Polish With Wax

Rub an apple on your sleeve and it shines. That\u27s because it has a natural wax covering that protects, preserves and beautifies just as any wax does

New Zest in Dinnerware Designs

With today\u27s modern living, homemakers have found that informal entertaining is a must. Dinnerware designers, recognizing this are now creating pottery and china featuring new shapes, colors and patterns

A proposal for 3d quantum gravity and its bulk factorization

Recent progress in AdS/CFT has provided a good understanding of how the bulk spacetime is encoded in the entanglement structure of the boundary CFT. However, little is known about how spacetime emerges directly from the bulk quantum theory. We address this question in an effective 3d quantum theory of pure gravity, which describes the high temperature regime of a holographic CFT. This theory can be viewed as a $q$-deformation and dimensional uplift of JT gravity. Using this model, we show that the Bekenstein-Hawking entropy of a two-sided black hole equals the bulk entanglement entropy of gravitational edge modes. In the conventional Chern-Simons description, these black holes correspond to Wilson lines in representations of \PSL(2,\mathbb{R})\otimes \PSL(2,\mathbb{R}) . We show that the correct calculation of gravitational entropy suggests we should interpret the bulk theory as an extended topological quantum field theory associated to the quantum semi-group \SL^+_{q}(2,\mathbb{R})\otimes \SL^+_{q}(2,\mathbb{R}). Our calculation suggests an effective description of bulk microstates in terms of collective, anyonic degrees of freedom whose entanglement leads to the emergence of the bulk spacetime.Comment: Appendix expanded. Discussion of extended TQFT is expanded and moved to section 6. Added discussion of entropy formula in eq 4.2, comparison to Liouville theory below eq 2.41, and expanded remarks on relation to Teichmuller TQFT in section 6.4 and section

The Iowa Homemaker vol.34, no.3

Star your college goals, Gwen Olson, page 5 Encourage your Cyclones, Carolyn Shehan, page 6 Brighten up, Sally Young, page 9 Dollars for scholars, Becky Metcalf, page 10 Forecast, Donna Mumford, page 12 What’s new, Jean Redman, page 14 That missing leaf, Joan Mertens, page 17 Trends, Kay Scholten, page 1

The Iowa Homemaker vol.34, no.4

Weather or not, Jean Redman, page 5 Flaming dinners, Jane Brintlinger, page 6 You and AHEA, Sally Young, page 7 Polish with wax, Joan Mertens, page 8 What’s new, Donna Mumford, page 10 Sell ISC, Doris Jirsa, page 11 Do it yourself, Mary Vandecar, page 12 Trends, Carolyn Shehan, page 1

The Iowa Homemaker vol.34, no.1

Treat to Eat, Dorothy Will, page 5 Light Beautiful, Mary Vandecar, page 6 Look Pert in Pellon, Barbara Gerling and Doris Jirsa, page 7 Look Ahead, page 8 New Zest in Dinnerware Designs, Joan Mertens, page 9 Try Sleep, Mary Odegard, page 10 Practice What They Teach, Vivian Johnson, page 13 Their Goal – Good Housekeeping, Nancy Fox, page 14 What’s New, page 16 Trends, Jean Wilkerson, page 1

Unravelling data for rapid evidence-based response to COVID-19: a summary of the unCoVer protocol

Introduction unCoVer - Unravelling data for rapid evidence-based response to COVID-19 - is a Horizon 2020-funded network of 29 partners from 18 countries capable of collecting and using real-world data (RWD) derived from the response and provision of care to patients with COVID-19 by health systems across Europe and elsewhere. unCoVer aims to exploit the full potential of this information to rapidly address clinical and epidemiological research questions arising from the evolving pandemic. Methods and analysis From the onset of the COVID-19 pandemic, partners are gathering RWD from electronic health records currently including information from over 22 000 hospitalised patients with COVID-19, and national surveillance and screening data, and registries with over 1 900 000 COVID-19 cases across Europe, with continuous updates. These heterogeneous datasets will be described, harmonised and integrated into a multi-user data repository operated through Opal-DataSHIELD, an interoperable open-source server application. Federated data analyses, without sharing or disclosing any individual-level data, will be performed with the objective to reveal patients' baseline characteristics, biomarkers, determinants of COVID-19 prognosis, safety and effectiveness of treatments, and potential strategies against COVID-19, as well as epidemiological patterns. These analyses will complement evidence from efficacy/safety clinical trials, where vulnerable, more complex/heterogeneous populations and those most at risk of severe COVID-19 are often excluded. Ethics and dissemination After strict ethical considerations, databases will be available through a federated data analysis platform that allows processing of available COVID-19 RWD without disclosing identification information to analysts and limiting output to data aggregates. Dissemination of unCoVer's activities will be related to the access and use of dissimilar RWD, as well as the results generated by the pooled analyses. Dissemination will include training and educational activities, scientific publications and conference communications.info:eu-repo/semantics/publishedVersio

Protection of Spanish Ibex (Capra pyrenaica) against Bluetongue Virus Serotypes 1 and 8 in a Subclinical Experimental Infection

Many wild ruminants such as Spanish ibex (Capra pyrenaica) are susceptible to Bluetongue virus (BTV) infection, which causes disease mainly in domestic sheep and cattle. Outbreaks involving either BTV serotypes 1 (BTV-1) and 8 (BTV-8) are currently challenging Europe. Inclusion of wildlife vaccination among BTV control measures should be considered in certain species. In the present study, four out of fifteen seronegative Spanish ibexes were immunized with a single dose of inactivated vaccine against BTV-1, four against BTV-8 and seven ibexes were non vaccinated controls. Seven ibexes (four vaccinated and three controls) were inoculated with each BTV serotype. Antibody and IFN-gamma responses were evaluated until 28 days after inoculation (dpi). The vaccinated ibexes showed significant (P<0.05) neutralizing antibody levels after vaccination compared to non vaccinated ibexes. The non vaccinated ibexes remained seronegative until challenge and showed neutralizing antibodies from 7 dpi. BTV RNA was detected in the blood of non vaccinated ibexes from 2 to the end of the study (28 dpi) and in target tissue samples obtained at necropsy (8 and 28 dpi). BTV-1 was successfully isolated on cell culture from blood and target tissues of non vaccinated ibexes. Clinical signs were unapparent and no gross lesions were found at necropsy. Our results show for the first time that Spanish ibex is susceptible and asymptomatic to BTV infection and also that a single dose of vaccine prevents viraemia against BTV-1 and BTV-8 replication

Chord diagrams, exact correlators in spin glasses and black hole bulk reconstruction

The exact 2-point function of certain physically motivated operators in SYK-like spin glass models is computed, bypassing the Schwinger-Dyson equations. The models possess an IR low energy conformal window, but our results are exact at all time scales. The main tool developed is a new approach to the combinatorics of chord diagrams, allowing to rewrite the spin glass system using an auxiliary Hilbert space, and Hamiltonian, built on the space of open chord diagrams. We argue the latter can be interpreted as the bulk description and that it reduces to the Schwarzian action in the low energy limit.Comment: 38 pages, 6 figure

Streptococcus pneumoniae Serotype 1 Capsular Polysaccharide Induces CD8+CD28− Regulatory T Lymphocytes by TCR Crosslinking

Zwitterionic capsular polysaccharides (ZPS) of commensal bacteria are characterized by having both positive and negative charged substituents on each repeating unit of a highly repetitive structure that has an α-helix configuration. In this paper we look at the immune response of CD8+ T cells to ZPSs. Intraperitoneal application of the ZPS Sp1 from Streptococcus pneumoniae serotype 1 induces CD8+CD28− T cells in the spleen and peritoneal cavity of WT mice. However, chemically modified Sp1 (mSp1) without the positive charge and resembling common negatively charged polysaccharides fails to induce CD8+CD28− T lymphocytes. The Sp1-induced CD8+CD28− T lymphocytes are CD122lowCTLA-4+CD39+. They synthesize IL-10 and TGF-β. The Sp1-induced CD8+CD28− T cells exhibit immunosuppressive properties on CD4+ T cells in vivo and in vitro. Experimental approaches to elucidate the mechanism of CD8+ T cell activation by Sp1 demonstrate in a dimeric MHC class I-Ig model that Sp1 induces CD8+ T cell activation by enhancing crosslinking of TCR. The expansion of CD8+CD28− T cells is independent, of direct antigen-presenting cell/T cell contact and, to the specificity of the T cell receptor (TCR). In CD8+CD28− T cells, Sp1 enhances Zap-70 phosphorylation and increasingly involves NF-κB which ultimately results in protection versus apoptosis and cell death and promotes survival and accumulation of the CD8+CD28− population. This is the first description of a naturally occurring bacterial antigen that is able to induce suppressive CD8+CD28− T lymphocytes in vivo and in vitro. The underlying mechanism of CD8+ T cell activation appears to rely on enhanced TCR crosslinking. The data provides evidence that ZPS of commensal bacteria play an important role in peripheral tolerance mechanisms and the maintenance of the homeostasis of the immune system