Potential human transmission of amyloid β pathology: surveillance and risks

Studies in experimental animals show transmissibility of amyloidogenic proteins associated with prion diseases, Alzheimer's disease, Parkinson's disease, and other neurodegenerative diseases. Although these data raise potential concerns for public health, convincing evidence for human iatrogenic transmission only exists for prions and amyloid β after systemic injections of contaminated growth hormone extracts or dura mater grafts derived from cadavers. Even though these procedures are now obsolete, some reports raise the possibility of iatrogenic transmission of amyloid β through putatively contaminated neurosurgical equipment. Iatrogenic transmission of amyloid β might lead to amyloid deposition in the brain parenchyma and blood vessel walls, potentially resulting in cerebral amyloid angiopathy after several decades. Cerebral amyloid angiopathy can cause life-threatening brain haemorrhages; yet, there is no proof that the transmission of amyloid β can also lead to Alzheimer's dementia. Large, long-term epidemiological studies and sensitive, cost-efficient tools to detect amyloid are needed to better understand any potential routes of amyloid β transmission and to clarify whether other similar proteopathic seeds, such as tau or α-synuclein, can also be transferred iatrogenically

LES RUPTURES UTERINES SPONTANEES (A PROPOS D'UN CAS DE RUPTURE A 28 SA PAR PLACENTA INCRETA)

LYON1-BU Santé (693882101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Irradiation campaign in the EOLE critical facility of fiber optic Bragg gratings dedicated to the online temperature measurement in zero power research reactors

International audienceThe control of temperature during operation of zero power research reactors participates to the overall control of experimentation conditions and reveals itself of a major importance when measuring neutronic parameters such as multiplication factors. Within the framework of the refurbishment of the MASURCA facility, the development of a new temperature measurement system based on the optical fiber Bragg grating (FBG) technology is under consideration. In a first step, a series of FBGs is irradiated in the EOLE critical facility with the aim to select the most appropriate. Online temperature measurements are performed during a set of irradiations that should allow reaching a fast neutron fluence of nearly 5·1014 n.cm-2 and a total gamma dose lower than 4 kGy. The results obtained, especially the Bragg wavelength shifts during the irradiation campaign, are discussed in this paper and compared to data from standard PT100 temperature sensors to highlight possible radiation effects on sensor performances. Work to be conducted during the second step of the project, aiming to a feasibility demonstration using a MASURCA assembly, is also presented