Reviewing Research Trends:A Scientometric Approach Using Gunshot Residue (GSR) Literature as an Example

The ability to manage, distil and disseminate the significant amount of information that is available from published literature is fast becoming a core and critical skill across all research domains, including that of forensic science. In this study, a simplified scientometric approach has been applied to available literature on gunshot residue (GSR) as a test evidence type aiming to evaluate publication trends and explore the interconnectivity between authors. A total of 731 publications were retrieved using the search engine ‘Scopus’ and come from 1589 known authors, of whom 401 contributed to more than one research output on this subject. Out of the total number of publications, only 35 (4.8%) were found to be Open Access (OA). The Compound Annual Growth Rate (CAGR) for years 2006 and 2016 reveals a much higher growth in publications relating to GSR (8.0%) than the benchmark annual growth rate of 3.9%. The distribution of a broad spectrum of keywords generated from the publications confirms a historical trend, in particular regarding the use of analytical techniques, in the study of gunshot residue. The results inform how relevant information extracted from a bibliometric search can be used to explore, analyse and define new research areas

Masses and age of the Chemically Peculiar double-lined binary χ\chi~Lupi

8 pages, accepted in AandAWe aim at measuring the stellar parameters of the two Chemically Peculiar components of the B9.5Vp HgMn + A2 Vm double-lined spectroscopic binary HD141556, whose period is $15.25$~days. We combined historical radial velocity measurements with new spatially resolved astrometric observations from PIONIER/VLTI to reconstruct the three-dimensional orbit of the binary, and thus obtained the individual masses. We fit the available photometric points together with the flux ratios provided by interferometry to constrain the individual sizes, which we compared to predictions from evolutionary models.The individual masses of the components are \Ma = 2.84 \pm 0.12\ \Msun and \Mb = 1.94 \pm 0.09\ \Msun. The dynamical distance is compatible with the Hipparcos parallax. We find linear stellar radii of \Ra=2.85 \pm 0.15\ \Rsun and \Rb=1.75 \pm 0.18\ \Rsun. This result validates a posteriori the flux ratio used in previous detailed abundance studies. We determine a sub-solar initial metallicity $Z=0.012\pm0.003$ and an age of $(2.8\pm0.3)\times10^8\$years. Our results imply that the primary rotates more slowly than its synchronous velocity, while the secondary is probably synchronous. We show that strong tidal coupling during the pre-main sequence evolution followed by a full decoupling at zero-age main sequence provides a plausible explanation for these very low rotation rates

Changing trends in novel benzodiazepine use within Scottish prisons:detection, quantitation, prevalence, and modes of use

Drug use within prisons is increasingly complex and unpredictable. Benzodiazepines are currently one of the most common drugs detected in individuals leaving Scottish prisons; however, understanding illicit benzodiazepine use within prisons and assessing the potential harm to individuals is challenging due to the lack of available analytical data on the substances circulating. Increasingly, materials, such as paper and clothing, infused with novel benzodiazepines have been identified as a smuggling route into Scottish prisons. Methods were developed for the qualitative and quantitative analysis of benzodiazepines using gas chromatography–mass spectrometry (GC–MS) and applied to 495 seized samples from 11 Scottish prisons, including papers, cards, blotters, powders, tablets, and clothing. Evolution in the benzodiazepines being detected was demonstrated, with etizolam being the most prevalent throughout 2020/2021 following which flubromazepam and bromazolam detections increased. Additionally, significant changes in the smuggling methods and drug formats detected occurred over time following policy changes within prisons. These data represent the first reported widescale etizolam quantitation data and demonstrate high levels of variability across all sample types, most notably within tablets (0.34–2.33 mg per tablet). Additionally, concentration mapping of a whole seized card sample revealed the total concentration of drug present (312.5 mg) and demonstrated variability across the surface of the card (1.16–1.87 mg/cm 2). These data highlight the challenges of consistent dosing for individuals and the high risks of unintentional overdose. Increased understanding of the challenge of such drug smuggling and benzodiazepine use will aid in the development of strategies to reduce supply and mitigate harm.</p

Haematological consequences of acute uncomplicated falciparum malaria: a WorldWide Antimalarial Resistance Network pooled analysis of individual patient data

Background: Plasmodium falciparum malaria is associated with anaemia-related morbidity, attributable to host, parasite and drug factors. We quantified the haematological response following treatment of uncomplicated P. falciparum malaria to identify the factors associated with malarial anaemia. Methods: Individual patient data from eligible antimalarial efficacy studies of uncomplicated P. falciparum malaria, available through the WorldWide Antimalarial Resistance Network data repository prior to August 2015, were pooled using standardised methodology. The haematological response over time was quantified using a multivariable linear mixed effects model with nonlinear terms for time, and the model was then used to estimate the mean haemoglobin at day of nadir and day 7. Multivariable logistic regression quantified risk factors for moderately severe anaemia (haemoglobin < 7 g/dL) at day 0, day 3 and day 7 as well as a fractional fall ≥ 25% at day 3 and day 7. Results: A total of 70,226 patients, recruited into 200 studies between 1991 and 2013, were included in the analysis: 50,859 (72.4%) enrolled in Africa, 18,451 (26.3%) in Asia and 916 (1.3%) in South America. The median haemoglobin concentration at presentation was 9.9 g/dL (range 5.0–19.7 g/dL) in Africa, 11.6 g/dL (range 5.0–20.0 g/dL) in Asia and 12.3 g/dL (range 6.9–17.9 g/dL) in South America. Moderately severe anaemia (Hb < 7g/dl) was present in 8.4% (4284/50,859) of patients from Africa, 3.3% (606/18,451) from Asia and 0.1% (1/916) from South America. The nadir haemoglobin occurred on day 2 post treatment with a mean fall from baseline of 0.57 g/dL in Africa and 1.13 g/dL in Asia. Independent risk factors for moderately severe anaemia on day 7, in both Africa and Asia, included moderately severe anaemia at baseline (adjusted odds ratio (AOR) = 16.10 and AOR = 23.00, respectively), young age (age < 1 compared to ≥ 12 years AOR = 12.81 and AOR = 6.79, respectively), high parasitaemia (AOR = 1.78 and AOR = 1.58, respectively) and delayed parasite clearance (AOR = 2.44 and AOR = 2.59, respectively). In Asia, patients treated with an artemisinin-based regimen were at significantly greater risk of moderately severe anaemia on day 7 compared to those treated with a non-artemisinin-based regimen (AOR = 2.06 [95%CI 1.39–3.05], p < 0.001). Conclusions: In patients with uncomplicated P. falciparum malaria, the nadir haemoglobin occurs 2 days after starting treatment. Although artemisinin-based treatments increase the rate of parasite clearance, in Asia they are associated with a greater risk of anaemia during recovery