Holocene Selection for Variants Associated With General Cognitive Ability: Comparing Ancient and Modern Genomes

Human populations living during the Holocene underwent considerable microevolutionary change. It has been theorized that the transition of Holocene populations into agrarianism and urbanization brought about culture-gene co-evolution that favored via directional selection genetic variants associated with higher general cognitive ability (GCA). To examine whether GCA might have risen during the Holocene, we compare a sample of 99 ancient Eurasian genomes (ranging from 4.56 to 1.21 kyr BP) with a sample of 503 modern European genomes (Fst= 0.013), using three different cognitive polygenic scores (130 SNP, 9 SNP and 11 SNP). Significant differences favoring the modern genomes were found for all three polygenic scores (odds ratios = 0.92,p= 001; .81,p= 037; and .81,p= .02 respectively). These polygenic scores also outperformed the majority of scores assembled from random SNPs generated via a Monte Carlo model (between 76.4% and 84.6%). Furthermore, an indication of increasing positive allele count over 3.25 kyr was found using a subsample of 66 ancient genomes (r= 0.22,pone-tailed= .04). These observations are consistent with the expectation that GCA rose during the Holocene

How cognitive genetic factors influence fertility outcomes: A mediational SEM analysis

Utilizing a newly released cognitive Polygenic Score (PGS) from Wave IV of Add Health (n = 1,886), structural equation models (SEMs) examining the relationship between PGS and fertility (which is approximately 50% complete in the present sample), employing measures of verbal IQ and educational attainment as potential mediators, were estimated. The results of indirect pathway models revealed that verbal IQ mediates the positive relationship between PGS and educational attainment, and educational attainment in turn mediates the negative relationship between verbal IQ and a latent fertility measure. The direct path from PGS to fertility was non-significant. The model was robust to controlling for age, sex, and race; furthermore, the results of a multigroup SEM revealed no significant differences in the estimated path coeficients across sex. These results indicate that those predisposed towards higher verbal IQ by virtue of higher PGS values are also predisposed towards trading fertility against time spent in education, which contributes to those with higher PGS values producing fewer offspring at this stage in their life course

The Kinematics and Dynamics of the Globular Clusters and the Planetary Nebulae of NGC 5128

A new kinematic and dynamic study of the halo of the giant elliptical galaxy, NGC 5128, is presented. From a spectroscopically confirmed sample of 340 globular clusters and 780 planetary nebulae, the rotation amplitude, rotation axis, velocity dispersion, and the total dynamical mass are determined for the halo of NGC 5128. The globular cluster kinematics were searched for both radial dependence and metallicity dependence by subdividing the globular cluster sample into 158 metal-rich ([Fe/H] > -1.0) and 178 metal-poor ([Fe/H] < -1.0) globular clusters. Our results show the kinematics of the metal-rich and metal-poor subpopulations are quite similar. The kinematics are compared to the planetary nebula population where differences are apparent in the outer regions of the halo. The total mass of NGC 5128 is found using the Tracer Mass estimator (Evans et al. 2003), to determine the mass supported by internal random motions, and the spherical component of the Jeans equation to determine the mass supported by rotation. We find a total mass of (1.0+/-0.2) x 10^(12) Msun from the planetary nebulae data out to a projected radius of 90 kpc and (1.3+/-0.5) x 10^(12) Msun from the globular clusters out to a projected radius of 50 kpc. Lastly, we present a new and homogeneous catalog of known globular clusters in NGC 5128. This catalog combines all previous definitive cluster identifications from radial velocity studies and HST imaging studies, as well as 80 new globular clusters from a study of M.A. Beasley et al. (2007, in preparation).Comment: Accepted in the Astronomical Journal,52 pages, 13 figures, 6 tables - Changes made to Table 1 from originally submitted 0704.118

Morphology of Cu clusters supported on reconstructed polar ZnO (0001) and (000[1]) surfaces†

Unbiased Monte Carlo procedures are applied to investigate the structure of Cu clusters of various sizes deposited over reconstructed polar ZnO surfaces. Four distinct reconstructed polar ZnO surfaces (two Zn terminated (0001) reconstructions and two O terminated (000[1 with combining macron]) reconstructions) were investigated, having previously been determined to be the most stable under typical conditions, as revealed by the grand canonical ensemble studies. Random sampling was performed considering ∼400 000 random initial structural configurations of Cu atoms over the ZnO surfaces, with each structure being optimised using interatomic potential techniques, and the most stable resultant structures being refined using a plane-wave DFT approach. The investigation reveals the key role of surface adatoms and vacancies arising from the reconstruction of the polar ZnO surface in determining the morphology of deposited Cu clusters. Strong Cu–Zn interactions play an essential role in Cu cluster growth, with reconstructed polar ZnO surfaces featuring sites with undercoordinated Zn surface atoms promoting highly localised three dimensional Cu cluster morphologies, whist reconstructions featuring undercoordinated O atoms tend to result in more planar Cu clusters, in order to maximise the favourable Cu–Zn interaction. This is the first study that evaluates the thermodynamically most stable Cu/ZnO structures using realistic reconstructed ZnO polar surfaces, and thus provides valuable insights into the factors affecting Cu cluster growth over ZnO surfaces, as well as model catalyst surfaces that can be utilised in future computational studies to explore catalytic activity for key processes such as CO2 and CO hydrogenation to methanol

Genomic comparison of diverse Salmonella serovars isolated from swine.

Food animals act as a reservoir for many foodborne pathogens. Salmonella enterica is one of the leading pathogens that cause food borne illness in a broad host range including animals and humans. They can also be associated with a single host species or a subset of hosts, due to genetic factors associated with colonization and infection. Adult swine are often asymptomatic carriers of a broad range of Salmonella servoars and can act as an important reservoir of infections for humans. In order to understand the genetic variations among different Salmonella serovars, Whole Genome Sequences (WGS) of fourteen Salmonella serovars from swine products were analyzed. More than 75% of the genes were part of the core genome in each isolate and the higher fraction of gene assign to different functional categories in dispensable genes indicated that these genes acquired for better adaptability and diversity. High concordance (97%) was detected between phenotypically confirmed antibiotic resistances and identified antibiotic resistance genes from WGS. The resistance determinants were mainly located on mobile genetic elements (MGE) on plasmids or integrated into the chromosome. Most of known and putative virulence genes were part of the core genome, but a small fraction were detected on MGE. Predicted integrated phage were highly diverse and many harbored virulence, metal resistance, or antibiotic resistance genes. CRISPR (Clustered regularly interspaced short palindromic repeats) patterns revealed the common ancestry or infection history among Salmonella serovars. Overall genomic analysis revealed a great deal of diversity among Salmonella serovars due to acquired genes that enable them to thrive and survive during infection

Parent-offspring resemblance for educational attainment reduces with increased social class in a global sample: evidence for the compensatory advantage hypothesis

IntroductionThe degree to which (self-reported) social class predicts parent-offspring resemblance for educational attainment (EA) is examined in a globally representative dataset of 69,116 individuals sourced from 56 countries.MethodsA hierarchical general linear model is used to predict participant EA with the two-way interaction between class and parental EA, after controlling for regional effects, the main effects of age, class, parental EA, and interactions among these.ResultsSocial class-by-parental EA interaction negatively predicts participant EA (semipartial r = −0.04, 95% CI = −0.05 to −0.03), meaning that among those who report belonging to a “higher” social class, the degree of parent-offspring resemblance for EA is reduced, contrary to the Scarr-Rowe hypothesis, which holds that genetic influences on cognitive ability and related phenotypes (captured here in part by parent-offspring resemblance) should be greater among those from higher socioeconomic status (SES) backgrounds. These results replicate using a quantile regression model, where it was found that among those with lower social class ordinals, the strength of the parent-participant EA association is significantly stronger relative to those in the highest ordinal. No significant sex differences are present.DiscussionThese findings are consistent with the compensatory advantage hypothesis, which predicts decreased heritability of EA and related phenotypes among affluent families, as increased access to educational resources should enhance opportunities for cognitive growth in a way that compensates for intrinsic disadvantages

Chemodynamics of Compact Stellar Systems in NGC 5128: How similar are Globular Clusters, Ultra-Compact Dwarfs, and Dwarf Galaxies?

Velocity dispersion measurements are presented for luminous GCs in NGC 5128 derived from high-res. UVES spectra. The measurements are made with the pPXF code that parametrically recovers line-of-sight velocity dispersions. Combining the measured velocity dispersions with surface photometry and structural parameter data from HST enables both dynamical masses and M/L ratios to be derived. The fundamental plane relations of these clusters are investigated in order to fill the apparent gap between the relations of Local Group GCs and more massive early-type galaxies. It is found that the properties of these massive stellar systems match those of nuclear clusters in dwarf elliptical galaxies and UCDs better than those of Local Group GCs, and that all objects share similarly old (>8 Gyr) ages, suggesting a possible link between the formation and evolution of dE,Ns, UCDs and massive GCs. We find a very steep correlation between dynamical (M/L) ratio and dynamical mass of the form (M/L)_dyn ~ M_dyn^(0.24+/-0.02) above M_dyn = 2x10^6 Msol. Formation scenarios are investigated with a chemical abundance analysis using absorption line strengths calibrated to the Lick/IDS index system. The results lend support to two scenarios contained within a single general formation scheme. Old, massive, super-solar [alpha/Fe] systems are formed on short (<100 Myr) timescales through the merging of single-collapse GCs which themselves are formed within single, giant molecular clouds. More intermediate- and old-aged (~3-10 Gyr), solar- to sub-solar [alpha/Fe] systems are formed on much longer (~Gyr) timescales through the stripping of dE,Ns in the 10^13-10^15 Msol potential wells of massive galaxies and galaxy clusters.Comment: 12 pages (ApJ style) with 11 figures and 7 tables, accepted for publication in Ap

Sinistrality is associated with (slightly) lower general intelligence: a data synthesis and consideration of secular trend data in handedness

The relationship between the general factor of intelligence (g) and handedness is investigated using a combined sample of 23511 respondents from three large databases: the NLSY’79 (US), NLSY’97 (US) and NCDS (UK). Dextrals – those who use their right hands were found to be 1.22 IQ points higher than sinistrals (left handers) after controling for sex and age and correcting for sources of measurement error. To see if the association between IQ and handedness was strongest on the abilities that were the best measures of g, the method of correlated vectors was used to test for moderation. Across the three studies, g was found to very weakly negatively moderate the association between ability measure and handedness (ρ=-.023, K=3, N=23511), however in the NLSY’79, the coding speed subtest was an outlier in terms of the strength of its association with handedness. Its removal yielded indications of positive moderation in this dataset, which when aggregated boosted the overall vector correlation value to .539 (K=3, N=23511), suggesting that g might be an important moderator of this relationship. Secondary analysis of secular trend data on the changing percentage of sinistrals in Western populations indicates that overall, sinistrality has increased, entailing a g decline of .106 points over 150 years (.006 points per decade). The secular increase in sinistrality is consistent with other data indicating long-term declines in developmental stability and may stem from some combination of increasing mutation load and advancing maternal age in Western populations

Moral foundations tracked over 200 years of lexicographic data, and their predictors

The prediction that reduction of negative selection decreases group-level competitiveness, as reflected in increased individual-focused and diminished group-focused moral foundations, is tested. To measure this hypothesized shift in moral foundations, we conduct a culturomic analysis of the utilization frequencies of items sourced from the moral foundations item pool, tracked among Britannic populations from 1800 to 1999 using Google Ngram Viewer. The resultant higher-order factor, which tracks increasing individualizing values and decreasing binding values, is termed Asabiyyah (capturing social cohesion and collective purpose). Two predictors of this factor are examined: change in the strength of intergroup competition and change in levels of indicators of developmental instability. Both the strength of intergroup competition and levels of developmental instability associate with Asabiyyah. Rising developmental instability mediates the impact of inter-group competition, indicating that reduced between-group competition might have relaxed negative selection against mutations, which might reduce Asabiyyah via their effects on inter-genomic transactions. These results must be interpreted carefully, given the clear real-world evidence that explicit commitment to group-oriented values often features in harmful and maladaptive social and political ideologies of an extreme character

Probing the Intermediate-Age Globular Clusters in NGC 5128 from Ultraviolet Observations

We explore the age distribution of the globular cluster (GC) system of the nearby elliptical galaxy NGC 5128 using ultraviolet (UV) photometry from Galaxy Evolution Explorer (GALEX) observations, with UV - optical colors used as the age indicator. Most GCs in NGC 5128 follow the general trends of GCs in M31 and Milky Way in UV - optical color-color diagram, which indicates that the majority of GCs in NGC 5128 are old similar to the age range of old GCs in M31 and Milky Way. A large fraction of spectroscopically identified intermediate-age GC (IAGC) candidates with ~ 3-8 Gyr are not detected in the FUV passband. Considering the nature of intermediate-age populations being faint in the far-UV (FUV) passband, we suggest that many of the spectroscopically identified IAGCs may be truly intermediate in age. This is in contrast to the case of M31 where a large fraction of spectroscopically suggested IAGCs are detected in FUV and therefore may not be genuine IAGCs but rather older GCs with developed blue horizontal branch stars. Our UV photometry strengthens the results previously suggesting the presence of GC and stellar subpopulation with intermediate age in NGC 5128. The existence of IAGCs strongly indicates the occurrence of at least one more major star formation episode after a starburst at high redshift.Comment: 8 pages, 3 figures, accepted for ApJ Lette