Correlation Function of Galaxy Groups

We use the Updated Zwicky Catalog of galaxies (Falco et al. 1999) to generate a catalog of groups, by means of a friend-of-friend algorithm. The correlation length of the total sample is well fitted with a power law $\xi(r)=(r/r_0)^\gamma$ with parameters $r_0=9.0 \pm 0.4 h^{-1}Mpc$ and $\gamma = -1.67 \pm 0.09$ for values of $r<70 h^{-1} Mpc$. Three subsamples defined by the range of group virial masses ${\cal M}$ were used to have their clustering properties examined throughout the autocorrelation function. We find an increase of the amplitude of the correlation function according to the group masses which extends the results of the $r_0-d_c$ relation for galaxy systems at small $d_c$. For completeness we have also analyzed a sample of groups obtained from the Southern Sky Redshift Survey (da Costa et al.1998) in the range of virial masses $5\times10^{12}M_{\odot}<{\cal M}<4\times10^{14}M_{\odot}$ to compare the results with those obtained from GUZC.Comment: 9 figures, accepted for publication in Ap

FACTORES PSICOLÓGICOS QUE INCIDEN EN LOS JUGADORES PROFESIONALES DE SAMPAS BOYACÁ EN COMPETENCIA

Los jugadores del club deportivo Sampas en la ciudad de Tunja- Boyacá, son jugadores profesionales de Fútbol sala. Durante los torneos disputados se obtenían mínimos resultados a pesar del trabajo realizado en los entrenamientos, con relación a la preparación física. Esta situación es susceptible de investigar para identificar otros elementos que, influyen en el rendimiento deportivo como los psicológicos, a través de un estudio cuantitativo, de tipo no experimental descriptivo, con la aplicación del cuestionario de características psicológicas relacionado con el rendimiento deportivo (CPRD), el cual describe los factores psicológicos que inciden en los jugadores de futbol sala objeto de estudio en competencia, y es el resultado de un proceso de investigación que puntualiza, el estado psicológico en el cual se encuentran estos jugadores profesionales antes de una competencia, la muestra fueron 12 jugadores profesionales con edades entre los 19 y 31 años boyacenses, realizada antes de un encuentro deportivo clasificatorio a cuartos de final de la liga argos Fútbol sala, y donde se logra establecer que el (CPRD) fue la técnica adecuada para realizar un análisis de los factores psicológicos que inciden en los jugadores en competencias, se encontró que los factores psicológicos que inciden en competencias en el equipo de Sampas en orden de importancia son; control de estrés, influencia, cohesión de equipo, motivación y habilidad mental.se logro al final del estudio determinar que el estrés es el factor que presenta mayor incidencia al momento de competir con un percentil de 80 según la tabla de baremos y además que la motivación y la habilidad mental los factores que requieren menos intervención por parte del especialista y que la estrategia de intervención psicofisiológica fue la adecuada para fortalecer el grupo en competencia

Quasar-galaxy and AGN-galaxy cross-correlations

We compute quasar-galaxy and AGN-galaxy cross-correlation functions for samples taken from the \cite{VCV98} catalog of quasars and active galaxies, using tracer galaxies taken from the Edinburgh/Durham Southern Catalog. The sample of active galaxy targets shows positive correlation at projected separations $r_p < 6 h^{-1} Mpc$ consistent with the usual power-law. On the other hand, we do not find a statistically significant positive quasar-galaxy correlation signal except in the range $3 h^{-1} Mpc < r_p < 6 h^{-1} Mpc$ where we find similar AGN-galaxy and quasar-galaxy correlation amplitudes. At separations $r_p<3 h^{-1} Mpc$ a strong decline of quasar-galaxy correlations is observed, suggesting a significant local influence of quasars in galaxy formation. In an attempt to reproduce the observed cross-correlation between quasars and galaxies, we have performed CDM cosmological hydrodynamical simulations and tested the viability of a scenario based on the model developed by \cite{silkrees98}. In this scheme a fraction of the energy released by quasars is considered to be transferred into the baryonic component of the intergalactic medium in the form of winds. The results of the simulations suggest that the shape of the observed quasar-galaxy cross-correlation function could be understood in a scenario where a substantial amount of energy is transferred to the medium at the redshift of maximum quasar activity.Comment: 11 pages, 9 figures. Accepted for publication in Ap

Bioactivity of semisynthetic eugenol derivatives against Spodoptera frugiperda (Lepidoptera: Noctuidae) larvae infesting maize in Colombia

The anti-acetylcholinesterase, larvicidal, antifeedant activities and general toxicity of 15 semisynthetic eugenol derivatives based on clove oil (including the own oil), were evaluated against the maize armyworm, Spodoptera frugiperda (J.E. Smith). Therefore, promising eugenol molecules were classified with larvicidal, anti-acetylcholinesterase and antifeedant activities for controlling this pest. During structure–activity relationship studies and physicochemical profile analysis, it was found that among tested molecules 1-15, eugenol 1, prenyl eugenol 4, isoeugenol 8 and isoeugenol acetate 11 exhibited lethal effects LD50 at concentrations < 1 mg/g of insect. On the other hand, eugenol 1, metallyl eugenol 3, isoeugenol 8 and isoeugenol acetate 11 showed a good antifeedant activity (CE50 =158-209 µg/mL) with a high antifeedant index (70-78 %) at concentration 1000 µg/mL, possessing a weak antiacetylcholinesterase activity (IC50 = 21-31 g/mL). According to their ecotoxicological profiles (LC50 = 2033.1-6303.8 µg/mL on Artemia salina larvae), isoeugenol 8 and its acetate derivative 11 could be potential used in control of the growth, feeding, or reproduction of S. frugiperda larvae, acting as moderate insecticidal acetylcholinesterase inhibitors and/or antifeedant molecules. Such structure–activity relationship studies could stimulate the identification of lead structures from natural sources for the development of larvicidal and deterrent products against S. frugiperda and related insect pests.Fil: Vargas Méndez, Leonor Y.. Universidad Santo Tomás; ColombiaFil: Sanabria Flórez, Pedro L.. Universidad Santo Tomás; ColombiaFil: Saavedra Reyes, Laura Marcela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina. Universidad Santo Tomás; ColombiaFil: Merchan Arenas, Diego R.. Universidad Industrial Santander; ColombiaFil: Kouznetsov, Vladimir V.. Universidad Industrial Santander; Colombi

Характеристики и методы лечения основных нежелательных явлений у пациентов с распространенным почечно-клеточным раком, получающих терапию комбинацией ленватиниба с пембролизумабом на основании результатов исследования CLEAR

.Введение. Комбинация ленватиниба с пембролизумабом продемонстрировала значительное улучшение показателей выживаемости без прогрессирования и общей выживаемости у пациентов с распространенным почечно-клеточным раком по сравнению с сунитинибом в исследовании CLEAR (Clinicaltrials.gov: NCT02811861).Цель исследования – на основании данных исследования CLEAR охарактеризовать основные нежелательные явления (НЯ) (предпочтительные термины сгруппированы в соответствии с обзором регулирующего органа), ассоциированные с использованием комбинации ленватиниба с пембролизумабом, и привести стратегии их преодоления.Материалы и методы. Проанализирована безопасность комбинации ленватиниба с пембролизумабом у 352 пациентов, включенных в исследование CLEAR. Наиболее важные НЯ были выбраны на основании частоты их встречаемости (≥30 %). Оценено время до появления НЯ и описаны подходы к их лечению.Результаты. Наиболее частыми НЯ были повышенная утомляемость (63,1 %), диарея (61,9 %), скелетно-мышечные боли (58,0 %), гипотиреоз (56,8 %) и гипертония (56,3 %). НЯ ≥III степени тяжести, зафиксированные у ≥5 % пациентов, включали гипертонию (28,7 %), диарею (9,9 %), повышенную утомляемость (9,4 %), снижение массы тела (8,0 %) и протеинурию (7,7 %). Медиана времени до появления первых симптомов основных НЯ составила приблизительно 5 мес (около 20 нед) с момента начала лечения. Стратегии эффективного преодоления НЯ включали мониторинг исходных показателей, изменение дозы препарата и/или назначение сопутствующих медикаментозных препаратов.Заключение. Профиль безопасности комбинации ленватиниба с пембролизумабом соответствовал известному профилю каждого из 2 препаратов, применяемых в монорежиме. НЯ рассматривались как преодолимые с помощью таких подходов, как мониторинг, изменение доз и поддерживающая терапия. Активное и своевременное выявление НЯ и их лечение важны для безопасности пациента и продолжения лечения.Идентификатор исследования на Clinicaltrials.gov: NCT0281186

Circulating concentrations of free triiodothyronine are associated with central adiposity and cardiometabolic risk factors in young euthyroid adults

Funding for open access charge: Universidad de Granada/CBUA. This study was funded by the Spanish Ministry of Economy and Competitiveness via the Fondo de Investigacion Sanitaria del Instituto de Salud Carlos III (PI13/01393), by the Retos de la Sociedad program (DEP2016-79512-R), European Regional Development Funds (ERDF), the Spanish Ministry of Education (FPU13/04365), the Fundacion Iberoamericana de Nutricion (FINUT), the Redes Tematicas de Investigacion Cooperativa RETIC (Red SAMID RD16/0022), the AstraZeneca HealthCare Foundation, the University of Granada Plan Propio de Investigacion 2016-Excellence actions: Unit of Excellence on Exercise and Health (UCEES)-and Plan Propio de Investigacion 2018-the Programa Contratos-Puente and Contratos Perfeccionamiento de Doctores, the Junta de Andalucia, Consejeria de Conocimiento, Investigacion y Universidades (ERDF; ref. SOMM17/6107/UGR), and the Fundacion Alfonso Martin Escudero (grant awarded to GSD).Thyroid dysfunction is associated with classic cardiometabolic risk factors in humans. However, this relationship remains unclear in young euthyroid adults. The present work examines the associations of circulating thyroid hormones (THs) and thyroid-stimulating hormone (TSH) concentrations with body composition and cardiometabolic risk factors in young euthyroid adults. A total of 106 sedentary, euthyroid adults (72 women; 22 ± 2 years old) participated in this cross-sectional study. THs and TSH serum concentrations were determined in fasting conditions (6 h). Body composition (fat mass (FM), lean mass (LM), and visceral adipose tissue (VAT)) was determined by dual-energy X-ray absorptiometry, anthropometric parameters (weight, height, and waist circumference) were measured, and neck adipose tissue mass was quantified through computed tomography (CT) scanning. Cardiometabolic risk factors including fasting glucose and lipid metabolism markers, hepatic phosphatase and transaminases, and blood pressure were also assessed. Free triiodothyronine (FT3) concentration was positively associated with body mass index, LM, VAT, and waist circumference (all P ≤ 0.038). FT3 was also associated with glucose, insulin, HOMA-IR, fatty liver index, and blood pressure (all P < 0.024). All the associations were attenuated when adjusting for sex. In contrast, we found no associations of TSH or free thyroxine with any body composition parameter or cardiometabolic risk factors. In conclusion, FT3 is associated with central adiposity and cardiometabolic risk factors including insulin resistance, fatty liver index, and mean, systolic and diastolic blood pressure in young euthyroid adults. ClinicalTrials.gov identifier: NCT02365129.Universidad de Granada/CBUASpanish Government PI13/01393Retos de la Sociedad program DEP2016-79512-REuropean CommissionSpanish Government FPU13/04365Fundacion Iberoamericana de Nutricion (FINUT)Redes Tematicas de Investigacion Cooperativa RETIC Red SAMID RD16/0022AstraZenecaUniversity of Granada Plan Propio de Investigacion 2016-Excellence actions: Unit of Excellence on Exercise and Health (UCEES)Plan Propio de Investigacion 2018-the Programa Contratos-PuenteContratos Perfeccionamiento de DoctoresJunta de AndaluciaConsejeria de Conocimiento, Investigacion y Universidades (ERDF) SOMM17/6107/UGRFundacion Alfonso Martin Escuder

Cluster-Galaxy Correlations in CDM Models

We study the ability of COBE-normalized CDM models to reproduce observed properties of the distribution of galaxies and clusters using N-body numerical simulations. We analyze the galaxy-galaxy and cluster-galaxy two-point correlation functions, $\xi_{gg}$ and $\xi_{cg}$, in open ($\Omega_{0}=0.4, \Omega_{\Lambda}=0, \sigma_8=0.75$), and flat ($\Omega_{0}=0.3, \Omega_{\Lambda}=0.7, \sigma_8=1.05$) CDM models which both reproduce the observed abundances of rich clusters of galaxies. To compare models with observations we compute projected cross-correlation functions $\omega_{gg}$ and $\omega_{cg}$ to derive the corresponding $\xi_{gg}$ and $\xi_{cg}$. We use target galaxies selected from Las Campanas Redshift Survey, target clusters selected from the APM Cluster Survey and tracer galaxies from the Edinburgh Durham Sky Survey catalog.Comment: 13 pages, 6 figures, to appear in: The Astrophysical Journa

Differential requirements for actin during yeast and mammalian endocytosis

Key features of clathrin-mediated endocytosis have been conserved across evolution. However, endocytosis in Saccharomyces cerevisiae is completely dependent on a functional actin cytoskeleton, whereas actin appears to be less critical in mammalian cell endocytosis. We reveal that the fundamental requirement for actin in the early stages of yeast endocytosis is to provide a strong framework to support the force generation needed to direct the invaginating plasma membrane into the cell against turgor pressure. By providing osmotic support, pressure differences across the plasma membrane were removed and this reduced the requirement for actin-bundling proteins in normal endocytosis. Conversely, increased turgor pressure in specific yeast mutants correlated with a decreased rate of endocytic patch invagination