Lay epidemiology and the interpretation of low-risk drinking guidelines by adults in the United Kingdom

Aims To explore how the concept of lay epidemiology can enhance understandings of how drinkers make sense of current UK drinking guidelines. Methods Qualitative study using 12 focus groups in four sites in northern England and four sites in central Scotland. Participants were 66 male and female drinkers, aged between 19 and 65 years, of different socio-economic backgrounds. Data were analysed thematically using a conceptual framework of lay epidemiology. Results Current drinking guidelines were perceived as having little relevance to participants' drinking behaviours and were generally disregarded. Daily guidelines were seen as irrelevant by drinkers whose drinking patterns comprised heavy weekend drinking. The amounts given in the guidelines were seen as unrealistic for those motivated to drink for intoxication, and participants measured alcohol intake in numbers of drinks or containers rather than units. Participants reported moderating their drinking, but this was out of a desire to fulfil work and family responsibilities, rather than concerns for their own health. The current Australian and Canadian guidelines were preferred to UK guidelines, as they were seen to address many of the above problems. Conclusions Drinking guidelines derived from, and framed within, solely epidemiological paradigms lack relevance for adult drinkers who monitor and moderate their alcohol intake according to their own knowledge and risk perceptions derived primarily from experience. Insights from lay epidemiology into how drinkers regulate and monitor their drinking should be used in the construction of drinking guidelines to enhance their credibility and efficacy

A new approach to measuring drinking cultures in Britain

First paragraph: When governments propose changes to alcohol policies, the announcement is often followed by public debate on the potential for the policy to change the country’s drinking culture. However, specifying what the drinking culture is, what is problematic about it, what it should be changed to, what interventions might trigger such a change and whether success has been achieved have all been problematic topics in alcohol policy discourse and the research literature

Local instability signatures in ALMA observations of dense gas in NGC7469

We present an unprecedented measurement of the disc stability and local instability scales in the luminous infrared Seyfert 1 host, NGC7469, based on ALMA observations of dense gas tracers and with a synthesized beam of 165 x 132 pc. While we confirm that non-circular motions are not significant in redistributing the dense interstellar gas in this galaxy, we find compelling evidence that the dense gas is a suitable tracer for studying the origin of its intensely high-mass star forming ring-like structure. Our derived disc stability parameter accounts for a thick disc structure and its value falls below unity at the radii in which intense star formation is found. Furthermore, we derive the characteristic instability scale and find a striking agreement between our measured scale of ~ 180 pc, and the typical sizes of individual complexes of young and massive star clusters seen in high-resolution images.Comment: Accepted for publication in ApJ Letter

Dyadic Coping Among Couples with COPD: A Pilot Study

COPD (chronic obstructive pulmonary disease) is associated with psychological distress for patients as well as their partners. Dyadic coping can be negatively impacted by stressors. This study's objective was to compare the dyadic coping of couples in which one partner suffered from COPD with healthy couples of the same age. A total of 43 complete couples with COPD and 138 healthy couples participated in this pilot study. The surveys were sent by mail. The response rate of the COPD sample was 24.3%. In order to analyze the effect of gender and role (patient vs. partner) on dyadic coping, linear mixed models were calculated. To analyze the effect of gender and group (COPD group vs. normative comparison group) on dyadic coping, two-way analyses of variance were calculated for independent samples. COPD patients and their partners indicated that the patients received more support and were less able to provide support to their partners. This difference was also evident in comparison with the normative comparison group. In addition, couples with COPD perceived higher levels of negative coping and provided a considerably lower assessment of their positive dyadic coping. The dyadic coping of couples with COPD is unbalanced and more negative when compared to that of healthy couples. Interventions aimed at supporting COPD couples should seek to improve couples' dyadic coping in addition to individual coping strategie

Audience synchronies in live concerts illustrate the embodiment of music experience

A study of 132 audience members of three classical public concerts (all three staged the same chamber music pieces by Ludwig van Beethoven, Brett Dean, and Johannes Brahms) had the goal of analyzing the physiological and motor responses of audiences. It was assumed that the music would induce synchronous physiology and movement in listeners (induction synchrony). In addition to hypothesizing that such synchronies would be present, we expected that they were linked to participants' aesthetic experiences, their affect and personality traits, which were assessed by questionnaires before and after the concerts. Clear evidence was found of physiological synchrony (heart rate, respiration rate, skin conductance response) as well as movement synchrony of the audiences, whereas breathing behavior was not synchronized. Thus the audiences of the three concerts resonated with the music, their music perception was embodied. There were links between the bodily synchrony and aesthetic experiences: synchrony, especially heart-rate synchrony, was higher when listeners felt moved emotionally and inspired by a piece, and were immersed in the music. Personality traits were also associated with the individual contributions to induction synchrony

ALMA follows streaming of dense gas down to 40 pc from the supermassive black hole in NGC1097

We present a kinematic analysis of the dense molecular gas in the central 200 parsecs of the nearby galaxy NGC1097, based on Cycle 0 observations with the Atacama Large Millimeter/sub-millimeter Array (ALMA). We use the HCN(4-3) line to trace the densest interstellar molecular gas, and quantify its kinematics, and estimate an inflow rate for the molecular gas. We find a striking similarity between the ALMA kinematic data and the analytic spiral inflow model that we have previously constructed based on ionized gas velocity fields on larger scales. We are able to follow dense gas streaming down to 40 pc distance from the supermassive black hole in this Seyfert 1 galaxy. In order to fulfill marginal stability, we deduce that the dense gas is confined to a very thin disc, and we derive a dense gas inflow rate of 0.09 Msun/yr at 40 pc radius. Combined with previous values from the Ha and CO gas, we calculate a combined molecular and ionized gas inflow rate of 0.2 Msun/yr at 40 pc distance from the central supermassive black hole of NGC1097.Comment: Accepted for Publication in the ApJ Letter

Metabolic landscape of the male mouse gut identifies different niches determined by microbial activities.

Distinct niches of the mammalian gut are populated by diverse microbiota, but the contribution of spatial variation to intestinal metabolism remains unclear. Here we present a map of the longitudinal metabolome along the gut of healthy colonized and germ-free male mice. With this map, we reveal a general shift from amino acids in the small intestine to organic acids, vitamins and nucleotides in the large intestine. We compare the metabolic landscapes in colonized versus germ-free mice to disentangle the origin of many metabolites in different niches, which in some cases allows us to infer the underlying processes or identify the producing species. Beyond the known impact of diet on the small intestinal metabolic niche, distinct spatial patterns suggest specific microbial influence on the metabolome in the small intestine. Thus, we present a map of intestinal metabolism and identify metabolite-microbe associations, which provide a basis to connect the spatial occurrence of bioactive compounds to host or microorganism metabolism