Quantum metrology and its application in biology

Quantum metrology provides a route to overcome practical limits in sensing devices. It holds particular relevance to biology, where sensitivity and resolution constraints restrict applications both in fundamental biophysics and in medicine. Here, we review quantum metrology from this biological context, focusing on optical techniques due to their particular relevance for biological imaging, sensing, and stimulation. Our understanding of quantum mechanics has already enabled important applications in biology, including positron emission tomography (PET) with entangled photons, magnetic resonance imaging (MRI) using nuclear magnetic resonance, and bio-magnetic imaging with superconducting quantum interference devices (SQUIDs). In quantum metrology an even greater range of applications arise from the ability to not just understand, but to engineer, coherence and correlations at the quantum level. In the past few years, quite dramatic progress has been seen in applying these ideas into biological systems. Capabilities that have been demonstrated include enhanced sensitivity and resolution, immunity to imaging artifacts and technical noise, and characterization of the biological response to light at the single-photon level. New quantum measurement techniques offer even greater promise, raising the prospect for improved multi-photon microscopy and magnetic imaging, among many other possible applications. Realization of this potential will require cross-disciplinary input from researchers in both biology and quantum physics. In this review we seek to communicate the developments of quantum metrology in a way that is accessible to biologists and biophysicists, while providing sufficient detail to allow the interested reader to obtain a solid understanding of the field. We further seek to introduce quantum physicists to some of the central challenges of optical measurements in biological science.Comment: Submitted review article, comments and suggestions welcom

Quantum optomechanics beyond the quantum coherent oscillation regime

Interaction with a thermal environment decoheres the quantum state of a mechanical oscillator. When the interaction is sufficiently strong, such that more than one thermal phonon is introduced within a period of oscillation, quantum coherent oscillations are prevented. This is generally thought to preclude a wide range of quantum protocols. Here, we introduce a pulsed optomechanical protocol that allows ground state cooling, general linear quantum non-demolition measurements, optomechanical state swaps, and quantum state preparation and tomography without requiring quantum coherent oscillations. Finally we show how the protocol can break the usual thermal limit for sensing of impulse forces.Comment: 6 pages, 3 figure

High temperature reliability of power module substrates

The thermal cycling reliability of candidate copper and aluminium power substrates has been assessed for use at temperatures exceeding 300°C peak using a combination of thermal cycling, nanoindentation and finite element modelling to understand the relative stresses and evolution of the mechanical properties. The results include the relative cycling lifetimes up to 350°C, demonstrating almost an order of magnitude higher lifetime for active metal brazed Al / AlN substrates over Cu / Si3N4, but four times more severe roughening and cracking of the Ni-P plating's on the Al / AlN (DBA) substrates. The nonlinear finite element modelling illustrated that the yield strength of the metal and the thickness of the ceramic are the main stress controlling factors, but comparisons with the cycling lifetime results demonstrated that the fracture toughness (resistance) of the ceramic is the over-riding controlling factor for the overall passive thermal cycling lifetimes. In order to achieve the highest substrate lifetime for the highly stressed high temperature thermal cycled applications, the optimum solution appears to be annealed copper, brazed on to a thicker than normal or higher fracture toughness Si3N4 ceramic

Cavity optoelectromechanical regenerative amplification

Cavity optoelectromechanical regenerative amplification is demonstrated. An optical cavity enhances mechanical transduction, allowing sensitive measurement even for heavy oscillators. A 27.3 MHz mechanical mode of a microtoroid was linewidth narrowed to 6.6\pm1.4 mHz, 30 times smaller than previously achieved with radiation pressure driving in such a system. These results may have applications in areas such as ultrasensitive optomechanical mass spectroscopy

Fundamental constraints on particle tracking with optical tweezers

A general quantum limit to the sensitivity of particle position measurements is derived following the simple principle of the Heisenberg microscope. The value of this limit is calculated for particles in the Rayleigh and Mie scattering regimes, and with parameters which are relevant to optical tweezers experiments. The minimum power required to observe the zero-point motion of a levitating bead is also calculated, with the optimal particle diameter always smaller than the wavelength. We show that recent optical tweezers experiments are within two orders of magnitude of quantum limited sensitivity, suggesting that quantum optical resources may soon play an important role in high sensitivity tracking applications

Magellan LDSS3 emission confirmation of galaxies hosting metal-rich Lyman-alpha absorption systems

Using the Low Dispersion Survey Spectrograph 3 at the Magellan II Clay Telescope, we target {candidate absorption host galaxies} detected in deep optical imaging {(reaching limiting apparent magnitudes of 23.0-26.5 in $g, r, i,$ and $z$ filters) in the fields of three QSOs, each of which shows the presence of high metallicity, high $N_{\rm HI}$ absorption systems in their spectra (Q0826-2230: $z_{abs}$=0.9110, Q1323-0021: $z_{abs}=0.7160$, Q1436-0051: $z_{abs}=0.7377, 0.9281$). We confirm three host galaxies {at redshifts 0.7387, 0.7401, and 0.9286} for two of the Lyman-$\alpha$ absorption systems (one with two galaxies interacting). For these systems, we are able to determine the star formation rates (SFRs); impact parameters (from previous imaging detections); the velocity shift between the absorption and emission redshifts; and, for one system, also the emission metallicity.} Based on previous photometry, we find these galaxies have L$>$L$^{\ast}$. The [O II] SFRs for these galaxies are in the range $11-25$ M$_{\odot}$ yr$^{-1}$ {(uncorrected for dust)}, while the impact parameters lie in the range $35-54$ kpc. {Despite the fact that we have confirmed galaxies at 50 kpc from the QSO, no gradient in metallicity is indicated between the absorption metallicity along the QSO line of sight and the emission line metallicity in the galaxies.} We confirm the anti-correlation between impact parameter and $N_{\rm HI}$ from the literature. We also report the emission redshift of five other galaxies: three at $z_{em}>z_{QSO}$, and two (L$<$L$^{\ast}$) at $z_{em}<z_{QSO}$ not corresponding to any known absorption systems.Comment: 14 pages, 7 figures, 4 tables, accepted to MNRA

Why are Mountaintops Cold? The Transition of Surface Lapse Rate on Dry Planets

Understanding surface temperature is important for habitability. Recent work on Mars has found that the dependence of surface temperature on elevation (surface lapse rate) converges to zero in the limit of a thin CO2 atmosphere. However, the mechanisms that control the surface lapse rate are still not fully understood. It remains unclear how the surface lapse rate depends on both greenhouse effect and surface pressure. Here, we use climate models to study when and why "mountaintops are cold". We find the tropical surface lapse rate increases with the greenhouse effect and with surface pressure. The greenhouse effect dominates the surface lapse rate transition and is robust across latitudes. The pressure effect is important at low latitudes in moderately opaque atmospheres. A simple model provides insights into the mechanisms of the transition. Our results suggest that topographic cold-trapping may be important for the climate of arid planets.Comment: 14 pages, 4 figures; accepted for publication on Geophysical Research Letter

Called to Safety? Individual and Combined Effects of Safety Climate and Occupational Callings on Aviator Safety Performance

This study examined the individual and combined effects of two potential antecedents to aviation-related safety performance: safety climate and occupational callings. Research exploring the importance of occupational callings to the safety domain is in its nascent stages. The extent that someone is living a calling may explain variance in actual safety performance above that which can be explained by safety climate alone. Survey data from aviators in a flight training program were analyzed to evaluate the ability of occupational calling assessments to inform the potential for safety mishaps within the aviation industry. Results indicate that both safety climate and occupational callings may inform the potential for safety mishaps better than either alone. Occupational callings may be used to augment safety climate assessments in monitoring and improving aviation safety performance

Statistics of heart failure and mechanical circulatory support in 2020

Heart failure is increasing in prevalence, with approximately 26 million patients affected worldwide. This represents a significant cause of morbidity and mortality. Statistics regarding heart failure patient age, hospitalization likelihood, and mortality differ significantly by country. Heart failure patients are typically classified by ejection fraction, with distinct phenotypes associated with reduced ejection fraction (rEF) or preserved ejection fraction (pEF). Heart failure has a significant financial impact related to hospitalization, medication, and procedural expenses. The costs of heart failure also extend to the reduced quality of life conferred by heart failure symptoms. Management of heart failure includes a variety of interventions, including mechanical circulatory support (MCS). MCS, including left ventricular assist devices (LVADs), right ventricular assist devices (RVADs) and extracorporeal membrane oxygenation (ECMO), has been a means of managing end stage heart failure. Given the relative scarcity of transplant organs, the utilization of MCS, particularly as a bridge to transplantation (BTT) has grown significantly. In this review, we discuss statistics related to heart failure and MCS. We evaluate how patients are classified and examine global trends and regional differences. We then address MCS therapies, the costs associated with heart failure, the impact of heart failure on patient quality of life, and data regarding morbidity and mortality