118 research outputs found
Quasi-Normal Modes of Schwarzschild Anti-De Sitter Black Holes: Electromagnetic and Gravitational Perturbations
We study the quasi-normal modes (QNM) of electromagnetic and gravitational
perturbations of a Schwarzschild black hole in an asymptotically Anti-de Sitter
(AdS) spacetime. Some of the electromagnetic modes do not oscillate, they only
decay, since they have pure imaginary frequencies. The gravitational modes show
peculiar features: the odd and even gravitational perturbations no longer have
the same characteristic quasinormal frequencies. There is a special mode for
odd perturbations whose behavior differs completely from the usual one in
scalar and electromagnetic perturbation in an AdS spacetime, but has a similar
behavior to the Schwarzschild black hole in an asymptotically flat spacetime:
the imaginary part of the frequency goes as 1/r+, where r+ is the horizon
radius. We also investigate the small black hole limit showing that the
imaginary part of the frequency goes as r+^2. These results are important to
the AdS/CFT conjecture since according to it the QNMs describe the approach to
equilibrium in the conformal field theory.Comment: 2 figure
Global modelling of the early Martian climate under a denser CO2 atmosphere: Water cycle and ice evolution
We discuss 3D global simulations of the early Martian climate that we have
performed assuming a faint young Sun and denser CO2 atmosphere. We include a
self-consistent representation of the water cycle, with atmosphere-surface
interactions, atmospheric transport, and the radiative effects of CO2 and H2O
gas and clouds taken into account. We find that for atmospheric pressures
greater than a fraction of a bar, the adiabatic cooling effect causes
temperatures in the southern highland valley network regions to fall
significantly below the global average. Long-term climate evolution simulations
indicate that in these circumstances, water ice is transported to the highlands
from low-lying regions for a wide range of orbital obliquities, regardless of
the extent of the Tharsis bulge. In addition, an extended water ice cap forms
on the southern pole, approximately corresponding to the location of the
Noachian/Hesperian era Dorsa Argentea Formation. Even for a multiple-bar CO2
atmosphere, conditions are too cold to allow long-term surface liquid water.
Limited melting occurs on warm summer days in some locations, but only for
surface albedo and thermal inertia conditions that may be unrealistic for water
ice. Nonetheless, meteorite impacts and volcanism could potentially cause
intense episodic melting under such conditions. Because ice migration to higher
altitudes is a robust mechanism for recharging highland water sources after
such events, we suggest that this globally sub-zero, `icy highlands' scenario
for the late Noachian climate may be sufficient to explain most of the fluvial
geology without the need to invoke additional long-term warming mechanisms or
an early warm, wet Mars.Comment: Minor revisions to text, one new table, figs. 1,3 11 and 18 redon
Molecular Fingerprint-Derived Similarity Measures for Toxicological Read-Across: Recommendations for Optimal Use
Computational approaches are increasingly used to predict toxicity, in part due to pressures to find alternatives to animal testing. Read-across is the ânew paradigmâ which aims to predict toxicity by identifying similar, data rich, source compounds. This assumes that similar molecules tend to exhibit similar activities, i.e. molecular similarity is integral to read-across. Various molecular fingerprints and similarity measures may be used to calculate molecular similarity. This study investigated the value and concordance of the Tanimoto similarity values calculated using six widely used fingerprints within six toxicological datasets. There was considerable variability in the similarity values calculated from the various molecular fingerprints for diverse compounds, although they were reasonably concordant for homologous series acting via a common mechanism. The results suggest generic fingerprint-derived similarities are likely to be optimally predictive for local datasets, i.e. following sub-categorisation. Thus, for read-across, generic fingerprint-derived similarities are likely to be most predictive after chemicals are placed into categories (or groups), then similarity is calculated within those categories, rather than for a whole chemically diverse dataset
Whole-genome sequencing reveals host factors underlying critical COVID-19
Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genesâincluding reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)âin critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease
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