Innovation and growth in family-owned Mexican SMEs

This paper studies the relationship between innovation and the level of growth in family-owned small and medium-sized enterprises (SMEs), this is done within the context of Mexico. The conceptual framework of analysis is based on the hypothesis that innovation in products, processes and management systems contribute to the achievement of growth in family-owned SMEs. To test this hypothesis, a model of structural equation of second order was developed with data collected from 206 family-owned SMEs located in the state of Aguascalientes, Mexico. The empirical evidence provided by the analysis supports the hypothesis, showing that family-owned SMEs that increase their innovation activities will also significantly increase their opportunities for growth. This finding can be used to inform the business growth strategies formulated by the owners, or managers, of family-owned SEMs. These also indicate policy-makers that by designing effective policies and providing incentives to support innovation in family-owned SMEs, the government would not only contribute to the growth of these organisations but also to the growth of their regions and countries. Despite the importance of innovation and family-owned SMEs, evidence suggests that studies focused on investigating innovation in this type of organisations are very limited. This paper fills this gap by providing a refined understanding of the relationship between innovation and growth in family-owned SMEs

Activity of Thioallyl Compounds From Garlic Against Giardia duodenalis Trophozoites and in Experimental Giardiasis

Fresh aqueous extracts (AGEs) and several thioallyl compounds (TACs) from garlic have an important antimicrobial activity that likely involves their interaction with exposed thiol groups at single aminoacids or target proteins. Since these groups are present in Giardia duodenalis trophozoites, in this work we evaluated the anti-giardial activity of AGE and several garlic's TACs. In vitro susceptibility assays showed that AGE affected trophozoite viability initially by a mechanism impairing cell integrity and oxidoreductase activities while diesterase activities were abrogated at higher AGE concentrations. The giardicidal activities of seven TACs were related to the molecular descriptor HOMO (Highest Occupied Molecular Orbital) energy and with their capacity to modify the –SH groups exposed in giardial proteins. Interestingly, the activity of several cysteine proteases in trophozoite lysates was inhibited by representative TACs as well as the cytopathic effect of the virulence factor giardipain-1. Of these, allicin showed the highest anti-giardial activity, the lower HOMO value, the highest thiol-modifying activity and the greatest inhibition of cysteine proteases. Allicin had a cytolytic mechanism in trophozoites with subsequent impairment of diesterase and oxidoreductase activities in a similar way to AGE. In addition, by electron microscopy a marked destruction of plasma membrane and endomembranes was observed in allicin-treated trophozoites while cytoskeletal elements were not affected. In further flow cytometry analyses pro-apoptotic effects of allicin concomitant to partial cell cycle arrest at G2 phase with the absence of oxidative stress were observed. In experimental infections of gerbils, the intragastric administration of AGE or allicin decreased parasite numbers and eliminated trophozoites in experimentally infected animals, respectively. These data suggest a potential use of TACs from garlic against G. duodenalis and in the treatment of giardiasis along with their additional benefits in the host's health

Evidence of spatial clustering of childhood acute lymphoblastic leukemia cases in Greater Mexico City: report from the Mexican Inter-Institutional Group for the identification of the causes of childhood leukemia

BackgroundA heterogeneous geographic distribution of childhood acute lymphoblastic leukemia (ALL) cases has been described, possibly, related to the presence of different environmental factors. The aim of the present study was to explore the geographical distribution of childhood ALL cases in Greater Mexico City (GMC).MethodsA population-based case-control study was conducted. Children <18 years old, newly diagnosed with ALL and residents of GMC were included. Controls were patients without leukemia recruited from second-level public hospitals, frequency-matched by sex, age, and health institution with the cases. The residence address where the patients lived during the last year before diagnosis (cases) or the interview (controls) was used for geolocation. Kulldorff’s spatial scan statistic was used to detect spatial clusters (SCs). Relative risks (RR), associated p-value and number of cases included for each cluster were obtained.ResultsA total of 1054 cases with ALL were analyzed. Of these, 408 (38.7%) were distributed across eight SCs detected. A relative risk of 1.61 (p<0.0001) was observed for the main cluster. Similar results were noted for the remaining seven ones. Additionally, a proximity between SCs, electrical installations and petrochemical facilities was observed.ConclusionsThe identification of SCs in certain regions of GMC suggest the possible role of environmental factors in the etiology of childhood ALL

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Analysis of null sets (zero catch) made by the Mexican tuna purse seine fleet (2000–2013)

The world tuna fishing fleet is dominated by purse seine boats. Purse seine sets are sometimes unsuccessful in capturing fish; these unsuccessful attempts are known as null sets. Null sets have been widely documented and the numbers indicate that they happen in large proportions. In Mexico, the tuna fishery represents the second most important fishery by volume and value. The frequency of occurrence of null sets during the period 2000–2013 was analyzed to identify the regions, periods, and oceanographic conditions (e.g., ENSO) related to them. Null sets on free-swimming fish schools and between June and July had a higher relative representation. The region with highest relative occurrence was the mouth of the Gulf of California (between August and October). A positive correlation was observed between the occurrence of null sets on free-swimming fish schools and the Multivariate El Niño Index. The maximum values of occurrence of null sets were related to those months in which the water column structure presented changes. Comprehension of this phenomenon (null sets) and its relation to natural events is of importance for the fishery, as there could be repercussions for the economy and management of the resource

Depth and hydrodynamics as tools to select aquaculture areas in the coastal zone

An index was created for the spatial classification of oyster cultivation areas in terms of their potential productivity in Falsa Bay, San Quintín (Baja California, Mexico). The index included two main variables crucial for oyster development: food availability and depth. Food availability was based on the final distribution of particulate organic material; it is a passive variable that is transported by tidal currents. A balance was obtained between the volume incorporated into the bay by tidal inflow and its consumption by the organisms distributed in the cultivated areas, which are characterized by the percentage of cultivated areas within the bay. The distribution area of depth was obtained from a five-interval classification scale that allowed the identification of the highest and least exposure of the cultivation area to the proposed food availability. Both criteria were combined into one value in order to divide the bay region into zones in relative terms and determine which are the best suited for oyster cultivation. Given the characteristics of the area and production volume, food availability did not appear to be a limiting factor, and culture depth was the main factor controlling the zonal quality. A comparison of the index values and cultivated oyster growth rates showed that the higher index values corresponded to faster growth rates and vice versa.

Acute Exercise Effect on Glomerular Filtration in the Elderly

Introduction: There is a decrease in Glomerular Filtration Rate (GFR) in older adults and the exercise practice may lead to changes in renal function. Purpose: To evaluate the effect of different intensities of acute exercise on elderly population GFR. Methods: 20 apparently healthy older adults (69,8 ± 4 years) performed 3 exercise tests a week apart: one maximal and 2 submaximal (80% and 60%). Blood samples were collected to determine serum creatinine and to estimate GFR, before and after each exercise test. Results: A significant post-exercise decline in GFR, estimated from serum creatinine values, was observed in the maximal and submaximal 80% tests (p <0,05). Conclusion: Maximum and sub-maximum acute physical exercise at 80% intensity causes a decrease in glomerular filtration in apparently healthy older adults

Three-dimensional exchange flows in a semi-enclosed bay: Numerical simulations and high frequency radar observations

In this work we present the exchange flows between a semi-enclosed Bay and the adjacent ocean as measured by a real-time coastal observing system in Baja California, Mexico. Several sources of information as numerical modeling, currents profile data, high frequency radar observations and drifters tracking, all together show an interesting three-dimensional structure to the exchange flows. The northern entrance (relatively shallow, ~40 m at its deepest portion) showed an estuarine-like exchange pattern, with a net outflow at the shallow parts and inflow at the deepest, suggesting that the frictional effect is more important than the earth's rotation, as typically observed in relatively small bodies of water like estuaries and coastal lagoons. On the other hand, the southern entrance (with a ~400 m deep canyon) is more complex, with recurrent anticyclonic exchange pattern with inflows at the western limit and outflows at the east. We suggest that the vertical structure of this circulation may be sustained by the deep canyon which lowers the thermocline, but further investigation is needed