387 research outputs found
Black-Jewish Tensions and Modern Antisemitism in America
This paper explores the theme of antisemitism as it relates to the relationship between Blacks and Jews. It looks at the history of the relationship and how it came to crumble during the 1960s and 1970s
Optimal Control of Hybrid Optomechanical Systems for Generating Non-Classical States of Mechanical Motion
Cavity optomechanical systems are one of the leading experimental platforms
for controlling mechanical motion in the quantum regime. We exemplify that the
control over cavity optomechanical systems greatly increases by coupling the
cavity also to a two-level system, thereby creating a hybrid optomechanical
system. If the two-level system can be driven largely independently of the
cavity, we show that the non-linearity thus introduced enables us to steer the
extended system to non-classical target states of the mechanical oscillator
with Wigner functions exhibiting significant negative regions. We illustrate
how to use optimal control techniques beyond the linear regime to drive the
hybrid system from the near ground state into a Fock target state of the
mechanical oscillator. We base our numerical optimization on realistic
experimental parameters for exemplifying how optimal control enables the
preparation of decidedly non-classical target states, where naive control
schemes fail. Our results thus pave the way for applying the toolbox of optimal
control in hybrid optomechanical systems for generating non-classical
mechanical states.Comment: 19 pages, 6 figures. Published versio
Nonlinear dynamics induced by parallel and orthogonal optical injection in 1550 nm Vertical-Cavity Surface-Emitting Lasers (VCSELs)
We report a first experimental study of the nonlinear dynamics appearing in a 1550 nm single-mode VCSEL subject to parallel and to orthogonal optical injection. For the first time to our knowledge we report experimentally measured stability maps identifying the boundaries between regions of different nonlinear dynamics for both cases of polarized injection. A rich variety of nonlinear behaviours, including periodic (limit cycle, period doubling) and chaotic dynamics have been experimentally observed. ©2010 Optical Society of America
Tunable microwave signal generator with an optically-injected 1310nm QD-DFB laser
Tunable microwave signal generation with frequencies ranging from below 1 GHz to values over 40 GHz is demonstrated experimentally with a 1310nm Quantum Dot (QD) Distributed-Feedback (DFB) laser. Microwave signal generation is achieved using the period 1 dynamics induced in the QD DFB under optical injection. Continuous tuning in the positive detuning frequency range of the quantum dot's unique stability map is demonstrated. The simplicity of the experimental configuration offers promise for novel uses of these nanostructure lasers in Radio-over-Fiber (RoF) applications and future mobile networks. © 2013 Optical Society of America
Grip strength cut-points from the Swiss DO-HEALTH population
BACKGROUND: While grip strength (GS) is commonly assessed using a Dynamometer, the Martin Vigorimeter was proposed as an alternative method especially in older adults. However, its reference values for Swiss older adults are missing. We therefore aimed to derive sex- and age-specific GS cut-points for the dominant and non-dominant hand (DH; NDH) using the Martin Vigorimeter. Additionally, we aimed to identify clinically relevant weakness and assess convergent validity with key markers of physical function and sarcopenia in generally healthy Swiss older adults. METHODS: This cross-sectional analysis includes baseline data from Swiss participants enrolled in DO-HEALTH, a 3-year randomized controlled trial in community-dwelling adults age 70 + . For both DH and NDH, 4 different definitions of weakness to derive GS cut-points by sex and age category (≤ 75 vs. > 75 years) were used: i) GS below the median of the 1st quintile, ii) GS below the upper limit of the 1st quintile, iii) GS below 2-standard deviation (SD) of the sex- and age-specific mean in DO-HEALTH Swiss healthy agers (i.e. individuals without major chronic diseases, disabilities, cognitive impairment or mental health issues) and iv) GS below 2.5-SD of the sex- and age-specific mean in DO-HEALTH Swiss healthy agers. To assess the proposed cut-points' convergent validity, we assessed their association with gait speed, time to complete the 5 Times Sit-To-Stand (5TSTS) test, and present sarcopenia. RESULTS: In total, 976 participants had available GS at the DH (mean age 75.2, 62% women). According to the 4 weakness definitions, GS cut-points at the DH ranged from 29-42 and 25-39 kPa in younger and older women respectively, and from 51-69 and 31-50 kPa in younger and older men respectively. Overall, weakness prevalence ranged from 2.0% to 19.3%. Definitions of weakness using the median and the upper limit of the 1st GS quintile were most consistently associated with markers of physical performance. Weak participants were more likely to have lower gait speed, longer time to complete the 5TSTS, and sarcopenia, compared to participants without weakness. CONCLUSIONS: In generally healthy Swiss older adults, weakness defined by the median or the upper limit of the 1st GS quintile may serve as reference to identify clinically relevant weakness. Additional research is needed in less healthy populations in order to derive representative population-based cut-points
Castleman's disease in the head of the pancreas: report of a rare clinical entity and current perspective on diagnosis, treatment, and outcome
<p>Abstract</p> <p>Background</p> <p>Castleman's disease of the pancreas is a very rare condition that may resemble more common disease entities as well as pancreatic cancer.</p> <p>Case presentation</p> <p>Here we report the case of a 58-year-old African American male with an incidentally discovered lesion in the head of the pancreas. The specimen from his pancreaticoduodectomy contained a protuberant, encapsulated mass, exhibiting microscopic features most consistent with localized/unicentric Castleman's disease. These included florid follicular hyperplasia with mantle/marginal zone hyperplasia along with focal progressive transformation of germinal centers admixed with involuted germinal centers.</p> <p>Conclusion</p> <p>To date, eight cases of Castleman's disease associated with the pancreas have been described in the world literature. We report the first case of unicentric disease situated within the head of the pancreas. In addition, we discuss the diagnostic dilemma Castleman's disease may present to the pancreatic surgeon and review current data on pathogenesis, treatment, and outcome.</p
Estimating dominant runoff modes across the conterminous United States
Effective natural resource planning depends on understanding the prevalence of runoff generating processes. Within a specific area of interest, this demands reproducible, straightforward information that can complement available local data and can orient and guide stakeholders with diverse training and backgrounds. To address this demand within the contiguous United States (CONUS), we characterized and mapped the predominance of two primary runoff generating processes: infiltration‐excess and saturation‐excess runoff (IE vs. SE, respectively). Specifically, we constructed a gap‐filled grid of surficial saturated hydraulic conductivity using the Soil Survey Geographic and State Soil Geographic soils databases. We then compared surficial saturated hydraulic conductivity values with 1‐hr rainfall‐frequency estimates across a range of return intervals derived from CONUS‐scale random forest models. This assessment of the prevalence of IE versus SE runoff also incorporated a simple uncertainty analysis, as well as a case study of how the approach could be used to evaluate future alterations in runoff processes resulting from climate change. We found a low likelihood of IE runoff on undisturbed soils over much of CONUS for 1‐hr storms with return intervals \u3c5 years. Conversely, IE runoff is most likely in the Central United States (i.e., Texas, Louisiana, Kansas, Missouri, Iowa, Nebraska, and Western South Dakota), and the relative predominance of runoff types is highly sensitive to the accuracy of the estimated soil properties. Leveraging publicly available data sets and reproducible workflows, our approach offers greater understanding of predominant runoff generating processes over a continental extent and expands the technical resources available to environmental planners, regulators, and modellers
P04-12. Characterization of leukopak PBMC phenotypes and biotypes for optimal performance in HIV-1 neutralization assays
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