Effective refractive index tensor for weak field gravity

Gravitational lensing in a weak but otherwise arbitrary gravitational field can be described in terms of a 3 x 3 tensor, the "effective refractive index". If the sources generating the gravitational field all have small internal fluxes, stresses, and pressures, then this tensor is automatically isotropic and the "effective refractive index" is simply a scalar that can be determined in terms of a classic result involving the Newtonian gravitational potential. In contrast if anisotropic stresses are ever important then the gravitational field acts similarly to an anisotropic crystal. We derive simple formulae for the refractive index tensor, and indicate some situations in which this will be important.Comment: V1: 8 pages, no figures, uses iopart.cls. V2: 13 pages, no figures. Significant additions and clarifications. This version to appear in Classical and Quantum Gravit

Visual pattern recognition as a means to optimising building performance?

Visual pattern recognition as a means to optimising building performance

CMB-S4 Science Book, First Edition

This book lays out the scientific goals to be addressed by the next-generation ground-based cosmic microwave background experiment, CMB-S4, envisioned to consist of dedicated telescopes at the South Pole, the high Chilean Atacama plateau and possibly a northern hemisphere site, all equipped with new superconducting cameras. CMB-S4 will dramatically advance cosmological studies by crossing critical thresholds in the search for the B-mode polarization signature of primordial gravitational waves, in the determination of the number and masses of the neutrinos, in the search for evidence of new light relics, in constraining the nature of dark energy, and in testing general relativity on large scales

CMB-S4 Science Book, First Edition

This book lays out the scientific goals to be addressed by the next-generation ground-based cosmic microwave background experiment, CMB-S4, envisioned to consist of dedicated telescopes at the South Pole, the high Chilean Atacama plateau and possibly a northern hemisphere site, all equipped with new superconducting cameras. CMB-S4 will dramatically advance cosmological studies by crossing critical thresholds in the search for the B-mode polarization signature of primordial gravitational waves, in the determination of the number and masses of the neutrinos, in the search for evidence of new light relics, in constraining the nature of dark energy, and in testing general relativity on large scales

NBEA: Developmental disease gene with early generalized epilepsy phenotypes

NBEA is a candidate gene for autism, and de novo variants have been reported in neurodevelopmental disease (NDD) cohorts. However, NBEA has not been rigorously evaluated as a disease gene, and associated phenotypes have not been delineated. We identified 24 de novo NBEA variants in patients with NDD, establishing NBEA as an NDD gene. Most patients had epilepsy with onset in the first few years of life, often characterized by generalized seizure types, including myoclonic and atonic seizures. Our data show a broader phenotypic spectrum than previously described, including a myoclonic-astatic epilepsy-like phenotype in a subset of patients. Ann Neurol 2018;84:796-803