¿Inclusión real o simulación? Estudio exploratorio de una campaña publicitaria para la comunidad gay en México

The gay community has generally been stereotyped and excluded from spaces in our society. This is reflected in political or commercial advertising campaigns, with those that have been inclusive being very scarce at a global level. With the aim of analyzing the mechanisms in the current dynamics of advertising campaigns, the present case study makes a literature review and a reflection on this social fact, addressing the feasibility and need to give voice to this community, making a critical analysis of the importance of being inclusive in today's society, suggesting a proposal based on Gross (2001) model applied in advertising campaigns for the gay community in Mexico, and Moreno (2006), that could lead to a huge potential for both Mexican companies and advertising agencies to address this community, not only as a market element, but also as an element of social justice. The results suggest that the existing gap in advertising is evident both in Mexico and Latin American context and including these communities seems to be relevant for both its economies and societies.La comunidad gay generalmente ha sido estereotipada y excluida de los espacios en nuestra sociedad. Esto se refleja en las campañas publicitarias políticas o comerciales, y las que han sido inclusivas son muy escasas a nivel mundial. Con el objetivo de reflexionar sobre qué y cómo serían los mecanismos bajo la comunidad gay percibe su diversidad e inclusión en la dinámica actual de las campañas publicitarias, y qué diseño de estos podría implementarse para una posible modificación de este escenario, el presente estudio de caso hace una revisión de la literatura y reflexión sobre este hecho social, abordando la viabilidad y la necesidad de dar voz a esta comunidad, haciendo un análisis crítico de la importancia de ser inclusivo en la sociedad actual, sugiriendo una propuesta basada en el modelo de Gross (2001) y Moreno (2006) aplicado en campañas publicitarias para comunidad gay en México, que podría conducir a un gran potencial tanto para empresas y agencias de publicidad el también dirigirse hacia esta comunidad, no solo como un elemento de mercado, sino también como elemento de justicia social. Los resultados sugieren que la brecha existente en la publicidad es evidente tanto en el contexto de México como en América Latina, e incluir estas comunidades se sugiere relevante tanto para sus economías como para sus sociedades

Modelling ligand selectivity of serine proteases using integrative proteochemometric approaches improves model performance and allows the multi-target dependent interpretation of features

FWN – Publicaties zonder aanstelling Universiteit Leide

Polypharmacology Modelling Using Proteochemometrics (PCM): Recent Methodological Developments, Applications to Target Families, and Future Prospects

Peer reviewe

MAGIC and H.E.S.S. detect VHE gamma rays from the blazar OT081 for the first time: a deep multiwavelength study

https://pos.sissa.it/395/815/pdfPublished versio

Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study

Summary Background Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally. Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of the seven most common gastrointestinal congenital anomalies in low-income, middle-income, and high-income countries globally, and identified factors associated with mortality. Methods We did a multicentre, international prospective cohort study of patients younger than 16 years, presenting to hospital for the first time with oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis, exomphalos, anorectal malformation, and Hirschsprung’s disease. Recruitment was of consecutive patients for a minimum of 1 month between October, 2018, and April, 2019. We collected data on patient demographics, clinical status, interventions, and outcomes using the REDCap platform. Patients were followed up for 30 days after primary intervention, or 30 days after admission if they did not receive an intervention. The primary outcome was all-cause, in-hospital mortality for all conditions combined and each condition individually, stratified by country income status. We did a complete case analysis. Findings We included 3849 patients with 3975 study conditions (560 with oesophageal atresia, 448 with congenital diaphragmatic hernia, 681 with intestinal atresia, 453 with gastroschisis, 325 with exomphalos, 991 with anorectal malformation, and 517 with Hirschsprung’s disease) from 264 hospitals (89 in high-income countries, 166 in middleincome countries, and nine in low-income countries) in 74 countries. Of the 3849 patients, 2231 (58·0%) were male. Median gestational age at birth was 38 weeks (IQR 36–39) and median bodyweight at presentation was 2·8 kg (2·3–3·3). Mortality among all patients was 37 (39·8%) of 93 in low-income countries, 583 (20·4%) of 2860 in middle-income countries, and 50 (5·6%) of 896 in high-income countries (p<0·0001 between all country income groups). Gastroschisis had the greatest difference in mortality between country income strata (nine [90·0%] of ten in lowincome countries, 97 [31·9%] of 304 in middle-income countries, and two [1·4%] of 139 in high-income countries; p≤0·0001 between all country income groups). Factors significantly associated with higher mortality for all patients combined included country income status (low-income vs high-income countries, risk ratio 2·78 [95% CI 1·88–4·11], p<0·0001; middle-income vs high-income countries, 2·11 [1·59–2·79], p<0·0001), sepsis at presentation (1·20 [1·04–1·40], p=0·016), higher American Society of Anesthesiologists (ASA) score at primary intervention (ASA 4–5 vs ASA 1–2, 1·82 [1·40–2·35], p<0·0001; ASA 3 vs ASA 1–2, 1·58, [1·30–1·92], p<0·0001]), surgical safety checklist not used (1·39 [1·02–1·90], p=0·035), and ventilation or parenteral nutrition unavailable when needed (ventilation 1·96, [1·41–2·71], p=0·0001; parenteral nutrition 1·35, [1·05–1·74], p=0·018). Administration of parenteral nutrition (0·61, [0·47–0·79], p=0·0002) and use of a peripherally inserted central catheter (0·65 [0·50–0·86], p=0·0024) or percutaneous central line (0·69 [0·48–1·00], p=0·049) were associated with lower mortality. Interpretation Unacceptable differences in mortality exist for gastrointestinal congenital anomalies between lowincome, middle-income, and high-income countries. Improving access to quality neonatal surgical care in LMICs will be vital to achieve Sustainable Development Goal 3.2 of ending preventable deaths in neonates and children younger than 5 years by 2030

Chemoinformatics and Artificial Intelligence Colloquium: Progress and Challenges to Develop Bioactive Compounds

We report the main conclusions of the first Chemoinformatics and Artificial Intelligence Colloquium, Mexico City (virtual), June 15-17, 2022. Fifteen lectures were presented during a virtual and public event with speakers from industry, academia, and non-for-profit organizations. 1,290 participants, mainly students, and academics from more than 60 countries had registered. During the meeting, applications, challenges, and opportunities in drug discovery, de novo drug design, ADME-Tox (Adsorption, Distribution, Metabolism, Excretion and Toxicity) property predictions, organic chemistry and peptides, and antibiotic resistance were discussed. The program along with the recordings of all sessions is freely available at https://www.difacquim.com/english/events/2022-colloquium/

Real inclusion or simulation? An exploration of advertising campaigns and the gay community in Mexico

The gay community has generally been stereotyped and excluded from spaces in our society. This is reflected in political or commercial advertising campaigns, with those that have been inclusive being very scarce at a global level. With the aim of analyzing the mechanisms in the current dynamics of advertising campaigns, the present case study makes a literature review and a reflection on this social fact, addressing the feasibility and need to give voice to this community, making a critical analysis of the importance of being inclusive in today's society, suggesting a proposal based on Gross (2001) model applied in advertising campaigns for the gay community in Mexico, and Moreno (2006), that could lead to a huge potential for both Mexican companies and advertising agencies to address this community, not only as a market element, but also as an element of social justice. The results suggest that the existing gap in advertising is evident both in Mexico and Latin American context and including these communities seems to be relevant for both its economies and societies.La comunidad gay generalmente ha sido estereotipada y excluida de los espacios en nuestra sociedad. Esto se refleja en las campañas publicitarias políticas o comerciales, y las que han sido inclusivas son muy escasas a nivel mundial. Con el objetivo de reflexionar sobre qué y cómo serían los mecanismos bajo la comunidad gay percibe su diversidad e inclusión en la dinámica actual de las campañas publicitarias, y qué diseño de estos podría implementarse para una posible modificación de este escenario, el presente estudio de caso hace una revisión de la literatura y reflexión sobre este hecho social, abordando la viabilidad y la necesidad de dar voz a esta comunidad, haciendo un análisis crítico de la importancia de ser inclusivo en la sociedad actual, sugiriendo una propuesta basada en el modelo de Gross (2001) y Moreno (2006) aplicado en campañas publicitarias para comunidad gay en México, que podría conducir a un gran potencial tanto para empresas y agencias de publicidad el también dirigirse hacia esta comunidad, no solo como un elemento de mercado, sino también como elemento de justicia social. Los resultados sugieren que la brecha existente en la publicidad es evidente tanto en el contexto de México como en América Latina, e incluir estas comunidades se sugiere relevante tanto para sus economías como para sus sociedades

MAGIC detection of short-term variability of the high-peaked BL Lac object 1ES 0806+524

ISSN:0035-8711ISSN:1365-2966ISSN:1365-871