The role of endothelial cells in hematologic malignancies

A neoformação vascular constitui evento essencial para que ocorra o desenvolvimento humano. Nesta fase, o sistema vascular sofre expansão. Células endoteliais maduras (ECs) irão compor a parede dos vasos, enquanto células endoteliais oriundas da medula óssea (MO) migram para locais de neoformação vascular com subseqüente diferenciação em células endoteliais maduras. Processos fisiológicos e patológicos como câncer têm a angiogênese como importante componente. Estudos correlacionam a angiogênese com a agressividade tumoral em alguns tipos de tumores incluindo hematológicos, o que ressalta a importância da terapia antiangiogênica como alvo de pesquisas cada vez mais profundas. Neste artigo de revisão enfocamos o papel da angiogênese nas neoplasias hematológicas com ênfase em possíveis alvos terapêuticos.Vascular neoformation is an essential event in the development of the human body. In this phase vascular networks undergo expansion. Mature endothelial cells constitute the structure of vessel walls so endothelial cells from bone marrow migrate to sites of vascular neoformation with subsequent differentiation as mature endothelial cells (endothelial progenitor cells). Physiopathological and pathological processes such as cancer use angiogenesis as an important component for growth. Studies correlate angiogenesis with aggressive tumors for some types of tumors, including hematological malignancies, thereby highlighting the importance of anti-angiogenic therapy

Using chatbot technology to improve Brazilian adolescents' body image and mental health at scale: Randomized controlled trial

Accessible, cost-effective, and scalable mental health interventions are limited, particularly in low- and middle-income countries, where disparities between mental health needs and services are greatest. Microinterventions (ie, brief, stand-alone, or digital approaches) aim to provide immediate reprieve and enhancements in mental health states and offer a novel and scalable framework for embedding evidence-based mental health promotion techniques into digital environments. Body image is a global public health issue that increases young peoples' risk of developing more severe mental and physical health issues. Embedding body image microinterventions into digital environments is one avenue for providing young people with immediate and short-term reprieve and protection from the negative exposure effects associated with social media. This 2-armed, fully remote, and preregistered randomized controlled trial assessed the impact of a body image chatbot containing microinterventions on Brazilian adolescents' state and trait body image and associated well-being outcomes. Geographically diverse Brazilian adolescents aged 13-18 years (901/1715, 52.54% girls) were randomized into the chatbot or an assessment-only control condition and completed web-based self-assessments at baseline, immediately after the intervention time frame, and at 1-week and 1-month follow-ups. The primary outcomes were mean change in state (at chatbot entry and at the completion of a microintervention technique) and trait body image (before and after the intervention), with the secondary outcomes being mean change in affect (state and trait) and body image self-efficacy between the assessment time points. Most participants who entered the chatbot (258/327, 78.9%) completed ≥1 microintervention technique, with participants completing an average of 5 techniques over the 72-hour intervention period. Chatbot users experienced small significant improvements in primary (state: P<.001, Cohen d=0.30, 95% CI 0.25-0.34; and trait body image: P=.02, Cohen d range=0.10, 95% CI 0.01-0.18, to 0.26, 95% CI 0.13-0.32) and secondary outcomes across various time points (state: P<.001, Cohen d=0.28, 95% CI 0.22-0.33; trait positive affect: P=.02, Cohen d range=0.15, 95% CI 0.03-0.27, to 0.23, 95% CI 0.08-0.37; negative affect: P=.03, Cohen d range=-0.16, 95% CI -0.30 to -0.02, to -0.18, 95% CI -0.33 to -0.03; and self-efficacy: P=.02, Cohen d range=0.14, 95% CI 0.03-0.25, to 0.19, 95% CI 0.08-0.32) relative to the control condition. Intervention benefits were moderated by baseline levels of concerns but not by gender. This is the first large-scale randomized controlled trial assessing a body image chatbot among Brazilian adolescents. Intervention attrition was high (531/858, 61.9%) and reflected the broader digital intervention literature; barriers to engagement were discussed. Meanwhile, the findings support the emerging literature that indicates microinterventions and chatbot technology are acceptable and effective web-based service provisions. This study also offers a blueprint for accessible, cost-effective, and scalable digital approaches that address disparities between health care needs and provisions in low- and middle-income countries. Clinicaltrials.gov NCT04825184; http://clinicaltrials.gov/ct2/show/NCT04825184. RR2-10.1186/s12889-021-12129-1. [Abstract copyright: ©Emily L Matheson, Harriet G Smith, Ana C S Amaral, Juliana F F Meireles, Mireille C Almeida, Jake Linardon, Matthew Fuller-Tyszkiewicz, Phillippa C Diedrichs. Originally published in JMIR mHealth and uHealth (https://mhealth.jmir.org), 19.06.2023.

Educação Física Escolar: Percepções do Aluno com Deficiência1

RESUMO: a inclusão de alunos com deficiência é prevista em lei e manter boas estruturas físicas e pedagógicas na escola é um ponto fundamental para que o acesso possa acontecer. A Educação Física faz parte desta inclusão e pode proporcionar grandes melhoras na qualidade de vida de alunos com deficiência. Este estudo teve como objetivo compreender as percepções do aluno com deficiência a respeito das aulas de Educação Física. Para isso foi realizada uma pesquisa de natureza qualitativa utilizando para coleta de dados uma entrevista semiestruturada a qual foi gravada, transcrita e posteriormente analisada. A amostra foi constituída de 20 alunos com deficiência matriculados em escolas regulares da cidade de Santos Dumont - MG. A partir das entrevistas, destacou-se a percepção do aluno com deficiência a respeito da Educação Física escolar; o entendimento deles quanto ao conceito de qualidade de vida; as melhoras proporcionadas na qualidade de vida através da Educação Física; as facilidades e as dificuldades nas aulas; e as questões concernentes à relação aluno/professor e aluno/aluno. Os resultados dessa pesquisa podem auxiliar a comunidade escolar e o professor de Educação Física a melhorarem a inclusão nas escolas regulares. Além disso, as percepções dos alunos com deficiência sobre as aulas podem ajudar o professor na busca de um ambiente melhor com aulas que atendam a todos e proporcionem uma melhor qualidade de vida

A list of land plants of Parque Nacional do Caparaó, Brazil, highlights the presence of sampling gaps within this protected area

Brazilian protected areas are essential for plant conservation in the Atlantic Forest domain, one of the 36 global biodiversity hotspots. A major challenge for improving conservation actions is to know the plant richness, protected by these areas. Online databases offer an accessible way to build plant species lists and to provide relevant information about biodiversity. A list of land plants of “Parque Nacional do Caparaó” (PNC) was previously built using online databases and published on the website "Catálogo de Plantas das Unidades de Conservação do Brasil." Here, we provide and discuss additional information about plant species richness, endemism and conservation in the PNC that could not be included in the List. We documented 1,791 species of land plants as occurring in PNC, of which 63 are cited as threatened (CR, EN or VU) by the Brazilian National Red List, seven as data deficient (DD) and five as priorities for conservation. Fifity-one species were possible new ocurrences for ES and MG states

Avaliação psicométrica do Questionário de Mudança Corporal para adolescentes

Resumo O estudo objetivou analisar a validade de construto, consistência interna e reprodutibilidade do Questionário de Mudança Corporal (QMC). Foram avaliados 439 meninas e meninos (13 a 22 anos). A validade de construto foi avaliada por meio da análise fatorial exploratória e correlações entre os escores do QMC, Body Shape Questionnaire (BSQ) e Escala de Silhuetas (ES). A confiabilidade foi acessada usando-se a consistência interna, e a reprodutibilidade pelo teste-reteste e pela correlação intraclasse. A escala apresentou estrutura fatorial composta por seis fatores, os quais representaram quase em sua totalidade as subescalas do instrumento. As correlações para a amostra total entre o QMC e as outras escalas variaram de 0,37 a 0,46. A consistência interna apresentou valores entre 0,78 e 0,96 para cada um dos fatores, e a correlação intraclasse foi condizente com uma boa reprodutibilidade. Os escores do teste-reteste não apresentaram diferenças significantes para a amostra total e entre os sexos. Conclui-se que o QMC apresenta boas qualidades psicométricas para os adolescentes brasileiros

Agreement Between 2 Bioimpedance Devices for Estimating Body Composition in Pregnant Women

INTRODUCTION: Body composition is an important metric in pregnant women for assessing risk of metabolic disorders such as gestational diabetes mellitus. The InBody (IB) 720 and InBody 230 (InBody, Seoul, South Korea) are multi-frequency bioelectrical impedance analysis (BIA) devices used to estimate body composition. The IB720 is a research-grade device while the IB230 is a portable device. Previous studies have assessed the agreement of BIA devices in general population adults but not in pregnant women. The purpose of this investigation was to evaluate the reliability of the IB230 and IB720 to measure total body water (TBW), total lean mass (TLM), and total fat mass (TFM) in pregnant women. METHODS: Thirty-two pregnant women (27.0±7.8 years; BMI 31.8±4.5 kg/m2, 68.8% Caucasian) were evaluated using the IB720 and the IB230 at 19-21 weeks gestation. Total body water (TBW), total lean mass (TLM), and total fat mass (TFM) were estimated and compared using Pearson’s correlation coefficients. RESULTS: Average TBW was 34.8±5.1kg from IB720 and 34.9±5.41kg from IB230. Average TLM was 47.7±7.0kg from IB720 and 45.6±11.4kg from IB230. Average TFM was 34.7±15.2kg from IB720 and 34.6±14.7kg from IB230. Measures from IB720 and IB230 were strongly correlated for TBW, TLM, and TFM (r = 0.994, 0.663, 0.998, respectively, p\u3c0.01 for all (2-tailed)). CONCLUSION: The IB720 and IB230 produced similar measurements for TBW, TLM, and TFM. The data suggest that the portable and more accessible IB230 was in agreement with the IB720 and can be used to estimate body composition in pregnant women