264 research outputs found
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Macrophages promote epithelial proliferation following infectious and non-infectious lung injury through a Trefoil factor 2-dependent mechanism.
Coordinated efforts between macrophages and epithelia are considered essential for wound healing, but the macrophage-derived molecules responsible for repair are poorly defined. This work demonstrates that lung macrophages rely upon Trefoil factor 2 to promote epithelial proliferation following damage caused by sterile wounding, Nippostrongylus brasiliensis or Bleomycin sulfate. Unexpectedly, the presence of T, B, or ILC populations was not essential for macrophage-driven repair. Instead, conditional deletion of TFF2 in myeloid-restricted CD11cCre TFF2 flox mice exacerbated lung pathology and reduced the proliferative expansion of CD45- EpCAM+ pro-SPC+ alveolar type 2 cells. TFF2 deficient macrophages had reduced expression of the Wnt genes Wnt4 and Wnt16 and reconstitution of hookworm-infected CD11cCre TFF2flox mice with rWnt4 and rWnt16 restored the proliferative defect in lung epithelia post-injury. These data reveal a previously unrecognized mechanism wherein lung myeloid phagocytes utilize a TFF2/Wnt axis as a mechanism that drives epithelial proliferation following lung injury
A non-BRICHOS surfactant protein c mutation disrupts epithelial cell function and intercellular signaling
We show that I73T mutation leads to impaired processing of proSP-C in alveolar type II cells, alters their stress tolerance and surfactant lipid composition, and activates cells of the immune system. In addition, we show that some of the mentioned cellular aspects behind the disease can be modulated by application of pharmaceutical drugs commonly applied in the ILD therapy
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Baseline insecticide tolerances and cross-resistance in Choristoneura rosaceana and Pandemis pyrusana (Lepidoptera : Tortricidae)
The Century Survey Galactic Halo Project III: A Complete 4300 deg^2 Survey of Blue Horizontal Branch Stars in the Metal-Weak Thick Disk and Inner Halo
We present a complete spectroscopic survey of 2414 2MASS-selected blue
horizontal branch (BHB) candidates selected over 4300 deg^2 of the sky. We
identify 655 BHB stars in this non-kinematically selected sample. We calculate
the luminosity function of field BHB stars and find evidence for very few hot
BHB stars in the field. The BHB stars located at a distance from the Galactic
plane |Z|<4 kpc trace what is clearly a metal-weak thick disk population, with
a mean metallicity of [Fe/H]= -1.7, a rotation velocity gradient of
dv_{rot}/d|Z|= -28+-3.4 km/s in the region |Z|<6 kpc, and a density scale
height of h_Z= 1.26+-0.1 kpc. The BHB stars located at 5<|Z|<9 kpc are a
predominantly inner-halo population, with a mean metallicity of [Fe/H]= -2.0
and a mean Galactic rotation of -4+-31 km/s. We infer the density of halo and
thick disk BHB stars is 104+-37 kpc^-3 near the Sun, and the relative
normalization of halo to thick-disk BHB stars is 4+-1% near the Sun.Comment: 12 pages in emulateapj format, accepted for publication in February
A
Very Metal-poor Stars in the Outer Galactic Bulge Found by the Apogee Survey
Despite its importance for understanding the nature of early stellar
generations and for constraining Galactic bulge formation models, at present
little is known about the metal-poor stellar content of the central Milky Way.
This is a consequence of the great distances involved and intervening dust
obscuration, which challenge optical studies. However, the Apache Point
Observatory Galactic Evolution Experiment (APOGEE), a wide-area, multifiber,
high-resolution spectroscopic survey within Sloan Digital Sky Survey III
(SDSS-III), is exploring the chemistry of all Galactic stellar populations at
infrared wavelengths, with particular emphasis on the disk and the bulge. An
automated spectral analysis of data on 2,403 giant stars in twelve fields in
the bulge obtained during APOGEE commissioning yielded five stars with low
metallicity([Fe/H]), including two that are very metal-poor
[Fe/H] by bulge standards.
Luminosity-based distance estimates place the five stars within the outer
bulge, where other 1,246 of the analyzed stars may reside. A manual reanalysis
of the spectra verifies the low metallicities, and finds these stars to be
enhanced in the -elements O, Mg, and Si without significant
-pattern differences with other local halo or metal-weak thick-disk
stars of similar metallicity, or even with other more metal-rich bulge stars.
While neither the kinematics nor chemistry of these stars can yet definitively
determine which, if any, are truly bulge members, rather than denizens of other
populations co-located with the bulge, the newly-identified stars reveal that
the chemistry of metal-poor stars in the central Galaxy resembles that of
metal-weak thick-disk stars at similar metallicity.Comment: 6 pages, 3 figures, 2 table
Tracing chemical evolution over the extent of the Milky Way's Disk with APOGEE Red Clump Stars
We employ the first two years of data from the near-infrared, high-resolution
SDSS-III/APOGEE spectroscopic survey to investigate the distribution of
metallicity and alpha-element abundances of stars over a large part of the
Milky Way disk. Using a sample of ~10,000 kinematically-unbiased red-clump
stars with ~5% distance accuracy as tracers, the [alpha/Fe] vs. [Fe/H]
distribution of this sample exhibits a bimodality in [alpha/Fe] at intermediate
metallicities, -0.9<[Fe/H]<-0.2, but at higher metallicities ([Fe/H]=+0.2) the
two sequences smoothly merge. We investigate the effects of the APOGEE
selection function and volume filling fraction and find that these have little
qualitative impact on the alpha-element abundance patterns. The described
abundance pattern is found throughout the range 5<R<11 kpc and 0<|Z|<2 kpc
across the Galaxy. The [alpha/Fe] trend of the high-alpha sequence is
surprisingly constant throughout the Galaxy, with little variation from region
to region (~10%). Using simple galactic chemical evolution models we derive an
average star formation efficiency (SFE) in the high-alpha sequence of ~4.5E-10
1/yr, which is quite close to the nearly-constant value found in
molecular-gas-dominated regions of nearby spirals. This result suggests that
the early evolution of the Milky Way disk was characterized by stars that
shared a similar star formation history and were formed in a well-mixed,
turbulent, and molecular-dominated ISM with a gas consumption timescale (1/SFE)
of ~2 Gyr. Finally, while the two alpha-element sequences in the inner Galaxy
can be explained by a single chemical evolutionary track this cannot hold in
the outer Galaxy, requiring instead a mix of two or more populations with
distinct enrichment histories.Comment: 18 pages, 17 figures. Accepted for publication in Ap
Groups of Galaxies in AEGIS: The 200 ksec Chandra Extended X-ray Source catalogue
We present the discovery of seven X-ray emitting groups of galaxies selected
as extended X-ray sources in the 200 ksec Chandra coverage of the
All-wavelength Extended Groth Strip International Survey (AEGIS). In addition,
we report on AGN activity associated to these systems. Using the DEEP2 Galaxy
Redshift Survey coverage, we identify optical counterparts and determine
velocity dispersions. In particular, we find three massive high-redshift groups
at z>0.7, one of which is at z=1.13, the first X-ray detections of
spectroscopically selected DEEP2 groups. We also present a first look at the
the L_X-T, L_X-sigma, and sigma-T scaling relations for high-redshift massive
groups. We find that the properties of these X-ray selected systems agree well
with the scaling relations of similar systems at low redshift, although there
are X-ray undetected groups in the DEEP2 catalogue with similar velocity
dispersions. The other three X-ray groups with identified redshifts are
associated with lower mass groups at z~0.07 and together form part of a large
structure or "supergroup" in the southern portion of the AEGIS field. All of
the low-redshift systems are centred on massive elliptical galaxies, and all of
the high-redshift groups have likely central galaxies or galaxy pairs. All of
the central group galaxies host X-ray point sources, radio sources, and/or show
optical AGN emission. Particularly interesting examples of central AGN activity
include a bent-double radio source plus X-ray point source at the center of a
group at z=0.74, extended radio and double X-ray point sources associated to
the central galaxy in the lowest-redshift group at z=0.066, and a bright green
valley galaxy (part of a pair) in the z=1.13 group which shows optical AGN
emission lines.Comment: accepted to MNRAS, 15 pages, 11 figures, for version with full
resolution figures see http://www.ucolick.org/~tesla/aegis_groups.ps.g
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