131 research outputs found
Phonon quantum nondemolition measurements in nonlinearly coupled optomechanical cavities
In the field of cavity optomechanics, proposals for quantum nondemolition (QND) measurements of phonon number provide a promising avenue by which one can study the quantum nature of nanoscale mechanical resonators. Here we investigate these QND measurements for an optomechanical system whereby quadratic coupling arises due to shared symmetries between a single optical resonance and a mechanical mode. We establish a relaxed limit on the amount of linear coupling that can exist in this type of system while still allowing for QND measurements of mechanical Fock states. The ability to perform optomechanical QND measurements of this nature would allow one to probe the decoherence of these mesoscopic states, providing an experimental test bed for quantum collapse theories
Observation and interpretation of motional sideband asymmetry in a quantum electro-mechanical device
Quantum electro-mechanical systems offer a unique opportunity to probe
quantum noise properties in macroscopic devices, properties which ultimately
stem from the Heisenberg Uncertainty Principle. A simple example of this is
expected to occur in a microwave parametric transducer, where mechanical motion
generates motional sidebands corresponding to the up and down
frequency-conversion of microwave photons. Due to quantum vacuum noise, the
rates of these processes are expected to be unequal. We measure this
fundamental imbalance in a microwave transducer coupled to a radio-frequency
mechanical mode, cooled near the ground state of motion. We also discuss the
subtle origin of this imbalance: depending on the measurement scheme, the
imbalance is most naturally attributed to the quantum fluctuations of either
the mechanical mode or of the electromagnetic field
Generalized nonreciprocity in an optomechanical circuit via synthetic magnetism and reservoir engineering
Synthetic magnetism has been used to control charge neutral excitations for
applications ranging from classical beam steering to quantum simulation. In
optomechanics, radiation-pressure-induced parametric coupling between optical
(photon) and mechanical (phonon) excitations may be used to break time-reversal
symmetry, providing the prerequisite for synthetic magnetism. Here we design
and fabricate a silicon optomechanical circuit with both optical and mechanical
connectivity between two optomechanical cavities. Driving the two cavities with
phase-correlated laser light results in a synthetic magnetic flux, which in
combination with dissipative coupling to the mechanical bath, leads to
nonreciprocal transport of photons with 35dB of isolation. Additionally,
optical pumping with blue-detuned light manifests as a particle non-conserving
interaction between photons and phonons, resulting in directional optical
amplification of 12dB in the isolator through direction. These results indicate
the feasibility of utilizing optomechanical circuits to create a more general
class of nonreciprocal optical devices, and further, to enable novel
topological phases for both light and sound on a microchip.Comment: 18 pages, 8 figures, 4 appendice
Attitudinal and socio-structural determinants of cervical cancer screening and HPV vaccination uptake: a quantitative multivariate analysis
Aim: The introduction of the human papillomavirus (HPV) vaccine enables for the first time in the history of cancer prevention the possibility of combating the major cause of a cancer even before its onset. The secondary prevention measure of cervical cancer screening has thus been complemented by a primary prevention measure. The aim of this study is to analyse the determinants of uptake of preventive measures against cervical cancer as a basis for comparing the determinants of screening attendance with those of HPV vaccination attendance. Subject and methods: A population-based representative survey comprising 760 randomly selected women aged 14 to 65 was performed in the German federal state of Mecklenburg-Western Pomerania. Prevention behaviour, attitudes towards cervical cancer screening and HPV vaccination, and knowledge about cervical cancer and HPV were investigated by means of a structured questionnaire. Descriptive analyses and multivariate logistic regression analyses were conducted to identify the determinants of screening and HPV vaccine uptake. Results: Attendance both at screening and at HPV vaccination was best predicted by attitudinal factors. Positive connotations of cancer prevention measures and utility expectations, fear of cancer and high subjective risk perception were conducive to attendance at screening and HPV vaccination. Screening attendance was less regular among women of lower socioeconomic status. In contrast, HPV vaccination uptake was higher for young women with lower educational attainment and lower social class. Knowledge did not impact prevention behaviour significantly. There is no trade-off between screening and vaccination attendance; the vast majority of respondents was aware of the necessity of regular screening attendance even when vaccinated against HPV. Conclusions: Uptake rates for existing primary and secondary prevention measures against cervical cancer can be enhanced by fostering perceptions of utility and positive connotations of regular screening and becoming vaccinated against HPV. Elderly women in particular should be encouraged to attend screening by means of a recall system. Given the low overall level of knowledge about cervical cancer and its risk factors, there is a need for education about the necessity and utility of prevention to reach women of all social classes
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Molecular Mechanisms of the Efficacy of Cold Atmospheric Pressure Plasma (CAP) in Cancer Treatment
Recently, the potential use of cold atmospheric pressure plasma (CAP) in cancer treatment has gained increasing interest. Especially the enhanced selective killing of tumor cells compared to normal cells has prompted researchers to elucidate the molecular mechanisms for the efficacy of CAP in cancer treatment. This review summarizes the current understanding of how CAP triggers intracellular pathways that induce growth inhibition or cell death. We discuss what factors may contribute to the potential selectivity of CAP towards cancer cells compared to their non-malignant counterparts. Furthermore, the potential of CAP to trigger an immune response is briefly discussed. Finally, this overview demonstrates how these concepts bear first fruits in clinical applications applying CAP treatment in head and neck squamous cell cancer as well as actinic keratosis. Although significant progress towards understanding the underlying mechanisms regarding the efficacy of CAP in cancer treatment has been made, much still needs to be done with respect to different treatment conditions and comparison of malignant and non-malignant cells of the same cell type and same donor. Furthermore, clinical pilot studies and the assessment of systemic effects will be of tremendous importance towards bringing this innovative technology into clinical practice. © 2020 by the authors. Licensee MDPI, Basel, Switzerland
Recommended from our members
Molecular mechanisms of the efficacy of cold atmospheric pressure plasma (CAP) in cancer treatment
Recently, the potential use of cold atmospheric pressure plasma (CAP) in cancer treatment has gained increasing interest. Especially the enhanced selective killing of tumor cells compared to normal cells has prompted researchers to elucidate the molecular mechanisms for the efficacy of CAP in cancer treatment. This review summarizes the current understanding of how CAP triggers intracellular pathways that induce growth inhibition or cell death. We discuss what factors may contribute to the potential selectivity of CAP towards cancer cells compared to their non-malignant counterparts. Furthermore, the potential of CAP to trigger an immune response is briefly discussed. Finally, this overview demonstrates how these concepts bear first fruits in clinical applications applying CAP treatment in head and neck squamous cell cancer as well as actinic keratosis. Although significant progress towards understanding the underlying mechanisms regarding the efficacy of CAP in cancer treatment has been made, much still needs to be done with respect to different treatment conditions and comparison of malignant and non-malignant cells of the same cell type and same donor. Furthermore, clinical pilot studies and the assessment of systemic effects will be of tremendous importance towards bringing this innovative technology into clinical practice. © 2020 by the authors. Licensee MDPI, Basel, Switzerland
The 2017 Plasma Roadmap: Low temperature plasma science and technology
Journal of Physics D: Applied Physics published the first Plasma Roadmap in 2012 consisting of the individual perspectives of 16 leading experts in the various sub-fields of low temperature plasma science and technology. The 2017 Plasma Roadmap is the first update of a planned series of periodic updates of the Plasma Roadmap. The continuously growing interdisciplinary nature of the low temperature plasma field and its equally broad range of applications are making it increasingly difficult to identify major challenges that encompass all of the many sub-fields and applications. This intellectual diversity is ultimately a strength of the field. The current state of the art for the 19 sub-fields addressed in this roadmap demonstrates the enviable track record of the low temperature plasma field in the development of plasmas as an enabling technology for a vast range of technologies that underpin our modern society. At the same time, the many important scientific and technological challenges shared in this roadmap show that the path forward is not only scientifically rich but has the potential to make wide and far reaching contributions to many societal challenges.I Adamovich et al 2017 J. Phys. D: Appl. Phys. 50 32300
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