210 research outputs found
Spin-dynamics simulations of the triangular antiferromagnetic XY model
Using Monte Carlo and spin-dynamics methods, we have investigated the dynamic
behavior of the classical, antiferromagnetic XY model on a triangular lattice
with linear sizes . The temporal evolutions of spin configurations
were obtained by solving numerically the coupled equations of motion for each
spin using fourth-order Suzuki-Trotter decompositions of exponential operators.
From space- and time-displaced spin-spin correlation functions and their
space-time Fourier transforms we obtained the dynamic structure factor for momentum and frequency . Below
(Kosterlitz-Thouless transition), both the in-plane () and the
out-of-plane () components of exhibit very strong
and sharp spin-wave peaks. Well above , and
apparently display a central peak, and spin-wave signatures are still seen in
. In addition, we also observed an almost dispersionless domain-wall
peak at high below (Ising transition), where long-range order
appears in the staggered chirality. Above , the domain-wall peak
disappears for all . The lineshape of these peaks is captured reasonably
well by a Lorentzian form. Using a dynamic finite-size scaling theory, we
determined the dynamic critical exponent = 1.002(3). We found that our
results demonstrate the consistency of the dynamic finite-size scaling theory
for the characteristic frequeny and the dynamic structure factor
itself.Comment: 8 pages, RevTex, 10 figures, submitted to PR
Vortex behavior near a spin vacancy in 2D XY-magnets
The dynamical behavior of anisotropic two dimensional Heisenberg models is
still a matter of controversy. The existence of a central peak at all
temperatures and a rich structure of magnon peaks are not yet understood. It
seems that the central peaks are related, in some way, to structures like
vortices. In order to contribute to the discussion of the dynamical behavior of
the model we use Monte Carlo and spin dynamics simulations as well analytical
calculations to study the behavior of vortices in the presence of nonmagnetic
impurities. Our simulations show that vortices are attracted and trapped by the
impurities. Using this result we show that if we suppose that vortices are not
very much disturbed by the presence of the impurities, then they work as an
attractive potential to the vortices explaining the observed behavior in our
simulations.Comment: 4 pages, 6 figure
Follistatin-controlled activin-HNF4 alpha-coagulation factor axis in liver progenitor cells determines outcome of acute liver failure
Background and Aims In patients with acute liver failure (ALF) who suffer from massive hepatocyte loss, liver progenitor cells (LPCs) take over key hepatocyte functions, which ultimately determines survival. This study investigated how the expression of hepatocyte nuclear factor 4 alpha (HNF4 alpha), its regulators, and targets in LPCs determines clinical outcome of patients with ALF. Approach and Results Clinicopathological associations were scrutinized in 19 patients with ALF (9 recovered and 10 receiving liver transplantation). Regulatory mechanisms between follistatin, activin, HNF4 alpha, and coagulation factor expression in LPC were investigated in vitro and in metronidazole-treated zebrafish. A prospective clinical study followed up 186 patients with cirrhosis for 80 months to observe the relevance of follistatin levels in prevalence and mortality of acute-on-chronic liver failure. Recovered patients with ALF robustly express HNF4 alpha in either LPCs or remaining hepatocytes. As in hepatocytes, HNF4 alpha controls the expression of coagulation factors by binding to their promoters in LPC. HNF4 alpha expression in LPCs requires the forkhead box protein H1-Sma and Mad homolog 2/3/4 transcription factor complex, which is promoted by the TGF-beta superfamily member activin. Activin signaling in LPCs is negatively regulated by follistatin, a hepatocyte-derived hormone controlled by insulin and glucagon. In contrast to patients requiring liver transplantation, recovered patients demonstrate a normal activin/follistatin ratio, robust abundance of the activin effectors phosphorylated Sma and Mad homolog 2 and HNF4 alpha in LPCs, leading to significantly improved coagulation function. A follow-up study indicated that serum follistatin levels could predict the incidence and mortality of acute-on-chronic liver failure. Conclusions These results highlight a crucial role of the follistatin-controlled activin-HNF4 alpha-coagulation axis in determining the clinical outcome of massive hepatocyte loss-induced ALF. The effects of insulin and glucagon on follistatin suggest a key role of the systemic metabolic state in ALF.Cancer Signaling networks and Molecular Therapeutic
On the mechanisms governing gas penetration into a tokamak plasma during a massive gas injection
A new 1D radial fluid code, IMAGINE, is used to simulate the penetration of gas into a tokamak plasma during a massive gas injection (MGI). The main result is that the gas is in general strongly braked as it reaches the plasma, due to mechanisms related to charge exchange and (to a smaller extent) recombination. As a result, only a fraction of the gas penetrates into the plasma. Also, a shock wave is created in the gas which propagates away from the plasma, braking and compressing the incoming gas. Simulation results are quantitatively consistent, at least in terms of orders of magnitude, with experimental data for a D 2 MGI into a JET Ohmic plasma. Simulations of MGI into the background plasma surrounding a runaway electron beam show that if the background electron density is too high, the gas may not penetrate, suggesting a possible explanation for the recent results of Reux et al in JET (2015 Nucl. Fusion 55 093013)
Velocity-space sensitivity of the time-of-flight neutron spectrometer at JET
The velocity-space sensitivities of fast-ion diagnostics are often described by so-called weight functions. Recently, we formulated weight functions showing the velocity-space sensitivity of the often dominant beam-target part of neutron energy spectra. These weight functions for neutron emission spectrometry (NES) are independent of the particular NES diagnostic. Here we apply these NES weight functions to the time-of-flight spectrometer TOFOR at JET. By taking the instrumental response function of TOFOR into account, we calculate time-of-flight NES weight functions that enable us to directly determine the velocity-space sensitivity of a given part of a measured time-of-flight spectrum from TOFOR
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