65 research outputs found
Noble gases in deepwater oils of the U.S. Gulf of Mexico
Author Posting. Š American Geophysical Union, 2018. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Geochemistry, Geophysics, Geosystems 19(11), (2018): 4218-4235. doi: 10.1029/2018GC007654Hydrocarbon migration and emplacement processes remain underconstrained despite the vast potential economic value associated with oil and gas. Noble gases provide information about hydrocarbon generation, fluid migration pathways, reservoir conditions, and the relative volumes of oil versus water in the subsurface. Produced gas HeâNeâArâKrâXe data from two distinct oil fields in the Gulf of Mexico (Genesis and HooverâDiana) are used to calibrate a model that takes into account both waterâoil solubility exchange and subsequent gas cap formation. Reconstructed noble gas signatures in oils reflect simple (twoâphase) oilâwater exchange imparted during migration from the source rock to the trap, which are subsequently modified by gas cap formation at current reservoir conditions. Calculated, oil to water volume ratios ( urn:x-wiley:15252027:media:ggge21714:ggge21714-math-0001) in Tertiaryâsourced oils from the HooverâDiana system are 2â3 times greater on average than those in the Jurassic sourced oils from the Genesis reservoirs. Higher urn:x-wiley:15252027:media:ggge21714:ggge21714-math-0002 in HooverâDiana versus Genesis can be interpreted in two ways: either (1) the Hoover reservoir interval has 2â3 times more oil than any of the individual Genesis reservoirs, which is consistent with independent estimates of oil in place for the respective reservoirs, or (2) Genesis oils have experienced longer migration pathways than HooverâDiana oils and thus have interacted with more water. The ability to determine a robust urn:x-wiley:15252027:media:ggge21714:ggge21714-math-0003, despite gas cap formation and possible gas cap loss, is extremely powerful. For example, when volumetric hydrocarbon ratios are combined with independent estimates of hydrocarbon migration distance and/or formation fluid volumes, this technique has the potential to differentiate between large and small oil accumulations.We thank ExxonMobil for funding and providing the samples. In addition, we thank James Scott and two anonymous reviewers for their comprehensive and constructive reviews, as well as Janne BlichertâToft for editorial handling.2019-04-1
Determining fluid migration and isolation times in multiphase crustal domains using noble gases
Geochemical characteristics in subsurface fluid systems provide a wealth of information about fluid sources, migration, and storage conditions. Determining the extent of fluid interaction (aquifer-hydrocarbon connectivity) is important for oil and gas production and waste storage applications, but is not tractable using traditional seismic methods. Furthermore, the residence time of fluids is critical in such systems and can vary from tens of thousands to billions of years. Our understanding of the transport length scales in multiphase systems, while equally important, is more limited. Noble gas data from the Rotliegend natural gas field, northern Germany, are used here to determine the length scale and isolation age of the combined water-gas system. We show that geologically bound volume estimates (i.e., gas to water volume ratios) match closed-system noble gas model predictions, suggesting that the Rotliegend system has remained isolated as a closed system since hydrocarbon formation. Radiogenic helium data show that fluid isolation occurred 63â129 m.y. after rock and/or groundwater deposition (ca. 300 Ma), which is consistent with known hydrocarbon generation from 250 to 140 Ma, thus corroborating long-term geologic isolation. It is critical that we have the ability to distinguish between fluid systems that, despite phase separation, have remained closed to fluid loss from those that have lost oil or gas phases. These findings are the first to demonstrate that such systems remain isolated and fully gas retentive on time scales >100 m.y. over >10 km length scales, and have broad implications for saline aquifer CO2 disposal site viability and hydrocarbon resource prediction, which both require an understanding of the length and time scales of crustal fluid transport pathways
Nitric oxide-independent vasodilator rescues heme-oxidized soluble guanylate cyclase from proteosomal degradation
Background: Nitric oxide (NO) is an essential vasodilator. In vascular diseases, oxidative stress attenuates NO signaling by both chemical scavenging of free NO and oxidation and down-regulation of its major intracellular receptor, the alpha/beta heterodimeric heme-containing soluble guanylate cyclase (sGC). Oxidation can also induce loss of sGC's heme and responsiveness to NO.
Results: sGC activators such as BAY 58-2667 bind to oxidized/heme-free sGC and reactivate the enzyme to exert disease-specific vasodilation. Here we show that oxidation-induced down-regulation of sGC protein extends to isolated blood vessels. Mechanistically, degradation was triggered through sGC ubiquitination and proteasomal degradation. The heme-binding site ligand, BAY 58-2667, prevented sGC ubiquitination and stabilized both alpha and beta subunits.
Conclusion: Collectively, our data establish oxidation-ubiquitination of sGC as a modulator of NO/cGMP signaling and point to a new mechanism of action for sGC activating vasodilators by stabilizing their receptor, oxidized/heme-free sGC
Vertically coupled double quantum dots in magnetic fields
Ground-state and excited-state properties of vertically coupled double
quantum dots are studied by exact diagonalization. Magic-number total angular
momenta that minimize the total energy are found to reflect a crossover between
electron configurations dominated by intra-layer correlation and ones dominated
by inter-layer correlation. The position of the crossover is governed by the
strength of the inter-layer electron tunneling and magnetic field. The magic
numbers should have an observable effect on the far infra-red optical
absorption spectrum, since Kohn's theorem does not hold when the confinement
potential is different for two dots. This is indeed confirmed here from a
numerical calculation that includes Landau level mixing. Our results take full
account of the effect of spin degrees of freedom. A key feature is that the
total spin, , of the system and the magic-number angular momentum are
intimately linked because of strong electron correlation. Thus jumps hand
in hand with the total angular momentum as the magnetic field is varied. One
important consequence of this is that the spin blockade (an inhibition of
single-electron tunneling) should occur in some magnetic field regions because
of a spin selection rule. Owing to the flexibility arising from the presence of
both intra-layer and inter-layer correlations, the spin blockade is easier to
realize in double dots than in single dots.Comment: to be published in Phys. Rev. B1
'Magic coins' and 'magic squares': the discovery of astrological sigils in the Oldenburg Letters
Enclosed in a 1673 letter to Henry Oldenburg were two drawings of a series of astrological sigils, coins and amulets from the collection of Strasbourg mathematician Julius Reichelt (1637â1719). As portrayals of particular medieval and early modern sigils are relatively rare, this paper will analyse the role of these medals in medieval and early modern medicine, the logic behind their perceived efficacy, and their significance in early modern astrological and cabalistic practice. I shall also demonstrate their change in status in the late seventeenth century from potent magical healing amulets tied to the mysteries of the heavens to objects kept in a cabinet for curiosos. The evolving perception of the purpose of sigils mirrored changing early modern beliefs in the occult influences of the heavens upon the body and the natural world, as well as the growing interests among virtuosi in collecting, numismatics and antiquities
Acclimation in plants - the Green Hub consortium
Acclimation is the capacity to adapt to environmental changes within the lifetime of an individual. This ability allows plants to cope with the continuous variation in ambient conditions to which they are exposed as sessile organisms. Because environmental changes and extremes are becoming even more pronounced due to the current period of climate change, enhancing the efficacy of plant acclimation is a promising strategy for mitigating the consequences of global warming on crop yields. At the cellular level, the chloroplast plays a central role in many acclimation responses, acting both as a sensor of environmental change and as a target of cellular acclimation responses. In this Perspective article, we outline the activities of the Green Hub consortium funded by the German Science Foundation. The main aim of this research collaboration is to understand and strategically modify the cellular networks that mediate plant acclimation to adverse environments, employing Arabidopsis, tobacco (Nicotiana tabacum) and Chlamydomonas as model organisms. These efforts will contribute to 'smart breeding' methods designed to create crop plants with improved acclimation properties. To this end, the model oilseed crop Camelina sativa is being used to test modulators of acclimation for their potential to enhance crop yield under adverse environmental conditions. Here we highlight the current state of research on the role of gene expression, metabolism and signalling in acclimation, with a focus on chloroplast-related processes. In addition, further approaches to uncovering acclimation mechanisms derived from systems and computational biology, as well as adaptive laboratory evolution with photosynthetic microbes, are highlighted
Acclimation in plants â the Green Hub consortium
Acclimation is the capacity to adapt to environmental changes within the lifetime of an individual. This ability allows plants to cope with the continuous variation in ambient conditions to which they are exposed as sessile organisms. Because environmental changes and extremes are becoming even more pronounced due to the current period of climate change, enhancing the efficacy of plant acclimation is a promising strategy for mitigating the consequences of global warming on crop yields. At the cellular level, the chloroplast plays a central role in many acclimation responses, acting both as a sensor of environmental change and as a target of cellular acclimation responses. In this Perspective article, we outline the activities of the Green Hub consortium funded by the German Science Foundation. The main aim of this research collaboration is to understand and strategically modify the cellular networks that mediate plant acclimation to adverse environments, employing Arabidopsis, tobacco (Nicotiana tabacum) and Chlamydomonas as model organisms. These efforts will contribute to âsmart breedingâ methods designed to create crop plants with improved acclimation properties. To this end, the model oilseed crop Camelina sativa is being used to test modulators of acclimation for their potential to enhance crop yield under adverse environmental conditions. Here we highlight the current state of research on the role of gene expression, metabolism and signalling in acclimation, with a focus on chloroplastârelated processes. In addition, further approaches to uncovering acclimation mechanisms derived from systems and computational biology, as well as adaptive laboratory evolution with photosynthetic microbes, are highlighted.Deutsche Forschungsgemeinschaft
http://dx.doi.org/10.13039/501100001659Peer Reviewe
Post-stroke inhibition of induced NADPH oxidase type 4 prevents oxidative stress and neurodegeneration
Ischemic stroke is the second leading cause of death worldwide. Only one moderately effective therapy exists, albeit with contraindications that exclude 90% of the patients. This medical need contrasts with a high failure rate of more than 1,000 pre-clinical drug candidates for stroke therapies. Thus, there is a need for translatable mechanisms of neuroprotection and more rigid thresholds of relevance in pre-clinical stroke models. One such candidate mechanism is oxidative stress. However, antioxidant approaches have failed in clinical trials, and the significant sources of oxidative stress in stroke are unknown. We here identify NADPH oxidase type 4 (NOX4) as a major source of oxidative stress and an effective therapeutic target in acute stroke. Upon ischemia, NOX4 was induced in human and mouse brain. Mice deficient in NOX4 (Nox4(-/-)) of either sex, but not those deficient for NOX1 or NOX2, were largely protected from oxidative stress, blood-brain-barrier leakage, and neuronal apoptosis, after both transient and permanent cerebral ischemia. This effect was independent of age, as elderly mice were equally protected. Restoration of oxidative stress reversed the stroke-protective phenotype in Nox4(-/-) mice. Application of the only validated low-molecular-weight pharmacological NADPH oxidase inhibitor, VAS2870, several hours after ischemia was as protective as deleting NOX4. The extent of neuroprotection was exceptional, resulting in significantly improved long-term neurological functions and reduced mortality. NOX4 therefore represents a major source of oxidative stress and novel class of drug target for stroke therapy
Report from NA49
The most recent data of NA49 on hadron production in nuclear collisions at
CERN SPS energies are presented. Anomalies in the energy dependence of pion and
kaon production in central Pb+Pb collisions are observed. They suggest that the
onset of deconfinement is located at about 30 AGeV. Large multiplicity and
transverse momentum fluctuations are measured for collisions of intermediate
mass systems at 158 AGeV. The need for a new experimental programme at the CERN
SPS is underlined.Comment: invited talk presented at Quark Matter 2004, 10 page
- âŚ