Integrative approaches to guide conservation decisions:Using genomics to define conservation units and functional corridors

Climate change and increasing habitat loss greatly impact species survival, requiring range shifts, phenotypic plasticity and/or evolutionary change for long-term persistence, which may not readily occur unaided in threatened species. Therefore, defining conservation actions requires a detailed assessment of evolutionary factors. Existing genetic diversity needs to be thoroughly evaluated and spatially mapped to define conservation units (CUs) in an evolutionary context, and we address that here. We also propose a multidisciplinary approach to determine corridors and functional connectivity between CUs by including genetic diversity in the modelling while controlling for isolation by distance and phylogeographic history. We evaluate our approach on a Near Threatened Iberian endemic rodent by analysing genotyping-by-sequencing (GBS) genomic data from 107 Cabrera voles (Microtus cabrerae), screening the entire species distribution to define categories of CUs and their connectivity: We defined six management units (MUs) which can be grouped into four evolutionarily significant units (ESUs) and three (putatively) adaptive units (AUs). We demonstrate that the three different categories of CU can be objectively defined using genomic data, and their characteristics and connectivity can inform conservation decision-making. In particular, we show that connectivity of the Cabrera vole is very limited in eastern Iberia and that the pre-Pyrenean and part of the Betic geographic nuclei contribute the most to the species genetic diversity. We argue that a multidisciplinary framework for CU definition is essential and that this framework needs a strong evolutionary basis. © 2018 John Wiley & Sons Lt

Telemedicine as an Untapped Opportunity for Parkinson's Nurses Training in Personalized Care Approaches

(1) Background: Parkinson nurses (PN) take over important functions in the telemedical care of person's with Parkinson's disease (PwPs). This requires special competencies that have so far been largely unexplored. The aim of the article is to identify competencies of PN operating in a personalized care model. (2) Methods: This study employed a qualitative approach. Based on the competency framework for telenursing, PN were asked about their competencies using a qualitative online survey. (3) Results: The results show that PN need competencies on a personal and organizational level, as well as in the relationship with PwPs. PN have developed these skills through professional exchange, training, and personal experience. In addition, both hindering and beneficial factors for the development of competencies could be identified. (4) Conclusions: Competency development for telemedical care is complex and must be designed and promoted in a targeted manner

Telemedicine as an Untapped Opportunity for Parkinson's Nurses Training in Personalized Care Approaches

(1) Background: Parkinson nurses (PN) take over important functions in the telemedical care of person’s with Parkinson’s disease (PwPs). This requires special competencies that have so far been largely unexplored. The aim of the article is to identify competencies of PN operating in a personalized care model. (2) Methods: This study employed a qualitative approach. Based on the competency framework for telenursing, PN were asked about their competencies using a qualitative online survey. (3) Results: The results show that PN need competencies on a personal and organizational level, as well as in the relationship with PwPs. PN have developed these skills through professional exchange, training, and personal experience. In addition, both hindering and beneficial factors for the development of competencies could be identified. (4) Conclusions: Competency development for telemedical care is complex and must be designed and promoted in a targeted manner

Response to Letter by Saenz-Farret et al. on "Rating Scales for Behavioral Symptoms in Huntington's Disease: Critique and Recommendations"

Stress-related psychiatric disorders across the life spa

Matroid matching : the power of local search

We consider the classical matroid matching problem. Unweighted matroid matching for linearly represented matroids was solved by Lovász, and the problem is known to be intractable for general matroids. We present a polynomial-time approximation scheme for unweighted matroid matching for general matroids. In contrast, we show that natural linear-programming relaxations that have been studied have an $\Omega(n)$ integrality gap, and, moreover, $\Omega(n)$ rounds of the Sherali--Adams hierarchy are necessary to bring the gap down to a constant. More generally, for any fixed $k \geq 2$ and $\epsilon>0$, we obtain a $(k/2+\epsilon)$-approximation for matroid matching in $k$-uniform hypergraphs, also known as the matroid $k$-parity problem. As a consequence, we obtain a $(k/2+\epsilon)$-approximation for the problem of finding the maximum-cardinality set in the intersection of $k$ matroids. We also give a $3/2$-approximation for the weighted version of a special case of matroid matching, the matchoid problem

Transducer-based evaluation of tremor

The International Parkinson and Movement Disorder Society established a task force on tremor that reviewed the use of transducer-based measures in the quantification and characterization of tremor. Studies of accelerometry, electromyography, activity monitoring, gyroscopy, digitizing tablet-based measures, vocal acoustic analysis, and several other transducer-based methods were identified by searching PubMed.gov. The availability, use, acceptability, reliability, validity, and responsiveness were reviewed for each measure using the following criteria: (1) used in the assessment of tremor; (2) used in published studies by people other than the developers; and (3) adequate clinimetric testing. Accelerometry, gyroscopy, electromyography, and digitizing tablet-based measures fulfilled all three criteria. Compared to rating scales, transducers are far more sensitive to changes in tremor amplitude and frequency, but they do not appear to be more capable of detecting a change that exceeds random variability in tremor amplitude (minimum detectable change). The use of transducer-based measures requires careful attention to their limitations and validity in a particular clinical or research setting. © 2016 International Parkinson and Movement Disorder Society. © 2016 International Parkinson and Movement Disorder Societ

Transducer-based evaluation of tremor

10.1002/mds.26671Movement Disorders3191327-1336MOVD

Rating scales for behavioral symptoms in Huntington's disease: Critique and recommendations

Stress-related psychiatric disorders across the life spa

Parkinson's Disease Subtypes: Critical Appraisal and Recommendations

BACKGROUND: In Parkinson’s disease (PD), there is heterogeneity in the clinical presentation and underlying biology. Research on PD subtypes aims to understand this heterogeneity with potential contribution for the knowledge of disease pathophysiology, natural history and therapeutic development. There have been many studies of PD subtypes but their impact remains unclear with limited application in research or clinical practice. OBJECTIVE: To critically evaluate PD subtyping systems. METHODS: We conducted a systematic review of PD subtypes, assessing the characteristics of the studies reporting a subtyping system for the first time. We completed a critical appraisal of their methodologic quality and clinical applicability using standardized checklists. RESULTS: We included 38 studies. The majority were cross-sectional (n = 26, 68.4%), used a data-driven approach (n = 25, 65.8%), and non-clinical biomarkers were rarely used (n = 5, 13.1%). Motor characteristics were the domain most commonly reported to differentiate PD subtypes. Most of the studies did not achieve the top rating across items of a Methodologic Quality checklist. In a Clinical Applicability Checklist, the clinical importance of differences between subtypes, potential treatment implications and applicability to the general population were rated poorly, and subtype stability over time and prognostic value were largely unknown. CONCLUSION: Subtyping studies undertaken to date have significant methodologic shortcomings and most have questionable clinical applicability and unknown biological relevance. The clinical and biological signature of PD may be unique to the individual, rendering PD resistant to meaningful cluster solutions. New approaches that acknowledge the individual-level heterogeneity and that are more aligned with personalized medicine are needed

Architectural Regeneration Through Public Education in Portugal

The architectural regeneration of historic school buildings in Portugal clearly illustrates how different architects may use the core principles of architectural regeneration to successfully adapt schools to meet twenty‐first century educational requirements. The liceus are purpose‐designed secondary schools, built from the late nineteenth century up until the democratic revolution in 1974. The significance of early liceus is reflected in their monumental mass and façade design. As educational practices change, so are these buildings required to adapt. As in the case of new architectural design, there was no single way to do this and architects favoured different approaches. This case study shows that, despite this variety, the awareness of the existing building values and conservation principles in each case generated a greater desire to act ethically and consider cultural and social sustainability