1,666 research outputs found

    Sample-size determination and adherence in randomised controlled trials published in anaesthetic journals

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    Background: Sample-size calculations are critical to ensure that randomised control trials return robust and reliable results. The estimated treatment effects used in these calculations is often significantly different from the actual treatment effect and can dramatically impact trial validity.Methods: This study examined sample-size calculations in randomised controlled trials designed to show superiority between two-arm parallel groups with a single primary outcome that were published in the top five anaesthetic journals for 2014 (as per Thomson Reuters impact factors). In particular, it sought to determine treatment effect estimations used in a priori sample-size calculations and compare them with actual treatment effects.Results: A PubMed search identified 209 possible articles; 52 were drawn for full text review; and 28 were included in the final analysis. The relative difference between expected and actual event rates was greater than 20% in 80% of trials and greater than 50% in 44% of trials.Conclusions: Unrealistic assumptions of treatment effects in randomised controlled trials published in anaesthesia journals are common. Trial sample sizes should be calculated thoughtfully and realistically and should be fully reported in both trial protocols and publications. Researchers should be aware of the opportunity cost as well as the possible dangers to patients when unrealistic assumptions are made. Where possible researchers should collaborate to achieve meaningful trial sample sizes to ensure robust clinical findings.Keywords: anaesthesia, clinical trial, power calculations, sample size, treatment effect, type II erro

    The Pattern Speed of the Galactic Bar

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    Most late-type stars in the solar neighborhood have velocities similar to the local standard of rest (LSR), but there is a clearly separated secondary component corresponding to a slower rotation and a mean outward motion. Detailed simulations of the response of a stellar disk to a central bar show that such a bi-modality is expected from outer-Lindblad resonant scattering. When constraining the run of the rotation curve by the proper motion of Sgr A* and the terminal gas velocities, the value observed for the rotation velocity separating the two components results in a value of (53+/-3)km/s/kpc for the pattern speed of the bar, only weakly dependent on the precise values for Ro and bar angle phi.Comment: 5 pages LaTeX, 2 Figs, accepted for publication in ApJ Letter

    The Visibility of Galactic Bars and Spiral Structure At High Redshifts

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    We investigate the visibility of galactic bars and spiral structure in the distant Universe by artificially redshifting 101 B-band CCD images of local spiral galaxies from the Ohio State University Bright Spiral Galaxy Survey. Our artificially redshifted images correspond to Hubble Space Telescope I-band observations of the local galaxy sample seen at z=0.7, with integration times matching those of both the very deep Northern Hubble Deep Field data, and the much shallower Flanking Field observations. The expected visibility of galactic bars is probed in two ways: (1) using traditional visual classification, and (2) by charting the changing shape of the galaxy distribution in "Hubble space", a quantitative two-parameter description of galactic structure that maps closely on to Hubble's original tuning fork. Both analyses suggest that over 2/3 of strongly barred luminous local spirals i.e. objects classified as SB in the Third Reference Catalog) would still be classified as strongly barred at z=0.7 in the Hubble Deep Field data. Under the same conditions, most weakly barred spirals (classified SAB in the Third Reference Catalog) would be classified as regular spirals. The corresponding visibility of spiral structure is assessed visually, by comparing luminosity classifications for the artificially redshifted sample with the corresponding luminosity classifications from the Revised Shapley Ames Catalog. We find that for exposures times similar to that of the Hubble Deep Field spiral structure should be detectable in most luminous low-inclination spiral galaxies at z=0.7 in which it is present. [ABRIDGED]Comment: Accepted for publication in The Astronomical Journa

    Kinematics of Spiral Arm Streaming in M51

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    We use CO and H alpha velocity fields to study the gas kinematics in the spiral arms and interarms of M51 (NGC 5194), and fit the 2D velocity field to estimate the radial and tangential velocity components as a function of spiral phase (arm distance). We find large radial and tangential streaming velocities, which are qualitatively consistent with the predictions of density wave theory and support the existence of shocks. The streaming motions are complex, varying significantly across the galaxy as well as along and between arms. Aberrations in the velocity field indicate that the disk is not coplanar, perhaps as far in as 20\arcsec\ (800 pc) from the center. Velocity profile fits from CO and H alpha are typically similar, suggesting that most of the H alpha emission originates from regions of recent star formation. We also explore vortensity and mass conservation conditions. Vortensity conservation, which does not require a steady state, is empirically verified. The velocity and density profiles show large and varying mass fluxes, which are inconsistent with a steady flow for a single dominant global spiral mode. We thus conclude that the spiral arms cannot be in a quasi-steady state in any rotating frame, and/or that out of plane motions may be significant.Comment: 50 pages, including 20 figures; Accepted for publication in ApJ. PDF version with high resolution figures available at http://www.astro.umd.edu/~shetty/Research

    Dynamical Friction and the Distribution of Dark Matter in Barred Galaxies

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    We use fully self-consistent N-body simulations of barred galaxies to show that dynamical friction from a dense dark matter halo dramatically slows the rotation rate of bars. Our result supports previous theoretical predictions for a bar rotating within a massive halo. On the other hand, low density halos, such as those required for maximum disks, allow the bar to continue to rotate at a high rate. There is somewhat meager observational evidence indicating that bars in real galaxies do rotate rapidly and we use our result to argue that dark matter halos must have a low central density in all high surface brightness disk galaxies, including the Milky Way. Bars in galaxies that have larger fractions of dark matter should rotate slowly, and we suggest that a promising place to look for such candidate objects is among galaxies of intermediate surface brightness.Comment: 6 pages, Latex, 3 figures, Accepted by Ap.J.L., revised copy, includes an added paragrap
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