread global and regional increases in neural activity, as measured by fALFF signal. These findings along- side the higher fALFF signal in normal-weight participants compared to participants with severe obesity in an independent dataset suggest an early recovery in the neural activity signal level after the surgery

Centre d’histoire et de théorie des arts

Séminaire collectifAvec la participation de Sylviane Agacinski, Jacques Aumont, Jean-Claude Bonne, Giovanni Careri, Annie Cohen-Solai, Danièle Cohn, Georges Didi-Huberman, Patricia Falguières, André Gunthert, François Lissarrague, Éric Michaud Temporalités de l’art Nous avons continué à explorer différents aspects de la question de la temporalité de l’art aussi bien du point de vue du temps de l’œuvre que du point de vue du temps des opérations de production et de réception des œuvres. Patric..