2,998 research outputs found
Development and three-dimensional morphology of the zygomaticotemporal suture in primate skulls
Cranial sutures are an essential part of the growing skull, allowing bones to increase in size during growth, with their morphology widely believed to be dictated by the forces and displacements that they experience. The zygomaticotemporal suture in primates is located in the relatively weak zygomatic arch, and externally it appears a very simple connection. However, large forces are almost certainly transmitted across this suture, suggesting that it requires some level of stability while also allowing controlled movements under high loading. Here we examine the 2- and 3-dimensional (3D) morphology of the zygomaticotemporal suture in an ontogenetic series of Macaca fascicularis skulls. High resolution microcomputed tomography data sets were examined, and virtual and physical 3D replicas were created to assess both structure and general stability. The zygomaticotemporal suture is much more complex than its external appearance suggests, with interlocking facets between the adjacent zygomatic and temporal bones. It appears as if some movement is permitted across the suture in younger animals, but as they approach adulthood the complexity of the suture's interlocking bone facets reaches a level where these movements become minimal
A PI3K-mediated negative feedback regulates Drosophila motor neuron excitability
Negative feedback can act as a homeostatic mechanism to maintain neuronal activity at a particular specified value. At the Drosophila neuromuscular junction, a mutation in the type II metabotropic glutamate receptor gene (mGluRA) increased motor neuron excitability by disrupting an autocrine, glutamate-mediated negative feedback. We show that mGluRA mutations increase neuronal excitability by preventing PI3 kinase (PI3K) activation and consequently hyperactivating the transcription factor Foxo. Furthermore, glutamate application increases levels of phospho-Akt, a product of PI3K signaling, within motor nerve terminals in an mGluRA-dependent manner. In humans, PI3K and type II mGluRs are implicated in epilepsy, neurofibromatosis, autism, schizophrenia and other neurological disorders; however, neither the link between type II mGluRs and PI3K, nor the role of Foxo in the control of neuronal excitability, had been previously reported. Our work suggests that some of the deficits in these neurological disorders might result from disruption of glutamate-mediated homeostasis of neuronal excitability
Total hemispherical emittance measured at high temperatures by the calorimetric method
A calorimetric vacuum emissometer (CVE) capable of measuring total hemispherical emittance of surfaces at elevated temperatures was designed, built, and tested. Several materials with a wide range of emittances were measured in the CVE between 773 to 923 K. These results were compared to values calculated from spectral emittance curves measured in a room temperature Hohlraum reflectometer and in an open-air elevated temperature emissometer. The results differed by as much as 0.2 for some materials but were in closer agreement for the more highly-emitting, diffuse-reflecting samples. The differences were attributed to temperature, atmospheric, and directional effects, and errors in the Hohlraum and emissometer measurements (plus or minus 5 percent). The probable error of the CVE measurements was typically less than 1 percent
An Investigation into the Prevalence, Quantification, and Survival of Escherichia coli in Stormwater Basin Sediment of Withers Swash, Myrtle Beach, SC
2012 S.C. Water Resources Conference - Exploring Opportunities for Collaborative Water Research, Policy and Managemen
Using Technology the Founders Never Dreamed of: Cell Phones as Tracking Devices and the Fourth Amendment
Masticatory biomechanics in the rabbit : a multi-body dynamics analysis
Acknowledgement We thank Sue Taft (University of Hull) for the µCT-scanning of the rabbit specimen used in this study. We also thank Raphaël Cornette, Jacques Bonnin, Laurent Dufresne, and l'Amicale des Chasseurs Trappistes (ACT) for providing permission and helping us capture the rabbits used for the in vivo bite force measurements at la Réserve Naturelle Nationale de St Quentin en Yvelines, France.Peer reviewedPublisher PD
PRELIMINARY EVALUATION OF A GRANULAR TRIMETHACARB FORMULATION FOR DETERRING GRAZING BY AMERICAN COOTS
In a 0.2 ha flight pen, groups of 4 American coots were tested to determine if their grazing activity could be affected by application of a registered granular-trimethacarb insecticide. In the 3 days following treatment (3 kg/ha, a.i.), grazing activity in the treated portions of the 200 m2 experimental plots was reduced an average of 47X. Overall use of the treated areas followed a similar pattern but was less consistent among groups. The addition of methylpyrazine, a strong odorant, produced a strong initial suppression of grazing activity in the treated halves of the plots. However, subsequent rain and a change in the coots\u27 grazing behavior prevented a definitive evaluation of the methylpyrazine treatment. Two birds that died during the trimethacarb-only portion of the study did not have abnormally low levels of brain cholinesterase. However, this finding does not preclude the possibility that they were unable to distinguish treated from untreated grass and consumed lethal amounts of trimethacarb. Additional investigation of methylpyrazine appears warranted; such materials may act to decrease the likelihood that birds will ingest lethal quantities of repellent
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