FACTORES DE RIESGO DE RINUSINUSITIS COMO COMPLICACION DE RINITIS ALERGICA EN PACIENTES ADULTOS JOVENES. CONSULTA EXTERNA DE OTORRINOLARINGOLOGIA DEL HOSPITAL CENTRAL UNIVERSITARIO DR. ANTONIO MARIA PINEDA. VENEZUELA

La Rinitis al\ue9rgica y rinusinusitis, es una enfermedad que afecta a la poblaci\uf3n general y, aunque no es grave, tiene importancia en la calidad de vida y el rendimiento escolar. El diagn\uf3stico precoz es necesario para evitar complicaciones y de esta manera establecer un protocolo de tratamiento. En este orden de idea, se realiz\uf3 un estudio de corte transversal, con el objetivo de determinar los factores de riesgo de rinusinusitis como complicaci\uf3n de Rinitis Al\ue9rgica en pacientes adultos j\uf3venes que acudieron a la consulta externa de otorrinolaringolog\ueda del Hospital Universitario Dr. "Antonio Mar\ueda Pineda". La muestra fue no probabil\uedstica de tipo intencional, conformada por 85 pacientes que cumplieron los criterios de inclusi\uf3n del total de pacientes diagnosticados con Rinitis Al\ue9rgica que asistieron a la consulta del servicio de Otorrinolaringolog\ueda. Se utiliz\uf3 un cuestionario mixto y la observaci\uf3n para el examen f\uedsico. Se report\uf3 entre los resultados: 55% de las personas tienen edades entre 15 a 20 a\uf1os, siendo predominante el grupo masculino (54%), la sintomatolog\ueda vari\uf3 seg\ufan la escala EVA destac\ue1ndose la molestia moderada en prurito (50%) y estornudos (47%). Por otra parte, 85% de los pacientes mostraron cambios Tomogr\ue1ficos; asimismo, el Seno Paranasal m\ue1s afectado (42%) fue el etmoidal; en cuanto a los factores de riesgo la exposici\uf3n a sustancias qu\uedmicas e irritantes fue estad\uedsticamente significativa (p 1; 0.95-1.72). Se espera los resultados sirvan de marco de referencia a los interesados en el tema para la realizaci\uf3n de estudios ulteriores en distintos centros de salud a nivel regional y nacional, lo cual contribuir\ue1 al diagn\uf3stico, terap\ue9utica acertada y control sucesivo de dichas patolog\uedas. PALABRAS CLAVE: Rinosinusitis. Rinitis Al\ue9rgica. Factores de Riesgo. ABSTRACT Allergic Rhinitis and rinusinusitis, is a disease that affects the general population, though not serious, is important in the quality of life and school performance. Early diagnosis is necessary to avoid complications and thus establish a treatment protocol. A cross-sectional study was conducted in order to determine risk factors rinusinusitis as a complication of allergic rhinitis in young adult patients attending the outpatient department of otolaryngology at the Hospital Central Universitario Dr. "Antonio Maria Pineda". The sample was not random aspirational, consisting of 85 patients who met the criteria for inclusion of all patients diagnosed with allergic rhinitis who attended the consultation service of Otolaryngology. A mixed questionnaire and observation for the physical examination was used. It was reported between the results: 55 % of people are aged 15-20 years, being predominantly male group ( 54 % ) , symptoms varied by VAS highlighting the moderate discomfort pruritus ( 50%) and sneezing ( 47 % ) . Moreover, 85 % of patients showed changes tomographic; Also, the Paranasal Sinus most affected ( 42 %) was the ethmoid; regarding risk factors and exposure to chemical irritants was statistically significant ( p 1; 0.95-1.72 ) . It is hoped the results serve as a frame of reference for those interested in the subject to perform further studies in different health centers at regional and national level , which will contribute to the diagnosis , successful therapy and subsequent control of these diseases. KEY WORDS: Rhinosinusitis. Allergic rhinitis. Risk Factors. <br

Callus culture development of two varieties of Tagetes erecta and carotenoid production

Background: The properties of natural pigments, such as antioxidants, functional,medical, and nutraceutical, have demonstrated the advantages of these natural compounds over synthetic ones. Some products are accepted only when they are pigmented with natural, food-quality colorants: for example poultry products (manly marigold flower extracts). Carotenoids such as \u3b2-carotene, \u3b2-criptoxanthin and lutein are very attractive as natural food colorants due to their antioxidant and pro-vitamin activities which provide additional value to the target products. Marigold ( Tagetes erecta ) is an Asteraceous ornamental plant native to Mexico, and it is also important as a carotenoid source for industrial and medicinal purposes but nowadays its production is destined mainly for ornamental purposes. Results: Friable callus of T. erecta yellow flower (YF) and white flower (WF) varieties was induced from leaf explants on Murashige and Skoog (MS) medium supplemented with 9.0 \u3bcM 4-dichlorophenoxyacetic acid (2,4-D) and 8.8 \u3bcM benzyladenine (BA). Calluses developed from both varieties were different in pigmentation. Extract characterization from callus cultures was carried out by high-performance liquid chromatography (HPLC). This analytical process detected several carotenoids; the main pigments in extracts from YF callus were lutein and zeaxanthin, whereas in the extracts of the WF callus the main pigmentswere lutein, zeaxanthin, \u3b2-cryptoxanthin and \u3b2-carotene. Callus cultures of T. erecta accumulated pigments even after several rounds of subculture. Conclusions: WF callus appeared to be a suitable candidate as a source of different carotenoids, and tested varieties could represent an alternative for further studies about in vitro pigment production

TOI-1055 b: Neptunian planet characterised with HARPS, TESS, and CHEOPS

Context. TOI-1055 is a Sun-like star known to host a transiting Neptune-sized planet on a 17.5-day orbit (TOI-1055 b). Radial velocity (RV) analyses carried out by two independent groups using nearly the same set of HARPS spectra have provided measurements of planetary masses that differ by ∼2σ. Aims. Our aim in this work is to solve the inconsistency in the published planetary masses by significantly extending the set of HARPS RV measurements and employing a new analysis tool that is able to account and correct for stellar activity. Our further aim was to improve the precision on measurements of the planetary radius by observing two transits of the planet with the CHEOPS space telescope. Methods. We fit a skew normal function to each cross correlation function extracted from the HARPS spectra to obtain RV measurements and hyperparameters to be used for the detrending. We evaluated the correlation changes of the hyperparameters along the RV time series using the breakpoint technique. We performed a joint photometric and RV analysis using a Markov chain Monte Carlo scheme to simultaneously detrend the light curves and the RV time series. Results. We firmly detected the Keplerian signal of TOI-1055 b, deriving a planetary mass of Mb = 20.4-2.5+2.6 MO (∼12%). This value is in agreement with one of the two estimates in the literature, but it is significantly more precise. Thanks to the TESS transit light curves combined with exquisite CHEOPS photometry, we also derived a planetary radius of Rb = 3.490-0.064+0.070 RO (∼1.9%). Our mass and radius measurements imply a mean density of ρb = 2.65-0.35+0.37 g cm-3 (∼14%). We further inferred the planetary structure and found that TOI-1055 b is very likely to host a substantial gas envelope with a mass of 0.41-0.20+0.34 MO and a thickness of 1.05-0.29+0.30 RO. Conclusions. Our RV extraction combined with the breakpoint technique has played a key role in the optimal removal of stellar activity from the HARPS time series, enabling us to solve the tension in the planetary mass values published so far for TOI-1055 b

Factores de riesgo de rinusinusitis como complicaci\uf3n de rinitis al\ue9rgica en pacientes adultos jovenes. Consulta externa de otorrinolaringolog\ueda Hospital Central Universitario Dr. "Antonio Mar\ueda Pineda"

La Rinitis al\ue9rgica y rinusinusitis, es una enfermedad que afecta a la poblaci\uf3n general y, aunque no es grave, tiene importancia en la calidad de vida y el rendimiento escolar. El diagn\uf3stico precoz es necesario para evitar complicaciones y de esta manera establecer un protocolo de tratamiento. En este orden de idea, se realiz\uf3 un estudio de corte transversal, con el objetivo de determinar los factores de riesgo de rinusinusitis como complicaci\uf3n de Rinitis Al\ue9rgica en pacientes adultos j\uf3venes que acudieron a la consulta externa de otorrinolaringolog\ueda del Hospital Universitario Dr. \u93Antonio Mar\ueda Pineda\u94. La muestra fue no probabil\uedstica de tipo intencional, conformada por 85 pacientes que cumplieron los criterios de inclusi\uf3n del total de pacientes diagnosticados con Rinitis Al\ue9rgica que asistieron a la consulta del servicio de Otorrinolaringolog\ueda. Se utiliz\uf3 un cuestionario mixto y la observaci\uf3n para el examen f\uedsico. Se report\uf3 entre los resultados: 55% de las personas tienen edades entre 15 a 20 a\uf1os, siendo predominante el grupo masculino (54%), la sintomatolog\ueda vari\uf3 seg\ufan la escala EVA destac\ue1ndose la molestia moderada en prurito (50%) y estornudos (47%). Por otra parte, 85% de los pacientes mostraron cambios Tomogr\ue1ficos; asimismo, el Seno Paranasal m\ue1s afectado (42%) fue el etmoidal; en cuanto a los factores de riesgo la exposici\uf3n a sustancias qu\uedmicas e irritantes fue estad\uedsticamente significativa (p< 0.05), no obstante, epidemiol\uf3gicamente no es un factor de riesgo (Rp > 1; 0.95-1.72). Se espera los resultados sirvan de marco de referencia a los interesados en el tema para la realizaci\uf3n de estudios ulteriores en distintos centros de salud a nivel regional y nacional, lo cual contribuir\ue1 al diagn\uf3stico, terap\ue9utica acertada y control sucesivo de dichas patolog\uedas

Dosimetry of 51MnCl2 and 52MnCl2 for PET application

Manganese has been so far mainly used for in-vivo animal studies of tissue anatomy of liver, kidneys, heart and pancreas, as well as to monitor cellular activity, cytoarchitecture and neuronal tract tracing in the brain by using the so-called Manganese-Enhanced Magnetic Resonance Imaging (MEMRI)-based techniques. However, the large amount of manganese necessary for MEMRI may induce neurotoxic effects that result in manganism, a neurological syndrome similar to Parkinson\u2019s disease. The much higher sensitivity of positron emission tomography (PET) over MRI enables, instead, the use of non-toxic trace level concentrations of Mn. The radioisotopes 52Mn (t1/2= 5.591 d, \u3b2+= 29.4%, E(\u3b2+)avg= 241.6 keV) and 51Mn (t1/2= 45.59 min, \u3b2+=97.1%, E(\u3b2+)avg = 970.2 keV) have already been used for preclinical PET imaging in the past, mainly administered in free ionic form as MnCl2 1-2. However, internal radiation dose assessment due to the administration of 52MnCl2 to humans is still missing, while only one study has been reported for 51MnCl2 dosimetry calculations2. The aim of this work is to fill this gap by assessing the radiation effective dose (ED) of 51MnCl2 and 52MnCl2

New distribution record of Cybocephalus kathrynae (Coleoptera, Cybocephalidae) on Mona Island, Puerto Rico

New distribution record of Cybocephalus Kathrynae (Coleoptera, Cybocephalidae) on Mona Island, Puerto Rico. A new record of Cybocephalus kathrynae T.R. Smith (Cybocephalidae) is reported for Puerto Rico. Adults were collected from the flowers of Mammillaria nivosa (Cactaceae) on Mona Island Reserve. Prior to this study, this beetle species was only reported for Monroe and Miami-Dade Counties, Florida, USA.<br>Novo registro de distribuição de Cybocephalus Kathrynae (Coleoptera, Cybocephalidae) na Ilha de Mona, Puerto Rico. Um novo registro de Cybocephalus kathrynae T. R. Smith (Cybocephalidae) é reportado para Puerto Rico. Os adultos foram coletados em flores de Mammillaria nivosa (Cactaceae) na Reserva da Ilha de Mona. Antes da realização deste estudo, esta espécie apenas havia sido registrada nos condados de Monroe e Miami-Dade na Florida, EUA

Dosimetric analysis of the contribution of Radionuclides Coproduced through natV(p,x)47Sc reaction route in Cyclotron Irradiation

Scandium presents different radionuclides with good imaging and therapeutic properties for the development of theranostic radiopharmaceuticals. In particular, 47Sc (t1/2= 3.35 d) has suitable features both for SPECT imaging, thanks to the 159 keV \u3b3-ray emission, and for treatment of small-size tumours, thanks to the intense \u3b2 12 emission (mean \u3b2 12 energy: 162.0 keV). Its efficacy has been demonstrated at preclinical stage, but its low availability has however limited the application of 47Sc-based radiopharmaceuticals to the clinic. Among the different proposed production routes, the natV(p,x)47Sc nuclear reaction is of particular interest, due to the low-cost and easy availability of the target material, as well as the widespread availability of medium-energy cyclotrons. However, the nuclear cross section of this reaction is quite low and small amounts of Sc radioactive contaminants are co-produced. The aim of this work is to evaluate the contribution of Sc-contaminants to the patient radiation dose

CUBES: cassegrain U-band Brazil-ESO spectrograph

CUBES is a high-efficiency, medium-resolution (R 3c20,000) ground based UV (300\u2013400 nm) spectrograph, to be installed in the cassegrain focus of one of ESO\u2019s VLT unit telescopes in 2017/18. The CUBES project is a joint venture between ESO and IAG/USP, and LNA/MCTI. CUBES will provide access to a wealth of new and relevant information for stellar as well as extragalactic sources. Main science cases include the study of beryllium and heavy elements in metal-poor stars, the direct determination of carbon, nitrogen and oxygen abundances by study of molecular bands in the UV range, as well as the study of active galactic nuclei and the quasar absorption lines. With a streamlined modern instrument design, high efficiency dispersing elements and UV-sensitive detectors, it will give a significant gain in sensitivity over existing ground based medium-high resolution spectrographs, enabling vastly increased sample sizes accessible to the astronomical community. We present here a brief overview of the project including the status, science cases and a discussion of the design options