803 research outputs found

    Promotion of proliferation and metastasis of hepatocellular carcinoma by LncRNA00673 based on the targeted-regulation of notch signaling pathway

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    we read with great interest the paper by Dr. Chen et al1, recently published in European Review for Medical and Pharmacological Sciences and titled ‘‘Promotion of proliferation and metastasis of hepatocellular carcinoma by LncRNA00673 based on the targeted-regulation of notch signaling pathway’’. Authors concluded that lncRNA00673 is highly expressed and may be a potential target for the treatment of Hepatocellular Carcinoma (HCC). Moreover, according to authors, it can promote the proliferation and metastasis of HCC by the regulation of Notch signaling pathway. We congratulate the authors for their interesting work

    Two Phase Bubble Columns: the Determinants of the Flow Regime Transitions

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    The fluid dynamics in large-diameter bubble columns can be described by an analytical relation between two global flow parameters, the drift flux and the gas holdup. This relation, named bubble column operating curve, builds on five flow regime transitions. In order to determine the variables influencing the flow regime transitions, a statistical approach was derived by coupling: (1) the ordinary least squares method (OLS) to determine the relationship between the variables, (2) the variance inflation factor (VIF) to check for multicollinearity issues, and (3) the least absolute shrinkage and selection operator (LASSO), to select suitable variables. It was found that the geometrical characteristics of the sparger strongly influence the flow regime transitions, and uniform aeration is essential for all the regimes to exist. Increasing the superficial liquid velocity in the counter-current mode destabilises the mono-dispersed and poly-dispersed homogeneous flow regimes. As for the aspect ratio, an increase in the column aspect ratio slightly destabilises the existing flow regimes. The statistical method identifies viscosity as the only significative variable concerning the liquid phase properties

    The Borexino Thermal Monitoring & Management System and simulations of the fluid-dynamics of the Borexino detector under asymmetrical, changing boundary conditions

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    A comprehensive monitoring system for the thermal environment inside the Borexino neutrino detector was developed and installed in order to reduce uncertainties in determining temperatures throughout the detector. A complementary thermal management system limits undesirable thermal couplings between the environment and Borexino's active sections. This strategy is bringing improved radioactive background conditions to the region of interest for the physics signal thanks to reduced fluid mixing induced in the liquid scintillator. Although fluid-dynamical equilibrium has not yet been fully reached, and thermal fine-tuning is possible, the system has proven extremely effective at stabilizing the detector's thermal conditions while offering precise insights into its mechanisms of internal thermal transport. Furthermore, a Computational Fluid-Dynamics analysis has been performed, based on the empirical measurements provided by the thermal monitoring system, and providing information into present and future thermal trends. A two-dimensional modeling approach was implemented in order to achieve a proper understanding of the thermal and fluid-dynamics in Borexino. It was optimized for different regions and periods of interest, focusing on the most critical effects that were identified as influencing background concentrations. Literature experimental case studies were reproduced to benchmark the method and settings, and a Borexino-specific benchmark was implemented in order to validate the modeling approach for thermal transport. Finally, fully-convective models were applied to understand general and specific fluid motions impacting the detector's Active Volume.Comment: arXiv admin note: substantial text overlap with arXiv:1705.09078, arXiv:1705.0965

    Maximum-likelihood retrieval of volcanic ash concentration and particle size from ground-based scanning lidar

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    An inversion methodology, named maximum-likelihood (ML) volcanic ash light detection and ranging (Lidar) retrieval (VALR-ML), has been developed and applied to estimate volcanic ash particle size and ash mass concentration within volcanic plumes. Both estimations are based on the ML approach, trained by a polarimetric backscattering forward model coupled with a Monte Carlo ash microphysical model. The VALR-ML approach is applied to Lidar backscattering and depolarization profiles, measured at visible wavelength during two eruptions of Mt. Etna, Catania, Italy, in 2010 and 2011. The results are compared with those of ash products derived from other parametric retrieval algorithms. A detailed comparison among these different retrieval techniques highlights the potential of VALR-ML to determine, on the basis of a physically consistent approach, the ash cloud area that must be interdicted to flight operations. Moreover, the results confirm the usefulness of operating scanning Lidars near active volcanic vents

    Capability of non liner eddy viscosity model in predicting complex flows

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    Paper presented at the 6th International Conference on Heat Transfer, Fluid Mechanics and Thermodynamics, South Africa, 30 June - 2 July, 2008.The research field of the study is related with turbulence modeling. The general objective is the implementation in a commercial code, of two equations Non Linear Eddy Viscosity Model (NLEVM) which removes Boussinesq linear approximation for the Reynolds stress tensor. The work described in the paper implements a second order k-ε model based over Shih, Zhu and Lumley (1993) [1] and Craft, Launder and Suga (1996) [2] in the finite volume commercial code ANSYS-FLUENT v. 6.3.26, by writing additional subroutines. The model has been validated through experimental and DNS data available in the literature. The benchmarks shown in this paper are the straight Square Duct [8] and the Backward-Facing Step [9, 10]. After the validation, the model has been used for predicting the flow behavior for complex industrial applications. The geometry used is similar to the bowl-shape downcomer of nuclear reactor. This is an application field of interest still under study by the same research group and an international consortium.vk201

    Laparoscopic Excision of Endometriosis May Require Unilateral Parametrectomy

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    Nerve-sparing complete excision of endometriosis may not be possible. In these patients, unilateral parametrectomy may be a reasonable alternative management strategy

    Current preventive policies and practices against Vaccine-Preventable Diseases and tuberculosis targeted for workers from hospitals of the Sardinia Region, Italy

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    Introduction. Health care Workers are exposed to infectious diseases more than the general population. Many of these infections are preventable by vaccination. The objective in this study is to investigate whether, how, and which vaccination underwent Sardinia Health Care Workers (HCWs) and the variability of policies in different Hospital Health Managements of the whole region. Methods. In March 2013, we enrolled the Hospital Health Management of all the 32 Sardinia hospitals. We investigate on immunity against vaccine-preventable diseases and education campaigns about recommended vaccinations for HCWs. Flu, hepatitis B, measles-mumps-rubella, varicella and tuberculosis were the objects of our research. Results. In most of the hospitals, influenza vaccination coverage among HCWs is less than 6%. Hepatitis B antibody assay was performed in all the respondent hospitals but only 14 had available data as collected electronically. Most of the hospitals did not perform serological tests for the evaluation of antibodies against Varicella, Measles, Mumps and Rubella in their HCWs. In 30 hospitals Mantoux test was replaced or integrated by "in vitro" test for health surveillance protocols. Conclusions. This method produced a large amount of data in small time and at a low cost. Sending back data to respective Hospital Health Management (HHM) we took a step towards greater awareness of the issue of biological risks of HCWs and of vaccine coverage
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