MATHEMATICAL MODEL OF RESONATOR CHAINS IN EXTERNAL MAGNETIC FIELD

Subject of Research.The paper considers a spectral problem for chains of weakly coupled ball-shaped resonators under the action of an external magnetic field. Two basic geometries are studied composed of identical resonators: the chain with a single kink and the one with symmetric branching. The vector of magnetic field induction is assumed to be perpendicular to the plane including the centers of resonators that are forming the chain. The delta-like potentials with the same intensity are applied to all contact points. Method. The mathematical model of the chain consisting of identical resonators interacting with each other via a single point is constructed in the framework of the theory of self-adjoint extensions of symmetric operators. The modification of Neumann formulas was used for adjoint operator description. Both systems have a periodicity in parts and the model itself is constructed in such way that it becomes possible to use the transfer matrix approach to obtain the spectrum of the model Hamiltonian. Main Results. The structure of the spectrum for both chains is analytically described; namely, all equations and inequalities are obtained, which give the possibility to find the bands of the continuous spectrum, as well as the energy values ​​related to the discrete spectrum. Numerical simulation clearly demonstrates the structure of the continuous spectrum of the systems depending on the model parameters. Practical Relevance. Since the model has different variable parameters, it can be used to construct real systems that have certain spectral properties. The geometries considered in this paper are the basic elements for the construction of more complex systems

Trade in services in the Baltic States: evolution and future prospects

Trade in services in the Baltic States has traditionally been overlooked. The main objective of this article is to assess the current situation and the future prospects of trade in those services used as intermediate inputs using data from the World Input-Output Database. Unlike previous works we do not only analyze direct trade but also indirect trade, that is, the trade in intermediate services contained in goods. The results show that although traditional services reported major shares in the total volume of intermediate services exports in the Baltic States, other categories of more knowledge-intensive services are gaining importance. First published online: 08 Jun 201

The Effect of Processing Route on Properties of HfNbTaTiZr High Entropy Alloy

High entropy alloys (HEA) have been one of the most attractive groups of materials for researchers in the last several years. Since HEAs are potential candidates for many (e.g., refractory, cryogenic, medical) applications, their properties are studied intensively. The most frequent method of HEA synthesis is arc or induction melting. Powder metallurgy is a perspective technique of alloy synthesis and therefore in this work the possibilities of synthesis of HfNbTaTiZr HEA from powders were studied. Blended elemental powders were sintered, hot isostatically pressed, and subsequently swaged using a special technique of swaging where the sample is enveloped by a titanium alloy. This method does not result in a full density alloy due to cracking during swaging. Spark plasma sintering (SPS) of mechanically alloyed powders resulted in a fully dense but brittle specimen. The most promising result was obtained by SPS treatment of gas atomized powder with low oxygen content. The microstructure of HfNbTaTiZr specimen prepared this way can be refined by high pressure torsion deformation resulting in a high hardness of 410 HV10 and very fine microstructure with grain size well below 500 nm.11Ysciescopu

Students virtual and social identity in the process of humanities study: The problems of its correction

© 2016, Econjournals. All rights reserved.The relevance of the research problem is reasoned by global use of Internet technologies, altering the forms of personal self-identification: Atransition of the external world and human individuality in a digital code, the creation of informational imprint in space of the worldwide web, the alienation of the student youth in society, the substitution of reality by virtual world. In this direction a significant potential belongs to humanities, studying of which contributes to the interpenetration and mutual reinforcement of students’ social and virtual identification based on universal norms, values, value orientations, correction of virtual identity redundancy in real society. This article is aimed at scientifically-methodical substantiation of structure and content of pedagogical correction of higher school students’ self-identification in the process of humanities’ study. The leading method in this problem study is a method of modeling of the structure and content of students’ self-identification pedagogical correction in the process of humanitarian disciplines’ study. The article presents the theoretical and methodological foundations of the design and implementation of student’s social and virtual identity correction’s model, its discursive content and mechanisms, structure and new forms’ content in the process of humanities’ study. The presented materials in the article contribute to evidence-based correction of students virtual and social identity in the process of humanities’ study and are recommended to use for teachers, methodologists, university information departments’ programmers, improvement of qualification and teacher retraining courses’ attendants

Clinical case: difficulties in managing a patient diagnosed with tuberculosis + HIV infection with functional kidney damage

The purpose of the study is to analyze the features of the course of tuberculosis, combined with HIV infection and functional kidney damage.Цель исследования — проанализировать особенности течения туберкулеза, сочетанного с ВИЧ-инфекцией и функциональным поражением почек

Influence of Heat Treatment on Defect Structures in Single-Crystalline Blade Roots Studied by X-ray Topography and Positron Annihilation Lifetime Spectroscopy

Single-crystalline superalloy CMSX-4 is studied in the as-cast state and after heat treatment, with material being taken from turbine blade castings. The effect of the heat treatment on the defect structure of the root area near the selector/root connection is emphasized. Multiscale analysis is performed to correlate results obtained by X-ray topography and positron annihilation lifetime spectroscopy (PALS). Electron microscopy observations were also carried out to characterize the inhomogeneity in dendritic structure. The X-ray topography was used to compare defects of the misorientation nature, occurring in as-cast and treated states. The type and concentration of defects before and after heat treatment in different root areas were determined using the PALS method, which enables voids, mono-vacancies, and dislocations to be taken into account. In this way, differences in the concentration of defects caused by heat treatment are rationalized

Доклиническое токсикологическое изучение алофаниба — аллостерического ингибитора рецептора фактора роста фибробластов 2 типа

Background. Inhibition of fibroblast growth factor receptor type 2 (FGFR2) appears to be appropriate in patients with tumors expressing or amplifying FGFR2. The toxicity of allosteric FGFR2 inhibitors has not been previously studied.Purpose. Evaluation of the toxicity of the anticancer drug alofanib (RPT835), allosteric inhibitor of fibroblast growth factor receptor 2 type (FGFR2), in standard experimental in-vivo models in rodents and non-rodents.Material and methods. The general toxic effect of the alofanib was studied in an acute and chronic experiment on outbred animals (rats and rabbits) of both sexes. An experimental study was conducted in accordance with the ethical principles of handling laboratory animals.Results. The assumption that inhibition of FGFR2 provides a low level of toxicity has been proved. It was established that alofanib belongs to the 4 class of low-toxic chemical substances according to the classification of hazard levels of toxic effects of drugs and to the low-risk drugs by the value of the index of the therapeutic action, as well as to the 3 class (low-toxic drugs) according to the class of hazards for clinical application. Alofanib doesn»t cause allergenic and immunotoxic effects as well as doesn»t have pyrogenic properties. Increase of phosphates level (class-specific adverse effect of FGFR2 inhibitors) was statistically significant but less evident. During the study was noticed such an adverse effect as inhibition of spermatogenesis.Conclusion. Alofanib belongs to the classes of low-hazard and low-toxic chemicals and can be studied in a clinical study.Актуальность. Ингибирование рецептора фактора роста фибробластов 2 типа (ФРФР2) представляется целесообразным у больных с опухолями, экспрессирующими или амплифицирующими ФРФР2. Токсичность аллостерических ингибиторов ФРФР2 ранее не изучалась.Цель исследования. Оценка токсичности противоопухолевого препарата алофаниб (RPT835), аллостерического ингибитора рецептора фактора роста фибробластов 2 типа (ФРФР2), в стандартных экспериментальных моделях in vivo на грызунах и негрызунах.Материалы и методы. Общетоксическое действие препарата было изучено в остром и хроническом эксперименте на беспородных животных (крысах и кроликах) обоего пола. Экспериментальное исследование было проведено в соответствии с этическими принципами обращения с лабораторными животными.Результаты. Предположение о том, что ингибирование только одного рецептора ФРФР2 обеспечит низкий уровень токсичности, подтвердилось. Установлено, что алофаниб относится к 4 классу малотоксичных химических веществ по классификации степени опасности токсического действия лекарственных средств и к малоопасным лекарственным препаратам по величине индекса широты терапевтического действия, а также к 3 классу (малотоксичный лекарственный препарат) в соответствии с классом опасности для клинического применения. Алофаниб не оказывает аллергизирующего и иммунотоксичного действия и не обладает пирогенными свойствами. Увеличение уровня фосфатов (класс-специфического нежелательного явления ФРФР ингибиторов) было статистически достоверным, но маловыраженным. В исследовании отмечен такой побочный эффект как угнетение сперматогенеза.Заключение. Алофаниб относится к классам малоопасным и малотоксичных химических веществ и может изучаться в клиническом исследовании

A New Method for Treating Burn Wounds Using Targeted Delivery of Medicinal Substances by Magnetic Nanocarrier (Experimental Part)

Проведено экспериментальное исследование на лабораторных животных по изучению эффективности адресной доставки мази левомеколь с помощью магнитных наночастиц и внешнего магнитного поля при термических ожогах. В исследовании принимало участие 20 крыс с двумя очагами ожога. Крысы были разделены на 4 группы: без лечения, терапия с использованием мази левомеколь, лечение с использованием наночастиц, мази левомеколь и внешнего магнитного поля и только магнитотерапии. При гистологическом исследовании на 14-е сутки во всех группах в зоне термического повреждения кожи были отмечены признаки глубокого ожога III и IV степени с распространением некроза на всю глубину дермы и на мышцы. В группе с наночастицами, мазью левомеколь и магнитным полем на фоне уменьшения воспаления отмечалось очаговое появление грануляционной ткани. Таким образом, гистологические исследования ожогового раневого процесса лабораторных животных показали, что использование инновационного биологически активного ранозаживляющего средства на основе наночастиц в сочетании с мазью левомеколь улучшает регенерацию тканей и приводит к ускорению эпителизации, что в целом повышает результаты лечения ожоговой раны. Использование внешнего магнитного поля способствует адресной доставке лечебного нанокомплекса и поддержанию оптимальной концентрации препарата в ранеExperimental studies have been carried out on laboratory animals to investigate the effectiveness of targeted delivery of levomekol ointment using magnetic nanoparticles and an external magnetic field for treatment of thermal burns. The study involved 20 rats, with two burns on each. The rats were divided into 4 groups: untreated; treated with levomekol ointment; treated with levomekol ointment associated with nanoparticles and an external magnetic field; and treated with magnetic field alone. Histological examination was conducted on Day 14, and in all groups, in the thermal burn zone of the skin there were signs of deep three- and four-degree burns with necrosis spread through the dermis, reaching the muscle. In the group with levomekol ointment associated with nanoparticles and magnetic field, inflammation was decreased, and focal granulation tissue formation was observed. Thus, histological studies of the burn wound process in laboratory animals showed that the use of an innovative biologically active wound healing agent based on nanoparticles in combination with the levomecol ointment improved tissue regeneration and accelerated epithelialization, which enhanced the effectiveness of burn wound treatment. The use of an external magnetic field facilitated targeted delivery of the therapeutic nanosystem and maintenance of the optimal concentration of the drug in the woun

INFORMATIONAL AND COMMUNICATIVE COMPETENCE FORMATION IN THE TEXT ACTIVITY PROCESS

The paper is devoted to the problem of fostering the informational and communicative competence, regarded as the capability of meaningful work with information, its personalized understanding and implementation in professional activity. As a solution to the problem, the author indicates the developing potential of text activity, performed in a dialog enriched by ideas of hermeneutics and meaning-making. The competence in question should be developed stage-by-stage by role-playing the professionally focused situations; applying the symbolic contextual approach by A. A. Verbitsky; using different tasks to enable understanding, comprehension of new semantics, correlation with students' personal experience; and promoting self-understanding, selfawareness and value attitude. The above activities  should result in training competent experts with a broad cultural outlook and capability to adapt to and work in the modern information society, find creative solutions to the complex challenges, and communicate in the global cross-cultural environment

Information and communication fostering as the part of teacher`s practice-oriented research activity

В статье обосновывается потребность развития исследовательской деятельности у современных специалистов, которая должна быть в основе практикоориентированной подготовки в многоуровневом российском педагогическом образовании. При этом условием развития исследовательской культуры, согласно современным требованиям, может быть формирование информационно-коммуникативной компетентности, которая в авторской трактовке представляет собой способность понимания и развития гуманитарных смыслов предметной информации в общении и профессиональной деятельности. В основе методологии данного исследования лежат: компетентностный подход (И. А. Зимняя, А. В. Хуторской и др.) социально-личностный подход (В. И. Загвязинский), семиосоциопсихологическая теория (Т. М. Дридзе), основы педагогической герменевтики (А. Ф. Закирова), закономерности смыслообразования (Е. Г. Белякова), знаково-контекстное обучение (А. А. Вербицкий). Процесс формирования информационно-коммуникативной компетентности рассмотрен на примере подготовки педагогов, поскольку инновационный потенциал у обучающихся гуманитарной, естественнонаучной и инженерной областей не может быть заложен, если преподаватели вуза и школьные учителя сами не будут владеть исследовательской культурой и транслировать ее другим. Технология формирования информационно-коммуникативной компетентности основана на механизме интеграции профессионального и гуманитарного контекста средствами текстовой деятельности как осмысленной работы с текстами в условиях диалога и выстроена в логике определенных этапов ее освоения: мотивация и актуализация субъектного опыта; осмысление предметного содержания текста; интерпретация гуманитарного контекста; смысловое обобщение полученного опыта. При этом через текстовую деятельность формируются способности работать с информацией, используя диалог, групповое взаимодействие, что позволяет проникнуть в содержание предметных текстов, выйти к гуманитарным смыслам профессиональной деятельности и обеспечивает подготовку к реальной практической . In the article the demand to develop research activity of modern professionals which should form the basis of practice-oriented training within the multilevel system of Russian education. The research culture can be developed under the condition of forming information-communicative competence as an ability to understand and develop humanitarian meanings of subject information in communication and professional activity. The methodological basis of this research is formed by: the competence approach (I. A. Zimnyaya, A. V. Khutorskoy, etc.), the socio-personal approach (V. I. Zagvyazinsky), the semiosociopsychological theory (T. M. Dridze), the bases of pedagogical hermeneutics (A. F. Zakirova), the laws of meaningmaking (E. G. Belyakova), and contextual training (A. A. Verbitsky). The process of fostering the information-communicative competence is presented employing the example of teacher-training activity, as if university and school teachers don't have research culture, they can't broadcast it to future humanitarian, natural-science and engineering professionals to develop their innovative potential. The technology of fostering the information-communicative competence is based on the mechanism of reading comprehension as intelligent work with texts in the conditions of a dialogue and the process is built in the logics of its development: motivation and activation of subject experience; understanding of the subject content of the text; interpretation of the humanitarian context; semantic summary of the new experience. With help of reading comprehension it becomes possible to foster abilities of working with information, using dialogue and group interaction. At the same time this allows to get into the contents of subject texts, to comprehend humanitarian meanings of professional activity, and to realize the readiness for professional activity