Les fistules congenitales de la levre inferieure : a propos d’une observation

Objectifs : Les fistules congénitales de la lèvre inférieure sont rares pouvant être soit isolées soit associées à d’autres malformations notamment les fentes vélopalatines. Le but de notre étude est de rappeler à travers une observation les éléments épidémiologiques, cliniques, étiopathogéniques et les modalités thérapeutiques de cette affection.Méthode : Nous présentons le cas d’une fillette âgée de 9 ans qui présente une double fistule labiale inférieure sans autres malformations associées, mais l’enquête étiologique retrouve 10 cas similaires dans la famille.Résultats : une excision complète du trajet fistuleux a été réalisée chez notre patiente avec un bon résultat esthétique et une absence de récidive après un recul d’une année.Conclusion : la découverte de fistules labiales inférieures impose un bilan complet à la recherche de malformations associées ainsi qu’une enquête familiale.Mots-clés : fistules labiales - malformations congénitalesPurpose of study: Congenital lower lip fistulae are rare and can be either isolated or associated with other malformations, namely soft palatal clefts. Our study aims at recalling through an observation the epidemiological, clinical etiopathogenic elements and the therapeutic courses of this disorder.Method: We present the case of a 9-year old little girl with a lower lip double fistula and no other accompanying malformation. The etiological study reveals 10 similar cases within the family.Results: A complete excision of the fistulous path has been carried out on our patient with a good esthetic result and the absence of a recurrence a year later.Conclusion: Finding out lower lip fistulae requires a thorough check up for associated malformations as well as a family inquiry.Key-words: lip fistulae- congenital malformation

Craniofacial Cephalometric Characteristics and Open Bite Deformity in Individuals with Amelogenesis Imperfecta-A Systematic Review and Meta-Analysis.

BACKGROUND Individuals with amelogenesis imperfecta (AI) often present with malocclusions, especially a dental or skeletal anterior open bite (AOB). OBJECTIVES To evaluate the craniofacial characteristics in individuals with AI. MATERIAL AND METHODS A systematic literature search was conducted with the PubMed, Web of Science, Embase and Google Scholar databases to identify studies relating to the cephalometric characteristics of individuals with AI, without any language or publication date restrictions. The grey literature was searched using Google Scholar, Opengrey and Worldcat. Only studies with a suitable control group for comparison were included. Data extraction and a risk of bias assessment were carried out. A meta-analysis was performed using the random effects model for cephalometric variables that were evaluated in at least three studies. RESULTS The initial literature search yielded 1857 articles. Following the removal of duplicates and a screening of the records, seven articles were included in the qualitative synthesis, representing a total of 242 individuals with AI. Four studies were included in the quantitative synthesis. The meta-analysis results showed that individuals with AI present a smaller SNB angle and larger ANB angle than those of control groups in the sagittal plane. In the vertical plane, those with AI present a smaller overbite and larger intermaxillary angle than those without AI. No statistically significant differences were found for the SNA angle when comparing the two groups. CONCLUSIONS Individuals with AI seem to present with more vertical craniofacial growth, leading to an increased intermaxillary angle and decreased overbite. This possibly leads to a more retrognathic mandible with a larger ANB angle due to an anticipated posterior mandibular rotation

La diffusion de l'oléiculture dans les vallées du Moyen Atlas, un moyen pour protéger et restaurer les forêts (Khenifra, Maroc) -

La sédentarisation des populations semi-nomades dans des communes du Moyen Atlas (Maroc) s'accompagne d'une régression rapide des surfaces forestières. Dans certains douars, près de 70% des terrains boisés ont été détruits au cours des dernières décennies ou sont fortement dégradés. Trois facteurs expliqueraient ce repli : le surpâturage, les prélèvements délictueux de bois et depuis 1992, la répétition des sécheresses. Pour préserver les ressources forestières, le Haut Commissariat des Eaux et Forêts et à la lutte contre la désertification restaure des sols érodés en installant des pinèdes, prend en charge la gestion des forêts de protection et finance des campagnes de plantation d'arbres fruitiers à travers tout le pays. L'objet du présent article est de mieux comprendre les relations entre les populations locales et leurs forêts, et de s'interroger sur l'efficacité ressentie des politiques publiques en matière de protection des ressources forestière

Grande tache pigmentée pileuse révélant une forme familiale de la maladie de Von Recklinghausen

La neurofibromatose de type 1 (NF1) ou maladie de Von Recklinghausen appartient au groupe de maladies appelées phacomatoses. C'est une affection autosomique dominante relativement rare. La NF1 est caractérisée par une extrême variabilité clinique que l'on retrouve également au sein d'une même famille. Le tableau clinique de la NF1 associe, le plus souvent, de multiples taches café au lait, des lentigines axillaires ou inguinales, des neurofibromes cutanés et des nodules de Lisch. Les difficultés d'apprentissage sont fréquentes et peuvent être graves dans certaines formes cliniques. Il est important de détecter précocement les neurofibromes plexiformes, les gliomes intracérébraux, les tumeurs des gaines nerveuses, les anomalies vasculaires et les dysplasies osseuses. L'évolution est imprévisible ce qui rend le pronostic incertain par une éventuelle survenue dedégénérescence malignes. Nous rapportons ici l'observation d'une grande tache cutanée pigmentée pilleuse de découverte fortuite qui nous a révélé deux cas familiaux de neurofibromatose 1 d'expression différente

Epidermal growth factor receptor mediates the vascular dysfunction but not the remodeling induced by aldosterone/salt

Pathophysiological aldosterone (aldo)/mineralocorticoid receptor signaling has a major impact on the cardiovascular system, resulting in hypertension and vascular remodeling. Mineralocorticoids induce endothelial dysfunction, decreasing vasorelaxation in response to acetylcholine and increasing the response to vasoconstrictors. Activation of the epidermal growth factor receptor (EGFR) is thought to mediate the vascular effects of aldo, but this has yet to be demonstrated in vivo. In this study, we analyzed the molecular and functional vascular consequences of aldo-salt challenge in the waved 2 mouse, a genetic model with a partial loss of EGFR tyrosine kinase activity. Deficient EGFR activity is associated with global oxidative stress and endothelial dysfunction. A decrease in EGFR activity did not affect the arterial wall remodeling process induced by aldo-salt. By contrast, normal EGFR activity was required for the aldo-induced enhancement of phenylephrine- and angiotensin II-mediated vasoconstriction. In conclusion, this in vivo study demonstrates that EGFR plays a key role in aldosterone-mediated vascular reactivity

Quality of life in breast cancer patients with cancer treatment-related cardiac dysfunction: a qualitative study

Contains fulltext : 251384.pdf (Publisher’s version ) (Open Access)BACKGROUND: Although improved breast cancer (BC) treatment has decreased mortality, these anti-cancer regimens may have serious cardiovascular side effects that affect patients' long-term prognosis and quality of life (QoL). BC patients with cancer treatment-related cardiac dysfunction (CTRCD) can suffer from a variety of symptoms, such as dyspnoea and fatigue. The impact of CTRCD after BC treatment on patients' daily life has not been qualitatively explored yet. AIMS: This study aims to explore the influence of CTRCD on QoL of women with BC, as defined by the concept of positive health. Second, we aim to evaluate the personal experience with cardiac surveillance during the BC trajectory. METHODS AND RESULTS: A qualitative study with semi-structured interviews was conducted and thematically analysed to explore the QoL and healthcare experiences of BC patients with CTRCD. Twelve patients participated in this study. Five themes are selected in response to the study objective: (i) patients: overwhelming fatigue, (ii) patients: mental burden of anxiety, (iii) social setting: lack of understanding and acceptance, (iv) medical specialists: lack of knowledge and acknowledgement, and (v) patients: need for personalized care. CONCLUSION: This study identified core components of the impact CTRCD has on the QoL of BC patients. Patients experienced an increased health-related burden due to CTRCD, affecting their physical, social, and psychosocial well-being. Healthcare experiences were largely affected by a lack of acknowledgement and professional communication. Patients underlined the need for personalized care during follow-up

The development of an emphatic educator : implementing psychodynamic pedagogy through drama in education

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A cytomegalovirus-based vaccine provides long-lasting protection against lethal Ebola virus challenge after a single dose

This is the author accepted manuscript. The final version is available fromElsevier via the DOI in this record.Ebola virus (Zaire ebolavirus; EBOV) is a highly lethal hemorrhagic disease virus that most recently was responsible for two independent 2014 outbreaks in multiple countries in Western Africa, and the Democratic Republic of the Congo, respectively. Herein, we show that a cytomegalovirus (CMV)-based vaccine provides durable protective immunity from Ebola virus following a single vaccine dose. This study has implications for human vaccination against ebolaviruses, as well as for development of a 'disseminating' vaccine to target these viruses in wild African great apes.We thank Dr U. Koszinowski (Max von Pettenkofer-Institute, Ludwig-Maximilians-University, Germany) for providing the pSMfr3 MCMV BAC, and Dr D. Court (NCI-Frederick, MD) for providing the lambda-based recombination system used to construct the original MCMV/ZEBOV-NPCTL construct. We appreciate K. Marshall (VGTI, OR) and J. Bailey (NIAID, MT) for their organization and coordination of animals used in the study. We also thank the members of Rocky Mountain Veterinary Branch (DIR, NIAID, NIH) for assistance with animal care. Finally, we thank Drs H. Ebihara (DIR, NIAID, NIH), A. Marzi (DIR, NIAID, NIH), P. Barry (University of California at Davis, CA), M. Cranfield (Mountain Gorilla Veterinary Project, Baltimore, MD) for insightful discussions. This study was supported by R21 (AI088442) and the Intramural Research Program of the NIAID, NIH; and University of Plymouth, School of Biomedical and Healthcare Sciences internal funding