Ni–Zn hydroxide-based bi-phase multiscale porous nanohybrids : physico-chemical properties

Please read abstract in the article.The Algerian minister programhttps://link.springer.com/journal/132042020-05-25hj2020Physic

Lower-limb lengths and angles in children older than six years: Reliability and reference values by EOS® stereoradiography

Lower-limb alignment in children is classically assessed clinically or based on conventional radiography, which is associated with projection bias. Low-dose biplanar radiography was described recently as an alternative to conventional imaging. The primary objective of this study was to assess the reliability of length and angle values inferred from 3D reconstructions in children seen in everyday practice. The secondary objective was to obtain reference values for goniometry parameters in children. The paediatric reliability study was done in 18 volunteers who were divided into three groups based on whether they were typically developing (TD) children, had skeletal development abnormalities, or had cerebral palsy. The reference data were obtained in 129 TD children. Each study participant underwent biplanar radiography with 3D reconstruction performed by experts and radiology technicians. Goniometry parameters were computed automatically. Reproducibility was assessed based on the intra-class coefficient (ICC) and the ISO 5725 standard (standard deviation of reproducibility, SDR). For length parameters, the ICCs ranged from 0.94 to 1.00 and the SDR from 2.1 to 3.5 mm. For angle parameters, the ICC and SDR ranges were 0.60–0.95 and 0.9°–4.6°, respectively. No significant differences were found across experts or radiology technicians. Age-specific reference data are reported. These findings confirm the reliability of low-dose biplanar radiography for assessing lower-limb parameters in children seen in clinical practice. In addition, the study provides reference data for commonly measured parameters

Convergent Evidence from Mouse and Human Studies Suggests the Involvement of Zinc Finger Protein 326 Gene in Antidepressant Treatment Response

OBJECTIVES: The forced swim test (FST) is a commonly used model to predict antidepressant efficacy. Uncovering the genetic basis of the model may unravel the mechanism of antidepressant treatment. METHODS: FVB/NJ (FVB) and C57BL/6J (B6) were first identified as the response and non-response strains to fluoxetine (a serotonin-specific reuptake inhibitor antidepressant) treatment in the mouse FST. Simple-interval (SIM) and composite-interval (CIM) mappings were applied to map the quantitative trait loci (QTLs) of the anti-immobility effect of fluoxetine in FST (FST(FLX)) in 865 male B6×FVB-F2 mice. The brain mRNA expressions of the gene with the maximum QTL-linkage signal for FST(FLX) after the FST were compared between B6 and FVB mice and also compared between fluoxetine and saline treatment. The association of the variants in the human homologue of the mouse FST(FLX)-QTL gene with major depressive disorder (MDD) and antidepressant response were investigated in 1080 human subjects (MDD/control = 582/498). RESULTS: One linkage signal for FST(FLX)-QTL was detected at an intronic SNP (rs6215396) of the mouse Zfp326 gene (maximal CIM-LOD = 9.36). The Zfp326 mRNA expression in the FVB thalamus was significantly down-regulated by fluoxetine in the FST, and the higher FVB-to-B6 Zfp326 mRNA expressions in the frontal cortex, striatum and hypothalamus diminished after fluoxetine treatment. Two coding-synonymous SNPs (rs2816881 and rs10922744) in the human homologue of Zfp326, ZNF326, were significantly associated with the 8-week antidepressant treatment response in the MDD patients (Bonferroni-corrected p = 0.004-0.028). CONCLUSIONS: The findings suggest the involvement of the Zfp326 and ZNF326 genes in antidepressant treatment response

A systematic review showing the lack of diagnostic criteria and tools developed for lower-limb cellulitis

BACKGROUND: Cellulitis can be a difficult diagnosis to make. Furthermore, 31% of patients admitted from the emergency department with suspected lower-limb cellulitis have been misdiagnosed, with incorrect treatment potentially resulting in avoidable hospital admission and the prescription of unnecessary antibiotics. OBJECTIVES: We sought to identify diagnostic criteria or tools that have been developed for lower-limb cellulitis. METHODS: We conducted a systematic review using Ovid MEDLINE and Embase databases in May 2018, with the aim of describing diagnostic criteria and tools developed for lower-limb cellulitis, and we assessed the quality of the studies identified using the Quality Assessment of Diagnostic Accuracy Studies-2 tool. We included all types of study that described diagnostic criteria or tools. RESULTS: Eight observational studies were included. Five studies examined biochemical markers, two studies assessed imaging and one study developed a diagnostic decision model. All eight studies were considered to have a high risk for bias in at least one domain. The quantity and quality of available data was low and results could not be pooled owing to the heterogeneity of the findings. CONCLUSIONS: There is a lack of high-quality publications describing criteria or tools for diagnosing lower-limb cellulitis. Future studies using prospective designs, validated in both primary and secondary care settings, are needed. What's already known about this topic? Diagnosing lower-limb cellulitis on first presentation is challenging. Approximately one in three patients admitted from the emergency department with suspected lower-limb cellulitis do not have cellulitis and are given another diagnosis on discharge. Consequently, this results in potentially avoidable hospital admissions and the prescription of unnecessary antibiotics. There are no diagnostic criteria available for lower-limb cellulitis in the U.K. What does this study add? This systematic review has identified a key research gap in the diagnosis of lower-limb cellulitis. There is a current lack of robustly developed and validated diagnostic criteria or tools for use in clinical practice

Faune aquatique et qualité de l’eau des puits et sources de la région d’Oum-El-Bouaghi (Nord-Est algérien)

Une étude récente réalisée dans la région d’Oum-El-Bouaghi, dans le Nord-Est de l’Algérie, avait comme objectif de rechercher et de préciser la relation pouvant exister entre la qualité de l’eau des puits et des sources et la diversité de la faune aquatique présente dans ces habitats. Pour cela une quinzaine de stations (16 puits et 2 sources) ont fait l’objet, périodiquement, d’une étude de la qualité de l’eau et d’un échantillonnage de la faune. Les stations retenues ont été choisies en raison de la diversité de leur faune mais aussi et surtout parce qu’elles présentaient entre elles certaines différences évidentes (profondeur de la nappe, nature du substratum, protection des puits et utilisation de l’eau par la population locale), qui pouvaient laisser espérer une certaine diversité. Les principales composantes physico-chimiques de la qualité de l’eau ont donc été mesurées puis une analyse en composantes principales (ACP) a été réalisée à partir des valeurs moyennes de chaque paramètre; on a pu révéler ainsi l’existence d’une variation spatiale relativement marquée de ces descripteurs, faisant apparaître quatre groupes de stationstrès inégaux et bien différenciés : un premier groupe de 11 puits situés à l’aval hydraulique de la zone d’étude, où l’eau présente des teneurs élevées en ions azotés et phosphorés indicateurs de pollution; à l’opposé un autre groupe de 5 puits, situés plus en amont, où l’eau présente au contraire de faibles concentrations de substances azotées et d’ions phosphorés, donc des stations peu ou pas polluées; enfin deux autres groupes bien séparés, chacun correspondant à une source, dont l’eau est aussi de qualité relativement bonne. La faune aquatique de ces puits et sources a également été échantillonnée de façon périodique. La richesse faunistique globale des stations apparaît faiblement corrélée avec la qualité de l’eau, mais en revanche la richesse spécifique de la faune stygobie (celle qui vit dans la nappe phréatique) et plus encore l’abondance de ces espèces stygobies, diminuent de façon significative avec la pollution. La faune stygobie dans son ensemble, et particulièrement le groupe des Crustacés péracarides, apparaît ainsi comme un très bon indicateur de la qualité de l’eau de ces puits et des sources

Vibratory monitoring of gear transmissions in variable regime

This paper falls within the context of diagnosis of rotating machines in speed variable regime. Based on simulation signals, this work has the purpose to find relevant indicators for the diagnosis of gear transmissions in a variable regime. Two indicators are proposed; the first indicator is the RMS value applied to the vibration signal divided by its corresponding instantaneous frequency. The second is the normalised gear frequency by averaging speed. The gear frequency and averaging speed are estimated from the spectrogram. To test the proposed indicators simulate signals have been used. These signals are the results of a dynamic modelling of the gears transmission and are calculated by using the Newmark integration diagram. This dynamic modelling takes into account the eccentricity defect

Comportement thermomécanique de l’alliage 600 en flexion 4 points

Ce travail s’intéresse à l’endommagement de l’alliage base nickel 600 connu sous le nom commercial d’inconel 600 utilisé particulièrement au niveau des circuits primaires des réacteurs nucléaires à eau pressurisée. Ainsi, des essais de flexion 4 points sont effectués à l’aide d’un montage spécifique sous vide secondaire, dans un domaine de température répondant aux conditions réelles de fonctionnement des générateurs de vapeur s’étalant de 350 à 550°C. Le suivi de ces essais en conditions in situ par émission acoustique a permis de vérifier l’absence d’endommagement des échantillons utilisés. Les courbes des contraintes en fonction de la flèche obtenues à partir des données expérimentales qui sont la force et le déplacement conduisent à la détermination du module de Young et de la limite d’élasticité du matériau. D’autres essais, sous air et sous vapeur d’eau sont envisagés, afin de pouvoir remonter jusqu’au comportement viscoplastique de l’inconel 600 dans la gamme de température visée, par méthode inverse.Mots Clés: inconel 600; corrosion sous contrainte; oxydation; émission acoustique; flexion 4 points. This work concerns the damage of a nickel-based alloy known under the commercial name Inconel 600, usually used on the level of the primary circuits of the pressurized water nuclear reactors. The 4 points bending tests are carried out under secondary vacuum. In order to answer the real conditions of the operations, the temperature range which explored is chosen between 350°C to 550°C. The use of acoustic emission shows that there is no damage of the sample itself during such mechanical tests. From the curves of stress-strain and deflection, obtained from experimental tests; mechanical characteristics of material such as the Young modulus and the yield strength are determinate. Other tests under air and water vapour are considered in order to be able to obtain the viscoplastic behaviour of material in the range of temperature concerned by inverse method.Keywords: inconel 600; stress corrosion cracking; oxidation; acoustic emission; 4 points bending.