17 research outputs found
MĂ©lanome endobronchique
- Author
- Publication venue
- African Field Epidemiology Network
- Publication date
- Field of study
Le mélanome malin a un potentiel métastatique important. Les métastases pulmonaires du mélanome sont communes cependant la localisation endobronchique reste rare et pose le problème de son origine primitive ou secondaire. Nous rapportons le cas d’un mélanome pulmonaire qui présente des particularités intéressantes: une lésion cutanée présumée primitive totalement régressive, la présentation radio clinique mimant parfaitement un cancer bronchique primitif, un aspect endoscopique bourgeonnant et grisâtre dont l’étude histologique a permis de poser le diagnostic, une agressivité tumorale avec une extension intracardiaque et bourgeon tumoral intra cavitaire. A travers cette observation, les auteurs étudient les caractéristiques radio-cliniques pouvant distinguer le mélanome pulmonaire primitif du secondaire; la localisation endobronchique avec une revue de la littérature sur les métastases endo bronchiques; le bilan d’extension à entamer en cas de mélanome pulmonaire ainsi que les difficultés thérapeutiques posés par ce type de lésion dont le pronostic reste péjoratif
The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance
- Author
- Aanniz Tarek
- Abar Aden Elmi
- Abbad Anass
- Abdelfattah May
- Abdelhamid W.
- Abdella Saro
- Abdellah Faouzi
- Abdelmjid El Oualid
- Abdelmoula Fatma
- Abdelmoulah F.
- Abderrahmane Maaroufi
- Abderrazak Rfaki
- Abdillahi Idil Salah
- Abdissa Alemseged
- Abdo I.
- Abdoelraheem Mohamed Hassan
- Abe Haruka
- Abebe Markos
- Abechi Priscilla
- Abera Adugna
- Abi Rachid
- Abias Abe G.
- Abichu Getachew
- Abid N.
- Abid Nabil
- Abid Salma
- Abilio Nuro
- Abimbola Sharon
- Abo Shama Noura M
- Abosede O.
- Aboubaker Mohamed Houmed
- Abouelhoda Mohamed
- Abouelnaga S.
- Abualas Elamin
- Abubeker Ramalia Chabi
- Abuelenein Ehab Abdelkader
- Abuzaid Nadir
- Abworo Edward O.
- Ada Diosdado Odjama Nseng
- Addidle Michael
- Adegbola Richard
- Adegnika Akim A.
- Adegnika Ayola Akim
- Adel Abd Monaem
- Adeniji Johnson A.
- Adepetun Tomiwa
- Adesegun A.
- Adesuyi Omoare
- Adetifa Ifedayo M. O.
- Adewumi Olubusuyi M.
- Adewumi Oluwatimilehin
- Adewumi Praise
- Adeyemi Kayode T.
- Adhikari Bishwo N.
- Adil El Hamouchi
- Adjiratou Aissatou B. A.
- Adnew Bethlehem
- Adu Bright
- Adu Eric
- Adusei-Poku Mildred
- Agbenyo Seyram Bless
- Agbodzi B.
- Ageez A.M.
- Agoti Charles N.
- Aguenaou Hassan
- Agwa Sara Hassan
- Agweyu Ambrose
- Ahmed El Bara
- Ahmed Elhadi A.
- Ahmed Hatem
- Ahmed M.
- Ahmed O. S.
- Ahmed Rahma
- Ahmed Shymaa S.
- Ahmed Side Mohamed
- Ahmed Yahaya Ali
- Ahouidi Ambroise
- Ahuka-Mundeke Steve
- Ahumibe Anthony
- Ahyong Vida
- Aissam El Aliani
- Ajayi Nnennaya A.
- Ajibaye Solomon
- Ajili F.
- Ajogbasile F.V.
- Ajogbasile Fehintola V.
- Akanbi Olusola Anuoluwapo
- Akenji Blaise MBoringong
- Akhoud Youssef
- Akinola Monilade
- Akogbeto Petas
- Akoua-Koffi Chantal G.
- Akpede George O.
- Al Onifade Fattah
- Alain Etoundi Mballa
- Alaoui Afaf
- Alaoui-Amine Sanaa
- Alarif Ahlam
- Alaruusi A. M.
- Albert MĂ©lanie
- AlEmam Adba Alfatih
- Alemayehu Dawit Hailu
- Alemu Fekadu
- Algheriani Raiva
- Ali Abraham
- Ali M.A.
- Ali Mohamed Ahmed
- Ali Mushal
- Ali Wael
- Alkarim Mona O.A.
- Allam Loubna
- Allam Mushal
- Allam Mushal
- Altamura Settimia
- Amar Narjis
- Amenga-Etego Lucas N.
- Amer K. E.
- Amer Khaled
- Amira Souissi
- Amoako Daniel G.
- Amoo Olufemi Samuel
- Amoth Patrick
- Amougou Marie
- Ampofo William K.
- Amuri Adrienne A.
- Amuzu Dominic S. Y.
- Amzazi SaaĂŻd
- Anang Abraham Kwabena
- Anas Abbad
- Andeko Julia C.
- Andersen Kristian
- Andersson Hana Sofia
- Andika Brian
- Andres Moreira-Soto
- Andriam Soa Fy
- Andriamandimby Soa Fy
- Anga Latifa
- Ange Dossou
- Angelov Angel
- Anna-Lena Sander
- Annajr B.
- Anoh Etilé A.
- Anscombe Catherine
- Antwerpen Markus H.
- Anu Campbell
- Anyaneji Ugochukwu J.
- Anyika Chinyere
- Aouni M.
- Appiah Vincent
- Appiah-Kubi Joyce
- Arena Fabio
- Arjaquah Augustina
- Arjarquah A.
- Armand Edang-Minko
- Armanious Riad Mounir
- Armoo Samuel
- Arnaldo Paulo
- Arnold Catherine E.
- Arrouchi Housna
- Artesi Maria
- Aryeetey Sherihane
- Asamoah Jesse Addo
- Asante Ivy A.
- Asare K.M.
- Ashton Philip
- Ashton Phillip
- Asiedu Ernest
- Asiedu-Bekoe Franklyn Egbe
- Asiimwe Stephen
- Askander Omar
- Asmamaw Kominist
- Assane Hamadi
- Assoumou Samira Zoa
- Atiga N.
- Attiku Keren Okyerebea
- Audu Rosemary A.
- Auld A.
- Awandare Gordon A.
- Awinda George
- Awunyo Sena
- Ayansola Oyeronke
- Ayei James
- Ayekaba Mitoha Ondo’o
- Ayivor-Djanie Reuben
- Aymane Bouzidi
- Ayo-Ale B.
- Ayoade F.
- Ayoola Joy
- Ayouba Ahidjo
- Aziz Ramy Karam
- Aziza Amuri
- Azman Andrew
- Aïssi Melchior A. Joël
- Ba-Diallo Awa
- Babatunde Sunday
- Baboo S. B.
- Badjo Ange
- Badou Yvette
- Bagaya Bernard Ssentalo
- Bah Mamadou Saliou
- Bahadoor B. S.
- Bahnassy A.A.
- Bajjou Tahar
- Baker David
- Baker Noah
- Bakhash Shah Mohamed
- Bakry U.
- Balde Aladje
- Balde Aladje
- Balm Michelle
- Bamourou Diané
- Banda R.
- Bane S.
- Barasa Edwine
- Barbet Marion
- Bareng Ontlametse T.
- Barilar Ivan
- Barkat Amina
- Barnes Kayla
- Barreh Guedi Ali
- Bashein Abdulla
- Bassène Hubert
- Batchi-Bouyou Armel L.
- Batchi-Bouyou Armel L.
- Bates Matthew
- Batra Dhwani
- Batra R.
- Bauer Peter
- Baxter Cheryl
- Bayih Abebe Genetu
- Bbosa Nicholas
- Bedford Trevor
- Bediako Yaw
- Bedié
- Bedri Shahinaz.A.
- Behillil Sylvie
- Bejon Philip
- Belarbi Essia
- Belfquih Bouchra
- Belkhir A.B.
- Bellefquih Abdelkrim Meziane
- Beloufa Mohamed Amine
- Belournou Grace Angong
- Ben Alaya Nissaf
- Ben Ayed I.
- Ben Boubaker Ilhem Boutiba
- Ben Boubaker Ilhem Boutiba
- Ben Kahla Alia
- Ben Khelil Jalila
- Ben Moussa Mohamed
- Ben Othman Roua
- Ben Romdhane Habiba
- Ben Sassi Manel
- Ben Sassi Mouna
- Benaissa Elmostafa
- Benhida Rachid
- Benkeroum Samira
- Benkirane Hasnae
- Bennett Andrew J.
- Benrahma Houda
- Bensaid M.
- Bensalem Aicha
- Benyahia Amel
- Bestehorn-Willmann Malena S.
- Bester Phillip A.
- Beyene Getachew Tesfaye
- Bhiman Jinal N.
- Bighignoli B.
- Bikangui Rodrigue
- Bimouhen Abderrahmane
- Bingono Sam O'neilla Oye
- Biscornet Leon
- Bishop-Lilly Kimberly A.
- Bitew Molalegne
- Bitrou S.M.
- Bizard MĂ©line
- Bióté Simão Tchuda
- Blackmore Timothy
- Blakiston Matt
- Bloomfield Max
- Bnouyahia Ikram
- Boatemaa Linda
- Bolajoko Bankole
- Bonney Evelyn Y.
- Bonney Joseph H. K.
- Bonney Kofi
- Bontems SĂ©bastien
- Bootsma Sacha
- Borrmann Steffen
- Boter Marjan
- Boujemla Bouchra
- Bours Vincent
- Boussoukou Ismael Pierrick Mikelet
- Bouzid Amal
- Bouzid Jawad
- Bracchitta Fiorenza
- Brechar Ludivine
- Bridges Daniel J.
- Briese Thomas
- Brisebarre Angela
- Brook Cara
- Bssaibis Fatna
- Budiaki Sylvie L.
- BUHARI Mikhail Olayinka
- Bulimo Wallace D
- Bunga Sudhir
- Butel Christelle
- Butera Yvan
- Bwogi Josephine
- Camara Alimou
- Camara Makhtar
- Campbell Allan
- Campbell Julian
- Cancino Irving
- Candé Adul
- Capel Camille
- Carey Omondi Francis
- Carniel Elisabeth
- Carr Rosina A. A.
- Carri Valeria Delli
- Carvalho Kevin S.
- Cassama Faatu
- Cedola Donatella
- Cer Regina Z.
- Chabert-Consen Marie Madeleine
- Chabuka L. B.
- Chabuka Lucious
- Chambaro H.
- Chammam Sara
- Chamman Sarra
- Chanda D.
- Changula K.
- Charlene Sonal P.
- Chawech H.
- Chenaoui Mohamed
- Chenwi Collins
- Chestakova Irina
- Chgouri Fatima
- Chilufya C.
- Chilufya Moses
- Chimedza Jasper
- Chinedu Ugwu
- Chipimo P.J.
- Chitanga S.
- Chitechi Esther
- Chitenje M.
- Chiwaula M. J.
- Choga Wonderful T.
- Chouati Taha
- Chouikha Anissa
- Christoffels Alan
- Chtourou A.
- Chukwu Chimaobi
- Chukwu G.
- Cigolo Jean-Claude Makangara
- Cisse Barada
- Clarisse Murebwayire
- Colson Philippe
- Comas Iñaki
- Combe Patrice
- Corman Victor Max
- Cortes Carlos
- Cotten Matthew
- Crawford M.
- Crespin Xavier
- Cá Milanca Agostinho
- D'Amore N.
- D'Aprile Annamaria
- Dadi Hailu
- Daghfous Riadh
- Dagnran Anoumou
- Dakka Hanae
- Dal Monego Simeone
- Damaris Matoke-Muhia
- Damena D.
- Damilari Dabiri
- Daniels Rodney S.
- Dao Sounkalo
- Daou Amadou
- Dara Antoine
- Daubenberger Claudia
- David Kumbelembe
- Davids Micheala
- Davies Mary-Ann
- Dawood R.M.
- Dawood Reham
- de Laurent Zaydah R.
- de Ligt Joep
- De Nittis Rosella
- de Oliveira Filho Edmilson F.
- de Oliveira Martins Leonardo
- de Oliveira Tulio
- De Sanctis R.
- de Silva Thushan I
- DeAlmeida Mary
- Debela Alemu Tike
- Delaney Kayla
- Delaporte Eric
- Delerce Jeremy
- Dellagi Koussay
- Deng Guohong
- Deng Lul Lojok
- DeRisi Joseph L.
- Derrar Fawzi
- Descheemaeker Patrick
- Deschenes Michael V.
- Desta Adey Feleke
- Detweiler Angela M.
- Devatchagni Syntyche
- Devaux Christian A.
- Dhaala Beatrice
- Dia Aminata
- Dia Ndongo
- Dia Yacine Amet
- Diab A.
- Diagne Diabou
- Diagne Moussa M.
- Diakite Mandiou
- Diallo Amadou
- Diallo Haby
- Diallo Penda Malhado
- Diallo Sada
- Diarra B.
- Diarra Bassirou
- Diaw Papa Alassane
- Diawara Idrissa
- Dieng Alle Baba
- Dieng Assane
- Diergaardt Azaria
- Diop Mamadou
- Diop Oumy
- Djimde Abdoulaye
- Djingarey Mamoudou Harouna
- Djomsi Dowbiss Meta
- Djontu Jean Claude
- Dobi Paul
- Donati Flora
- Dorkenoo Ameyo
- Doudou Fetouma
- Douffan Messanh
- Doumbia Seydou
- Draper C.
- Dratibi Fred A.
- Drinkovic Dragana
- Drosten Christian
- Duedu Kwabena O.
- Durkin Keith
- Dussart Philippe
- Dussart Philippe
- DĂĽrr Kouriba
- Ebied Fatma
- Ebong Ofonime
- Eckstein Simone
- Edu Emame
- Eggan Stephen M.
- Egli Adrian
- Egoh Ifunanya
- Egyir B.
- Ehlan Amivi
- El Amin Ghizlane
- El ansari Fatima Zahra
- El Atar Jalil
- El Fahime Elmostafa
- El Falaki Fatima
- El Guindy Nancy M.
- El Hady Yassine
- El Jaoudi Rachid
- El Jebari Hanen
- El Mazouri Safae
- El Mrimar Nadia
- El Sayes Mohamed
- El-Duah Philip
- El-Shaqnqery H.
- El-Shesheny Rabeh
- El-Taweel Ahmed
- El-Zayat M.
- Elahmer Omar
- Elalaoui Mly Abdelaziz
- Elannaz Hicham
- Elarab Hoda Ezz
- Elargoubi A.
- Elfihri Mohammed Walid Chemao
- Elgahzaly Hesham
- Elgohary Mohamed Abdel-Salam
- Elguindy Nancy
- Elhadidi Mohamed
- Elhag Khabab A.
- Elhamoumi Siham
- ElHefnawi Mahmoud
- Elhoseiny Mostfa
- Elhoseny M.M.
- Elhosieny F.W.
- Elisabeth Carniel
- Elkhateeb S.M.
- Elkochri Safae
- Ella Kevine Zang
- Ellis Sean
- ElMoussi Awatef
- Elnakib Mostfa
- Eloualid Mjid
- Elouanass M.
- Elouennass Mostafa
- Elroby Ola
- Elsaid Manal Hamdy
- Elsawy Laila
- Elsayed Ahmed
- Elshora Hagar
- Elsissy M.H.
- Elvy Juliet
- Elzagheid Adam I.
- EmbalĂł Bubacar Delgado Pinto
- Emna Gaies
- Emokpae Uyi
- Enatha Mukantwari
- Endjala Nathalia
- Engelbrecht Susan
- Ennibi H.
- Enouf Vincent
- Erameh Cyril
- Erhart Annette
- Eshun Miriam
- Essabbar Abdelomunim
- Essabbar Mouneem
- Essayagh Touria
- Essomba René G.
- Essone Paulin N.
- Estrella Luis A.
- Everatt Josie
- Exler Jan Felix
- Ezzelarab M.H.
- Fadeyi Abayomi
- Fageer Sameira M.
- Fageer Samira M.
- Faggioni G.
- Fahsbender E.
- Fainguem Ndine
- Faisal Muhammad
- Fakayode Oluwatosin
- Fakhfakh Ahmed
- Fall Mbengué
- Faouzi Abdellah
- Faouzia Zemmouri
- Farawyla H.
- Fares Wasfi
- Farghaly Ayman
- Faye Martin
- Faye Ousmane
- Feasey Nicholas
- Fedorov A.V.
- Fekkak Jamal
- Femi Ayoade
- Femi Oladiji
- Femi Saibu
- Fenollar Florence
- Ferjani Asma
- Ferjani Sana
- Fidelia Hinson
- Fikry A.E.
- Fillo S.
- Fki-berrajah L.
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- Foda Iman
- Fokam Joseph
- Folarino O.
- Folorunsho Francine
- Foster-Nyarko Ebenezer
- Foudi Martin Maidadi
- Foulkes Benjamin H.
- Fournier Pierre-Edouard
- Fowora Muinah Adenike
- Fowotade Adeola
- Francisco Ngiambudulu M.
- Frans Ndahafa
- Fred Tei-Maya
- Freed Nikki
- Freeman Josh
- Freitas R. H.
- Frempong Hilda Opoku
- Fuh-Neba T.
- Fwoloshi Somda Soro Georgina
- Gaaloul I.
- Gad Ahmed F.
- Gadzama Galadima
- Gaies Emna
- Galal
- Galiwango Ronald M.
- Galvao Bruna
- Garcia Guillermo
- Gardoul Mouhcine
- Gargouri S.
- Gargouri Saba
- Garry R.
- Garus-Oas Nathalia
- Gaseitsiwe Simani
- Gatare Swaibu
- Gaye-Gaye Astou
- Gdoura Mariem
- Gedeon Jude
- Gelanew Tesfaye
- George Uwem E.
- Gerard Izuwayo
- GeurtsvanKessel Corine H.
- Gevao Sahr
- Gharmaz Hamza
- Ghassan Adib
- Ghedira Kais
- Ghita Amalou
- Ghoulame Safae
- Giandhari Jennifer
- Gideon Nsubuga
- Giordani F.
- Girgis Samia Abdou
- Gismondo Maria Rita
- Githii Rachid
- Githinji George
- Gnimadi Thibaut Armel Cherif
- Goba Augustine
- Godwe Celestin
- Goedhals Dominique
- Goldstone R.
- Gomaa C.
- Gomaa Mokhtar
- Goodfellow Ian
- Goredema Alexander
- Gorman Richmond
- Gorova Vivianne
- Gosnell B. I.
- Gottberg A.
- Gouider Riadh
- Grace Chukwa
- Grad Alia
- Grant Donald S.
- Grantz Kyra
- Grayo Solène
- Greninger Alexander
- Guedouar Houssem
- Gueye Abdou Salam
- Gueye Khadim
- Gueye Ousseynou
- Guindo Ibrahima
- Gumbo Hlanai
- Gumede Nicksy
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- Gutema Gadissa
- Gutierrez Ana V.
- Gwayi S.
- Gyamfi Jones
- Gyapong John O.
- Hachid Aissam
- Hadad A.
- Haddad Sonia V.
- Hafez Hala
- Hafez M.M.
- Hailu Getnet
- Halafawy A.
- Halatoko Jacqueline Wemboo Afiwa
- Halilou Ibrahima
- Hamdani T.N.
- Hamdy M.S.
- Hammad M.
- Hammami A.
- Hammer David
- Hamza Ghamaz
- Hamzaoui Zaineb
- Handrick Susann
- Happi Anise N.
- Happi Christian
- Harding Doris
- Harvey R.
- Hassan Iman Abdillahi
- Hassan R.
- Hassan W.
- Hassany Mohamed
- Hawi Adede
- Hayette Marie-Pierre
- Heikel Jaafar
- Hellemans Jorn
- Helmy Sherine
- Hemlali Mouhssine
- Henson Sondes
- Heraud Jean-Michel
- Herring Belinda L.
- Hicham Charoute
- Hicham Elannaz
- Hihi Nardjes
- Hilali Abderraouf
- Hilali Farida
- Holland LaRinda A.
- Hoornaert Laurien
- Hope Virginia
- Hosch Salome
- Houda Harmak
- Houechenou Rotimi Myrabelle Avome
- Houhamdi Linda
- Hounkanrin Gildas
- Hounkpatin Benjamin
- Howard Julia
- Hsiao Marvin
- Hsiao Nei-yuan
- Hsu Sharon
- Huang Meei-Li
- Huddleston John
- Hultquist Judd F.
- Hussein Salah Eldin
- Ian Lipkin W.
- Ibrahim Muntaser elTayeb
- Ibrahim Samira F.
- Ibrahim Tomade A.M.
- Ige F.A.
- Iguosadolo Nosamiefan
- Ihazmad Hassan
- Ihekweazu Chikwe
- Iknane A.A.
- Imam Zeinab S.
- InglĂŞs L.
- Inndi Rui
- Intyre Leigh-Anne MC
- Iranzadeh Arash
- Ismael Nalia
- Ismail A.
- Ismail Arshad
- Isong Josiah Ayoola
- Issa Zoukaneirii
- Iwalokun Bamidele
- Iyanu Fred-Akintunwa
- Jain Komal
- Jalal D.
- Jalal Nourlil
- Jalloh Simbirie
- Jamal Fekkak
- Jambo Kondwani
- James Ayorinde Babatunde
- Jannoo N.
- Jefferies Sarah
- Jegede-Williams Anu
- Jelly Lauren
- Jerome Keith R
- Jimoh Yusuf
- Jiménez-Serrano Santiago
- Jo Wendy Karen
- JOEL Ireoluwa Yinka
- Johane Shirley
- Johnson Adeniji A.
- Johnson Bankole
- Joloba Moses
- Joseph Rageema
- Jouali Farah
- Jumaa A.B.
- Juru Agnes
- Kabamba Gabriel
- Kabanda Alice
- Kabatesi Francisca
- Kabbaj Hakima
- Kaboré Firmin
- Kacem Imen
- Kadjo Herve Albéric Adje
- Kagnissode Sidonie A.M.
- Kagoné Thérèse
- Kakai Clement G.
- Kalantar K.
- Kaleebu Pontiano
- Kamal Mohamed
- Kamara Santigie
- Kamel Mina
- Kamga Rodrigue
- Kamoun S.
- Kamulegeya Rogers
- Kandaswamy Krishna Kumar
- Kandeil Ahmed
- Kandeil Ahmed
- Kane Mouhamed
- Kane Ndéye Coumba Touré
- Kanjau Lilian
- Kanjerwa Oscar
- Kanteh Abdoulie
- Kanyerezi Stephen
- Kapata Nathan
- Kapata P.C.
- Kapaya F.
- Kapin'a M.
- Karidioula Safiatou
- Karim Wasim Abdul
- Karray Hakim H.
- Karray Hela
- Kartti Souad
- Kasambara W.
- Kasmy Zohour
- Kassab Reham
- Kassim Samar Kamal
- Katabazi Ashaba Fred
- Katagirya Eric
- Kateete David Patrick
- Katyshev A.D.
- Kavunga-Membo Hugo
- Kay Gemma L.
- Kayali Ghazi
- Kayed Ahmed E
- Kayeyi N.
- Kayiwa John T.
- Kayuki Charles
- Kazeem Akano
- Kazorina E.V.
- Kebabonye Malebogo
- Keita Alpha K.
- Keita Mamadou Bhoye
- Keita S.
- Keita Sakoba
- Kemi Adedotun-Sulaiman
- Kepler Lenora M.
- Kezakarayagwa Eric
- Khaireh Bouh Abdi
- Khalid Ennibi
- Khalifa Mohamed K.
- Khamadi Samoel Ashimosi
- Khan Adam K.
- Kharat N.
- Khardine Fayez
- Khardine Fayez Ahmed
- Kharrat Maher
- Khumalo Z.
- Kibet Gilbert
- Kiconco Jocelyn
- Kidane Eleni
- Kiemdé Franklin
- Kifude Carol
- Kigozi Edgar
- Kiiza Ronald
- Kim L.
- Kimita Gathii
- Kimotho J.
- Kingsley Ojide C.
- Kingsley Robert A.
- Kirimunda Samuel
- Kiritu Edward
- Kleinhans Bronwyn
- Kohoun Rodrigue K.
- Koita Demba
- Koivogui Joel
- Koka Hellen
- Kolomoets E.V.
- Kone Amadou
- Konou Abla A.
- Konstantinus Iyaloo S.
- Koné Amariane
- Koné Amariane M. M.
- Kooepile Legodile
- Koopmans Marion
- Koskei Edith
- Kossi Komlan
- Kotey Erasmus
- Kouriba Bourema
- Kourouma Kaba
- Kpeli Grace S.
- Krasnov Y.M.
- Krasnov Ya.M.
- Kritsky A.A.
- Kujabi Mariama
- Kumordjie Selassie
- Kutkat Omnia
- Kutyrev V.V.
- Kwasah Lorreta
- Kwenda S.
- Kyei George B.
- Laamarti Meriem
- Laamrti Rokaia
- Laatiris Abdelkader
- Ladhari Hafsia
- Lagare Adamou
- Laguda-Akingba Oluwakemi
- Lahlou Amine Idriss
- Lahlou Idriss-Amine
- Lahlou Kitane Driss
- Lako Richard Lino Loro
- Lalemi Mary
- Lambisia Arnold W.
- Lamboni Lallepak
- Lamiae Belayachi
- Langat Sombo
- Laraqui Abdelilah
- Laryea Dennis
- Latif Elwaleed M. Elamin Sara A.I
- Latifa Anga
- Layibo Yasser
- Le Viet Thanh
- Le-Viet Thanh
- Lee Justin
- Lee Kwok
- Leendertz Fabian
- Lefrançois Louise
- Lekana-Douki Bernard
- Lekana-Douki Sonia
- Lell Bertrand
- Lelo Eric A.
- Lemoine Frederick
- Lemtudo Alan
- Lesego Kuate-lere
- Lesetedi Onalethata
- Lessells Richard
- Lessler Justin
- Leta D.
- Leta Dereje
- Letaief A.
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- Oteng F.
- Otieno Edward
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- Ouadghiri Ouna
- Ouangole Garba
- Ouangraoua Soumeya
- Ouedraogo Abdoul-Salam
- Ouedraogo LĂ©opold
- Ouedraogo SaĂŻdou
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- Park Danny
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- Patel H.
- Patoo M.
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- Phiri Isaac
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- Playle Veronica
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- Pool Brigitte
- Popoola
- Povogui Moriba
- Pratt Catherine B.
- Preiser Wolfgang
- Prince-David Mireille
- Prosolek Sophie
- Puente Manoli Torres
- Quansah E.B.
- Quansah Evelyn Bonney
- Quashie P.
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- Quedraogo Rabia
- Rachakonda Sivaramakrishna
- Rachid Benhida
- Rafai Clotaire Donatien
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- Ragomzingba Frank E. Z.
- Raharinosy Vololoniaina
- Rahoui Jalila
- Raimond Petra
- Ramadan Dalia
- Ramaologa Sefetogi
- Ramphal Upasana
- Ramphal Yajna
- Ramuth Magalutcheemee
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- Ranaivoson Hafaliana C.
- Randriambolamanantsoa Tsiry
- Raouf A.
- Raoult Didier
- Rasmussen David A.
- Razafimanjato Helisoa
- Razanajatovo Norosoa H.
- Rebai Ahmed
- Reggad Ahmed
- Regragui Zakia
- Rehn A.
- Ren Xiaoyun
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- Reuben Sindayiheba
- Reynders Marijke
- Reynolds Steven J.
- Rhajaoui Mohamed
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- Rigby Jonathan
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- Roychoudhury Pavitra
- Rubin Sarah
- Rudder Steven
- Rufael Tesfaye
- Ruhweza Simon Peter
- Rujeni Nadine
- Rumunu John
- Rutayisire Robert
- Saad M.A.
- Saasa Ngonda
- Sabeti Pardis C.
- Sadeuh-Mba Serge Alain
- Sadji
- Sadji Adodo
- Sadji Y.A.
- Safer Mouna
- Safietou Sankhe
- Sahr Dumbuya Foday
- Sahr P.F.
- Saibu J.O.
- Saiid S.
- Saiid Samirah
- Saizonou Raoul
- Sakho Moustapha
- Salah D.
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- Salah H.
- Salako Babatunde L.
- Salama Abdullah
- Saleh A.A.
- Saleh M.
- Salifou Sourakatou
- Sall Amadou A.
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- Salma Loukman
- Salou M.
- Salou Mounerou
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- Samaté Dianke
- Sambou Masse
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- San James E.
- Sanaa-amine Alaoui
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- Sankhe Safietou
- Sankhe Safietou
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- Sawa H.
- Sawadogo Yacouba
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- Schaffner Stephen F.
- Scharnberg Jasmin
- Scheepers Cathrine
- Schindler Tobias
- Schlotterbeck Jasmin
- Schneider Julia
- Schubert Grit
- Seadawy M.G.
- Seadawy Mohamed
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- Seadawy Mohamed Gomaa
- Sedjro Eclou
- Seffar Myriam
- Sekhsokh Yassmin
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- Tefera D.A.
- Tefera Dessalegn Abeje
- Tegally Houriiyah
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- Tei-Maya
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- Tesfaye Abraham
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- Tesfaye Kassahun
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- Thiam Aminata Sileymane
- Thilliez Gaetan
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- Tollera Getachew
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- Umumararungu Esperance
- Umuringa Jeanne d’Arc
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- Ushijima Yuri
- Ussher James
- Utpatel Christian
- Uwanibe Jessica N.
- Uwituze Arlene
- van der Eijk Annemiek
- van der Linden Anne
- van der Linden Antje
- van der Werf Sylvie
- Van Rooyen G.
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- von Gottberg Anne
- Waberi Zeinab Ali
- Wadi Amira Suliaman
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- Wadula J.
- Wagner Philipp
- Wahab Kolawole Wasiu
- Waitumbi John
- Walter Mathias C.
- Wamala Joseph F.
- Wandera Dennis N.
- Wang Jing
- Wang Xiuhua
- Wani Gregory
- Wanjohi Dorcas W.
- Wanok Stephen
- Waruhiu C.N.
- Waruhiu Cecilia
- Wasfi Fares
- Watters Chaselynn M.
- Wawina-Bokalanga Tony
- Wayengera Misaki
- Wayoro Oby
- Webby R.
- Webby Richard
- Weldemariam A.G.
- Weldemariam Atsbeha G.
- Werno Anja
- Wiley Michael R.
- Wilkinson David
- Wilkinson Eduan
- Williamson Carolyn
- Wilson Shannon
- Woelfel R.
- Wohl Shirlee
- Wolh S.
- Wolter Nicole
- Wuduri Zara
- Wulf Ben
- Wurie I.
- Wurie Isatta
- Xavier Joicymara S.
- Xiang Zuzheng
- Xie Hong
- Yadouleton Anges
- Yadouleton Yahya
- Yakout Mostfa
- Yandoko Rivalyn Nakoune
- Yang Qi
- Yao Kouadio T.
- Yassine Kasmi
- Yassine Zouheir
- Yasuda Jiro
- Yatassaye Bouna
- Yeboah C.
- Yeboah Richmond
- Yeboah-Manu Dorothy
- Yemi Bright K.
- Yiaba Cyrus
- Yiaba Warren Cyrus
- Yu Popova A.
- Yusuf Nyam Itse
- Yusuf Yacob Mohamed
- Zablon J. Matoke D.
- Zablon J.O.
- Zaher Tarek Refaat Elnagdy Raafat
- Zahra El Ansari Fatima
- Zahran Manal Hamdy
- Zekri Abdel-Rahman N.
- Zhang J.
- Zhou Pei
- Zinyowera Sekesai
- Zong Minko O.
- Zongo Arsène
- Zorgani A.
- Zouaki Amal
- Zulu P.
- Zumla Ali
- Zumla Alimuddin
- Zuze Boitumelo
- Publication venue
- 'American Association for the Advancement of Science (AAAS)'
- Publication date
- 07/10/2022
- Field of study
INTRODUCTION
Investment in Africa over the past year with regard to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequencing has led to a massive increase in the number of sequences, which, to date, exceeds 100,000 sequences generated to track the pandemic on the continent. These sequences have profoundly affected how public health officials in Africa have navigated the COVID-19 pandemic.
RATIONALE
We demonstrate how the first 100,000 SARS-CoV-2 sequences from Africa have helped monitor the epidemic on the continent, how genomic surveillance expanded over the course of the pandemic, and how we adapted our sequencing methods to deal with an evolving virus. Finally, we also examine how viral lineages have spread across the continent in a phylogeographic framework to gain insights into the underlying temporal and spatial transmission dynamics for several variants of concern (VOCs).
RESULTS
Our results indicate that the number of countries in Africa that can sequence the virus within their own borders is growing and that this is coupled with a shorter turnaround time from the time of sampling to sequence submission. Ongoing evolution necessitated the continual updating of primer sets, and, as a result, eight primer sets were designed in tandem with viral evolution and used to ensure effective sequencing of the virus. The pandemic unfolded through multiple waves of infection that were each driven by distinct genetic lineages, with B.1-like ancestral strains associated with the first pandemic wave of infections in 2020. Successive waves on the continent were fueled by different VOCs, with Alpha and Beta cocirculating in distinct spatial patterns during the second wave and Delta and Omicron affecting the whole continent during the third and fourth waves, respectively. Phylogeographic reconstruction points toward distinct differences in viral importation and exportation patterns associated with the Alpha, Beta, Delta, and Omicron variants and subvariants, when considering both Africa versus the rest of the world and viral dissemination within the continent. Our epidemiological and phylogenetic inferences therefore underscore the heterogeneous nature of the pandemic on the continent and highlight key insights and challenges, for instance, recognizing the limitations of low testing proportions. We also highlight the early warning capacity that genomic surveillance in Africa has had for the rest of the world with the detection of new lineages and variants, the most recent being the characterization of various Omicron subvariants.
CONCLUSION
Sustained investment for diagnostics and genomic surveillance in Africa is needed as the virus continues to evolve. This is important not only to help combat SARS-CoV-2 on the continent but also because it can be used as a platform to help address the many emerging and reemerging infectious disease threats in Africa. In particular, capacity building for local sequencing within countries or within the continent should be prioritized because this is generally associated with shorter turnaround times, providing the most benefit to local public health authorities tasked with pandemic response and mitigation and allowing for the fastest reaction to localized outbreaks. These investments are crucial for pandemic preparedness and response and will serve the health of the continent well into the 21st century
Verifying the reliability of hybrid issued from the cross “Picholine marocaine clones X Picholine du Languedoc”
- Author
- Publication venue
- 'Academic Journals'
- Publication date
- 01/01/2007
- Field of study
UMR DAP, équipe AFEF Publication Inra prise en compte dans l'analyse bibliométrique des publications scientifiques mondiales sur les Fruits, les Légumes et la Pomme de terre. Période 2000-2012. http://prodinra.inra.fr/record/256699International audienceIn order to verify the reliability of hybrid population issued from crossing between 3 clones of "Picholinemarocaine" cultivar and the "Picholine du Languedoc" cultivar, the descendants and their parents wereanalysed using 35 microsatellite loci. No offspring resulted from self crossing of "Picholine marocaine"cultivar and 218 descendants among 220 analysed are legitimate. This study showed clearly asegregating population and may be used as a genetic material for linkage map construction and forphenotyping resistance traits related to Spilocaea oleagina diseas
Severe disseminated mycobacterial infection in a boy with a novel mutation leading to IFN-gamma R2 deficiency
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/09/2012
- Field of study
Mendelian susceptibility to mycobacterial diseases (MSMD) is a rare syndrome characterized by predisposition to severe, sometimes lethal, disease caused by otherwise poorly virulent mycobacteria. We report here a boy with a recurrent mycobacterial infection from the age of five months. Immunological analyses revealed an inability to respond to IFN-gamma, subsequent genetic analyses revealed a novel homozygous mutation, r.679G > A in the IFNGR2 gene, resulting in a G227R substitution, that caused IFN-gamma R2 deficiency. This is only the 8th mutation in IFN-gamma R2 known so far. The boy eventually died of hepatic coma due to liver failure at the age of five
Severe disseminated mycobacterial infection in a boy with a novel mutation leading to IFN-ÎłR2 deficiency
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- 30/09/2012
- Field of study
Immunogenetics and cellular immunology of bacterial infectious disease
Paediatric COVID-19 mortality: a database analysis of the impact of health resource disparity
- Author
- Aasiyah Rashan
- Abid Khatak
- Abigail Beane
- Adrian Streinu-Cercel
- Adrien Auvet
- Adrien Lemaignen
- Adrienne Chan
- Agnes Meybeck
- Agnes Sommet
- Agnieszka Oldakowska
- Agostinho Monteiro
- Ahmad Afiq Ramli
- Ahmad Kashfi Rahman
- Ahmed Farooq
- Aidan Burrell
- Albert Groenendijk
- Albert Sotto
- Albertus Beishuizen
- Aldric Manuel
- Alexa Debard
- Alexander Daniel Cornet
- Alexander J Mentzer
- Alexandra Bedossa
- Alexandra Coelho
- Alexandre Ducancelle
- Alexandre Gaymard
- Alexandre Hoctin
- Ali Hachemi
- Alif Adlan Thabit
- Alison M. Meynert
- Alistair Nichol
- Alpha Diallo
- Alphonsine Diouf
- AM Udara Attanyake
- Amanda Corley
- Amanda Rojek
- Amandine Gagneux-Brunon
- Amina Meziane
- Amirul Asyraf
- Amna Faheem
- Amélie Valran
- Ana Freitas Ribeiro
- Ana L Rios
- Ana Martins
- Ana Silva Filipe
- Anant Kataria
- Anca Streinu-Cercel
- Andrea Angheben
- Andrea Rossanese
- Andrew Dagens
- Andrew Udy
- Andrey Svistunov
- André Cabié
- André Dias
- Andy Law
- Anika Atique
- Anilawati Mat Jelani
- Anissa Chair
- Anja Grosse Lordemann
- Anjellica Chen
- Anna Beltrame
- Anne Conrad
- Anne Guillaumot
- Anne McCarthy
- Anne-Hélène Boivin
- Anne-Marie Guerguerian
- Anne-Sophie Boureau
- Anne-Sophie Resseguier
- Annelies Verbon
- Annemarie B. Docherty
- Annmarie O'Callaghan
- Ansley Hamer
- Anthony L. Loschner
- Anthony Lemeur
- Anthony Nghi
- Antoine Cheret
- Antoine Khalil
- Antoine Kimmoun
- Antoine Merckx
- Antonia Ho
- Antonio Lalueza
- AntĂłnio Mesquita
- Arabella Fahy
- Ardiyan Apriyana
- Arfan Ikram
- Aria Kekalih
- Arianne Joy Corpuz
- Arjen M Dondorp
- Arnaud Scherpereel
- Arsene Kpangon
- Ary Serpa Neto
- Asgar Rishu
- Ashraf Sheharyar
- Asma Moin
- Astarini Hidayah
- Attaur Rehman
- Audrey Barrelet
- Aurore Bousquet
- Aurélie Papadopoulos
- Aurélie Veislinger
- Aurélie Wiedemann
- Axelle Braconnier
- Azlan Mat Soom
- B. P Edouard Soum
- Barbara Wanjiru Citarella
- Basri Mat Nor
- Beatrice Alex
- Benedict Sim Heng
- Benjamin Bach
- Benjamin Lefèvre
- Benjamine Sarton
- Benoit Thill
- Benoit Visseaux
- Benoît Roze
- Bernard Cholley
- Bernardo Ferreira
- Bertrand Dussol
- Bharath Kumar Vijayaraghavan
- Bianca Boxma
- Biing Horng Lee
- Blandine Rammaert
- Bouchra Loufti
- Brenda Reeve
- Brigitte Elharrar
- Bronner P Gonçalves
- Bronner P. Gonçalves
- Bruno Levy
- Bruno Lina
- Bruno Pastene
- Bénédicte Lefebvre
- Bénédicte Rossignol
- Calum Semple
- Calvin Wong
- Cameron J. Fairfield
- Camile Bouisse
- Camille Couffignal
- Carine Roy
- Carlo Giaquinto
- Carlos Alexandre Brito
- Carlos Lumbreras Bermejo
- Carlos Pimentel
- Carola Pierobon
- Carolien van Netten
- Caroline Martins Rego
- Caroline Mudara
- Caroline Semaille
- Carolline Araujo
- Carrol Gamble
- Catarina EspĂrito Santo
- Catarina Pires
- Catherine A. Shaw
- Catherine Chakveatze
- Catherine Chirouze
- Catherine L. Hough
- Cecile Azoulay
- Cecile Yelnik
- Cedric Laouenan
- Ceila Sant'Ana Malaque
- Celina Turchi Martelli
- Chamira Kodippily
- Chan Chee Eng
- Charlene Da Silveira
- Charline Vauchy
- Charlotte Salmon Gandonniere
- Charlotte Summers
- Chian Hui Yeoh
- Chiara Simona Cardellino
- Chloe Donohue
- Christel Arnold-Day
- Christelle Chantalat Auger
- Christelle Delmas
- Christelle Paul
- Christelle Tual
- Christian Rabaud
- Christiana Kartsonaki
- Christl A Donnelly
- Christophe Fraser
- Christophe Rapp
- Christopher A. Green
- Claire Andrejak
- Claire LĂ©vy-Marchal
- Clara Flateau
- Clara Mouton Perrot
- Clare Jackson
- Clark D. Russell
- Claudia Figueiredo-Mello
- Claudia Milena Orozco-Chamorro
- Claudia Montes
- Claudina Cruz
- Claudine Badr
- Claudio Duarte Fonseca
- Clotilde Allavena
- Clément Le Bihan
- Colin McArthur
- Coline Jaud-Fischer
- Coralie Khan
- Coralie Tardivon
- Corine Delsing
- Corinne Daniel
- Cornelius Rau
- Courtney Greene
- Cynthia Braga
- Cyril Cadoz
- Cyril Le Bris
- CĂ©cile Goujard
- CĂ©cile Mear-Passard
- CĂ©cile Tromeur
- CĂ©dric Joseph
- CĂ©line Dorival
- CĂ©line Ficko
- CĂ©line Michelanglei
- CĂ©sar Vieira
- Dafsah Juzar
- Damien Bouhour
- Daniel Glikman
- Daniel Haber
- Daniel Marino
- Daniel Mathieu
- Daniel Munblit
- Daniel Perez
- Daniela Guerreiro
- Danielle Jaafar
- David L. Robertson
- David Maslove
- David Richardson
- David S.Y. Ong
- David Stuart
- David Thomson
- David Zucman
- Debby Bogaert
- Deepashankari Suppiah
- Dehbia Benkerrou
- Delphine Bachelet
- Delphine Bergeaud
- Delphine Lariviere
- Demetrios Kutsogiannis
- Denis Butnaru
- Denis Garot
- Denis Malvy
- Denisa Khoo
- Desy Rusmawatiningtyas
- Detlef Kindgen-Milles
- Dewi Guellec
- Diana AdriĂŁo
- Diana Hernández
- Diana PĂłvoas
- Diane Descamps
- Diane Ponscarme
- Didier Laureillard
- Diego Fernando Rincon
- Diogo Borges
- Diogo Lopes
- Diptesh Aryal
- Djura Piersma
- Dominique Deplanque
- Dominique Luton
- Dounia Bouhmani
- Douwe F. Postma
- Duc Nguyen
- Dyah Kanya Wati
- Dzawani Muhamad
- Eder Caceres
- Edmund Manning
- Eglantine Ferrand Devouge
- Egle Saviciute
- Elias Iosifidis
- Elisa Demonchy
- Elisabeth Botelho-Nevers
- Elise Artaud-Macari
- Ellen Shadowitz
- Elodie Curlier
- Elsa Nyamankolly
- Ema Leal
- Eman Al Qasim
- Emma C. Thomson
- Emma Clarke
- Emma Costigan
- Emmanuel Roilides
- Emmanuelle A Dankwa
- Emmanuelle Denis
- Emmanuelle Mercier
- Eric D'ortenzio
- Eric Delaveuve
- Eric Oziol
- Eric Senneville
- Erlina Burhan
- Ernita Akmal
- Erwan Fourn
- Erwan L'her
- Esteban Garcia-Gallo
- Etienne De Montmollin
- Eva Geraud
- Eva Miranda Marwali
- Eve Defous
- Evert-Jan Wils
- Ewa Talarek
- Ewen M. Harrison
- Fabio S. Taccone
- Fabrice Laine
- Fakhir Haidri
- Fanny Vuotto
- Fara Diop
- Farah Nadiah Bidin
- Felwa Bin Humaid
- Fernando Augusto Bozza
- Fernando Maltez
- Filipa Cardoso
- Filipe Cardoso
- Fiona Griffiths
- Firouzé Bani-Sadr
- Florence Jego
- Florent Peelman
- Florentia Kaguelidou
- France Mentré
- François Angoulvant
- François Bissuel
- François Bompart
- François Dubos
- François Goehringer
- François Lellouche
- François Martin Carrier
- François Téoulé
- François-Xavier Catherine
- François-Xavier Ferrand
- François-Xavier Lescure
- FĂ©lix Djossou
- Gabriel Macheda
- Gail Carson
- Gamage Dona Priyadarshani
- Gan Ee Xian
- Ganesh Kumar
- Gary Leeming
- Geoffrey Liegeon
- Georges Le Falher
- Georgios Pollakis
- Geraldine Goco
- Gianluigi Li Bassi
- Gilles Peytavin
- Giri Shan Rajahram
- Giulia Bertoli
- Graham S. Cooke
- Grazielle Viana Ramos
- Gry Kloumann Bekken
- Grégory Corvaisier
- Gugapriyaa Muyandy
- Guillame Louis
- Guillaume Lingas
- Guillaume Martin-Blondel
- Guillermo Giordano
- Guillermo Maestro de la Calle
- Guylaine Castor-Alexandre
- Gwenaël Le Moal
- Gwenhaël Colin
- Ha Sha Lene
- Hajnal-Gabriela Illes
- Hanan Fateena
- Hanna Renk
- Hannah Habraken
- Hans Martin Bosse
- Harald Vonkeman
- Hashmi Madiha
- Hayley Hardwick
- Heidi Dalton
- Heidi Gruner
- Heidi Jean Dalton
- Heng Gee Lee
- Hervé Le Nagard
- Hiba Zayyad
- Hikombo Hitoto
- Himasha Muvindi
- Himed Musaab
- Hiu Jian Chua
- Hodane Yonis
- Hon Shen Png
- Hongru Ren
- Hubert Tessier-Grenier
- Huda Alfoudri
- Hugo Inácio
- Hugo Mouquet Ben Morton
- Hugues Aumaître
- Hugues Cordel
- Husna Begum
- Hwa Jin Cho
- Hélène Espérou
- Hélène Salvator
- Ikram Houas
- Ilka Engelmann
- Ilonka van Veen
- Ingrid G Bustos
- Irfan Khan
- Isabela Bolaños
- Isabelle Delacroix
- Isabelle Enderle
- Isabelle Fabre
- Isabelle Gorenne
- Isabelle Hoffmann
- Isabelle Michelet
- Isabelle Pironneau
- Ithan D. Peltan
- Ivy Cerelia Valerie
- J. Kenneth Baillie
- Jacky Y. Suen
- Jade Ghosn
- Jaganathan Selvanayagam
- Jaime Cruz Rojo
- Jake Dunning
- James Joshua Douglas
- James Lee
- James Scott-Brown
- James Vickers
- Jananee Thirumanickam
- Janet Harrison
- Janet T. Scott
- Jaques Sztajnbok
- Jarne Van Hattem
- Jason Bouziotis
- Jean Baptiste Assie
- Jean Christophe Lucet
- Jean-Benoît Arlet
- Jean-Charles Gagnard
- Jean-Charles Preiser
- Jean-Christophe Goffard
- Jean-Daniel Lelievre
- Jean-François Payen
- Jean-François Timsit
- Jean-Luc Diehl
- Jean-Marc Chapplain
- Jean-Marie Turmel
- Jean-SĂ©bastien Hulot
- Jeanne Sibiude
- Jeanne Truong
- Jee Yan Ong
- Jennifer Lee
- Jenny Lennon
- Jeremie Guedj
- Jess Gibson
- Jia Shyi Loy
- Jia Wei
- Jillian Deacon
- Jimmy Ming-Yang Hsu
- Jimmy Mullaert
- Jin Yi Goh
- Jo Dalton
- Joana Alves Cabrita
- Joana FerrĂŁo
- JoaquĂn Baruch
- Job van der Palen
- Johann Auchabie
- John F Fraser
- John Marshall
- Jolanta Popielska
- Jonathan Bitton
- Jonathan Chua
- Jonathan Remppis
- Jordan Zhien Toh
- Jorge Dantas
- Jorge Fernandes
- Jorge Paulos
- Jose Andres Calvache
- Jose M. Mandei
- Joshua Solomon
- José Casimiro
- José Ernesto Vidal
- José Luis Sobrino
- José Ramalho
- JoĂŁo EstevĂŁo
- JoĂŁo Teixeira
- Juan Luis BermĂşdez
- Jules Bauer
- Julian Chica
- Juliana Damas
- Julie Chas
- Julie Mankikian
- Julien Jabot
- Julien Moyet
- Julien Poissy
- Juliette Patrier
- Juliette Romaru
- Justine Pages MaĂŻder Pagadoy
- Jérémie Pasquier
- JĂ©rĂ´me Dimet
- Kah Chuan Lim
- Kalaiarasu Peariasamy
- Kalynn Kennon
- Karen Delavigne
- Karine Bezulier
- Karine Faure
- Karine Risso
- Karisha Sivam
- Karl Erik MĂĽller
- Karolina Nowicka
- Katharina Weil
- Kathy Brickell
- Katie O'Hearn
- Kazali Enagnon Alidjnou
- Kenneth A McLean
- Ker Hong Bee
- Kevin Katz
- Khor How Kiat
- Kim Keat Tan
- Kok Wei Hao
- Kong Yeow Kang
- Konrad Zawadka
- Krishna Bhavsar
- Kuan Pei Xuan
- Kusum Menon
- KĂ©vin Alexandre
- KĂ©vin Bouiller
- KĂ©vin Didier
- Laetitia Bodenes
- Lai Hui Pang
- Lance C.W. Turtle
- Lara Absil
- Lars Heggelund
- Laura Marsh
- Laura Merson
- Laure Goubert
- Lauren Deconninck
- Laurence Bouillet
- Laurence Maulin
- Laurent Abel
- Laurent Bitker
- Laurent Guilleminault
- Laurent Lefebvre
- Laurent Mandelbrot
- Laurent Plantier
- Laurent Richier
- Laurène Azemar
- Lee Lee Low
- Leong Chee Loon
- Leong Chin Tho
- Liem Luong
- Lila Bouadma
- Lim Lina
- Lim Saio Xian
- Lim Yuen Han
- Lina Morales Cely
- Linda O'Shea
- Lionel Eric Benjiman
- Lionel Piroth
- Lisa Norman
- Louis Gerbaud Morlaes
- Louise Sigfrid
- Lucia Moro
- Lucie Le Fevre
- Lucille Blumberg
- Luis Felipe Reyes
- LuĂs Val-Flores
- Lysa Tagherset
- M Azhari Taufik
- Mageswari Selvarajoo
- Mahdad Noursadeghi
- Maire-Laure Casanova
- Malcolm G. Semple
- Malte Kohns Vasconcelos
- Malte Kohns Vasconcelos
- Manuel Etienne
- Manuel Rosa-Calatrava
- Maram Zahran
- Marc Fabre
- Marc Lambert
- Marc Leone
- Marcel van den Berge
- Marcela Vieira Freire
- Margarida Torres
- Margaux Isnard
- Maria Amaral
- Maria Donnelly
- Maria Pokorska-Spiewak
- Maria Zambon
- Mariana CascĂŁo
- Marie Bartoli
- Marie Connor
- Marie Gominet
- Marie Lachatre
- Marie Lacoste
- Marie Lagrange
- Marie Langelot-Richard
- Marie Rafiq
- Marie-Capucine Tellier
- Marie-Charlotte Chopin
- Marie-Christine Carret
- Marie-Pierre Debray
- Marieke Haalboom
- Marielle Boyer-Besseyre
- Marielle Buisson
- Marije Lowik
- Marina Esposito-Farèse
- Marina Lanza
- Marine Beluze
- Marine Livrozet
- Marion Le Maréchal
- Marion Noret
- Marion Schneider
- Marion Zabbe
- Marjolein Brusse-Keizer
- Mark G. Pritchard
- Mark Joseph
- Marlene Murris
- Marsilla Marzukie
- Marta Leal Santos
- Marta Torre
- Martin Guego
- Martin Martinot
- Martina Escher
- Martine Remy
- Mary Copland
- MarĂlia Andreia Fernandes
- Masliza Zahid
- Massimo Palmarini
- Mathieu Blot
- Mathieu Lesouhaitier
- Mathieu Mattei
- Mathilde Desvallées
- Matthew Hall
- Matthew Pellan Cheng
- Matthieu Revest
- Maude Bouscambert
- Maureen Masha
- Maxime Hentzien
- Maximilien Saint-Gilles
- Mayka Mergeay-Fabre
- Meera Chand
- Megan Coles
- Mehdi Mezidi
- Melissa Parker
- Menaldi Rasmin
- Merce Jourdain
- Mical Paul
- Michael Rose
- Michele Petrovic
- Michelle Girvan
- Miguel Pedrera Jiménez
- Minerva Cervantes-Gonzalez
- Minh Le
- Mirjam Evers
- Mohammad Shamsah
- Mohammed El Sanharawi
- Mohammed Quraishi
- Mohan Dass Pathmanathan
- Mohanaprasanth Balakrishnan
- Mohd Nazlin Kamarudin
- Mohiuddin Shiekh
- Morgane Gilg
- Morgane Snacken
- Moshe Matan
- MoĂŻse Machado
- Muhammad Aisar Kamaluddin
- Muhammad Ashraf
- Muhammad Fadhli Basri
- Muhammad Rayhan
- Murray Dryden
- Murray Wham
- Musharaf Sadat
- Mylène Maillet
- Mário Ferraz
- MĂ©lanie Roriz
- Nadia Ettalhaoui
- Nadia Malik
- Nadia Ouamara
- Nadiah Ismail
- Nadiah Kamarudin
- Nadir Hadri
- Nadirah Abdul Wahid
- Nadège Neant
- Nagarajan Ramakrishnan
- Nassima Si Mohammed
- Nathalie Allou
- Nathalie DeCastro
- Nathalie Dournon
- Nathalie Gault
- Nathalie Pansu
- Nathan Peiffer-Smadja
- Navy Lolong
- Nazreen Abu Bakar
- Neerusha Kaisbain
- Neurinda Permata Kusumastuti
- Ng Yong Muh
- Ng Yong Siang
- Nicholas Sedillot
- Nicholas Yee Hing
- Nick Daneman
- Nicolas Benech
- Nicolas Carlier
- Nicolas Ferriere
- Nicolas Terzi
- Nicole White
- Nidyanara Castanheira
- Nik Nur Mohamed
- Nikita Nekliudov
- Nina Jamieson
- Noelia GarcĂa Barrio
- Noor Hidayu Wahab
- Nor Arisah Misnan
- Nor Zaila Zaidan
- Nowneet Kumar Bhat
- NoéMie Mercier
- Noémie Tissot
- Noémie Vanel
- Nuno Germano
- Nur Amira
- Nurnaningsih Nurnaningsih
- Nurul Amani Noordin
- Nurul Faten Norharizam
- Nurul Najmee Abdulkadir
- Nurul Zaynah
- Oana Sândulescu
- Obada Yousif
- Odile Launay
- Ogechukwu Menkiti
- Oleksa Rewa
- Olivia V Swann
- Olivier Bouchaud
- Olivier Epaulard
- Olivier Lairez
- Olivier Lesens
- Olivier Picone
- Olivier Robineau
- Olivier Sanchez
- Olivier Terrier
- Ong Yiaw Joe
- Oriane Puechal
- Oryane Mabiala
- Ouifiya Kafif
- Pablo Serrano Balazote
- Pamela Combs
- Paola Rodari
- Paolo Cattaneo
- Parthena Savvidou
- Pascal Granier
- Pathik Dhanger
- Patricia Fontela
- Patricia Gordon
- Patricia Lizotte
- Patrick Archambault
- Patrick Imbert
- Patrick Rispal
- Patrick Rossignol
- Paul Campbell
- Paul Dunand
- Paul Henri Wicky
- Paul Klenerman
- Paul Le Turnier
- Paul Loubet
- Paul McNally
- Paul Tierney
- Paul van der Valk
- Paula Custodio
- Pauline Caraux-Paz
- Pavan Kumar Vecham
- Pedro Faria
- Peter de Vries
- Peter Horby
- Peter Kiiza
- Peter Openshaw
- Peter S Timashev
- Peter Van der Voort
- Petr Glybochko
- PG Ishara Udayanga
- Philippe Jouvet
- Philippine Eloy
- Phoebe Ampaw
- Piero L Olliaro
- Piero L. Olliaro
- Pierre Delobel
- Pierre Jaquet
- Pierre Tattevin
- Pierre-Adrien Bolze
- Pierre-François Sandrine
- Pierre-Marie Roger
- Pieter Depuydt
- Polina Bugaeva
- Prasan Kumar Panda
- Pratap Karpayah
- Quentin Le Hingrat
- Quentin Lepiller
- Quratul Ain Khan
- Rachael Parke
- Rachel Cregan
- Rachida Ouissa
- Rafael Freitas França
- Rafael Mahieu
- Raphael Favory
- Raphaël Borie
- Raquel Pinto
- Rashan Haniffa
- Rasidah Bt Senian
- Raul Neto
- Rebecca Hamidfar
- Renata Barbalho
- Richard S. Tedder
- Riinu Pius
- Rima Song
- Rita Alves
- Rob Klont
- Robert A Fowler
- Robert A. Fowler
- Roberta Cavalin
- Robin Kobbe
- Rodrigo DĂaz
- Romain Basmaci
- Romain Decours
- Romain Guery
- Romans Matulevics
- Ross Hendry
- Rostane Gaci
- Roxane Courtois
- Rozanah Abd Rahman
- Rui Caetano GarcĂŞs
- Rui Pereira
- Rupert Higgins
- Ruth Lyons
- Ryadh Pokeerbux
- Ryan Khoo
- Ryan S Thwaites
- Saad Nseir
- Sabelline Bouchez
- Sabina Kali
- Sabina Mason
- Sabine Cornelis
- Sabine Croonen
- Sadie Kelly
- Saef Umar Barnett
- Saijad Orakzai
- Sally Shrapnel
- Salma Jaafoura
- Samantha Lissauer
- Samira Laribi
- Samreen Ijaz
- Samuel Hinton
- Samuel Markowicz
- Sandrine Couffin-Cadiergues
- Sanka Sri Darshana
- Sanne Wesselius
- Santi Dewayanti
- Saptadi Yuliarto
- Sara Clohisey
- Sara Machado
- Sarah E McDonald
- Sarah Isgett
- Sarah Moore
- Sarah Redl
- Sarah Stabler
- Sarah Syahrin
- Sarah Tubiana
- Saye Khoo
- Scott Pharand
- Sebastien Preau
- Segolène Greffe
- Seán Keating
- Shahdattul Mawarni Taib
- Shaikh Sharjeel
- Shaminee Veeran
- Sharma Keshav
- Sheryl Ann Abdukahil
- Shiranee Sriskandan
- Shirin Tabrizi
- Shirley Sarfo-Mensah
- Shoban Raj Vasudayan
- Shona C Moore
- Sia Loong Tonnii
- Sim Choon Ean
- Simon Bessis
- Simon Forsyth
- Simon-Djamel Thiberville
- Siri Goepel
- Siti Nurul Ridzuan
- Siti Rohani Yakop
- Siti Zubaidah Othman
- Sivanesen Anthonidass
- Sobia Masood
- Sofia Cardoso
- Soizic Le Mestre
- Sophie Halpin
- Sophie Mahy
- Srinivas Murthy
- Stanislas Rebaudet
- Stella Rousset
- Stephanie Roberts
- Stephanie Yerkovich
- Stephen R Knight
- Steve Webb
- Stéphane Jaureguiberry
- Stéphane Lasry
- Stéphane Sallaberry
- Stéphanie Cousse
- Stéphanie Fry
- Subhash Acharya
- Sue Smith
- Suhaila Abdul Wahab
- Surain Raaj Thurai
- Suresh Kumar Chidambaram
- Sushil Khanal
- Suvintheran Thangavelu
- Swosti Joshi
- Syamin Asyraf Shahidan
- Sybille Bevilcaqua
- Sylvain Diamantis
- Sylvie Behilill
- Sylvie LeGac
- Sylvie Lion-Daolio
- Sylvie Van Der Werf
- Sze Kye Teoh
- SĂ©verine Ansart
- Tae Song
- Tahira Jamal Mohamed
- Tala Al-Dabbous
- Tan Pei Wen
- Tatiana Fonseca
- Teck Fung Wong
- Teresa Lawrence
- Thalha Rashan
- Tharmini Ravi
- Thavamany Kaleesvran
- Thibault Chiarabini
- Thierry Carmoi
- Thierry Mazzoni
- Thomas Flament
- Thomas Guimard
- Thomas Maitre
- Thomas Perpoint
- Thushan de Silva
- Théo Treoux
- Tiago Isidoro
- Tiffany Trouillon
- Timo Brandenburger
- Timothy M. Uyeki
- Ting Soo Chow
- Tiphaine Goulenok
- Todd C Lee
- Todd Karsies
- Tom Drake
- Tom Fletcher
- Tom Solomon
- Tony Trapani
- Tristan Gigante
- Tze Vee Soh
- Tze Yuan Tee
- Tânia Sequeira
- Valentine Campana
- Valeria Balan
- Valla Sahraei
- Valérie Gaborieau
- Valérie Garrait
- Valérie Gissot
- Vanessa Sancho-Shimizu
- Vanina Meysonnier
- Ventzislava Petrov-Sanchez
- Victor Fomin
- Victoria Manda
- Victoria Shaw
- Vilmaris Quinones-Cardona
- Vincent Dinot
- Vincent Dubée
- Vincent Enouf
- Vincent Langlois
- Vincent Le Moing
- Vincent Peigne
- Vincent Pestre
- Vincent Thibault
- Vinod Kumar
- Vinothini Krishnan
- VĂ©ronique Lemee
- VĂctor QuirĂłs González
- Waasila Jassat
- Walter Picard
- Wei Han Hoh
- Wei Shen Lim
- Wendy S. Barclay
- William A. Paxton
- William Dechert
- William Greenhalf
- Wilna Oosthuyzen
- Wim Dieperink
- Xavier Duval
- Xin Ci Wong
- Yael Dishon
- Yan Chyi Tan
- Yaseen Arabi
- Yasmin Gani
- Yazdan Yazdanpanah
- Yen Tsen Saw
- Yew Sing Wong
- Yi Bin Ho
- Yi Lin Lee
- Ymkje Stienstra
- Yoan Lavie-Badie
- Younes Ait Tamlihat
- Younes Kerroumi
- Yun Sii Ing
- Yusing Gu
- Yvelynne Kelly
- Yves Levy
- Zhang Duan Tham
- Zul Amali Kamaruddin
- Zulfiqar Sandhu
- Publication venue
- 'BMJ'
- Publication date
- 01/10/2022
- Field of study
Background The impact of the COVID-19 pandemic on paediatric populations varied between high-income countries (HICs) versus low-income to middle-income countries (LMICs). We sought to investigate differences in paediatric clinical outcomes and identify factors contributing to disparity between countries.Methods The International Severe Acute Respiratory and Emerging Infections Consortium (ISARIC) COVID-19 database was queried to include children under 19 years of age admitted to hospital from January 2020 to April 2021 with suspected or confirmed COVID-19 diagnosis. Univariate and multivariable analysis of contributing factors for mortality were assessed by country group (HICs vs LMICs) as defined by the World Bank criteria.Results A total of 12 860 children (3819 from 21 HICs and 9041 from 15 LMICs) participated in this study. Of these, 8961 were laboratory-confirmed and 3899 suspected COVID-19 cases. About 52% of LMICs children were black, and more than 40% were infants and adolescent. Overall in-hospital mortality rate (95% CI) was 3.3% [=(3.0% to 3.6%), higher in LMICs than HICs (4.0% (3.6% to 4.4%) and 1.7% (1.3% to 2.1%), respectively). There were significant differences between country income groups in intervention profile, with higher use of antibiotics, antivirals, corticosteroids, prone positioning, high flow nasal cannula, non-invasive and invasive mechanical ventilation in HICs. Out of the 439 mechanically ventilated children, mortality occurred in 106 (24.1%) subjects, which was higher in LMICs than HICs (89 (43.6%) vs 17 (7.2%) respectively). Pre-existing infectious comorbidities (tuberculosis and HIV) and some complications (bacterial pneumonia, acute respiratory distress syndrome and myocarditis) were significantly higher in LMICs compared with HICs. On multivariable analysis, LMIC as country income group was associated with increased risk of mortality (adjusted HR 4.73 (3.16 to 7.10)).Conclusion Mortality and morbidities were higher in LMICs than HICs, and it may be attributable to differences in patient demographics, complications and access to supportive and treatment modalities
Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study
- Author
- Abbas Ali
- Abdukahil Sheryl Ann
- Abe Ryuzo
- Abel Laurent
- Abreu Julia Rodriguez
- Absil Lara
- Acharya Subhash
- Acker Andrew
- AdriĂŁo Diana
- Ahmed Shakeel
- Ainscough Kate
- Aisa Tharwat
- Akimoto Takako
- Akmal Ernita
- Al Ageel Saleh
- Al Qasim Eman
- Al-dabbous Tala
- Al-Fares Abdulrahman
- Alalqam Razi
- Alegesan Senthilkumar
- Alegre Cynthia
- Alessi Marta
- Alex Beatrice
- Alexandre K. vin
- Alfoudri Huda
- Ali Imran
- Alidjnou Kazali Enagnon
- Aliudin Jeffrey
- Alkhafajee Qabas
- Allavena Clotilde
- Allou Nathalie
- Altaf Aneela
- Alves JoĂŁo
- Alves JoĂŁo Melo
- Alves Rita
- Amaral Maria
- Ampaw Phoebe
- Andini Roberto
- Andréjak Claire
- Angheben Andrea
- Angoulvant François
- Ansart S. verine
- Antonelli Massimo
- Apriyana Ardiyan
- Arabi Yaseen
- Aragao Irene
- Araujo Carolline
- Arcadipane Antonio
- Archambault Patrick
- Arenz Lukas
- Argin G.
- Arlet Jean-Benoît
- Arnold-Day Christel
- Arora Lovkesh
- Arora Rakesh
- Artaud-Macari Elise
- Aryal Diptesh
- Asensio Angel
- Asif Namra
- Asim Mohammad
- Assie Jean Baptiste
- Atif Minahel
- Atique Anika
- Attanyake A. M. Udara Lakshan
- Auchabie Johann
- Auger Christelle Chantalat
- Aumaitre Hugues
- Auvet Adrien
- Azemar Laurène
- Azoulay Cecile
- Bach Benjamin
- Bachelet Delphine
- Badr Claudine
- Baig Nadia
- Baillie J. Kenneth
- Bak Erica
- Bakakos Agamemnon
- Bal Andriy
- Balan Valeria
- Balazote Pablo Serrano
- Banheiro Bruno Sarmento
- Bani-Sadr Firouzé
- Barbalho Renata
- Barclay Wendy S.
- Barnikel Michaela
- Barrasa Helena
- Barrelet Audrey
- Barrigoto Cleide
- Barrio Noelia GarcĂa
- Bartoli Marie
- Baruch JoaquĂn
- Basmaci Romain
- Bassi Gianluigi Li
- Battaglini Denise
- Bauer Jules
- Beane Abigail
- Bedossa Alexandra
- Begum Husna
- Behilill Sylvie
- Beishuizen Albertus
- Bekken Gry Kloumann
- Beljantsev Aleksandr
- Bellemare David
- Beltrame Anna
- Beluze Marine
- Benech Nicolas
- Benkerrou Dehbia
- Bennett Suzanne
- Bento LuĂs
- Berdal Jan-Erik
- Bergeaud Delphine
- Bergin Hazel
- Bermejo Carlos Lumbreras
- BermĂşdez Juan Luis Cruz
- Bertoli Giulia
- Bertolino Lorenzo
- Bessis Simon
- Bevilcaqua Sybille
- Bezulier Karine
- Bhatt Amar
- Bhavsar Krishna
- Bianco Claudia
- Bissuel François
- Bitker Laurent
- Bitton Jonathan
- Blanco-Schweizer Pablo
- Blier Catherine
- Bloos Frank
- Blot Mathieu
- Boccia Filomena
- Bodenes Laetitia
- Bogaert Debby
- Boivin Anne-H. lène
- Bolze Pierre-Adrien
- Bompart François
- Borges Diogo
- Borie Raphaël
- Bosse Hans Martin
- Botelho-Nevers Elisabeth
- Bouadma Lila
- Bouchaud Olivier
- Bouchez Sabelline
- Bouhmani Dounia
- Bouhour Damien
- Bouiller K. vin
- Bouillet Laurence
- Bouisse Camile
- Boureau Anne-Sophie
- Bourke John
- Bouscambert Maude
- Bousquet Aurore
- Bouziotis Jason
- Boxma Bianca
- Boyer-Besseyre Marielle
- Boylan Maria
- Bozza Fernando
- Braconnier Axelle
- Braga Cynthia
- Brandenburger Timo
- Brazzi Luca
- Breen Dorothy
- Breen Patrick
- Brickell Kathy
- Brien Fionnuala O.
- Browne Alex
- Browne Shaunagh
- Brusse-Keizer Marjolein
- Buchtele Nina
- Buesaquillo Christian
- Bugaeva Polina
- Buisson Marielle
- Burhan Erlina
- Burrell Aidan
- Bustos Ingrid G.
- Butnaru Denis
- Cabie André
- Cabral Susana
- Cabrita Joana Alves
- Caceres Eder
- Cadoz Cyril
- Callaghan Annmarie O.
- Calligy Kate
- Calvache Jose Andres
- Campana Valentine
- Campbell Paul
- Camões João
- Canepa Cecilia
- Cantero Mireia
- Caraux-Paz Pauline
- Cardellino Chiara Simona
- Cardoso Filipa
- Cardoso Filipe
- Cardoso Nelson
- Cardoso Sofia
- Carelli Simone
- Carlier Nicolas
- Carmoi Thierry
- Carney Gayle
- Carqueja InĂŞs
- Carret Marie-Christine
- Carrier François Martin
- Carroll Ida
- Carson Gail
- Casanova Maire-Laure
- CascĂŁo Mariana
- Casey Siobhan
- Casimiro José
- Cassandra Bailey
- Castanheira Nidyanara
- Castañeda Silvia
- Castor-Alexandre Guylaine
- CastrillĂłn Henry
- Castro Ivo
- Catarino Ana
- Catherine François-Xavier
- Cattaneo Paolo
- Cavalin Roberta
- Cavalli Giulio Giovanni
- Cavayas Alexandros
- Ceccato Adrian
- Cely Lina Morales
- Cervantes-Gonzalez Minerva
- Chair Anissa
- Chakveatze Catherine
- Chan Adrienne
- Chand Meera
- Chapplain Jean-Marc
- Chas Julie
- Chaudry Mobin
- Chen Anjellica
- Chen Yih-Sharng
- Cheng Matthew Pellan
- Cheret Antoine
- Chia Jack Song
- Chiarabini Thibault
- Chica Julian
- Chirouze Catherine
- Chiumello Davide
- Cho Sung-Min
- Choileain Orna Ni
- Cholley Bernard
- Chopin Marie-Charlotte
- Cidade Jose Pedro
- Citarella Barbara Wanjiru
- Ciullo Anna
- Clarke Emma
- Clarke Jennifer
- Clohisey Sara
- Cobb Perren J.
- Codan Cassidy
- Cody Caitriona
- Coelho Alexandra
- Coles Megan
- Colin Gwenhaël
- Collins Michael
- Colombo Sebastiano Maria
- Combs Pamela
- Connor Marie
- Conrad Anne
- Contreras SofĂa
- Conway Elaine
- Cooke Graham S.
- Copland Mary
- Cordel Hugues
- Corley Amanda
- Cornelis Sabine
- Cornet Alexander Daniel
- Corpuz Arianne Joy
- Cortegiani Andrea
- Corvaisier Grégory
- Costigan Emma
- Couffignal Camille
- Couffin-Cadiergues Sandrine
- Courtois Roxane
- Cousse Stéphanie
- Cregan Rachel
- Croonen Sabine
- Crowl Gloria
- Crump Jonathan
- Cruz Claudina
- Csete Marc
- Cullen Ailbhe
- Cummings Matthew J.
- Curley Ger
- Curlier Elodie
- Curran Colleen
- Custodio Paula
- Cárcel Sheila
- da Silva Filipe Ana
- da Silveira Charlene
- Dabaliz Al-Awwab
- Dagens Andrew
- Dahly Darren
- Dalton Heidi
- Dalton Jo
- Daly Seamus
- Damas Juliana
- Daneman Nick
- Daniel Corinne
- Dankwa Emmanuelle A.
- Dantas Jorge
- Darshana B. P. Sanka Ruwan Sri
- de Brito Carlos Alexandre Antunes
- de Castro Maisa GuimarĂŁes
- de la Calle Guillermo Maestro
- de Loughry Gillian
- de Mendoza Diego
- de Montmollin Etienne
- de Oliveira França Rafael Freitas
- de Pinho Oliveira Ana Isabel
- de Rosa Rosanna
- de Silva Thushan
- de Vries Peter
- Deacon Jillian
- Dean David
- Debard Alexa
- Debray Marie-Pierre
- DeCastro Nathalie
- Dechert William
- Deconninck Lauren
- Decours Romain
- Defous Eve
- Delacroix Isabelle
- Delaveuve Eric
- Delavigne Karen
- Dell’Amore Andrea
- Delmas Christelle
- Delobel Pierre
- Delsing Corine
- Demonchy Elisa
- Denis Emmanuelle
- Deplanque Dominique
- Depuydt Pieter
- Descamps Diane
- Desvallées Mathilde
- Devouge Eglantine Ferrand
- Dewayanti Santi
- Dhanger Pathik
- Diallo Alpha
- Diamantis Sylvain
- Dias André
- Diaz Juan Jose
- Diaz Priscila
- Diaz Rodrigo
- Didier K. vin
- Diehl Jean-Luc
- Dieperink Wim
- Dimet J. rĂ´me
- Dinot Vincent
- Diop Fara
- Diouf Alphonsine
- Dishon Yael
- Djossou F. lix
- Docherty Annemarie B.
- Doherty Helen
- Dominguez Carmen Infante
- Dondorp Arjen M.
- Donnelly Christl A.
- Donnelly Maria
- Donohue Chloe
- Donohue Sean
- Donohue Yoann
- Doran Peter
- Dorival C. line
- Douglas James Joshua
- Dournon Nathalie
- Dow Denisse Bazan
- Downer Triona
- Downey Joanne
- Downing Mark
- Drake Tom
- Driscoll Aoife
- Dubee Vincent
- Dubos François
- Ducancelle Alexandre
- Dudman Susanne
- Dunand Paul
- Dunning Jake
- Duplaix Mathilde
- Duque Sara
- Durante-Mangoni Emanuele
- Durham Lucian
- Dussol Bertrand
- Duthoit Juliette
- Duval Xavier
- Dyrhol-Riise Anne Margarita
- D’Aragon Frédérick
- D’Ortenzio Eric
- Echeverria-Villalobos Marco
- Egan Siobhan
- Eira Carla
- Elapavaluru Subbarao
- Elharrar Brigitte
- Ellerbroek Jacobien
- Eloy Philippine
- Elshazly Tarek
- Enderle Isabelle
- Endo Tomoyuki
- Engelmann Ilka
- Enouf Vincent
- Epaulard Olivier
- Escher Martina
- Esperatti Mariano
- Esperou H. lène
- Esposito-Farese Marina
- EstevĂŁo JoĂŁo
- Etienne Manuel
- Ettalhaoui Nadia
- Everding Anna Greti
- Evers Mirjam
- Fabre Isabelle
- Fabre Marc
- Faheem Amna
- Fahy Arabella
- Fairfield Cameron J.
- Fakar Zul
- Fareed Komal
- Faria Pedro
- Farooq Ahmed
- Fatoni Arie Zainul
- Faure Karine
- Favory Raphaël
- Fayed Mohamed
- Feely Niamh
- Feeney Laura
- Fernandes Jorge
- Fernandes MarĂlia Andreia
- Fernandes Susana
- Ferrand François-Xavier
- Ferraz M. rio
- Ferreira Benigno
- Ferreira Bernardo
- Ferreira Isabel
- Ferreira S. lvia
- Ferrer-Roca Ricard
- Ferriere Nicolas
- FerrĂŁo Joana
- Ficko C. line
- Figueiredo-Mello Claudia
- Fiorda Juan
- Flament Thomas
- Flateau Clara
- Fletcher Tom
- Florio Letizia Lucia
- Flynn Deirdre
- Foley Claire
- Foley Jean
- Fomin Victor
- Fonseca Claudio Duarte
- Fonseca Tatiana
- Fontela Patricia
- Forsyth Simon
- Foster Denise
- Foti Giuseppe
- Fourn Erwan
- Fowler Robert A.
- Fraher Marianne
- Franch-Llasat Diego
- Fraser Christophe
- Fraser John F.
- Freire Marcela Vieira
- French Craig
- Friedrich Caren
- Fry Stéphanie
- Fuentes Nora
- Fuentes Yuli V.
- Fukuda Masahiro
- Gaborieau Valérie
- Gaci Rostane
- Gagliardi Massimo
- Gagnard Jean-Charles
- Gagneux-Brunon Amandine
- GaiĂŁo S. rgio
- Gallagher Phil
- Gamble Carrol
- Gandonniere Charlotte Salmon
- Garan Arthur
- Garcia Rebekha
- Garcia-Gallo Esteban
- GarcĂŞs Rui Caetano
- GarcĂa Ruth N. Jorge
- Garimella Navya
- Garot Denis
- Garrait Valérie
- Gauli Basanta
- Gault Nathalie
- Gavin Aisling
- Gavrylov Anatoliy
- Gaymard Alexandre
- Gebauer Johannes
- Geraud Eva
- Germano Nuno
- Ghosn Jade
- Giani Marco
- Gibson Jess
- Gigante Tristan
- Gilg Morgane
- Gilroy Elaine
- Giordano Guillermo
- Girvan Michelle
- Gissot Valérie
- Glikman Daniel
- Glybochko Petr
- Gnall Eric
- Goco Geraldine
- Goehringer François
- Goepel Siri
- Goffard Jean-Christophe
- Golob Jonathan
- Gominet Marie
- Gonzalez Alicia
- González V. ctor Quirós
- Gonçalves Bronner P.
- Gordon Patricia
- Gorenne Isabelle
- Goubert Laure
- Goujard C. cile
- Goulenok Tiphaine
- Grable Margarite
- Graf Jeronimo
- Grandin Edward Wilson
- Granerud Beathe Kiland
- Granier Pascal
- Grasselli Giacomo
- Green Christopher A.
- Greene Courtney
- Greenhalf William
- Greffe Segolène
- Grieco Domenico Luca
- Griffee Matthew
- Griffiths Fiona
- Groenendijk Albert
- Gruner Heidi
- Gu Yusing
- Guedj J. rémie
- Guego Martin
- Guellec Dewi
- Guerguerian Anne-Marie
- Guerreiro Daniela
- Guery Romain
- Guillaumot Anne
- Guilleminault Laurent
- Guimard Thomas
- GĂłmez-Junyent Joan
- Haalboom Marieke
- Haber Daniel
- Habraken Hannah
- Hachemi Ali
- Hadri Nadir
- Haidri Fakhir
- Hakak Sheeba
- Hall Adam
- Hall Matthew
- Halpin Sophie
- Hameed Jawad
- Hamer Ansley
- Hamidfar Rebecca
- Hammond Terese
- Haniffa Rashan
- Hardwick Hayley
- Harrison Ewen M.
- Harrison Janet
- Harrison Samuel Bernard Ekow
- Hasan Mohd Shahnaz
- Hashmi Junaid
- Hashmi Madiha
- Hayat Muhammad
- Hayes Ailbhe
- Hays Leanne
- Heerman Jan
- Heggelund Lars
- Hendry Ross
- Hennessy Martina
- Hentzien Maxime
- Herreros José Miguel Cisneros
- Hershey Andrew
- Hesstvedt Liv
- Hidayah Astarini
- Higgins Dawn
- Higgins Eibhilin
- Higgins Rupert
- Hinchion Rita
- Hinton Samuel
- Hitoto Hikombo
- Ho Antonia
- Hoctin Alexandre
- Hoffmann Isabelle
- Hoiting Oscar
- Holt Rebecca
- Holten Aleksander Rygh
- Holter Jan Cato
- Horby Peter
- Horcajada Juan Pablo
- Hoshino Koji
- Hoshino Kota
- Houas Ikram
- Hough Catherine L.
- Hssain Ali Ait
- Hsu Jimmy Ming-Yang
- Hulot Jean-S. bastien
- Humaid Felwa Bin
- Huo Stella
- Hurd Abby
- Hussain Iqbal
- Ibáñez-Prada Elsa D.
- Ijaz Samreen
- Ikram Arfan
- Illes Hajnal-Gabriela
- Imbert Patrick
- Imran Mohammad
- Imtiaz Aftab
- Inácio Hugo
- Ippolito Mariachiara
- Isgett Sarah
- Isidoro Tiago
- Isnard Margaux
- Ivulich Daniel
- Iñiguez Jonathan Samuel Chávez
- Jaafar Danielle
- Jaafoura Salma
- Jabot Julien
- Jackson Clare
- Jamieson Nina
- Jaquet Pierre
- Jaud-Fischer Coline
- Jaureguiberry Stéphane
- Jego Florence
- Jenum Synne
- Jiménez Miguel Pedrera
- Joseph C. dric
- Joseph Mark
- Joshi Swosti
- Jourdain Mercé
- Jouvet Philippe
- Jung Anna
- Juzar Dafsah
- Kafif Ouifiya
- Kaguelidou Florentia
- Kali Sabina
- Kalomoiri Smaragdi
- Kandamby Darshana Hewa
- Kandel Chris
- Kanwal Darakhshan
- Kartsonaki Christiana
- Kataria Anant
- Katz Kevin
- Kay Christy
- Keane Hannah
- Keating Seán
- Kelly Andrea
- Kelly Aoife
- Kelly Claire
- Kelly Niamh
- Kelly Sadie
- Kelly Yvelynne
- Kelsey Maeve
- Kennon Kalynn
- Kernan Maeve
- Kerroumi Younes
- Keshav Sharma
- Khalid Imrana
- Khalid Osama
- Khalil Antoine
- Khan Coralie
- Khan Irfan
- Khan Quratul Ain
- Khan Rashid Nasim
- Khanal Sushil
- Khatak Abid
- Khawaja Amin
- Kho Michelle E.
- Khoo Saye
- Khoso Nasir
- Kida Yuri
- Kiiza Peter
- Kildal Anders Benjamin
- Kimmoun Antoine
- Kindgen-Milles Detlef
- Kitamura Nobuya
- Klenerman Paul
- Klont Rob
- Knight Stephen R.
- Kobbe Robin
- Kodippily Chamira
- Koirala Sabin
- Kosgei Caroline
- Kpangon Arsène
- Krawczyk Karolina
- Kruglova Oksana
- Kumar Deepali
- Kumar Mukesh
- Kuriakose Dinesh
- Kurtzman Ethan
- Kutsogiannis Demetrios
- Kutsyna Galyna
- Kyriakoulis Konstantinos
- Lachatre Marie
- Lacoste Marie
- Laffey John G.
- Lagrange Marie
- Laine Fabrice
- Lairez Olivier
- Lakhey Sanjay
- Lalueza Antonio
- Lambert Marc
- Lamontagne François
- Langelot-Richard Marie
- Langlois Vincent
- Lantang Eka Yudha
- Lanza Marina
- Laouénan C. dric
- Laribi Samira
- Lariviere Delphine
- Lasry Stéphane
- Latif Naveed
- Launay Odile
- Laureillard Didier
- Lavie-Badie Yoan
- Law Andrew
- Lawrence Cassie
- Lawrence Teresa
- le Bihan Clément
- le Bris Cyril
- le Falher Georges
- le Fevre Lucie
- le Hingrat Quentin
- le Maréchal Marion
- le Mestre Soizic
- le Moal Gwenaël
- le Moing Vincent
- le Nagard Hervé
- le Turnier Paul
- le Minh
- Leal Ema
- Leathlobhair Niamh Ni
- Lee James
- Lee Jennifer
- Lee Su Hwan
- Lee Todd C.
- Leeming Gary
- Lefebvre B. nédicte
- Lefebvre Laurent
- Lefèvre Benjamin
- LeGac Sylvie
- Lelievre Jean-Daniel
- Lellouche François
- Lemaignen Adrien
- Lemee V. ronique
- Lemeur Anthony
- Lemmink Gretchen
- Lennon Jenny
- Leone Marc
- Leone Michela
- Lescure François-Xavier
- Lesens Olivier
- Lesouhaitier Mathieu
- Lester-Grant Amy
- Levy Bruno
- Levy Yves
- Levy-Marchal Claire
- Lewandowska Katarzyna
- LeĂłn Rafael
- Liaquat Ali
- Liegeon Geoffrey
- Lim Wei Shen
- Lima Chantre
- Lina Bruno
- Lind Andreas
- Lingas Guillaume
- Lion-Daolio Sylvie
- Liu Keibun
- Livrozet Marine
- Lizotte Patricia
- Loforte Antonio
- Lolong Navy
- Lopes Diogo
- Lordemann Anja Grosse
- Loschner Anthony L.
- Loubet Paul
- Loufti Bouchra
- Louis Guillame
- Lourenco Silvia
- Lovelace-Macon Lara
- Lowik Marije
- Lucet Jean Christophe
- Luna Carlos M.
- Luong Liem
- Luque Nestor
- Luton Dominique
- Lwin Nilar
- Lyons Ruth
- l’Her Erwan
- Maasikas Olavi
- Mabiala Oryane
- Machado MoĂŻse
- Machado Sara
- Macheda Gabriel
- Madiha Hashmi
- Mahieu Rafael
- Mahy Sophie
- Maia Ana Raquel
- Maier Lars S.
- Maillet Mylène
- Maitre Thomas
- Malaque Ana
- Malfertheiner Maximilian
- Malik Nadia
- Mallon Paddy
- Maltez Fernando
- Malvy Denis
- Manda Victoria
- Mandelbrot Laurent
- Mankikian Julie
- Manning Edmund
- Manuel Aldric
- Marino Daniel
- Marino Flávio
- Markowicz Samuel
- Marques Ana
- Marquis Catherine
- Marsh Brian
- Marsh Laura
- Marshal Megan
- Marshall John C.
- Martelli Celina Turchi
- Martin Emily
- Martin-Blondel Guillaume
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- Pereira Rui
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- Postma Douwe F.
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- Preiser Jean-Charles
- Prinssen Anton
- Pritchard Mark G.
- Priyadarshani Gamage Dona Dilanthi
- Proença Lucia
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- Pulicken Mathew
- Purcell Gregory
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- Rafiq Marie
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- Ramachandran Pratheema
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- Rana Asim
- Rangappa Rajavardhan
- Ranjan Ritika
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- Reid Liadain
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- Renk Hanna
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- Richardson Denise
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- Rios Ana L.
- Rishu Asgar
- Rispal Patrick
- Risso Karine
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- Roberto André
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- Robertson David L.
- Robineau Olivier
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- Rodari Paola
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- Roessler Bernhard
- Roger Pierre-Marie
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- Roncon-Albuquerque Roberto
- Roriz M. lanie
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- Rossignol Patrick
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- Scott Janet T.
- Scott-Brown James
- Sedillot Nicholas
- Seitz Tamara
- Selvanayagam Jaganathan
- Semaille Caroline
- Semedi Bambang Pujo
- Semple Malcolm G.
- Senneville Eric
- Sequeira Filipa
- Sequeira T. nia
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- Shah Naseem Ali
- Shamsah Mohammad
- Sharjeel Shaikh
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- Shaw Victoria
- Sheharyar Ashraf
- Shetty Rajesh Mohan
- Shi Haixia
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- Streinu-Cercel Adrian
- Streinu-Cercel Anca
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- Stuart David
- Suen Gabriel
- Suen Jacky Y.
- Sultana Asfia
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- Supic Dubravka
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- Syrigos Konstantinos
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- Szuldrzynski Konstanty
- Tabrizi Shirin
- Taccone Fabio S.
- Tagherset Lysa
- Taleb Sara
- Talsma Jelmer
- Tamlihat Younes Ait
- Tampubolon Maria Lawrensia
- Tanaka Hiroyuki
- Taqdees Huda
- Taqi Arshad
- Tardivon Coralie
- Tattevin Pierre
- Taufik M. Azhari
- Tawfik Hassan
- Tedder Richard S.
- Teixeira JoĂŁo
- Tejada Sofia
- Tellier Marie-Capucine
- Terpstra Pleun
- Terrier Olivier
- Terzi Nicolas
- Tessier-Grenier Hubert
- Tey Adrian
- Thakur Anand
- Thibault Vincent
- Thiberville Simon-Djamel
- Thill Benoît
- Thompson Shaun
- Thomson David
- Thomson Emma C.
- Thwaites Ryan S.
- Tierney Paul
- Tieroshyn Vadim
- Timashev Peter S.
- Timsit Jean-François
- Tissot Noémie
- Toki Maria
- Tonby Kristian
- Torre Marta
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- Torres Margarida
- Torres-Zevallos Hernando
- Towers Michael
- Trapani Tony
- Treoux Théo
- Tromeur C. cile
- Trontzas Ioannis
- Trouillon Tiffany
- Truong Jeanne
- Tual Christelle
- Tubiana Sarah
- Tuite Helen
- Turmel Jean-Marie
- Turtle Lance C. W.
- Twardowski Pawel
- Téoulé François
- Uchiyama Makoto
- Udayanga P. G. Ishara
- Udy Andrew
- Ullrich Roman
- Uribe Alberto
- Usman Asad
- Uva Maria Sousa
- Uyeki Timothy M.
- Vajdovics Cristinava
- Val-Flores LuĂs
- Valran Amélie
- van de Velde Stijn
- van den Berge Marcel
- van der Palen Job
- van der Valk Paul
- van der Vekens Nicky
- van der Voort Peter
- van der Werf Sylvie
- van Gulik Laura
- van Hattem Jarne
- van Netten Carolien
- van Veen Ilonka
- Vanel Noémie
- Vanoverschelde Henk
- Varghese Pooja
- Vasconcelos Malte Kohns
- Vauchy Charline
- Vecham Pavan Kumar
- Veislinger Aurélie
- Vencken Sebastian
- Ventura Sara
- Verbon Annelies
- Vickers James
- Vidal José Ernesto
- Vieira C. sar
- Vijayan Deepak
- Vijayaraghavan Bharath Kumar Tirupakuzhi
- Vijayaraghavan Bharath Kumar Tirupakuzhi
- Villanueva Joy Ann
- Villar Judit
- Villeneuve Pierre-Marc
- Villoldo Andrea
- Visseaux Benoit
- Visser Hannah
- Vitiello Chiara
- Vonkeman Harald
- Vuotto Fanny
- Wang Chih-Hsien
- Webb Steve
- Wei Jia
- Weil Katharina
- Wesselius Sanne
- West T. Eoin
- Wham Murray
- Whelan Bryan
- White Nicole
- Wicky Paul Henri
- Wiedemann Aurélie
- Wijaya Surya Otto
- Wille Keith
- Willems Suzette
- Williams Virginie
- Wils Evert-Jan
- Wong Calvin
- Xynogalas Ioannis
- Yamazaki Masaki
- Yazdanpanah Yazdan
- Yelnik C. cile
- Yerkovich Stephanie
- Yiu Ng Wing
- Yokoyama Toshiki
- Yonis Hodane
- Yousif Obada
- Yuliarto Saptadi
- Zaaqoq Akram
- Zabbe Marion
- Zahran Maram
- Zambon Maria
- Zanella Alberto
- Zayyad Hiba
- Zoufaly Alexander
- Zucman David
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/12/2022
- Field of study
Background: Up to 30% of hospitalised patients with COVID-19 require advanced respiratory support, including high-flow nasal cannulas (HFNC), non-invasive mechanical ventilation (NIV), or invasive mechanical ventilation (IMV). We aimed to describe the clinical characteristics, outcomes and risk factors for failing non-invasive respiratory support in patients treated with severe COVID-19 during the first two years of the pandemic in high-income countries (HICs) and low middle-income countries (LMICs). Methods: This is a multinational, multicentre, prospective cohort study embedded in the ISARIC-WHO COVID-19 Clinical Characterisation Protocol. Patients with laboratory-confirmed SARS-CoV-2 infection who required hospital admission were recruited prospectively. Patients treated with HFNC, NIV, or IMV within the first 24 h of hospital admission were included in this study. Descriptive statistics, random forest, and logistic regression analyses were used to describe clinical characteristics and compare clinical outcomes among patients treated with the different types of advanced respiratory support. Results: A total of 66,565 patients were included in this study. Overall, 82.6% of patients were treated in HIC, and 40.6% were admitted to the hospital during the first pandemic wave. During the first 24 h after hospital admission, patients in HICs were more frequently treated with HFNC (48.0%), followed by NIV (38.6%) and IMV (13.4%). In contrast, patients admitted in lower- and middle-income countries (LMICs) were less frequently treated with HFNC (16.1%) and the majority received IMV (59.1%). The failure rate of non-invasive respiratory support (i.e. HFNC or NIV) was 15.5%, of which 71.2% were from HIC and 28.8% from LMIC. The variables most strongly associated with non-invasive ventilation failure, defined as progression to IMV, were high leukocyte counts at hospital admission (OR [95%CI]; 5.86 [4.83–7.10]), treatment in an LMIC (OR [95%CI]; 2.04 [1.97–2.11]), and tachypnoea at hospital admission (OR [95%CI]; 1.16 [1.14–1.18]). Patients who failed HFNC/NIV had a higher 28-day fatality ratio (OR [95%CI]; 1.27 [1.25–1.30]). Conclusions: In the present international cohort, the most frequently used advanced respiratory support was the HFNC. However, IMV was used more often in LMIC. Higher leucocyte count, tachypnoea, and treatment in LMIC were risk factors for HFNC/NIV failure. HFNC/NIV failure was related to worse clinical outcomes, such as 28-day mortality. Trial registration This is a prospective observational study; therefore, no health care interventions were applied to participants, and trial registration is not applicable
Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study
- Author
- Abbas Ali
- Abdukahil Sheryl Ann
- Abe Ryuzo
- Abel Laurent
- Abreu Julia Rodriguez
- Absil Lara
- Acharya Subhash
- Acker Andrew
- AdriĂŁo Diana
- Ahmed Shakeel
- Ainscough Kate
- Aisa Tharwat
- Akimoto Takako
- Akmal Ernita
- Al Ageel Saleh
- Al Qasim Eman
- Al-dabbous Tala
- Al-Fares Abdulrahman
- Alalqam Razi
- Alegesan Senthilkumar
- Alegre Cynthia
- Alessi Marta
- Alex Beatrice
- Alexandre KĂ©vin
- Alfoudri Huda
- Ali Imran
- Alidjnou Kazali Enagnon
- Aliudin Jeffrey
- Alkhafajee Qabas
- Allavena Clotilde
- Allou Nathalie
- Altaf Aneela
- Alves JoĂŁo
- Alves JoĂŁo Melo
- Alves Rita
- Amaral Maria
- Ampaw Phoebe
- Andini Roberto
- Andréjak Claire
- Angheben Andrea
- Angoulvant François
- Ansart SĂ©verine
- Antonelli Massimo
- Apriyana Ardiyan
- Arabi Yaseen
- Aragao Irene
- Araujo Carolline
- Arcadipane Antonio
- Archambault Patrick
- Arenz Lukas
- Arlet Jean-Benoît
- Arnold-Day Christel
- Arora Lovkesh
- Arora Rakesh
- Artaud-Macari Elise
- Aryal Diptesh
- Aryal Diptesh
- Asensio Angel
- Asif Namra
- Asim Mohammad
- Assie Jean Baptiste
- Atif Minahel
- Atique Anika
- Attanyake A. M. Udara Lakshan
- Auchabie Johann
- Auger Christelle Chantalat
- Aumaitre Hugues
- Auvet Adrien
- Azemar Laurène
- Azoulay Cecile
- Bach Benjamin
- Bachelet Delphine
- Badr Claudine
- Baig Nadia
- Baillie J. Kenneth
- Bak Erica
- Bakakos Agamemnon
- Bal Andriy
- Balan Valeria
- Balazote Pablo Serrano
- Banheiro Bruno Sarmento
- Bani-Sadr Firouzé
- Barbalho Renata
- Barclay Wendy S.
- Barnikel Michaela
- Barrasa Helena
- Barrelet Audrey
- Barrigoto Cleide
- Barrio Noelia GarcĂa
- Bartoli Marie
- Baruch JoaquĂn
- Basmaci Romain
- Bassi Gianluigi Li
- Battaglini Denise
- Bauer Jules
- Beane Abigail
- Bedossa Alexandra
- Begum Husna
- Behilill Sylvie
- Beishuizen Albertus
- Bekken Gry Kloumann
- Beljantsev Aleksandr
- Bellemare David
- Beltrame Anna
- Beluze Marine
- Benech Nicolas
- Benkerrou Dehbia
- Bennett Suzanne
- Bento LuĂs
- Berdal Jan-Erik
- Bergeaud Delphine
- Bergin Hazel
- Bermejo Carlos Lumbreras
- BermĂşdez Juan Luis Cruz
- Bertoli Giulia
- Bertolino Lorenzo
- Bessis Simon
- Bevilcaqua Sybille
- Bezulier Karine
- Bhatt Amar
- Bhavsar Krishna
- Bianco Claudia
- Bissuel François
- Bitker Laurent
- Bitton Jonathan
- Blanco-Schweizer Pablo
- Blier Catherine
- Bloos Frank
- Blot Mathieu
- Boccia Filomena
- Bodenes Laetitia
- Bogaert Debby
- Boivin Anne-Hélène
- Bolze Pierre-Adrien
- Bompart François
- Borges Diogo
- Borie Raphaël
- Bosse Hans Martin
- Botelho-Nevers Elisabeth
- Bouadma Lila
- Bouchaud Olivier
- Bouchez Sabelline
- Bouhmani Dounia
- Bouhour Damien
- Bouiller KĂ©vin
- Bouillet Laurence
- Bouisse Camile
- Boureau Anne-Sophie
- Bourke John
- Bouscambert Maude
- Bousquet Aurore
- Bouziotis Jason
- Boxma Bianca
- Boyer-Besseyre Marielle
- Boylan Maria
- Bozza Fernando
- Braconnier Axelle
- Braga Cynthia
- Brandenburger Timo
- Brazzi Luca
- Breen Dorothy
- Breen Patrick
- Brickell Kathy
- Brien Fionnuala O.
- Browne Alex
- Browne Shaunagh
- Brusse-Keizer Marjolein
- Buchtele Nina
- Buesaquillo Christian
- Bugaeva Polina
- Buisson Marielle
- Burhan Erlina
- Burrell Aidan
- Bustos Ingrid G.
- Butnaru Denis
- Cabie André
- Cabral Susana
- Cabrita Joana Alves
- Caceres Eder
- Cadoz Cyril
- Callaghan Annmarie O.
- Calligy Kate
- Calvache Jose Andres
- Campana Valentine
- Campbell Paul
- Camões João
- Canepa Cecilia
- Cantero Mireia
- Caraux-Paz Pauline
- Cardellino Chiara Simona
- Cardoso Filipa
- Cardoso Filipe
- Cardoso Nelson
- Cardoso Sofia
- Carelli Simone
- Carlier Nicolas
- Carmoi Thierry
- Carney Gayle
- Carqueja InĂŞs
- Carret Marie-Christine
- Carrier François Martin
- Carroll Ida
- Carson Gail
- Casanova Maire-Laure
- CascĂŁo Mariana
- Casey Siobhan
- Casimiro José
- Cassandra Bailey
- Castanheira Nidyanara
- Castañeda Silvia
- Castor-Alexandre Guylaine
- CastrillĂłn Henry
- Castro Ivo
- Catarino Ana
- Catherine François-Xavier
- Cattaneo Paolo
- Cavalin Roberta
- Cavalli Giulio Giovanni
- Cavayas Alexandros
- Ceccato Adrian
- Cely Lina Morales
- Cervantes-Gonzalez Minerva
- Chair Anissa
- Chakveatze Catherine
- Chan Adrienne
- Chand Meera
- Chapplain Jean-Marc
- Chas Julie
- Chaudry Mobin
- Chen Anjellica
- Chen Yih-Sharng
- Cheng Matthew Pellan
- Cheret Antoine
- Chia Jack Song
- Chiarabini Thibault
- Chica Julian
- Chirouze Catherine
- Chiumello Davide
- Cho Sung-Min
- Choileain Orna Ni
- Cholley Bernard
- Chopin Marie-Charlotte
- Cidade Jose Pedro
- Citarella Barbara Wanjiru
- Ciullo Anna
- Clarke Emma
- Clarke Jennifer
- Clohisey Sara
- Cobb Perren J.
- Codan Cassidy
- Cody Caitriona
- Coelho Alexandra
- Coles Megan
- Colin Gwenhaël
- Collins Michael
- Colombo Sebastiano Maria
- Combs Pamela
- Connor Marie
- Conrad Anne
- Contreras SofĂa
- Conway Elaine
- Cooke Graham S.
- Copland Mary
- Cordel Hugues
- Corley Amanda
- Cornelis Sabine
- Cornet Alexander Daniel
- Corpuz Arianne Joy
- Cortegiani Andrea
- Corvaisier Grégory
- Costigan Emma
- Couffignal Camille
- Couffin-Cadiergues Sandrine
- Courtois Roxane
- Cousse Stéphanie
- Cregan Rachel
- Croonen Sabine
- Crowl Gloria
- Crump Jonathan
- Cruz Claudina
- Csete Marc
- Cullen Ailbhe
- Cummings Matthew J.
- Curley Ger
- Curlier Elodie
- Curran Colleen
- Custodio Paula
- Cárcel Sheila
- da Silva Filipe Ana
- Da Silveira Charlene
- Dabaliz Al-Awwab
- Dagens Andrew
- Dahly Darren
- Dalton Heidi
- Dalton Jo
- Daly Seamus
- Damas Juliana
- Daneman Nick
- Daniel Corinne
- Dankwa Emmanuelle A.
- Dantas Jorge
- Darshana B. P. Sanka Ruwan Sri
- de Brito Carlos Alexandre Antunes
- de Castro Maisa GuimarĂŁes
- de la Calle Guillermo Maestro
- de Loughry Gillian
- de Mendoza Diego
- De Montmollin Etienne
- de Oliveira França Rafael Freitas
- de Pinho Oliveira Ana Isabel
- De Rosa Rosanna
- de Silva Thushan
- de Vries Peter
- Deacon Jillian
- Dean David
- Debard Alexa
- Debray Marie-Pierre
- DeCastro Nathalie
- Dechert William
- Deconninck Lauren
- Decours Romain
- Defous Eve
- Delacroix Isabelle
- Delaveuve Eric
- Delavigne Karen
- Dell’Amore Andrea
- Delmas Christelle
- Delobel Pierre
- Delsing Corine
- Demonchy Elisa
- Denis Emmanuelle
- Deplanque Dominique
- Depuydt Pieter
- Descamps Diane
- Desvallées Mathilde
- Devouge Eglantine Ferrand
- Dewayanti Santi
- Dhanger Pathik
- Diallo Alpha
- Diamantis Sylvain
- Dias André
- Diaz Juan Jose
- Diaz Priscila
- Diaz Rodrigo
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- Docherty Annemarie B.
- Doherty Helen
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- Dondorp Arjen M.
- Donnelly Christl A.
- Donnelly Maria
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- Kobbe Robin
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- Lee James
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- Leeming Gary
- Lefebvre Bénédicte
- Lefebvre Laurent
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- Loubet Paul
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- Luong Liem
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- Maillet Mylène
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- Martelli Celina Turchi
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- McElroy Aine
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- McLean Kenneth A.
- McNally Paul
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- Moore Shona C.
- Morlaes Louis Gerbaud
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- Olliaro Piero L.
- Ong David S. Y.
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- Prinssen Anton
- Pritchard Mark G.
- Priyadarshani Gamage Dona Dilanthi
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- Semple Malcolm G.
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- Sequeira Filipa
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- Teixeira JoĂŁo
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- Thomson Emma C.
- Thwaites Ryan S.
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- Uyeki Timothy M.
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- Vidal José Ernesto
- Vieira CĂ©sar
- Vijayan Deepak
- Vijayaraghavan Bharath Kumar Tirupakuzhi
- Vijayaraghavan Bharath Kumar Tirupakuzhi
- Villanueva Joy Ann
- Villar Judit
- Villeneuve Pierre-Marc
- Villoldo Andrea
- Visseaux Benoit
- Visser Hannah
- Vitiello Chiara
- Vonkeman Harald
- Vuotto Fanny
- Wang Chih-Hsien
- Webb Steve
- Wei Jia
- Weil Katharina
- Wesselius Sanne
- West T. Eoin
- Wham Murray
- Whelan Bryan
- White Nicole
- Wicky Paul Henri
- Wiedemann Aurélie
- Wijaya Surya Otto
- Wille Keith
- Willems Suzette
- Williams Virginie
- Wils Evert-Jan
- Wong Calvin
- Xynogalas Ioannis
- Yamazaki Masaki
- Yazdanpanah Yazdan
- Yelnik CĂ©cile
- Yerkovich Stephanie
- Yiu Ng Wing
- Yokoyama Toshiki
- Yonis Hodane
- Yousif Obada
- Yuliarto Saptadi
- Zaaqoq Akram
- Zabbe Marion
- Zahran Maram
- Zambon Maria
- Zanella Alberto
- Zayyad Hiba
- Zoufaly Alexander
- Zucman David
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 13/09/2022
- Field of study
Background: Up to 30% of hospitalised patients with COVID-19 require advanced respiratory support, including high-flow nasal cannulas (HFNC), non-invasive mechanical ventilation (NIV), or invasive mechanical ventilation (IMV). We aimed to describe the clinical characteristics, outcomes and risk factors for failing non-invasive respiratory support in patients treated with severe COVID-19 during the first two years of the pandemic in high-income countries (HICs) and low middle-income countries (LMICs).
Methods: This is a multinational, multicentre, prospective cohort study embedded in the ISARIC-WHO COVID-19 Clinical Characterisation Protocol. Patients with laboratory-confirmed SARS-CoV-2 infection who required hospital admission were recruited prospectively. Patients treated with HFNC, NIV, or IMV within the first 24 h of hospital admission were included in this study. Descriptive statistics, random forest, and logistic regression analyses were used to describe clinical characteristics and compare clinical outcomes among patients treated with the different types of advanced respiratory support.
Results: A total of 66,565 patients were included in this study. Overall, 82.6% of patients were treated in HIC, and 40.6% were admitted to the hospital during the first pandemic wave. During the first 24 h after hospital admission, patients in HICs were more frequently treated with HFNC (48.0%), followed by NIV (38.6%) and IMV (13.4%). In contrast, patients admitted in lower- and middle-income countries (LMICs) were less frequently treated with HFNC (16.1%) and the majority received IMV (59.1%). The failure rate of non-invasive respiratory support (i.e. HFNC or NIV) was 15.5%, of which 71.2% were from HIC and 28.8% from LMIC. The variables most strongly associated with non-invasive ventilation failure, defined as progression to IMV, were high leukocyte counts at hospital admission (OR [95%CI]; 5.86 [4.83-7.10]), treatment in an LMIC (OR [95%CI]; 2.04 [1.97-2.11]), and tachypnoea at hospital admission (OR [95%CI]; 1.16 [1.14-1.18]). Patients who failed HFNC/NIV had a higher 28-day fatality ratio (OR [95%CI]; 1.27 [1.25-1.30]).
Conclusions: In the present international cohort, the most frequently used advanced respiratory support was the HFNC. However, IMV was used more often in LMIC. Higher leucocyte count, tachypnoea, and treatment in LMIC were risk factors for HFNC/NIV failure. HFNC/NIV failure was related to worse clinical outcomes, such as 28-day mortality. Trial registration This is a prospective observational study; therefore, no health care interventions were applied to participants, and trial registration is not applicable
Association of Country Income Level With the Characteristics and Outcomes of Critically Ill Patients Hospitalized With Acute Kidney Injury and COVID-19
- Author
- Abdukahil heryl Ann
- Abdulkadir Nurul Najmee
- Abe Ryuzo
- Abel Laurent
- Abrous Amal
- Absil Lara
- Acker Andrew
- Adachi Shingo
- AdriĂŁo Diana
- Ahmed Shakeel
- Ainscough Kate
- Airlangga Eka
- Aisa Tharwat
- Akimoto Takako
- Akmal Ernita
- Akwani Chika
- Al Ageel Saleh
- Al Qasim Eman
- Al-dabbous Tala
- Al-Fares Abdulrahman
- Alalqam Razi
- Alberti Angela
- Alegesan Senthilkumar
- Alessi Marta
- Alex Beatrice
- Alexandre KĂ©vin
- Alfoudri Huda
- Ali Imran
- Alidjnou Kazali Enagnon
- Aliudin Jeffrey
- Alkhafajee Qabas
- Allavena Clotilde
- Allou Nathalie
- Alves JoĂŁo
- Alves JoĂŁo Melo
- Alves Rita
- Amaral Maria
- Amira Nur
- Ampaw Phoebe
- Andini Roberto
- Andrey
- Andréjak Claire
- Angheben Andrea
- Angoulvant François
- Ansart SĂ©verine
- Anthonidass Sivanesen
- Antonelli Massimo
- Antunes de Brito Carlos Alexandre
- Apriyana Ardiyan
- Arabi Yaseen
- Aragao Irene
- Arancibia Francisco
- Araujo Carolline
- Arcadipane Antonio
- Archambault Patrick
- Arenz Lukas
- Arlet Jean-Benoît
- Arnold-Day Christel
- Arora Lovkesh
- Arora Rakesh
- Artaud-Macari Elise
- Aryal Diptesh
- Asensio Angel
- Ashraf Muhammad
- Assie Jean Baptiste
- Asyraf Amirul
- Atif Minahel
- Atikah Ahmad Ridzuan Siti Nurul
- Atique Anika
- Auchabie Johann
- Aumaitre Hugues
- Auvet Adrien
- Ayadi Kamaluddin Muhammad Aisar
- Azemar Laurène
- Azoulay Cecile
- Bach Benjamin
- Bachelet Delphine
- Badr Claudine
- Baillie J. Kenneth
- Baird J Kevin
- Bak Erica
- Bakakos Agamemnon
- Bakar Nazreen Abu
- Bal Andriy
- Balakrishnan Mohanaprasanth
- Balan Valeria
- Balazote Pablo Serrano
- Bani-Sadr Firouzé
- Barbalho Renata
- Barbosa Nicholas Yuri
- Barclay Wendy S.
- Barnett Saef Umar
- Barnikel Michaela
- Barrelet Audrey
- Barrigoto Cleide
- Barrio Noelia GarcĂa
- Bartoli Marie
- Baruch JoaquĂn
- Basmaci Romain
- Bassi Gianluigi Li
- Battaglini Denise
- Bauer Jules
- Bautista Rincon Diego Fernando
- Beane Abigail
- Bedossa Alexandra
- Bee Ker Hong
- Begum Husna
- Behilill Sylvie
- Beishuizen Albertus
- Bekken Gry Kloumann
- Beljantsev Aleksandr
- Bellemare David
- Beltrame Anna
- BeltrĂŁo Beatriz Amorim
- Beluze Marine
- Benech Nicolas
- Benjiman Lionel Eric
- Benkerrou Dehbia
- Bennett Suzanne
- Benny Binny
- Bento LuĂs
- Berdal Jan-Erik
- Bergeaud Delphine
- Bergin Hazel
- Bermejo Carlos Lumbreras
- Bernal Sobrino José Luis
- Bertoli Giulia
- Bertolino Lorenzo
- Bessis Simon
- Bevilcaqua Sybille
- Bezulier Karine
- Bhatt Amar
- Bhavsar Krishna
- Bianco Claudia
- Bidin Farah Nadiah
- Bin Kamarudin Mohd Nazlin
- Binti Mohd Yakop Siti Rohani
- Binti Zaidan Nor Zaila
- Bisoffi Zeno
- Bissuel François
- Biston Patrick
- Bitker Laurent
- Bitton Jonathan
- Blanco-Schweizer Pablo
- Blier Catherine
- Bloos Frank
- Blot Mathieu
- Blumberg Lucille
- Boccia Filomena
- Bodenes Laetitia
- Bogaert Debby
- Boivin Anne-Hélène
- Bolaños Isabela
- Bolze Pierre-Adrien
- Bompart François
- Borges Diogo
- Borie Raphaël
- Botelho-Nevers Elisabeth
- Bouadma Lila
- Bouchaud Olivier
- Bouchez Sabelline
- Bouhmani Dounia
- Bouhour Damien
- Bouiller KĂ©vin
- Bouillet Laurence
- Bouisse Camile
- Boureau Anne-Sophie
- Bourke John
- Bouscambert Maude
- Bousquet Aurore
- Bouziotis Jason
- Boxma Bianca
- Boyer-Besseyre Marielle
- Boylan Maria
- Bozza Fernando Augusto
- Braconnier Axelle
- Braga Cynthia
- Brazzi Luca
- Breen Dorothy
- Breen Patrick
- Brewster David
- Brickell Kathy
- Brien Fionnuala O.
- Browne Shaunagh
- Brusse-Keizer Marjolein
- Bryda Petra
- Buchtele Nina
- Bugaeva Polina
- Buisson Marielle
- Burhan Erlina
- Burrell Aidan
- Bustos Ingrid G.
- Butnaru Denis
- Cabie André
- Cabral Susana
- Cabrita Joana Alves
- Caceres Eder
- Cadoz Cyril
- Callaghan Annmarie O.
- Calligy Kate
- Calvache Jose Andres
- Campana Valentine
- Campbell Paul
- Campisi Josie
- Camões João
- Cantero Mireia
- Caraux-Paz Pauline
- Cardellino Chiara Simona
- Cardoso Filipa
- Cardoso Filipe
- Cardoso Nelson
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- Carelli Simone
- Carlier Nicolas
- Carmoi Thierry
- Carney Gayle
- Carqueja InĂŞs
- Carret Marie-Christine
- Carrier François Martin
- Carroll Ida
- Carson Gail
- Casanova Maire-Laure
- CascĂŁo Mariana
- Casey Siobhan
- Casimiro José
- Cassandra Bailey
- Castanheira Nidyanara
- Castor-Alexandre Guylaine
- Castro Ivo
- Catarino Ana
- Catherine François-Xavier
- Cattaneo Paolo
- Cavalin Roberta
- Cavayas Alexandros
- Cely Lina Morales
- Cervantes-Gonzalez Minerva
- Chair Anissa
- Chakveatze Catherine
- Chan Adrienne
- Chand Meera
- Chantalat Auger Christelle
- Chapplain Jean-Marc
- Charpentier Charlotte
- Chas Julie
- Chavez-Iniquez Jonathan Samuel
- Che Kamaruddin Zul Amali
- Chen Anjellica
- Chen Yih-Sharng
- Chenard LĂ©o
- Cheng Matthew Pellan
- Cheret Antoine
- Chia Jack Song
- Chiarabini Thibault
- Chica Julian
- Chidambaram Suresh Kumar
- Chirouze Catherine
- Chiumello Davide
- Cho Sung-Min
- Choileain Orna Ni
- Cholley Bernard
- Chopin Marie-Charlotte
- Chow Ting Soo
- Chow Yock Ping
- Chua Hiu Jian
- Chua Jonathan
- Chávez Iñiguez Jonathan Samuel
- Cidade Jose Pedro
- Citarella Barbara Wanjiru
- Citarella Barbara Wanjiru
- Ciullo Anna
- Clarke Jennifer
- Claure-Del Granado Rolando
- Claure-Del Granado Rolando
- Clohisey Sara
- Cobb Perren J.
- Codan Cassidy
- Cody Caitriona
- Coelho Alexandra
- Coles Jennifer
- Coles Megan
- Colin Gwenhaël
- Collins Michael
- Colombo Sebastiano Maria
- Combs Pamela
- Connolly Jennifer
- Connor Marie
- Conrad Anne
- Conway Elaine
- Cooke Graham S.
- Copland Mary
- Cordel Hugues
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- Cornelis Sabine
- Cornet Alexander Daniel
- Corpuz Arianne Joy
- Cortegiani Andrea
- Corvaisier Grégory
- Couffignal Camille
- Couffin-Cadiergues Sandrine
- Courtois Roxane
- Cousse Stéphanie
- Croonen Sabine
- Crowl Gloria
- Crump Jonathan
- Cruz BermĂşdez Juan Luis
- Cruz Claudina
- Csete Marc
- Cullen Ailbhe
- Curley Gerard
- Curlier Elodie
- Curran Colleen
- Custodio Paula
- D'Ortenzio Eric
- da Silva Filipe Ana
- Da Silva Fernanda Dias
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- Dabaliz Al-Awwab
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- Dalton Jo
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- Damas Juliana
- Daneman Nick
- Daniel Corinne
- Dankwa Emmanuelle A.
- Dantas Jorge
- de Loughry Gillian
- De Montmollin Etienne
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- de Silva Thushan
- de Vries Peter
- Dean David
- Debard Alexa
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- Dechert William
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- Dell'Amore Andrea
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- Deplanque Dominique
- Depuydt Pieter
- Desai Mehul
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- Devouge Eglantine Ferrand
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- Diallo Alpha
- Diamantis Sylvain
- Diaz Juan Jose
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- Dimet JĂ©rĂ´me
- Dinot Vincent
- Diop Fara
- Diouf Alphonsine
- Dishon Yael
- Djossou FĂ©lix
- Docherty Annemarie B.
- Doherty Helen
- Donnelly Christl A.
- Donnelly Maria
- Donohue Chloe
- Donohue Sean
- Donohue Yoann
- Doran Peter
- Dorival CĂ©line
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- Durham Lucian
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- Edwards Eleanor
- Egan Siobhan
- El Sanharawi Mohammed
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- Eloy Philippine
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- Endo Tomoyuki
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- Epaulard Olivier
- Escher Martina
- Esperatti Mariano
- Esperou Hélène
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- EstevĂŁo JoĂŁo
- Etienne Manuel
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- Everding Anna Greti
- Evers Mirjam
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- Fabre Marc
- Faheem Amna
- Fahy Arabella
- Fairfield Cameron J.
- Faria Pedro
- Fateena Hanan
- Fatoni Arie Zainul
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- Favory Raphaël
- Fayed Mohamed
- Feely Niamh
- Feeney Laura
- Fernandes Jorge
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- Ferraz Mário
- Ferreira Benigno
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- Fraser Christophe
- Fraser John F.
- Freire Marcela Vieira
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- Fukuda Masahiro
- G Argin
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- Greenhalf William
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- Hamidfar Rebecca
- Hammond Naomi
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- Harrison Janet
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- Opavsky Anne
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- Orozco-Chamorro Claudia Milena
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- Peariasamy Kalaiarasu
- Peek Giles J.
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- Postma Douwe F.
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- Powis Jeff
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- Prebensen Christian
- Preiser Jean-Charles
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- Quraishi Mohammed
- Qutishat Fadi
- Rabaud Christian
- Rafael Aldo
- Rafiq Marie
- Rahardjani Mutia
- Rahimi Amir Kamel
- Rahman Rozanah Abd
- Rainieri Fernando
- Rajahram Giri Shan
- Ramakrishnan Nagarajan
- Ramalho José
- Ramli Ahmad Afiq
- Rammaert Blandine
- Ramos Grazielle Viana
- Ranjan Ritika
- Rapp Christophe
- Rasmin Menaldi
- Ravi Tharmini
- Real Andre
- Rebaudet Stanislas
- Redl Sarah
- Reeve Brenda
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- Reid Liadain
- Reikvam Dag Henrik
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- Revest Matthieu
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- Tagherset Lysa
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- Tanaka Taku
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- Taufik M Azhari
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- Thomson David
- Thomson Emma C.
- Thorpe Mathew
- Thwaites Ryan S.
- Tierney Paul
- Tieroshyn Vadim
- Timashev Peter S.
- Timsit Jean-François
- Tirupakuzhi Vijayaraghavan Bharath Kumar
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- Turmel Jean-Marie
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- Twardowski Pawel
- Téoulé François
- Udy Andrew
- Ullrich Roman
- Uribe Alberto
- Usman Asad
- Uva Maria Sousa
- Uyeki Timothy M.
- Vajdovics Cristinava
- Val-Flores LuĂs
- Valran Amélie
- Van de Velde Stijn
- van den Berge Marcel
- van der Palen Job
- van der Valk Paul
- Van Der Vekens Nicky
- Van der Voort Peter
- Van Der Werf Sylvie
- van Gulik Laura
- Van Hattem Jarne
- van Netten Carolien
- van Veen Ilonka
- Vanel Noémie
- Vanoverschelde Henk
- Varghese Pooja
- Varrone Michael
- Vasudayan Shoban Raj
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- Vecham Pavan Kumar
- Veeran Shaminee
- Veislinger Aurélie
- Vencken Sebastian
- Ventura Sara
- Verbon Annelies
- Vidal José Ernesto
- Vieira CĂ©sar
- Villanueva Joy Ann
- Villoldo Andrea
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- Vitiello Chiara
- Vonkeman Harald
- Vuotto Fanny
- Wahab Noor Hidayu
- Wahab Suhaila Abdul
- Wahid Nadirah Abdul
- Wainstein Marina
- Wainstein Marina
- Walsh Laura
- Wang Chih-Hsien
- Webb Steve
- Wei Jia
- Wen Tan Pei
- Wesselius Sanne
- Wham Murray
- Whelan Bryan
- White Nicole
- Wicky Paul Henri
- Wiedemann Aurélie
- Wijaya Surya Otto
- Wille Keith
- Willems Sue
- Williams Bailey
- Williams Patricia J.
- Williams Virginie
- Wils Evert-Jan
- Wittman Jessica
- Wong Calvin
- Wong Teck Fung
- Wong Xin Ci
- Wong Yew Sing
- Xian Gan Ee
- Xian Lim Saio
- Xynogalas Ioannis
- Yamazaki Masaki
- Yang Toh Jordan Zhien
- Yarad Elizabeth
- Yazdanpanah Yazdan
- Yelnik CĂ©cile
- Yeoh Chian Hui
- Yerkovich Stephanie
- Yokoyama Toshiki
- Yonis Hodane
- Yousif Obada
- Zaaqoq Akram
- Zabbe Marion
- Zahid Masliza
- Zahran Maram
- Zambon Maria
- Zambrano Miguel
- Zanella Alberto
- Zaynah Nurul
- Zayyad Hiba
- Zoufaly Alexander
- Zucman David
- Publication venue
- Elsevier BV
- Publication date
- 26/05/2023
- Field of study
Introduction: Acute kidney injury (AKI) has been identified as one of the most common and significant problems in hospitalized patients with COVID-19. However, studies examining the relationship between COVID-19 and AKI in low- and low-middle income countries (LLMIC) are lacking. Given that AKI is known to carry a higher mortality rate in these countries, it is important to understand differences in this population. Methods: This prospective, observational study examines the AKI incidence and characteristics of 32,210 patients with COVID-19 from 49 countries across all income levels who were admitted to an intensive care unit during their hospital stay. Results: Among patients with COVID-19 admitted to the intensive care unit, AKI incidence was highest in patients in LLMIC, followed by patients in upper-middle income countries (UMIC) and high-income countries (HIC) (53%, 38%, and 30%, respectively), whereas dialysis rates were lowest among patients with AKI from LLMIC and highest among those from HIC (27% vs. 45%). Patients with AKI in LLMIC had the largest proportion of community-acquired AKI (CA-AKI) and highest rate of in-hospital death (79% vs. 54% in HIC and 66% in UMIC). The association between AKI, being from LLMIC and in-hospital death persisted even after adjusting for disease severity. Conclusions: AKI is a particularly devastating complication of COVID-19 among patients from poorer nations where the gaps in accessibility and quality of healthcare delivery have a major impact on patient outcomes