Alien Registration- Menchen, John P. (Gorham, Cumberland County)

https://digitalmaine.com/alien_docs/31704/thumbnail.jp

Neuronal Protection by a Novel C-terminal Hsp90 Modulator

Alzheimer's disease (AD), like most neurodegenerative disorders, is characterized by accumulation of misfolded and aggregated proteins, indicating that the protein quality control machinery is compromised. Enhancing the activity of molecular chaperones such as the `heat shock' proteins (Hsp's) that re-fold or signal degradation of damaged proteins may help remove protein oligomers/aggregates and prevent cell death. The goal of our studies was to characterize a novel, non-toxic Hsp90 modulator, KU-32, which protects primary cortical neurons against Aβ1-42, a toxic peptide found in AD brain. Pharmacokinetic studies indicated that KU-32 is blood brain barrier permeable and orally bioavailable. Using two AD mouse models, JNPL3 and rTg4510, which both contain the P301L Tau mutation and develop aberrant Tau tangles as well as cognitive impairments, we assessed KU-32 treatment in vivo. The JNPL3 mice were treated with 20 mg/kg of KU-32 or with 12.5% Captisol® (vehicle) five times a week for six months. Immunohistochemical studies indicated significant decreases of hyperphosphorylated Tau in the cortical region. The rTg4510 mice were treated with 60 mg/kg of KU-32 or with vehicle (5% Captisol®) twice a week for 10 weeks. Immunofluorescent analyses demonstrated significant protection against dendritic pathology and neuronal death in KU-32-treated vs vehicle-treated rTg4510 mice. Further studies were conducted to examine the potential mechanisms of drug action. We hypothesized that KU-32 activated the heat shock response leading to an increase in molecular chaperones involved in protein quality control such as Hsp70. Our data suggest that KU-32 is not acting through this mechanism, and further studies are needed to elucidate the mechanism. Overall, our in vivo results suggest that the novel Hsp90 modulator, KU-32, may have therapeutic potential for treatment of AD

Web historian: enabling multi-method and independent research with real-world web browsing history data

Research analyzing real-world web browsing data has generally been collected from digital service providers or the online panelists of corporate research panels. These approaches limit the replicability and the kind of work that can be done. Web Historian’s first tool, a Chrome browser extension addresses this problem by enabling researchers to securely collect web browsing history data from participants with a robust informed consent process, and direct benefits to participants. Data visualizations of web browsing history inform participants of what they are submitting to the research project and help them gain further knowledge of their own browsing habits. Web Historian uses data that are already on the user’s computer. Participants can submit up to 90 days of browsing history within just a few minutes. Since researchers can recruit participants themselves web browsing history data can be added to other forms of data collection, qualitative or quantitative. The visualizations can also be used for educational purposes

Dueling Repository Woes: Greater Needs, Fewer In-House Experts

This session will serve as a brief case study of how one college special collections unit navigated a particularly transitional year in which they faced an unparalleled increase in demand for digital collections access alongside a reduction of in-house technical support for their digital repository. As at other institutions, the COVID-19 pandemic majorly impacted the operations of Smith College Special Collections (SCSC), with a switch to remote teaching, cancelled fellowship visits, and physical collections that were suddenly inaccessible. To provide the remote access to archives and special collections needed to facilitate teaching and research, SCSC spun up a digitization-on-demand workflow. Using a pseudo “assembly line” model, SCSC digitized over 70,000 pages of material from over 1200 digitization requests between August 2020 and July 2021

Researching Real-World Web Use with Roxy: Collecting Observational Web Data with Informed Consent

Outside of a laboratory environment, it has been difficult for researchers to collect both behavioral and self-reported Web use data from the same participants. To address this challenge, we created Roxy, which is software that collects real-world Web-use data with participants' informed consent. Roxy gathers Web log data as well as the text and HTML code of each page visited by participants. In this workbench note, we describe Roxy's data-gathering capabilities and search functions, then illustrate how we used the software in a multimethod study. The use case examines selective exposure to political communication during the November 2010 U.S. general election campaign

Trust in ME: CBB Access Services Collaboration

Colby, Bates and Bowdoin (CBB) College libraries have a thirty-year history of working closely with one another that has created an extraordinary level of mutual trust. In 2010 we completed a 3-year Mellon funded collections grant, and as a result CBB agreed to share a single approval plan that automatically sends a single title to be shared by the three schools. CBB created a formal governance structure to coordinate the many aspects of our increased collaboration which embraces four major areas of our activities, one of which is Access Services. The group consults on and informs policies and procedures that impact all three libraries. Access Services sta have worked to implement standard loan policies for CBB faculty and students and provide a shared delivery service. CBB collections collaboration would not have been able to go forward had these loan policies, quick turnaround practices and e cient delivery not been in place. In the near future, the group will be looking to coordinate lost and missing procedures and evaluate reconciliation measures. Going forward, CBB Access Services anticipates many other issues that will need discussion as we present CBB collections as one. CBB Access Services sta would like to share some of the high (and challenging) points of our collaborative journey