Serum AGEs in black South African patients with type 2 diabetes

Objective: The objective of this study was to determine serum advanced glycation end products (AGEs) levels in black South African patients with and without type 2 diabetes (T2D) and to compare the results with those reported for other ethnic/race groups.Design: Analytical cross-sectional study.Setting and subjects: The study subjects consisted of 138 black South African patients with T2D and 81 non-diabetic patients at Dr George Mukhari Academic Hospital in Pretoria, South Africa.Outcome measures: Serum total AGEs (TAGEs), Nɛ-carboxymethyl-lysine (CML), Nɛ-carboxyethyl-lysine (CEL) and fluorescent AGEs (FAGEs).Results: Serum TAGEs, CML and CEL levels but not FAGEs were significantly higher in T2D patients than in non-diabetic patients. Serum TAGEs were lower than those reported for other ethnic/race groups whereas CML and FAGEs were within ranges reported for other ethnic/race groups. Only serum CEL levels were significantly higher in male than in female T2D patients and only serum FAGEs levels were negatively associated with age of the study subjects.Conclusions: With the exception of FAGEs, serum AGEs levels are significantly higher in T2D than in non-diabetic black South Africans patients. Also, serum TAGE levels black South African appear to be lower than those reported for other ethnic/race groups.Keywords: Black South Africans, serum AGEs, type 2 diabete

Production of charged pions, kaons, and (anti-)protons in Pb-Pb and inelastic pppp collisions at sNN\sqrt {s_{NN}} = 5.02 TeV

International audienceMid-rapidity production of $\pi^{\pm}$, $\rm{K}^{\pm}$ and ($\bar{\rm{p}}$)p measured by the ALICE experiment at the LHC, in Pb-Pb and inelastic pp collisions at $\sqrt{s_{\rm{NN}}}$ = 5.02 TeV, is presented. The invariant yields are measured over a wide transverse momentum ($p_{\rm{T}}$) range from hundreds of MeV/$c$ up to 20 GeV/$c$. The results in Pb-Pb collisions are presented as a function of the collision centrality, in the range 0$-$90%. The comparison of the $p_{\rm{T}}$-integrated particle ratios, i.e. proton-to-pion (p/$\pi$) and kaon-to-pion (K/$\pi$) ratios, with similar measurements in Pb-Pb collisions at $\sqrt{s_{\rm{NN}}}$ = 2.76 TeV show no significant energy dependence. Blast-wave fits of the $p_{\rm{T}}$ spectra indicate that in the most central collisions radial flow is slightly larger at 5.02 TeV with respect to 2.76 TeV. Particle ratios (p/$\pi$, K/$\pi$) as a function of $p_{\rm{T}}$ show pronounced maxima at $p_{\rm{T}}$ $\approx$ 3 GeV/$c$ in central Pb-Pb collisions. At high $p_{\rm{T}}$, particle ratios at 5.02 TeV are similar to those measured in pp collisions at the same energy and in Pb-Pb collisions at $\sqrt{s_{\rm{NN}}}$ = 2.76 TeV. Using the pp reference spectra measured at the same collision energy of 5.02 TeV, the nuclear modification factors for the different particle species are derived. Within uncertainties, the nuclear modification factor is particle species independent for high $p_{\rm{T}}$ and compatible with measurements at $\sqrt{s_{\rm{NN}}}$ = 2.76 TeV. The results are compared to state-of-the-art model calculations, which are found to describe the observed trends satisfactorily

Elliptic flow of electrons from heavy-flavour hadron decays at mid-rapidity in Pb–Pb collisions at √sNN = 2.76 TeV

The elliptic flow of electrons from heavy-flavour hadron decays at mid-rapidity (|y| < 0.7) is measured in Pb-Pb collisions at sNN−−−√=2.76 TeV with ALICE at the LHC. The particle azimuthal distribution with respect to the reaction plane can be parametrized with a Fourier expansion, where the second coefficient (v2) represents the elliptic flow. The v2 coefficient of inclusive electrons is measured in three centrality classes (0-10%, 10-20% and 20-40%) with the event plane and the scalar product methods in the transverse momentum (pT) intervals 0.5-13 GeV/c and 0.5-8 GeV/c, respectively. After subtracting the background, mainly from photon conversions and Dalitz decays of neutral mesons, a positive v2 of electrons from heavy-flavour hadron decays is observed in all centrality classes, with a maximum significance of 5.9σ in the interval 2< pT < 2.5 GeV/c in semi-central collisions (20-40%). The value of v2 decreases towards more central collisions at low and intermediate pT (0.5 < pT < 3 GeV/c). The v2 of electrons from heavy-flavour hadron decays at mid-rapidity is found to be similar to the one of muons from heavy-flavour hadron decays at forward rapidity (2.5 < y < 4). The results are described within uncertainties by model calculations including substantial elastic interactions of heavy quarks with an expanding strongly-interacting medium

Measurement of electrons from beauty-hadron decays in p-Pb collisions at sNN=5.02 \sqrt{s_{\mathrm{NN}}}=5.02 TeV and Pb-Pb collisions at sNN=2.76 \sqrt{s_{\mathrm{NN}}}=2.76 TeV

The production of beauty hadrons was measured via semi-leptonic decays at mid-rapidity with the ALICE detector at the LHC in the transverse momentum interval 1<p$_{T}$ < 8 GeV/c in minimum-bias p-Pb collisions at $\sqrt{s_{\mathrm{NN}}}=5.02$ TeV and in 1.3 < p$_{T}$ < 8 GeV/c in the 20% most central Pb-Pb collisions at $\sqrt{s_{\mathrm{NN}}}=2.76$ TeV. The pp reference spectra at $\sqrt{s_{\mathrm{NN}}}=5.02$ TeV and $\sqrt{s}=2.76$ TeV, needed for the calculation of the nuclear modification factors R$_{pPb}$ and R$_{PbPb}$, were obtained by a pQCD-driven scaling of the cross section of electrons from beauty-hadron decays measured at $\sqrt{s}=7$ TeV. In the p$_{T}$ interval 3 < p$_{T}$ < 8 GeV/c, a suppression of the yield of electrons from beauty-hadron decays is observed in Pb-Pb compared to pp collisions. Towards lower p$_{T}$, the R$_{PbPb}$ values increase with large systematic uncertainties. The R$_{pPb}$ is consistent with unity within systematic uncertainties and is well described by theoretical calculations that include cold nuclear matter effects in p-Pb collisions. The measured R$_{pPb}$ and these calculations indicate that cold nuclear matter effects are small at high transverse momentum also in Pb-Pb collisions. Therefore, the observed reduction of R$_{PbPb}$ below unity at high p$_{T}$ may be ascribed to an effect of the hot and dense medium formed in Pb-Pb collisions

Measurement of electrons from beauty-hadron decays in p–Pb collisions at √sNN = 5.02 TeV and Pb–Pb collisions at √sNN = 2.76 TeV

The production of beauty hadrons was measured via semi-leptonic decays at mid-rapidity with the ALICE detector at the LHC in the transverse momentum interval 1<pT<8 GeV/c in minimum-bias p-Pb collisions at sNN−−−√=5.02 TeV and in 1.3<pT<8 GeV/c in the 20% most central Pb-Pb collisions at sNN−−−√=2.76 TeV. The pp reference spectra at s√=5.02 TeV and s√=2.76 TeV, needed for the calculation of the nuclear modification factors RpPb and RPbPb, were obtained by a pQCD-driven scaling of the cross section of electrons from beauty-hadron decays measured at s√=7 TeV. In the pT interval 3<pT<8 GeV/c a suppression of the yield of electrons from beauty-hadron decays is observed in Pb-Pb compared to pp collisions. Towards lower pT, the RPbPb values increase with large systematic uncertainties. The RpPb is consistent with unity within systematic uncertainties and is well described by theoretical calculations that include cold nuclear matter effects in p-Pb collisions. The measured RpPb and these calculations indicate that cold nuclear matter effects are small at high transverse momentum also in Pb-Pb collisions. Therefore, the observed reduction of RPbPb below unity at high pT may be ascribed to an effect of the hot and dense medium formed in Pb-Pb collisions

Pseudorapidity dependence of the anisotropic flow of charged particles in Pb–Pb collisions at √sNN = 2.76 TeV

We present measurements of the elliptic (v2), triangular (v3) and quadrangular (v4) anisotropic azimuthal flow over a wide range of pseudorapidities (−3.5<η<5). The measurements are performed with Pb-Pb collisions at sNN−−−√=2.76 TeV using the ALICE detector at the Large Hadron Collider (LHC). The flow harmonics are obtained using two- and four-particle correlations from nine different centrality intervals covering central to peripheral collisions. We find that the shape of vn(η) is largely independent of centrality for the flow harmonics n=2−4, however the higher harmonics fall off more steeply with increasing |η|. We assess the validity of extended longitudinal scaling of v2 by comparing to lower energy measurements, and find that the higher harmonic flow coefficients are proportional to the charged particle densities at larger pseudorapidities. Finally, we compare our measurements to both hydrodynamical and transport models, and find they both have challenges when it comes to describing our data

J/ψ suppression at forward rapidity in Pb–Pb collisions at √sNN = 5.02 TeV

The inclusive J/ψ production has been studied in Pn-Pb and pp collisions at the centre-of-mass energy per nucleon pair sNN−−−√=5.02 TeV, using the ALICE detector at the CERN LHC. The J/ψ meson is reconstructed, in the centre-of-mass rapidity interval 2.5<y<4 and in the transverse-momentum range pT<12 GeV/c, via its decay to a muon pair. In this Letter, we present results on the inclusive J/ψ cross section in pp collisions at s√=5.02 TeV and on the nuclear modification factor RAA. The latter is presented as a function of the centrality of the collision and, for central collisions, as a function of the transverse momentum pT of the J/ψ. The measured RAA values indicate a suppression of the J/ψ in nuclear collisions and are then compared to our previous results obtained in Pb-Pb collisions at sNN−−−√=2.76 TeV. The ratio of the RAA values at the two energies is also computed and compared to calculations of statistical and dynamical models. The numerical value of the ratio for central events (0-10\% centrality) is 1.17±0.04(stat)±0.20(syst). In central events, as a function of pT, a slight increase of RAA with collision energy is visible in the region 2<pT<6 GeV/c. Theoretical calculations provide a good description of the measurements, within uncertainties