The use of isoxazoline and isoxazole scaffolding in the design of novel thiourea and amide liquid-crystalline compounds

The authors wish to thank the Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior - Brasil (CAPES) - Finance Code 001 for the fellowships and Conselho Nacional de Pesquisa Cientifica (CNPq, edital Universal) for the financial support grant n. 403075 2016-5.A series of novel thiourea and amide liquid crystals containing 5-membered isoxazoline and isoxazole rings were synthetized and the liquid crystal properties studied. Thioureas were obtained using a condensation reaction of benzoyl chlorides, arylamines and ammonium thiocyanate. The amides, on the other hand, were the byproduct of a quantitative reaction which used potassium cyanate as the starting material. Thiourea and amide derivatives were predominantly SmA mesophase inductors. A nematic mesophase was observed only for thioureas and amides containing an isoxazole ring. Additionaly, the liquid crystal behavior was also dependent on the relative position of nitrogen and oxygen atoms on the 5-membered heterocycle.publishersversionpublishe

Implications of flexible spacer rotational processes on the liquid crystal behavior of 4,5-dihydroisoxazole benzoate dimers

The synthesis of some novel non-symmetric liquid crystal dimers, {3-[4-(octyloxyphenyl)]-4,5-dihydroisoxazol-5-yl}alkyl 4-(decyloxy)benzoates (5a–d) and 4-{3-[4-(octyloxyphenyl)]-4,5-dihydroisoxazol-5-yl}alkyl 4-{[6-(octyloxy)naphthalen-2-yl]ethynyl}benzoate (9a–d), are reported. The liquid-crystalline properties, theoretical calculations based on the conformational aspects of the flexible alkyl spacer and X-ray experiments are discussed. The syntheses of the key intermediates, 2-{3-[4-(octyloxy)phenyl]-4,5-dihydroisoxazol-5-yl}alkanol (3a–d), presenting the flexible alkyl spacer were achieved through [3+2] cycloaddition reactions between nitrile oxides, which were generated in situ by oxidation of the respective aromatic oximes, and dipolarophile alkenols (CH2[double bond, length as m-dash]CH(CH2)nOH, n = 1, 2, 3, and 4). The benzoates 5a–d were synthesized through esterification of 3a–d and p-n-decyloxybenzoic acid (4). The esters 9a–d were synthesized through derivatization of isoxazolines 3a–d into 4-{3-[4-(octyloxyphenyl)]-4,5-dihydroisoxazol-5-yl}alkyl 4-bromobenzoate (7a–d) followed by a Sonogashira reaction with 2-ethynyl-6-octyloxynaphthalene (8). 5a and 5b showed a monotropic smectic C phase. 9a/c displayed a enantiotropic nematic (N) mesophase, whereas 9b/d showed a monotropic nematic mesophase. No mesophase was observed for 7a–d. An odd–even effect was observed for 5a–d and 9a–d associated with the crystal to isotropic phase transition and crystal to nematic phase, respectively, as the length of the spacer was increased from 1 to 4 carbon atoms. The transitional properties were higher for odd-numbered members (n = 1 and 3) for all of the series studied. The X-ray data of compounds 5a and 5b are in agreement with polarizing optical microscopy observations with the assignment of an SmC mesophase. Density functional theory calculations using the B3LYP hybrid functional with the level 6-311G(d,p) basis set were performed for molecules 5a–d to correlate the conformation of the flexible spacer and the transitional properties. The conformational analysis showed that the most stable conformation for 5a–d is one where all of the carbon atoms of the flexible spacer are orientated at 180° (antiperiplanar orientation) except for 5a because the spacer is too short. The odd-numbered members have a more bent shape and are less elongated molecules than the even-numbered members. Thus, mesomorphic behavior is dictated by the conformational constraint imposed by the flexible spacer on the mesogenic groups

Síntese e caracterização de copolímeros de cadeia lateral derivados de acrilatos de 4,5-di-hidroisoxazol e do (-)-mentol

Five monomers 5-[4-(5-cyano-4,5-dihydroisoxazol-3-yl)phenoxy]undecyl acrylate (7a); n-alkyl 3-{4-[5-(acryloyloxyundecyl)oxyphenyl]}-4,5-dihydroisoxazole-5-carboxylate (7b,c for n-butyl and n-hexyl, respectively); 3-{4-[5-(acryloyloxyundecyl) oxyphenyl]}-4,5-dihydroisoxazole-5-carboxylic acid (7d) and (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl acrylate (9) and the corresponding copolymers 10a-d,11 and homopolymers 12 from 7a and 13 from 9 were designed and synthesized. Except for acrylate 9 which is derived from (-)-menthol, all of the monomers belong to the series containing the isoxazoline ring linked to the acrylate unit by a flexible spacer chain of eleven methylene units. They presented low glass temperature and despite birefringence behavior, these copolymers showed no mesomorphic properties

The 2:1 cycloadducts from [3+2] 1,3-dipolar cycloaddition of nitrile oxide and vinylacetic acid. Synthesis and liquid crystal behaviour

Four liquid crystals (LC) 3,7a-bis(4-alkyloxyphenyl)-7,7a-dihydro-6H-isoxazolo[2,3-d][1,2,4]oxadiazol-6-yl)acetic acid (7a-d) were synthesised and the mesomorphic behaviour reported. The LCs were characterised as 2: 1 bisadducts, which were obtained from a double [3+2] 1,3-dipolar cycloaddition. In the first step, the cycloaddition of 4-alkyloxyphenylnitrile oxide (4a-d) and vinylacetic acid (5) gave the initial unobserved 1:1 cycloadducts 2-[3-(4-alkyloxyphenyl)-4,5-dihydroisoxazol-5-yl]acetic acid (6a-d). In the second step, the addition of a second equivalent of 4 to 6 yielded the 2: 1 bisadducts 7a-d without any traces of 6. All compounds 7a-d were unstable during the transition from the mesophase to the isotropic state upon first heating as evidenced by the large peaks in the differential scanning calorimetry traces. Due to the chemical instability of the compounds upon heating, the transition temperature related to the smectic C to smectic A transitions was acquired by means of an image processing method. X-Ray diffraction experiments were also used to analyse the liquid-crystalline phases. A theoretical calculation was performed using density functional theory (DFT) methods at the PBE1PBE/6-311+G(2d,p) level (with solvent effect) in order to get information about the energetic profile of the 2: 1 cycloaddition. DFT studies revealed that the cycloaddition process is controlled by the HOMO(dipolarophile) - LUMO(1,3-dipole), and that the double [3+2] 1,3-dipolar cycloaddition reaction is quite possible.CNPq [471194-2008-5]CAPESINCT-Catalise[PROCAD-2007/CAPES

Synthesis and mesomorphic properties of side chain liquid-crystalline biphenyl-phenyl polyacrylates

The synthesis and characterization of two chiral side-chain liquid crystal based on polyacrylates having a biphenyl-phenyl system as a core unit are described. The chiral terminal chain is derived from L-isoleucine. In each case an undecyl spacer was used to connect the mesogenic group to the backbone. Smectic A phase was found for both polymers. The transitional properties were dependent on structural parameters such as backbone flexibility and chiral terminal chain connectivity

Photochemical behaviour of Schiff base liquid crystals based on isoxazole and isoxazoline ring. A kinetic approach

<p>The kinetic study on the hydrolysis of Schiff bases (SBs) <b>1a-c</b> and <b>2a-c</b> induced by UV-vis was undertaken as a complementary study of the stability in solution and in bulk of the SBs. Solutions in chloroform were exposed to UV-vis and acquisition data occurred for <b>1a-c</b> and for <b>2a-c</b> in 21°C, 30 °C, 35°C and 40°C. Kinetic profile for <b>1a-c</b> and <b>2a-c</b> displayed the similar photochemical behaviour in that four temperature values. At 21°C, two kinetic regimes were observed where the decomposition of SBs is faster at the initial stage, with no linear plot of absorbance vs time, and after the kinetic profile obeyed a linear behaviour. A mathematical treatment of the experimental data was applied, which allowed associating the initial stage data with a second-order reaction, and the final stage of the hydrolysis with a first-order reaction. The mechanism of photochemical hydrolysis of SBs <b>1a</b> and <b>2a</b> was addressed. It was composed of three parts, the excitation, then the isomerisation and activation processes of tetrahedral intermediate and, the last process, a collapse of the intermediate to the yielded products of the hydrolysis aldehydes and amines which were detected by their UV-vis spectrum.</p

When hydrogen bond tailors molecular packing in non-anisometric molecules. The case study of N-alkyl 1,3-diphenyl-4,5-dihydro-1H-pyrazole-5-carboximidamides

In this paper, we report the synthesis of novel liquid crystals (LCs) based on 5-membered pyrazoline heterocycle. The synthesis of pyrazoline derivative was carried out by 3 + 2] 1,3-dipolar cycloaddition reaction of benzaldehyde phenyl hydrazone (1) with acrylonitrile, mediated by chloramine-T as the oxidising agent, followed by addition of hydroxylamine hydrochloride, and subsequently alkylated with various alkyl chains to afforded the title compounds. The LCs properties were investigated using differential scanning calorimetry and polarising optical microscopy. For title compounds with longer alkyl chains, monotropic columnar hexagonal mesophase was characterised by XRD analysis. The mesophase-formation was driven by intermolecular hydrogen bonds despite their non-discoid molecular structure. GRAPHICS]